β-tubulin mutations

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		UTN	AA1	Tubulin	Tub Link	Species	Phenotype	AA3	Reference	Ref link	Keywords	Notes
		β1	M1I	Q9BVA1	https://www.uniprot.org/uniprotkb/Q9BVA1/entry	H. sapiens	TBB2B SNP, DOID:1115 / sarcoma	Met1Ile	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BVA1	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β1	M1R	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	TUBB SNP, DOID:4362 / cervical cancer	Met1Arg	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P07437	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β1	M1R	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:3571 / liver cancer	Met1Arg	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β2	D2G	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Uncertain significance, with D74G, tubulin beta-3	Asp2Gly	ClinVar 872055	https://www.ncbi.nlm.nih.gov/clinvar/variation/872055	Homo sapiens, human, clinical
		β2	R2A	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Benomyl supersensitive, with E3A, TUB2p	Arg2Ala	Reijo et al. 1994. Mol Biol Cell 5:29-43	https://pubmed.ncbi.nlm.nih.gov/8186463/	Saccharomyces cerevisiae, budding yeast, fungus
		β2	R2G	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Hereditory dystonia, tubulin beta-4A	Arg2Gly	Hersheson et al. 2013. Ann Neurol 73:546-53	https://pubmed.ncbi.nlm.nih.gov/23424103/	Homo sapiens, human, clinical
		β2	R2G	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Spasmodic dysphonia, tubulin beta-4A	Arg2Gly	Lohmann et al. 2013. Ann Neurol 73:537-45	https://pubmed.ncbi.nlm.nih.gov/23595291/	Homo sapiens, human, clinical
		β2	R2G	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Whispering dystonia, neuronal morphology, tubulin beta-4A	Arg2Gly	Curiel et al. 2017. Hum Mol Genet 26:4506-4518	https://pubmed.ncbi.nlm.nih.gov/28973395/	Homo sapiens, human, clinical
		β2	R2G	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Whispering dysphonia, TUBB4A	Arg2Gly	Garg et al. 2023. Ann Indian Acad Neurol 26: 195-7	https://pubmed.ncbi.nlm.nih.gov/37179668/	Homo sapiens, human, clinical
		β2	R2G	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Torsion dystonia, leukodystrophy, hypomyelinating, with R53G, R47G, tubulin beta-4A	Arg2Gly	ClinVar 50984	https://www.ncbi.nlm.nih.gov/clinvar/variation/50984	Homo sapiens, human, clinical
		β2	R2G	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	No polymerization differences, tubulin beta-4A	Arg2Gly	Krajka et al. 2022. Sci. Adv. 8:eabj9229.	https://pubmed.ncbi.nlm.nih.gov/35275727/	Homo sapiens, human, clinical
		β2	R2H	A0A8C0T7N2	https://www.uniprot.org/uniprotkb/A0A8C0T7N2/entry	C. familiaris	Macrothrombocytopenia, tubulin-beta-1	Arg2His	Gelain et al. 2014. Vet Clin Pathol 43:317-21	https://pubmed.ncbi.nlm.nih.gov/25060661/	Canis familiaris, dog
		β2	R2H	Q13885	https://www.uniprot.org/uniprotkb/Q13885/entry	H. sapiens	Tubulinopathy, brain malformations, tubulin beta-2A	Arg2His	Brock et al. 2021. J Med Genet 58:33-40	https://pubmed.ncbi.nlm.nih.gov/32571897/	Homo sapiens, human, clinical
		β2	R2K	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Defects in oocyte meiosis, tubulin beta-8	Arg2Lys	Feng et al. 2016. N Engl J Med 374:223-32	https://pubmed.ncbi.nlm.nih.gov/26789871/	Homo sapiens, human, clinical
		β2	R2K	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Oocyte maturation defect, tubulin beta-8	Arg2Lys	ClinVar 221268	https://www.ncbi.nlm.nih.gov/clinvar/variation/221270	Homo sapiens, human, clinical
		β2	R2L	Q13885	https://www.uniprot.org/uniprotkb/Q13885/entry	H. sapiens	Likely pathogenic, tubulin beta-2A	Arg2Leu	ClinVar 809860	https://www.ncbi.nlm.nih.gov/clinvar/variation/809860	Homo sapiens, human, clinical
		β2	R2M	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Infertility due to arrest in oocyte maturation, tubulin beta-8	Arg2Met	Chen et al. 2017. Hum Reprod 32:457-464.	https://pubmed.ncbi.nlm.nih.gov/27989988/	Homo sapiens, human, clinical
		β2	R2Q	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Hypomyelination, basal ganglia & cerebellum atrophy, tubulin beta-4A	Arg2Gln	Hamilton et al. 2014. Brain 137:1921-30	https://pubmed.ncbi.nlm.nih.gov/24785942/	Homo sapiens, human, clinical
		β2	R2Q	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Hypomyelination, basal ganglia & cerebellum atrophy (H-ABC), tubulin beta-4A	Arg2Gln	Miyatake et al. 2014. Neurology 82:2230-7	https://pubmed.ncbi.nlm.nih.gov/24850488/	Homo sapiens, human, clinical
		β2	R2Q	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with R53Q, R47Q, tubulin beta-4A	Arg2Gln	ClinVar 139452	https://www.ncbi.nlm.nih.gov/clinvar/variation/139452	Homo sapiens, human, clinical
		β2	R2S	Q9BVA1	https://www.uniprot.org/uniprotkb/Q9BVA1/entry	H. sapiens	TBB2B SNP, DOID:1115 / sarcoma	Arg2Ser	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BVA1	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β2	R2W	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:3963 / thyroid carcinoma	Arg2Trp	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β2	R2W	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Hypomyelination, basal ganglia & cerebellum atrophy, tubulin beta-4A, 2 patients	Arg2Trp	Hamilton et al. 2014. Brain 137:1921-30	https://pubmed.ncbi.nlm.nih.gov/24785942/	Homo sapiens, human, clinical
		β2	R2W	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Perturbed microtubule polymerization, tubulin beta-4A	Arg2Trp	Krajka et al. 2022. Sci. Adv. 8:eabj9229.	https://pubmed.ncbi.nlm.nih.gov/35275727/	Homo sapiens, human, clinical
		β2	R2W	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with R53W, R47W, tubulin beta-4A	Arg2Trp	ClinVar 267773	https://www.ncbi.nlm.nih.gov/clinvar/variation/267773	Homo sapiens, human, clinical
		β3	E3A	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Benomyl supersensitive, with R2A, TUB2p	Glu3Ala	Reijo et al. 1994. Mol Biol Cell 5:29-43	https://pubmed.ncbi.nlm.nih.gov/8186463/	Saccharomyces cerevisiae, budding yeast, fungus
		β3	E3D	P61857	https://www.uniprot.org/uniprotkb/P61857/entry	D. melanogaster	Intragenic suppressor of E194K Beta2tD allele	Glu3Asp	Fackenthal et al. 1995. Genetics 139:267-86	https://pubmed.ncbi.nlm.nih.gov/7705629/	Drosophila, fruitfly
		β3	E3G	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	TUBB SNP, DOID:9256 / colorectal cancer	Glu3Gly	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P07437	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β3	E3G	P99024	https://www.uniprot.org/uniprotkb/P99024/entry	M. musculus	Tubb5, viable heterozygote	Glu3Gly	Mutagenetix	https://mutagenetix.utsouthwestern.edu/incidental/incidental_rec.cfm?mid=515524	Mus musculus, mouse, tubulin beta-5	Wang et al. 2015. PNAS 112:E440-449 (PMID 25605905)
		β3	E3K	P12456	https://www.uniprot.org/uniprotkb/P12456/entry	C. elegans	Loss-of-function, shortened PLM-PN, mec-7	Glu3Lys	Lee et al. 2021. Mol Biol Cell. 15:331-347	https://pubmed.ncbi.nlm.nih.gov/33378215/	Caenorhabditis elegans, nematode, roundworm
		β3	E3Q	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:5041 / esophageal cancer	Glu3Gln	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13885	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β4	I4L	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	TUBB SNP, DOID:263 / kidney cancer	Ile4Leu	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P07437	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β4	I4L	Q9BVA1	https://www.uniprot.org/uniprotkb/Q9BVA1/entry	H. sapiens	TBB2B SNP, DOID:3371 / chondrosarcoma	Ile4Leu	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BVA1	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β4	I4L	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Infertility due to arrest in oocyte maturation, tubulin beta-8	Ile4Leu	Chen et al. 2017. Hum Reprod 32:457-464.	https://pubmed.ncbi.nlm.nih.gov/27989988/	Homo sapiens, human, clinical
		β4	I4L	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Female infertility, tubulin beta-8	Ile4Leu	Chen et al. 2019. Eur J Hum Genet 27:300-307	https://pubmed.ncbi.nlm.nih.gov/30297906/	Homo sapiens, human, clinical
		β4	I4L	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Female infertility, tubulin beta-8	Ile4Leu	Yang et al. 2021. Clin Genet 99:208-214	https://pubmed.ncbi.nlm.nih.gov/33009822/	Homo sapiens, human, clinical
		β4	I4L	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Human oocyte maturation defects and female infertility, TUBB8	Ile4Leu	Lin et al. 2023. Reprod Biomed Online 46(2):244-254	https://pubmed.ncbi.nlm.nih.gov/36463079/	Homo sapiens, human, clinical
		β5	V5A	P68371	https://www.uniprot.org/uniprotkb/P68371/entry	H. sapiens	TBB4B SNP, DOID:0070003 / blastoma	Val5Ala	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P68371	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β5	V5A	P68371	https://www.uniprot.org/uniprotkb/P68371/entry	H. sapiens	TBB4B SNP, DOID:1793 / pancreatic cancer	Val5Ala	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P68371	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β5	V5A	Q13885	https://www.uniprot.org/uniprotkb/Q13885/entry	H. sapiens	TBB2A SNP, DOID:10534 / stomach cancer	Val5Ala	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13885	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β5	V5L	Q13885	https://www.uniprot.org/uniprotkb/Q13885/entry	H. sapiens	TBB2A SNP, DOID:1909 / melanoma	Val5Leu	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13885	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β5	V5M	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:363 / uterine cancer	Val5Met	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β6	H6L	P10653	https://www.uniprot.org/uniprotkb/P10653/entry	A. nidulans	Benomyl resistant, tubulin beta-1	His6Leu	Jung et al. 1992. Cell Motil Cytoskeleton 22:170-4	https://pubmed.ncbi.nlm.nih.gov/1423663/	Aspergillus nidulans, fungus
		β6	H6N	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:3571 / liver cancer	His6Asn	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β6	H6N	Q9BVA1	https://www.uniprot.org/uniprotkb/Q9BVA1/entry	H. sapiens	TBB2B SNP, DOID:3571 / liver cancer	His6Asn	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BVA1	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β6	H6Q	Q9BVA1	https://www.uniprot.org/uniprotkb/Q9BVA1/entry	H. sapiens	TBB2B SNP, DOID:3571 / liver cancer	His6Gln	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BVA1	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β6	H6Q	Q9BVA1	https://www.uniprot.org/uniprotkb/Q9BVA1/entry	H. sapiens	TBB2B SNP, DOID:0070003 / blastoma	His6Gln	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BVA1	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β6	H6Q	J9W1R2	https://www.uniprot.org/uniprotkb/J9W1R2/entry	C. neoformans	Benzimidazole resistant, beta tubulin	His6Gln	Cruz et al. 1997. Microbiology 143:2003-8	https://pubmed.ncbi.nlm.nih.gov/9202476/	Cryptococcus neoformans, yeast, fungus
		β6	H6Y	P10653	https://www.uniprot.org/uniprotkb/P10653/entry	A. nidulans	Benomyl resistant, tubulin beta-1	His6Tyr	Jung et al. 1992. Cell Motil Cytoskeleton 22:170-4	https://pubmed.ncbi.nlm.nih.gov/1423663/	Aspergillus nidulans, fungus
		β6	H6Y	Q7Z7U2	https://www.uniprot.org/uniprotkb/Q7Z7U2/entry	M. fructicola	Benzimidazole resistant	His6Tyr	Ma et al. 2003. Appl Environ Microbiol 69:7145-52	https://pubmed.ncbi.nlm.nih.gov/14660360/	Monilinia fructicola, fungus
		β6	H6Y	P41799	https://www.uniprot.org/uniprotkb/P41799/entry	P. nodorum	Benomyl resistant, beta-tubulin	His6Tyr	Cooley & Caten. 1993. Mol Gen Genet 237:58-64	https://pubmed.ncbi.nlm.nih.gov/8455567/	Parastagonospora, AKA Septoria nodorum, fungus
		β7	I7F	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:8618 / oral cavity cancer	Ile7Phe	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β7	I7F	Q9CWF2	https://www.uniprot.org/uniprotkb/Q9CWF2/entry	M. musculus	Tubb2b, viable heterozygote	Ile7Phe	Mutagenetix	https://mutagenetix.utsouthwestern.edu/incidental/incidental_rec.cfm?mid=241766	Mus musculus, mouse, tubulin beta-2B	Wang et al. 2015. PNAS 112:E440-449 (PMID 25605905)
		β8	P8L	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Likely benign, with P131L, P125L, P80L, tubulin beta-4A	Pro8Leu	ClinVar 623922	https://www.ncbi.nlm.nih.gov/clinvar/variation/623922	Homo sapiens, human, clinical
		β8	P8S	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Torsion dystonia, with P125S, P131S, P80S, tubulin beta-4A	Pro8Ser	ClinVar 692150	https://www.ncbi.nlm.nih.gov/clinvar/variation/692150	Homo sapiens, human, clinical
		β8	Q8L	A0A650DFF5	https://www.uniprot.org/uniprotkb/A0A650DFF5/entry	P. sojae	Ethaboxam & zoxamide resistant	Gln8Leu	Peng et al. 2019. Phytopathology 109:2096-2106	https://pubmed.ncbi.nlm.nih.gov/31559903/	Phytophthora sojae, oomycete, fungus, plant pathogen
		β9	A9S	Q9BUF5	https://www.uniprot.org/uniprotkb/Q9BUF5/entry	H. sapiens	TBB6 SNP, DOID:3963 / thyroid carcinoma	Ala9Ser	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BUF5	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β9	A9V	Q9BVA1	https://www.uniprot.org/uniprotkb/Q9BVA1/entry	H. sapiens	TBB2B SNP, DOID:1793 / pancreatic cancer	Ala9Val	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BVA1	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β10	G10D	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:3963 / thyroid carcinoma	Gly10Asp	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β10	G10S	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:9256 / colorectal cancer	Gly10Ser	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β10	G10V	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:3963 / thyroid carcinoma	Gly10Val	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β12	C12A	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	No phenotype, TUB2p	Cys12Ala	Gupta et al. 2001. Cell Motil Cytoskeleton 49:67-77	https://pubmed.ncbi.nlm.nih.gov/11443737/	Saccharomyces cerevisiae, budding yeast, fungus
		β12	C12F	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:3571 / liver cancer	Cys12Phe	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β12	C12G	Q9BVA1	https://www.uniprot.org/uniprotkb/Q9BVA1/entry	H. sapiens	TBB2B SNP, DOID:1612 / breast cancer	Cys12Gly	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BVA1	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β12	C12S	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Haploid lethal mutation, TUB2p	Cys12Ser	Gupta et al. 2001. Cell Motil Cytoskeleton 49:67-77	https://pubmed.ncbi.nlm.nih.gov/11443737/	Saccharomyces cerevisiae, budding yeast, fungus
		β12	C12W	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:184 / bone cancer	Cys12Trp	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β12	C12X	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	Thyroid dysgenesis, abnormal platelet physiology, tubulin beta-1	Cys12X	Stoupa et al. 2018. EMBO Mol Med 10:e9569	https://pubmed.ncbi.nlm.nih.gov/30446499/	Homo sapiens, human, clinical
		β12	C12Y	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Infertility due to arrest in oocyte maturation, tubulin beta-8	Cys12Tyr	Chen et al. 2017. Hum Reprod 32:457-464.	https://pubmed.ncbi.nlm.nih.gov/27989988/	Homo sapiens, human, clinical
		β12	C12Y	P12456	https://www.uniprot.org/uniprotkb/P12456/entry	C. elegans	Loss-of-function, shortened PLM-PN, mec-7	Cys12Tyr	Lee et al. 2021. Mol Biol Cell. 15:331-347	https://pubmed.ncbi.nlm.nih.gov/33378215/	Caenorhabditis elegans, nematode, roundworm
		β13	G13A	Q9BVA1	https://www.uniprot.org/uniprotkb/Q9BVA1/entry	H. sapiens	Cerebellar dysplasia, tubulin beta-2B, 2 patients	Gly13Ala	Oegema et al. 2015. Hum Mol Genet 24:5213-25	https://pubmed.ncbi.nlm.nih.gov/26130693/	Homo sapiens, human, clinical
		β13	G13C	Q9BVA1	https://www.uniprot.org/uniprotkb/Q9BVA1/entry	H. sapiens	TBB2B SNP, DOID:3571 / liver cancer	Gly13Cys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BVA1	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β13	G13C	Q9BVA1	https://www.uniprot.org/uniprotkb/Q9BVA1/entry	H. sapiens	TBB2B SNP, DOID:0070003 / blastoma	Gly13Cys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BVA1	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β13	G13D	P68371	https://www.uniprot.org/uniprotkb/P68371/entry	H. sapiens	TBB4B SNP, DOID:3571 / liver cancer	Gly13Asp	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P68371	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β13	G13R	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:2531 / hematologic cancer	Gly13Arg	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β13	G13R	Q13885	https://www.uniprot.org/uniprotkb/Q13885/entry	H. sapiens	Cortical dysplasia, other brain malformations, with G98R, tubulin beta-2A	Gly13Arg	ClinVar 421739	https://www.ncbi.nlm.nih.gov/clinvar/variation/421739	Homo sapiens, human, clinical
		β13	G13S	P12456	https://www.uniprot.org/uniprotkb/P12456/entry	C. elegans	Loss-of-function, shortened PLM-PN, mec-7	Gly13Ser	Lee et al. 2021. Mol Biol Cell. 15:331-347	https://pubmed.ncbi.nlm.nih.gov/33378215/	Caenorhabditis elegans, nematode, roundworm
		β13	P13Q	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Dystonia (movement disorder), TUBB4A	Pro13Gln	Wu et al. 2022. J Mol Diag 24:262-273	https://pubmed.ncbi.nlm.nih.gov/35041927/	Homo sapiens, human, clinical
		β14	N14K	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:3571 / liver cancer	Asn14Lys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β14	N14S	Q9BVA1	https://www.uniprot.org/uniprotkb/Q9BVA1/entry	H. sapiens	TBB2B SNP, DOID:263 / kidney cancer	Asn14Ser	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BVA1	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β15	Q15K	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	Circumferential skin creases, Kunze Type, tubulin beta, 2 patients	Gln15Lys	Isrie et al. 2015. Am J Hum Genet. 97:790-800	https://pubmed.ncbi.nlm.nih.gov/26637975/	Homo sapiens, human, clinical
		β15	Q15K	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	Symmetric circumferential skin creases, tubulin beta	Gln15Lys	ClinVar 218925	https://www.ncbi.nlm.nih.gov/clinvar/variation/218925	Homo sapiens, human, clinical
		β15	Q15P	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:3571 / liver cancer	Gln15Pro	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β17	G17A	Q9D6F9	https://www.uniprot.org/uniprotkb/Q9D6F9/entry	M. musculus	Tubb4a, viable heterozygote	Gly17Ala	Mutagenetix	https://mutagenetix.utsouthwestern.edu/incidental/incidental_rec.cfm?mid=603372	Mus musculus, mouse, tubulin beta-4A	Wang et al. 2015. PNAS 112:E440-449 (PMID 25605905)
		β17	N17T	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	Cortical dysplasia, other brain malformations, with N89T, N45T, N109T, tubulin beta	Asn17Thr	ClinVar 802193	https://www.ncbi.nlm.nih.gov/clinvar/variation/802193	Homo sapiens, human, clinical
		β18	A18P	P10878	https://www.uniprot.org/uniprotkb/P10878/entry	T. gondii	Suppressor of G142S α1-tubulin defects, β1-tubulin	Ala18Pro	Ma et al. 2008. Genetics 180:845-56	https://pubmed.ncbi.nlm.nih.gov/18780736/	Toxoplasma gondii, parasite, protozoan
		β18	A18T	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:9256 / colorectal cancer	Ala18Thr	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β18	A18T	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:4362 / cervical cancer	Ala18Thr	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β18	A18V	Q9BVA1	https://www.uniprot.org/uniprotkb/Q9BVA1/entry	H. sapiens	TBB2B SNP, DOID:0070003 / blastoma	Ala18Val	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BVA1	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β18	A18V	Q9BVA1	https://www.uniprot.org/uniprotkb/Q9BVA1/entry	H. sapiens	TBB2B SNP, DOID:3571 / liver cancer	Ala18Val	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BVA1	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β18	A18V	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:3070 / malignant glioma	Ala18Val	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β19	A19K	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Required for Taxol binding, TUB2p	Ala19Lys	Gupta et al. 2003. PNAS 100:6394-7	https://pubmed.ncbi.nlm.nih.gov/12740436/	Saccharomyces cerevisiae, budding yeast, fungus
		β19	K19M	Q9BVA1	https://www.uniprot.org/uniprotkb/Q9BVA1/entry	H. sapiens	TBB2B SNP, DOID:11054 / urinary bladder cancer	Lys19Met	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BVA1	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β19	K19N	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:3571 / liver cancer	Lys19Asn	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β19	K19Q	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:363 / uterine cancer	Lys19Gln	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β19	V19M	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with V142M, V91M, V136M, tubulin beta-4A	Val19Met	ClinVar 847763	https://www.ncbi.nlm.nih.gov/clinvar/variation/847763	Homo sapiens, human, clinical
		β21	W21X	A0A8E5HT31	https://www.uniprot.org/uniprotkb/A0A8E5HT31/entry	U. virens	Carbendazin resistance, Uvβ1Tub	Trp21X	Song et al. 2022. J Fungi 8:1311	https://pubmed.ncbi.nlm.nih.gov/36547644/	Ustilaginoidea, fungus, rice false smut
		β22	E22A	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Recessive lethal, with E27A, D31A, TUB2p	Glu22Ala	Reijo et al. 1994. Mol Biol Cell 5:29-43	https://pubmed.ncbi.nlm.nih.gov/8186463/	Saccharomyces cerevisiae, budding yeast, fungus
		β22	E22G	P68371	https://www.uniprot.org/uniprotkb/P68371/entry	H. sapiens	TBB4B SNP, DOID:3070 / malignant glioma	Glu22Gly	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P68371	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β22	E22K	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:11054 / urinary bladder cancer	Glu22Lys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β22	E22K	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:1909 / melanoma	Glu22Lys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β22	M23T	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:263 / kidney cancer	Met23Thr	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β23	T23V	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Required for Taxol binding, TUB2p	Thr23Val	Gupta et al. 2003. PNAS 100:6394-7	https://pubmed.ncbi.nlm.nih.gov/12740436/	Saccharomyces cerevisiae, budding yeast, fungus
		β23	V23F	Q9BVA1	https://www.uniprot.org/uniprotkb/Q9BVA1/entry	H. sapiens	TBB2B SNP, DOID:10283 / prostate cancer	Val23Phe	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BVA1	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β23	V23F	Q9BVA1	https://www.uniprot.org/uniprotkb/Q9BVA1/entry	H. sapiens	TBB2B SNP, DOID:1793 / pancreatic cancer	Val23Phe	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BVA1	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β24	G24R	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Pathogenic, with G147R, G96R, G141R, tubulin beta-4A	Gly24Arg	ClinVar 429952	https://www.ncbi.nlm.nih.gov/clinvar/variation/429952	Homo sapiens, human, clinical
		β24	I24M	P68371	https://www.uniprot.org/uniprotkb/P68371/entry	H. sapiens	TBB4B SNP, DOID:1324 / lung cancer	Ile24Met	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P68371	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β24	I24T	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	TUBB SNP, DOID:5041 / esophageal cancer	Ile24Thr	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P07437	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β24	I24T	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Uncertain significance, tubulin beta-3	Ile24Thr	ClinVar 593935	https://www.ncbi.nlm.nih.gov/clinvar/variation/593935	Homo sapiens, human, clinical
		β24	I24V	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:3571 / liver cancer	Ile24Val	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β24	I24V	A2AQ07	https://www.uniprot.org/uniprotkb/A2AQ07/entry	M. musculus	Tubb1, viable heterozygote	Ile24Val	Mutagenetix	https://mutagenetix.utsouthwestern.edu/incidental/incidental_rec.cfm?mid=297420	Mus musculus, mouse, tubulin beta-1	Wang et al. 2015. PNAS 112:E440-449 (PMID 25605905)
		β25	A25V	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, torsion dystonia, with A31V, tubulin beta-4A	Ala25Val	ClinVar 330268	https://www.ncbi.nlm.nih.gov/clinvar/variation/330268	Homo sapiens, human, clinical
		β25	C25A	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Benomyl supersensitive, TUB2p	Cys25Ala	Gupta et al. 2001. Cell Motil Cytoskeleton 49:67-77	https://pubmed.ncbi.nlm.nih.gov/11443737/	Saccharomyces cerevisiae, budding yeast, fungus
		β25	C25S	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Benomyl supersensitive, TUB2p	Cys25Ser	Gupta et al. 2001. Cell Motil Cytoskeleton 49:67-77	https://pubmed.ncbi.nlm.nih.gov/11443737/	Saccharomyces cerevisiae, budding yeast, fungus
		β25	S25F	P12456	https://www.uniprot.org/uniprotkb/P12456/entry	C. elegans	Weak antimorph, moderately shortened neurites, mec-7	Ser25Phe	Zheng et al. 2017 Mol Biol Cell 28: 2786-2801	https://pubmed.ncbi.nlm.nih.gov/28835377/	Caenorhabditis elegans, nematode, roundworm
		β25	S25F	P12456	https://www.uniprot.org/uniprotkb/P12456/entry	C. elegans	Mechanosensitive, mild semi-dominant, mec-7	Ser25Phe	Savage et al. 1994. J Cell Sci 107:2165-75	https://pubmed.ncbi.nlm.nih.gov/7983175/	Caenorhabditis elegans, nematode, roundworm
		β25	S25G	P68371	https://www.uniprot.org/uniprotkb/P68371/entry	H. sapiens	TBB4B SNP, DOID:1115 / sarcoma	Ser25Gly	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P68371	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β25	S25G	Q9BVA1	https://www.uniprot.org/uniprotkb/Q9BVA1/entry	H. sapiens	Lissencephaly, tubulin beta-2B	Ser25Gly	Di Donato et al. 2018. Genet Med 20:1354-1364	https://pubmed.ncbi.nlm.nih.gov/29671837/	Homo sapiens, human, clinical
		β25	S25L	P61857	https://www.uniprot.org/uniprotkb/P61857/entry	D. melanogaster	B2t mutation, testes specific tubulin	Ser25Leu	Fackenthal et al. 1995. Genetics 139:267-86	https://pubmed.ncbi.nlm.nih.gov/7705629/	Drosophila, fruitfly
		β25	S25N	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	2-methoxyestradiol resistant, tubulin beta	Ser25Asn	Liaw et al. 2008. Mol Cancer Ther 7:3150-9	https://pubmed.ncbi.nlm.nih.gov/18852118/	Homo sapiens, human, clinical
		β26	D26E	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	Paclitaxel resistant, less stable microtubules, KB-3-1 line, tubulin beta	Asp26Glu	Hari et al. 2006. Mol Cancer Ther 5:270-8	https://pubmed.ncbi.nlm.nih.gov/16505100/	Homo sapiens, human, clinical
		β26	D26E	P69893	https://www.uniprot.org/uniprotkb/P69893/entry	C. griseus	Paclitaxel resistant, CHO cell line, tubulin beta-5	Asp26Glu	Yin et al. 2012. Pharm Res 29:2994-3006	https://pubmed.ncbi.nlm.nih.gov/22669706/	Cricetulus griseus, chinese hamster, rodent
		β26	D26N	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	TUBB SNP, DOID:11054 / urinary bladder cancer	Asp26Asn	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P07437	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β26	G26D	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Required for Taxol binding, TUB2p	Gly26Asp	Gupta et al. 2003. PNAS 100:6394-7	https://pubmed.ncbi.nlm.nih.gov/12740436/	Saccharomyces cerevisiae, budding yeast, fungus
		β26	G26D	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Uncertain significance, with G149D, G98D, G143D, tubulin beta-4A	Gly26Asp	ClinVar 499281	https://www.ncbi.nlm.nih.gov/clinvar/variation/499281	Homo sapiens, human, clinical
		β26	G26R	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Uncertain significance, with G149R, G143R, G98R, tubulin beta-4A	Gly26Arg	ClinVar 623921	https://www.ncbi.nlm.nih.gov/clinvar/variation/623921	Homo sapiens, human, clinical
		β26	G26S	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Cortical dysplasia, brain malformations, with G98S, tubulin beta-3	Gly26Ser	ClinVar 160191	https://www.ncbi.nlm.nih.gov/clinvar/variation/160191	Homo sapiens, human, clinical
		β26	G26S	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Uncertain significance, with G149S, G98S, G143S, tubulin beta-4A	Gly26Ser	ClinVar 450804	https://www.ncbi.nlm.nih.gov/clinvar/variation/450804	Homo sapiens, human, clinical
		β27	E27A	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Recessive lethal, with E22A, D31A, TUB2p	Glu27Ala	Reijo et al. 1994. Mol Biol Cell 5:29-43	https://pubmed.ncbi.nlm.nih.gov/8186463/	Saccharomyces cerevisiae, budding yeast, fungus
		β27	E27G	A2AQ07	https://www.uniprot.org/uniprotkb/A2AQ07/entry	M. musculus	Tubb1, viable heterozygote	Glu27Gly	Mutagenetix	https://mutagenetix.utsouthwestern.edu/incidental/incidental_rec.cfm?mid=706829	Mus musculus, mouse, tubulin beta-1	Wang et al. 2015. PNAS 112:E440-449 (PMID 25605905)
		β27	E27K	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:363 / uterine cancer	Glu27Lys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β27	E27K	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	TUBB SNP, DOID:11934 / head and neck cancer	Glu27Lys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P07437	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β28	H28R	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	TUBB SNP, DOID:1324 / lung cancer	His28Arg	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P07437	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β28	H28R	Q9BUF5	https://www.uniprot.org/uniprotkb/Q9BUF5/entry	H. sapiens	TBB6 SNP, DOID:10534 / stomach cancer	His28Arg	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BUF5	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β28	H28Y	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Female infertility, tubulin beta-8	His28Tyr	Zhao et al. 2020. J Assist Reprod Genet 37:1837-47.	https://pubmed.ncbi.nlm.nih.gov/32524331/	Homo sapiens, human, clinical
		β28	H28Y	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Infertility, with R306Sfs, , tubulin beta-8	His28Tyr	Zhang et al. 2023. J Assist Reprod Genet 40:753-763.	https://pubmed.ncbi.nlm.nih.gov/36735156/	Homo sapiens, human, clinical
		β28	G29C	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	TUBB SNP, DOID:2994 / germ cell cancer	Gly29Cys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P07437	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β29	G29C	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	TUBB SNP, DOID:2394 / ovarian cancer	Gly29Cys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P07437	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β29	G29D	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:1324 / lung cancer	Gly29Asp	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β29	G29E	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	Computational prediction, nsSNP causes protein destablization	Gly29Glu	Hussain et al. 2022. J Biomol Struct Dyn 11:1-11.	https://pubmed.ncbi.nlm.nih.gov/36218086/	Computational modeling, clinical
		β29	G29R	Q9BUF5	https://www.uniprot.org/uniprotkb/Q9BUF5/entry	H. sapiens	TBB6 SNP, DOID:1324 / lung cancer	Gly29Arg	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BUF5	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β29	G29R	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:363 / uterine cancer	Gly29Arg	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β29	G29V	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:3571 / liver cancer	Gly29Val	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β30	I30F	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:1324 / lung cancer	Ile30Phe	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β30	I30M	Q9BUF5	https://www.uniprot.org/uniprotkb/Q9BUF5/entry	H. sapiens	Uncertain significance, tubulin beta-6	Ile30Met	ClinVar 928696	https://www.ncbi.nlm.nih.gov/clinvar/variation/928696	Homo sapiens, human, clinical
		β31	A31V	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, torsion dystonia, with A25V, tubulin beta-4A	Ala31Val	ClinVar 330268	https://www.ncbi.nlm.nih.gov/clinvar/variation/330268	Homo sapiens, human, clinical
		β31	D31A	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Recessive lethal, with E22A, E27A, TUB2p	Asp31Ala	Reijo et al. 1994. Mol Biol Cell 5:29-43	https://pubmed.ncbi.nlm.nih.gov/8186463/	Saccharomyces cerevisiae, budding yeast, fungus
		β31	D31N	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:1909 / melanoma	Asp31Asn	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β31	D31N	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:10283 / prostate cancer	Asp31Asn	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β31	D31N	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:363 / uterine cancer	Asp31Asn	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β31	D31N	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:11054 / urinary bladder cancer	Asp31Asn	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β31	D31V	A2AQ07	https://www.uniprot.org/uniprotkb/A2AQ07/entry	M. musculus	Tubb1, viable heterozygote	Asp31Val	Mutagenetix	https://mutagenetix.utsouthwestern.edu/incidental/incidental_rec.cfm?mid=219399	Mus musculus, mouse, tubulin beta-1	Wang et al. 2015. PNAS 112:E440-449 (PMID 25605905)
		β31	Q31X	Q18817	https://www.uniprot.org/uniprotkb/Q18817/entry	C. elegans	Albendazole resistance, ben-1	Gln31X	Pallotto et al. 2022. Genetics 221:iyac093	https://pubmed.ncbi.nlm.nih.gov/35731216/	Caenorhabditis elegans, nematode, roundworm
		β32	P32L	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:1612 / breast cancer	Pro32Leu	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β33	A33S	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:1324 / lung cancer	Ala33Ser	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β33	A33T	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:9256 / colorectal cancer	Ala33Thr	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β33	I33I	Q9N2N6	https://www.uniprot.org/uniprotkb/Q9N2N6/entry	E. focardii	Cold stable adaptation (correlation, EFBT4)	Ile33Ile	Chiappori et al. 2012. Proteins 80:1154-60	https://pubmed.ncbi.nlm.nih.gov/22275059/	Euplotes focardii, extremophile, Antarctic ciliate
		β33	T33S	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	TUBB SNP, DOID:5041 / esophageal cancer	Thr33Ser	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P07437	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β33	T33S	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	Invasive ductal, low grade; taxane treatment, also contains T35N	Thr33Ser	Wang et al. 2017. Protoplasma 254:1163-1173	https://pubmed.ncbi.nlm.nih.gov/27943021/	Homo sapiens, human, clinical	Tubulin beta-1 chain
		β34	G34S	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:3070 / malignant glioma	Gly34Ser	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β34	G34S	P10878	https://www.uniprot.org/uniprotkb/P10878/entry	T. gondii	Suppressor of F52Y α1-tubulin defects, β1-tubulin	Gly34Ser	Ma et al. 2008. Genetics 180:845-56	https://pubmed.ncbi.nlm.nih.gov/18780736/	Toxoplasma gondii, parasite, protozoan
		β34	G34S	P12456	https://www.uniprot.org/uniprotkb/P12456/entry	C. elegans	Loss-of-function, shortened PLM-PN, mec-7	Gly34Ser	Zheng et al. 2017 Mol Biol Cell 28: 2786-2801	https://pubmed.ncbi.nlm.nih.gov/28835377/	Caenorhabditis elegans, nematode, roundworm	also see Lee et al. 2021. Mol Biol Cell. 15:331-347 (PMID 33378215)
		β34	G34S	P12456	https://www.uniprot.org/uniprotkb/P12456/entry	C. elegans	Mechanosensitive, mild recessive, mec-7	Gly34Ser	Savage et al. 1994. J Cell Sci 107:2165-75	https://pubmed.ncbi.nlm.nih.gov/7983175/	Caenorhabditis elegans, nematode, roundworm
		β35	S35R	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:1324 / lung cancer	Ser35Arg	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β35	T35A	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:3963 / thyroid carcinoma	Thr35Ala	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β35	T35I	P68371	https://www.uniprot.org/uniprotkb/P68371/entry	H. sapiens	TBB4B SNP, DOID:0060119 / pharynx cancer	Thr35Ile	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P68371	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β35	T35N	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	Invasive ductal, low grade; taxane treatment, also contains T33S	Thr35Asn	Wang et al. 2017. Protoplasma 254:1163-1173	https://pubmed.ncbi.nlm.nih.gov/27943021/	Homo sapiens, human, clinical	Tubulin beta-1 chain
		β36	D36N	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:0070003 / blastoma	Asp36Asn	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β36	D36N	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:3571 / liver cancer	Asp36Asn	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β36	E36K	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	Likely pathogenic, with E108K, E64K, E128K, tubulin beta	Glu36Lys	ClinVar 373428	https://www.ncbi.nlm.nih.gov/clinvar/variation/373428	Homo sapiens, human, clinical
		β36	Y36H	Q9BUF5	https://www.uniprot.org/uniprotkb/Q9BUF5/entry	H. sapiens	TBB6 SNP, DOID:1909 / melanoma	Tyr36His	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BUF5	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β36	Y36N	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:0070003 / blastoma	Tyr36Asn	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β37	H37N	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:3571 / liver cancer	His37Asn	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β37	Q37Q	Q9DD57	https://www.uniprot.org/uniprotkb/Q9DD57/entry	C. rastrospinosus	Cold stable adaptation (correlation, CrTbB2, AF255954)	Gln37Gln	Detrich et al. 2000. J Biol Chem 275:37038-47	https://pubmed.ncbi.nlm.nih.gov/10956651/	Chionodraco rastrospinosus, extremophile, icefish
		β37	Q37Q	Q78C12	https://www.uniprot.org/uniprotkb/Q78C12/entry	N. coriiceps	Cold stable adaptation (correlation, NcTbB2, AF255553)	Gln37Gln	Detrich et al. 2000. J Biol Chem 275:37038-47	https://pubmed.ncbi.nlm.nih.gov/10956651/	Notothenia coriiceps, extremophile, icefish
		β37	Q37Q	Q9DFT5	https://www.uniprot.org/uniprotkb/Q9DFT5/entry	N. coriiceps	Cold stable adaptation (correlation, NcTbB4, AF255555)	Gln37Gln	Detrich et al. 2000. J Biol Chem 275:37038-47	https://pubmed.ncbi.nlm.nih.gov/10956651/	Notothenia coriiceps, extremophile, icefish
		β37	R37H	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:1793 / pancreatic cancer	Arg37His	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β37	R37H	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:363 / uterine cancer	Arg37His	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β37	R37L	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:3571 / liver cancer	Arg37Leu	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β37	R37S	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:1324 / lung cancer	Arg37Ser	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β37	V37L	Q9BUF5	https://www.uniprot.org/uniprotkb/Q9BUF5/entry	H. sapiens	TBB6 SNP, DOID:3571 / liver cancer	Val37Leu	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BUF5	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β37	V37M	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Uncertain significance, tubulin beta-3	Val37Met	ClinVar 378837	https://www.ncbi.nlm.nih.gov/clinvar/variation/378837	Homo sapiens, human, clinical
		β38	G38E	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:1909 / melanoma	Gly38Glu	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β38	G38E	P12456	https://www.uniprot.org/uniprotkb/P12456/entry	C. elegans	No defects, mec-7	Gly38Glu	Zheng et al. 2017 Mol Biol Cell 28: 2786-2801	https://pubmed.ncbi.nlm.nih.gov/28835377/	Caenorhabditis elegans, nematode, roundworm	also see Lee et al. 2021. Mol Biol Cell. 15:331-347 (PMID 33378215)
		β38	G38R	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:3571 / liver cancer	Gly38Arg	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β38	G38W	Q9D6F9	https://www.uniprot.org/uniprotkb/Q9D6F9/entry	M. musculus	Tubb4a, viable heterozygote	Gly38Trp	Mutagenetix	https://mutagenetix.utsouthwestern.edu/incidental/incidental_rec.cfm?mid=249770	Mus musculus, mouse, tubulin beta-4A	Wang et al. 2015. PNAS 112:E440-449 (PMID 25605905)
		β38	R38R	Q9N2N6	https://www.uniprot.org/uniprotkb/Q9N2N6/entry	E. focardii	Cold stable adaptation (correlation, EFBT3)	Arg38Arg	Chiappori et al. 2012. Proteins 80:1154-60	https://pubmed.ncbi.nlm.nih.gov/22275059/	Euplotes focardii, extremophile, Antarctic ciliate
		β39	D39E	Q9BVA1	https://www.uniprot.org/uniprotkb/Q9BVA1/entry	H. sapiens	TBB2B SNP, DOID:0070003 / blastoma	Asp39Glu	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BVA1	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β39	D39E	Q9BVA1	https://www.uniprot.org/uniprotkb/Q9BVA1/entry	H. sapiens	TBB2B SNP, DOID:3571 / liver cancer	Asp39Glu	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BVA1	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β39	D39G	P69893	https://www.uniprot.org/uniprotkb/P69893/entry	C. griseus	Paclitaxel resistant, with F85L, tubulin beta-5	Asp39Gly	Yin et al. 2012. Pharm Res 29:2994-3006	https://pubmed.ncbi.nlm.nih.gov/22669706/	Cricetulus griseus, chinese hamster, rodent
		β40	D40A	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Benomyl resistant, with D41A, TUB2p	Asp40Ala	Reijo et al. 1994. Mol Biol Cell 5:29-43	https://pubmed.ncbi.nlm.nih.gov/8186463/	Saccharomyces cerevisiae, budding yeast, fungus
		β40	S40R	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:4362 / cervical cancer	Ser40Arg	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β41	A41T	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:363 / uterine cancer	Ala41Thr	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β41	D41A	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Benomyl resistant, with D40A, TUB2p	Asp41Ala	Reijo et al. 1994. Mol Biol Cell 5:29-43	https://pubmed.ncbi.nlm.nih.gov/8186463/	Saccharomyces cerevisiae, budding yeast, fungus
		β41	D41N	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:11054 / urinary bladder cancer	Asp41Asn	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β42	L42V	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Oocyte maturation arrest and infertility, TUBB8	Leu42Val	Yu et al. 2023. Reprod Sci 30:1376-82	https://pubmed.ncbi.nlm.nih.gov/36197634/	Homo sapiens, human, clinical
		β42	L42V	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Human oocyte maturation arrest and female infertility, TUBB8	Leu42Val	Li et al. 2022. Eur J Obstet Gynecol Reprod Biol 279:132-139	https://pubmed.ncbi.nlm.nih.gov/36335766/	Homo sapiens, human, clinical
		β42	Q42Q	Q7XYS0	https://www.uniprot.org/uniprotkb/Q7XYS0/entry	C. caldarium	Heat stable adaptation (correlation, AAP75759.2)	Gln42Gln	Arnold MS thesis (VPI)	https://vtechworks.lib.vt.edu/h&le/10919/9745?show=full	Cyanidium caldarium, extremophile, algae
		β42	Q42Q	A0A125YTB7	https://www.uniprot.org/uniprotkb/A0A125YTB7/entry	C. merolae	Heat stable adaptation (correlation)	Gln42Gln	Arnold MS thesis (VPI)	https://vtechworks.lib.vt.edu/h&le/10919/9745?show=full	Cyanidioschyzon merolae, extremophile, algae
		β43	Q43H	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:9256 / colorectal cancer	Gln43His	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β43	Q43P	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:9256 / colorectal cancer	Gln43Pro	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β43	Q43P	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	Reduced tubulin expression, tubulin beta	Gln43Pro	Freson et al. 2005. Blood 106:2356-62	https://pubmed.ncbi.nlm.nih.gov/15956286/	Homo sapiens, human, clinical
		β43	Q43P	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	Macrothrombocytopenia associated, tubulin beta-1	Gln43Pro	Kunishima et al. 2009. Blood 113:458-61	https://pubmed.ncbi.nlm.nih.gov/18849486/	Homo sapiens, human, clinical
		β44	K44A	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Benomyl resistant, with E45A, R46A, TUB2p	Lys44Ala	Reijo et al. 1994. Mol Biol Cell 5:29-43	https://pubmed.ncbi.nlm.nih.gov/8186463/	Saccharomyces cerevisiae, budding yeast, fungus
		β44	L44M	Q9BUF5	https://www.uniprot.org/uniprotkb/Q9BUF5/entry	H. sapiens	TBB6 SNP, DOID:363 / uterine cancer	Leu44Met	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BUF5	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β44	L44P	P68371	https://www.uniprot.org/uniprotkb/P68371/entry	H. sapiens	Invasive ductal, high grade; no treatment, also contains S275A, Q292R, A315T, V333I, N332A, N335S, T351V, A365S	Leu44Pro	Wang et al. 2017. Protoplasma 254:1163-1173	https://pubmed.ncbi.nlm.nih.gov/27943021/	Homo sapiens, human, clinical	Tubulin beta-4B chain
		β45	D45Y	P69893	https://www.uniprot.org/uniprotkb/P69893/entry	C. griseus	Colcimid & vinblastine resistant, CHO cell line, tubulin beta-5	Asp45Tyr	Hari et al. 2003. Mol Cancer Therap 2:597-605	https://pubmed.ncbi.nlm.nih.gov/12883031/	Cricetulus griseus, chinese hamster, rodent
		β45	D45Y	P69893	https://www.uniprot.org/uniprotkb/P69893/entry	C. griseus	Colcemid resistant, paclitaxel hypersensitive CHO cell line, tubulin beta-5	Asp45Tyr	Wang et al. 2004. Biochemistry 43:8965-73.	https://pubmed.ncbi.nlm.nih.gov/15248754/	Cricetulus griseus, chinese hamster, rodent
		β45	E45A	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Benomyl resistant, with K44A, R46A, TUB2p	Glu45Ala	Reijo et al. 1994. Mol Biol Cell 5:29-43	https://pubmed.ncbi.nlm.nih.gov/8186463/	Saccharomyces cerevisiae, budding yeast, fungus
		β45	E45D	P68371	https://www.uniprot.org/uniprotkb/P68371/entry	H. sapiens	Invasive lobular, low grade; no treatment, also contains N48S, V64I	Glu45Asp	Wang et al. 2017. Protoplasma 254:1163-1173	https://pubmed.ncbi.nlm.nih.gov/27943021/	Homo sapiens, human, clinical	Tubulin beta-4B chain
		β45	E45D	Q13885	https://www.uniprot.org/uniprotkb/Q13885/entry	H. sapiens	Invasive ductal, low grade; no treatment, also contains N48S, V64I, V170M, C201S, A296S, V316I	Glu45Asp	Wang et al. 2017. Protoplasma 254:1163-1173	https://pubmed.ncbi.nlm.nih.gov/27943021/	Homo sapiens, human, clinical	Tubulin beta-2A chain
		β45	E45K	Q9BUF5	https://www.uniprot.org/uniprotkb/Q9BUF5/entry	H. sapiens	TBB6 SNP, DOID:11054 / urinary bladder cancer	Glu45Lys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BUF5	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β45	E45Q	Q13885	https://www.uniprot.org/uniprotkb/Q13885/entry	H. sapiens	TBB2A SNP, DOID:1612 / breast cancer	Glu45Gln	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13885	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β45	E45V	A2AQ07	https://www.uniprot.org/uniprotkb/A2AQ07/entry	M. musculus	Tubb1, viable heterozygote	Glu45Val	Mutagenetix	https://mutagenetix.utsouthwestern.edu/incidental/incidental_rec.cfm?mid=320519	Mus musculus, mouse, tubulin beta-1	Wang et al. 2015. PNAS 112:E440-449 (PMID 25605905)
		β45	E45V	A2AQ07	https://www.uniprot.org/uniprotkb/A2AQ07/entry	M. musculus	Tubb1, viable heterozygote	Glu45Val	Mutagenetix	https://mutagenetix.utsouthwestern.edu/incidental/incidental_rec.cfm?mid=320519	Mus musculus, mouse, tubulin beta-1	Wang et al. 2015. PNAS 112:E440-449 (PMID 25605905)
		β45	N45T	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	Cortical dysplasia, other brain malformations, with N89T, N109T, N17T, tubulin beta	Asn45Thr	ClinVar 802193	https://www.ncbi.nlm.nih.gov/clinvar/variation/802193	Homo sapiens, human, clinical
		β46	R46A	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Benomyl resistant, with K44A, E45A, TUB2p	Arg46Ala	Reijo et al. 1994. Mol Biol Cell 5:29-43	https://pubmed.ncbi.nlm.nih.gov/8186463/	Saccharomyces cerevisiae, budding yeast, fungus
		β46	R46C	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:9256 / colorectal cancer	Arg46Cys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β46	R46C	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:1909 / melanoma	Arg46Cys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β46	R46C	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Female infertility, tubulin beta-8	Arg46Cys	Yang et al. 2021. Clin Genet 99:208-214	https://pubmed.ncbi.nlm.nih.gov/33009822/	Homo sapiens, human, clinical
		β46	R46K	Q13885	https://www.uniprot.org/uniprotkb/Q13885/entry	H. sapiens	TBB2A SNP, DOID:2531 / hematologic cancer	Arg46Lys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13885	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β46	R46M	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Laryngeal and cervical dystonia, TUBB4A	Arg46Met	Bally et al. 2021. Neurology 96: e1887-97	https://pubmed.ncbi.nlm.nih.gov/32943487/	Homo sapiens, human, clinical
		β46	R46M	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	DYT4 Dystonia, TUBB4A	Arg46Met	Bally et al. 2022. Mov Disord Clin Pract 9:659-675	https://pubmed.ncbi.nlm.nih.gov/35844288/	Homo sapiens, human, clinical
		β46	R46W	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Cortical dysplasia, brain malformations, tubulin beta-3	Arg46Trp	ClinVar 438582	https://www.ncbi.nlm.nih.gov/clinvar/variation/438582	Homo sapiens, human, clinical
		β47	G47S	Q13885	https://www.uniprot.org/uniprotkb/Q13885/entry	H. sapiens	Likely pathogenic, with G132S, tubulin beta-2A	Gly47Ser	ClinVar 421613	https://www.ncbi.nlm.nih.gov/clinvar/variation/421613	Homo sapiens, human, clinical
		β47	R47G	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Torsion dystonia, leukodystrophy, hypomyelinating, with R2G, R53G, tubulin beta-4A	Arg47Gly	ClinVar 50984	https://www.ncbi.nlm.nih.gov/clinvar/variation/50984	Homo sapiens, human, clinical
		β47	R47Q	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with R2Q, R53Q, tubulin beta-4A	Arg47Gln	ClinVar 139452	https://www.ncbi.nlm.nih.gov/clinvar/variation/139452	Homo sapiens, human, clinical
		β47	R47W	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with R53W, R2W, tubulin beta-4A	Arg47Trp	ClinVar 267773	https://www.ncbi.nlm.nih.gov/clinvar/variation/267773	Homo sapiens, human, clinical
		β48	N48D	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:5041 / esophageal cancer	Asn48Asp	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β48	N48D	P68371	https://www.uniprot.org/uniprotkb/P68371/entry	H. sapiens	TBB4B SNP, DOID:1909 / melanoma	Asn48Asp	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P68371	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β48	N48K	Q9BUF5	https://www.uniprot.org/uniprotkb/Q9BUF5/entry	H. sapiens	TBB6 SNP, DOID:1324 / lung cancer	Asn48Lys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BUF5	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β48	N48S	P68371	https://www.uniprot.org/uniprotkb/P68371/entry	H. sapiens	Invasive lobular, low grade; no treatment, also contains E45D, V64I	Asn48Ser	Wang et al. 2017. Protoplasma 254:1163-1173	https://pubmed.ncbi.nlm.nih.gov/27943021/	Homo sapiens, human, clinical	Tubulin beta-4B chain
		β48	N48S	Q13885	https://www.uniprot.org/uniprotkb/Q13885/entry	H. sapiens	Invasive ductal, low grade; no treatment, also contains E45D, V64I, V170M, C201S, A296S, V316I	Asn48Ser	Wang et al. 2017. Protoplasma 254:1163-1173	https://pubmed.ncbi.nlm.nih.gov/27943021/	Homo sapiens, human, clinical	Tubulin beta-2A chain
		β48	N48Y	P68371	https://www.uniprot.org/uniprotkb/P68371/entry	H. sapiens	TBB4B SNP, DOID:1324 / lung cancer	Asn48Tyr	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P68371	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β48	S48F	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	TUBB SNP, DOID:11054 / urinary bladder cancer	Ser48Phe	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P07437	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β49	R49W	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with R121W, R166W, R172W, tubulin beta-4A	Arg49Trp	ClinVar 837764	https://www.ncbi.nlm.nih.gov/clinvar/variation/837764	Homo sapiens, human, clinical
		β49	V49E	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:1324 / lung cancer	Val49Glu	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β49	V49G	Q13885	https://www.uniprot.org/uniprotkb/Q13885/entry	H. sapiens	Tubulinopathy, brain malformations, tubulin beta-2A	Val49Gly	Brock et al. 2021. J Med Genet 58:33-40	https://pubmed.ncbi.nlm.nih.gov/32571897/	Homo sapiens, human, clinical
		β49	V49M	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:363 / uterine cancer	Val49Met	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β49	V49M	Q13885	https://www.uniprot.org/uniprotkb/Q13885/entry	H. sapiens	Tubulinopathy, brain malformations, tubulin beta-2A	Val49Met	Brock et al. 2021. J Med Genet 58:33-40	https://pubmed.ncbi.nlm.nih.gov/32571897/	Homo sapiens, human, clinical
		β50	D50Y	R4S1I8	https://www.uniprot.org/uniprotkb/R4S1I8/entry	F. moniliforme	Benomyl resistant, cold sensitive	Asp50Tyr	Yan & Dickman. 1996. Appl Environ Microbiol 62:3053-6	https://pubmed.ncbi.nlm.nih.gov/8702300/	Fusarium moniliforme, fungus
		β50	Y50C	Q7Z9J7	https://www.uniprot.org/uniprotkb/Q7Z9J7/entry	G. zeae	Carbendazim resistant, β2-tubulin (no accession number)	Tyr50Cys	Qiu et al. 2011. Pest Man Sci 67:191-8	https://pubmed.ncbi.nlm.nih.gov/21077124/	Gibberella zeae, Fusarium graminearum, fungus
		β50	Y50H	Q9BUF5	https://www.uniprot.org/uniprotkb/Q9BUF5/entry	H. sapiens	TBB6 SNP, DOID:363 / uterine cancer	Tyr50His	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BUF5	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β51	Y51C	P68371	https://www.uniprot.org/uniprotkb/P68371/entry	H. sapiens	TBB4B SNP, DOID:10534 / stomach cancer	Tyr51Cys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P68371	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β51	Y51H	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:3963 / thyroid carcinoma	Tyr51His	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β51	Y51H	Q9CWF2	https://www.uniprot.org/uniprotkb/Q9CWF2/entry	M. musculus	Tubb2b, viable heterozygote	Tyr51His	Mutagenetix	https://mutagenetix.utsouthwestern.edu/incidental/incidental_rec.cfm?mid=14658	Mus musculus, mouse, tubulin beta-2B	Wang et al. 2015. PNAS 112:E440-449 (PMID 25605905)
		β52	N52H	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:0070003 / blastoma	Asn52His	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β52	N52H	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:3963 / thyroid carcinoma	Asn52His	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β52	N52I	P68371	https://www.uniprot.org/uniprotkb/P68371/entry	H. sapiens	TBB4B SNP, DOID:1909 / melanoma	Asn52Ile	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P68371	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β52	N52K	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:3571 / liver cancer	Asn52Lys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β52	N52K	P99024	https://www.uniprot.org/uniprotkb/P99024/entry	M. musculus	Tubb5, viable heterozygote	Asn52Lys	Mutagenetix	https://mutagenetix.utsouthwestern.edu/incidental/incidental_rec.cfm?mid=187233	Mus musculus, mouse, tubulin beta-5	Wang et al. 2015. PNAS 112:E440-449 (PMID 25605905)
		β52	N52S	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	Basal ganglia & cerebellar dysgenesis, tubulin beta	Asn52Ser	Sferra et al. 2020. Int J Mol Sci 21:1385	https://pubmed.ncbi.nlm.nih.gov/32085672/	Homo sapiens, human, clinical
		β53	E53K	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:11054 / urinary bladder cancer	Glu53Lys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β53	E53K	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:10534 / stomach cancer	Glu53Lys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β53	E53K	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:1909 / melanoma	Glu53Lys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β53	E53K	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:363 / uterine cancer	Glu53Lys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β53	E53K	A2AQ07	https://www.uniprot.org/uniprotkb/A2AQ07/entry	M. musculus	Tubb1, viable heterozygote	Glu53Lys	Mutagenetix	https://mutagenetix.utsouthwestern.edu/incidental/incidental_rec.cfm?mid=81285	Mus musculus, mouse, tubulin beta-1	Wang et al. 2015. PNAS 112:E440-449 (PMID 25605905)
		β53	I52I	Q9N2N6	https://www.uniprot.org/uniprotkb/Q9N2N6/entry	E. focardii	Cold stable adaptation (correlation, EFBT3)	Ile52Ile	Chiappori et al. 2012. Proteins 80:1154-60	https://pubmed.ncbi.nlm.nih.gov/22275059/	Euplotes focardii, extremophile, Antarctic ciliate
		β53	R53G	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Torsion dystonia, leukodystrophy, hypomyelinating, with R2G, R47G, tubulin beta-4A	Arg53Gly	ClinVar 50984	https://www.ncbi.nlm.nih.gov/clinvar/variation/50984	Homo sapiens, human, clinical
		β53	R53Q	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with R2Q, R47Q, tubulin beta-4A	Arg53Gln	ClinVar 139452	https://www.ncbi.nlm.nih.gov/clinvar/variation/139452	Homo sapiens, human, clinical
		β53	R53W	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with R2W, R47W, tubulin beta-4A	Arg53Trp	ClinVar 267773	https://www.ncbi.nlm.nih.gov/clinvar/variation/267773	Homo sapiens, human, clinical
		β54	A54D	P68371	https://www.uniprot.org/uniprotkb/P68371/entry	H. sapiens	TBB4B SNP, DOID:0070003 / blastoma	Ala54Asp	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P68371	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β54	A54D	P68371	https://www.uniprot.org/uniprotkb/P68371/entry	H. sapiens	TBB4B SNP, DOID:3571 / liver cancer	Ala54Asp	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P68371	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β54	A54T	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:363 / uterine cancer	Ala54Thr	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β54	A54V	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	TUBB SNP, DOID:3070 / malignant glioma	Ala54Val	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P07437	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β54	A54V	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:10283 / prostate cancer	Ala54Val	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β54	A54V	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:1793 / pancreatic cancer	Ala54Val	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β54	A54V	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Female infertility, , tubulin beta-8	Ala54Val	Xing et al. 2020. J Ovarian Res 13:42	https://pubmed.ncbi.nlm.nih.gov/32316999/	Homo sapiens, human, clinical
		β55	C55C	Q9N2N6	https://www.uniprot.org/uniprotkb/Q9N2N6/entry	E. focardii	Cold stable adaptation (correlation, EFBT3)	Cys55Cys	Chiappori et al. 2012. Proteins 80:1154-60	https://pubmed.ncbi.nlm.nih.gov/22275059/	Euplotes focardii, extremophile, Antarctic ciliate
		β55	S55L	Q9BUF5	https://www.uniprot.org/uniprotkb/Q9BUF5/entry	H. sapiens	TBB6 SNP, DOID:11054 / urinary bladder cancer	Ser55Leu	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BUF5	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β55	T55I	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:1909 / melanoma	Thr55Ile	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β55	Y55H	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:363 / uterine cancer	Tyr55His	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β56	G56D	P61857	https://www.uniprot.org/uniprotkb/P61857/entry	D. melanogaster	B2t mutation, testes specific tubulin	Gly56Asp	Fackenthal et al. 1995. Genetics 139:267-86	https://pubmed.ncbi.nlm.nih.gov/7705629/	Drosophila, fruitfly
		β56	G56V	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:1324 / lung cancer	Gly56Val	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β56	G56V	P68371	https://www.uniprot.org/uniprotkb/P68371/entry	H. sapiens	TBB4B SNP, DOID:3571 / liver cancer	Gly56Val	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P68371	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β56	Q56Q	Q9N2N6	https://www.uniprot.org/uniprotkb/Q9N2N6/entry	E. focardii	Cold stable adaptation (correlation, EFBT3)	Gln56Gln	Chiappori et al. 2012. Proteins 80:1154-60	https://pubmed.ncbi.nlm.nih.gov/22275059/	Euplotes focardii, extremophile, Antarctic ciliate
		β56	R56R	Q9N2N6	https://www.uniprot.org/uniprotkb/Q9N2N6/entry	E. focardii	Cold stable adaptation (correlation, EFBT4)	Arg56Arg	Chiappori et al. 2012. Proteins 80:1154-60	https://pubmed.ncbi.nlm.nih.gov/22275059/	Euplotes focardii, extremophile, Antarctic ciliate
		β56	T56T	Q7XYS0	https://www.uniprot.org/uniprotkb/Q7XYS0/entry	C. caldarium	Heat stable adaptation (correlation)	Thr56Thr	Arnold MS thesis (VPI)	https://vtechworks.lib.vt.edu/h&le/10919/9745?show=full	Cyanidium caldarium, extremophile, algae
		β56	T56T	A0A125YTB7	https://www.uniprot.org/uniprotkb/A0A125YTB7/entry	C. merolae	Heat stable adaptation (correlation)	Thr56Thr	Arnold MS thesis (VPI)	https://vtechworks.lib.vt.edu/h&le/10919/9745?show=full	Cyanidioschyzon merolae, extremophile, algae
		β57	G57D	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	TUBB SNP, DOID:1115 / sarcoma	Gly57Asp	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P07437	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β57	H57Q	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:1324 / lung cancer	His57Gln	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β57	Q57H	Q9BUF5	https://www.uniprot.org/uniprotkb/Q9BUF5/entry	H. sapiens	TBB6 SNP, DOID:363 / uterine cancer	Gln57His	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BUF5	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β58	K58A	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Cold sensitive, with R62A, TUB2p	Lys58Ala	Reijo et al. 1994. Mol Biol Cell 5:29-43	https://pubmed.ncbi.nlm.nih.gov/8186463/	Saccharomyces cerevisiae, budding yeast, fungus
		β58	K58N	P68371	https://www.uniprot.org/uniprotkb/P68371/entry	H. sapiens	TBB4B SNP, DOID:363 / uterine cancer	Lys58Asn	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P68371	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β58	K58N	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:3571 / liver cancer	Lys58Asn	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β58	K58N	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:0070003 / blastoma	Lys58Asn	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β58	K58N	Q9BUF5	https://www.uniprot.org/uniprotkb/Q9BUF5/entry	H. sapiens	TBB6 SNP, DOID:1612 / breast cancer	Lys58Asn	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BUF5	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β58	K58R	Q9BUF5	https://www.uniprot.org/uniprotkb/Q9BUF5/entry	H. sapiens	TBB6 SNP, DOID:0070003 / blastoma	Lys58Arg	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BUF5	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β58	K58R	Q9BVA1	https://www.uniprot.org/uniprotkb/Q9BVA1/entry	H. sapiens	TBB2B SNP, DOID:1909 / melanoma	Lys58Arg	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BVA1	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β58	K58T	Q9BVA1	https://www.uniprot.org/uniprotkb/Q9BVA1/entry	H. sapiens	TBB2B SNP, DOID:363 / uterine cancer	Lys58Thr	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BVA1	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β60	V60A	P69893	https://www.uniprot.org/uniprotkb/P69893/entry	C. griseus	Taxol resistant revertant of D45Y, CHO cell line, tubulin beta-5	Val60Ala	Wang et al. 2004. Biochemistry 43:8965-73.	https://pubmed.ncbi.nlm.nih.gov/15248754/	Cricetulus griseus, chinese hamster, rodent
		β60	V60A	P69893	https://www.uniprot.org/uniprotkb/P69893/entry	C. griseus	Paclitaxel resistant, CHO cell line, tubulin beta-5, sometimes with E376G	Val60Ala	Yin et al. 2012. Pharm Res 29:2994-3006	https://pubmed.ncbi.nlm.nih.gov/22669706/	Cricetulus griseus, chinese hamster, rodent
		β60	V60F	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	A549 human lung carcinoma line EpoB step up selection of B292, tubulin beta-1	Val60Phe	Yang et al. 2005. Mol Cancer Ther 4:987-95	https://pubmed.ncbi.nlm.nih.gov/15956256/	Homo sapiens, human, clinical
		β60	V60G	Q13885	https://www.uniprot.org/uniprotkb/Q13885/entry	H. sapiens	TBB2A SNP, DOID:1324 / lung cancer	Val60Gly	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13885	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β60	V60L	Q13885	https://www.uniprot.org/uniprotkb/Q13885/entry	H. sapiens	TBB2A SNP, DOID:1324 / lung cancer	Val60Leu	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13885	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β60	V60L	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Female infertility, tubulin beta-8	Val60Leu	Zhao et al. 2020. J Assist Reprod Genet 37:1837-47.	https://pubmed.ncbi.nlm.nih.gov/32524331/	Homo sapiens, human, clinical
		β60	V60M	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:2531 / hematologic cancer	Val60Met	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β60	V60M	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:1612 / breast cancer	Val60Met	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β60	V60M	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Human oocyte maturation arrest and female infertility, TUBB8	Val60Met	Li et al. 2022. Eur J Obstet Gynecol Reprod Biol 279:132-139	https://pubmed.ncbi.nlm.nih.gov/36335766/	Homo sapiens, human, clinical
		β61	P61A	P10878	https://www.uniprot.org/uniprotkb/P10878/entry	T. gondii	Suppressor of G142S α1-tubulin defects, β1-tubulin	Pro61Ala	Ma et al. 2008. Genetics 180:845-56	https://pubmed.ncbi.nlm.nih.gov/18780736/	Toxoplasma gondii, parasite, protozoan
		β61	P61L	P12456	https://www.uniprot.org/uniprotkb/P12456/entry	C. elegans	Weak antimorph, moderately shortened neurites, mec-7	Pro61Leu	Zheng et al. 2017 Mol Biol Cell 28: 2786-2801	https://pubmed.ncbi.nlm.nih.gov/28835377/	Caenorhabditis elegans, nematode, roundworm	also see Lee et al. 2021. Mol Biol Cell. 15:331-347 (PMID 33378215)
		β61	P61L	P12456	https://www.uniprot.org/uniprotkb/P12456/entry	C. elegans	Mechanosensitive, severe semi-dominant allele, mec-7	Pro61Leu	Savage et al. 1994. J Cell Sci 107:2165-75	https://pubmed.ncbi.nlm.nih.gov/7983175/	Caenorhabditis elegans, nematode, roundworm
		β61	P61S	Q9BVA1	https://www.uniprot.org/uniprotkb/Q9BVA1/entry	H. sapiens	TBB2B SNP, DOID:10534 / stomach cancer	Pro61Ser	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BVA1	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β61	P61S	P12456	https://www.uniprot.org/uniprotkb/P12456/entry	C. elegans	Weak antimorph, moderately shortened neurites, mec-7	Pro61Ser	Zheng et al. 2017 Mol Biol Cell 28: 2786-2801	https://pubmed.ncbi.nlm.nih.gov/28835377/	Caenorhabditis elegans, nematode, roundworm	also see Lee et al. 2021. Mol Biol Cell. 15:331-347 (PMID 33378215)
		β61	P61S	P12456	https://www.uniprot.org/uniprotkb/P12456/entry	C. elegans	Mechanosensitive, severe semi-dominant allele, mec-7	Pro61Ser	Savage et al. 1994. J Cell Sci 107:2165-75	https://pubmed.ncbi.nlm.nih.gov/7983175/	Caenorhabditis elegans, nematode, roundworm
		β61	P61T	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Female infertility, tubulin beta-8	Pro61Thr	Chen et al. 2019. Eur J Hum Genet 27:300-307	https://pubmed.ncbi.nlm.nih.gov/30297906/	Homo sapiens, human, clinical
		β61	R61P	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	Dandy Walker malformation, tubulin beta	Arg61Pro	Brar et al. 2022. Prenatal Diagnosis 42:1686–1693	https://pubmed.ncbi.nlm.nih.gov/36403095/	Homo sapiens, human, clinical	185G>A
		β62	R62A	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Cold sensitive, with K58A, TUB2p	Arg62Ala	Reijo et al. 1994. Mol Biol Cell 5:29-43	https://pubmed.ncbi.nlm.nih.gov/8186463/	Saccharomyces cerevisiae, budding yeast, fungus
		β62	R62C	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:1324 / lung cancer	Arg62Cys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β62	R62G	Q9BUF5	https://www.uniprot.org/uniprotkb/Q9BUF5/entry	H. sapiens	TBB6 SNP, DOID:363 / uterine cancer	Arg62Gly	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BUF5	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β62	R62G	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:0070003 / blastoma	Arg62Gly	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β62	R62G	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:3571 / liver cancer	Arg62Gly	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β62	R62K	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:4362 / cervical cancer	Arg62Lys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β62	R62Q	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:1909 / melanoma	Arg62Gln	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β62	R62Q	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:1612 / breast cancer	Arg62Gln	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β62	R62Q	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Extraocular congenital fibrosis syndrome, tubulin beta-3	Arg62Gln	Tischfield et al. 2010. Cell 140:74-87	https://pubmed.ncbi.nlm.nih.gov/20074521/	Homo sapiens, human, clinical
		β62	R62Q	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Inhibited axonal transport of vesicles and mitochondria, tubulin beta-3	Arg62Gln	Niwa et al. 2013. EMBO J 32:1352-64	https://pubmed.ncbi.nlm.nih.gov/23503589/	Homo sapiens, human, clinical	Model for CFEOM3
		β62	R62Q	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Disruption of netrin-1 mediated axonal repulsion, tubulin beta-3, HeLa cells	Arg62Gln	Shao et al. 2019. PLoS One 14:e0218811	https://pubmed.ncbi.nlm.nih.gov/31226147/	Homo sapiens, human, clinical
		β62	R62Q	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Congenital fibrosis of the extraocular muscles, tubulin beta-3	Arg62Gln	ClinVar 219254	https://www.ncbi.nlm.nih.gov/clinvar/variation/219254	Homo sapiens, human, clinical
		β62	R62W	Q9ERD7	https://www.uniprot.org/uniprotkb/Q9ERD7/entry	M. musculus	Tubb3, viable heterozygote	Arg62Trp	Mutagenetix	https://mutagenetix.utsouthwestern.edu/incidental/incidental_rec.cfm?mid=686995	Mus musculus, mouse, tubulin beta-3	Wang et al. 2015. PNAS 112:E440-449 (PMID 25605905)
		β63	A63P	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:3070 / malignant glioma	Ala63Pro	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β63	A63T	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:10534 / stomach cancer	Ala63Thr	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β63	A63T	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:363 / uterine cancer	Ala63Thr	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β63	A63T	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:3070 / malignant glioma	Ala63Thr	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β63	A63V	Q9BUF5	https://www.uniprot.org/uniprotkb/Q9BUF5/entry	H. sapiens	TBB6 SNP, DOID:5041 / esophageal cancer	Ala63Val	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BUF5	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β63	A63V	Q18817	https://www.uniprot.org/uniprotkb/Q18817/entry	C. elegans	Albendazole resistance, ben-1	Ala63Val	Pallotto et al. 2022. Genetics 221:iyac093	https://pubmed.ncbi.nlm.nih.gov/35731216/	Caenorhabditis elegans, nematode, roundworm
		β64	E64K	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	Likely pathogenic, with E108K, E128K, E36K, tubulin beta	Glu64Lys	ClinVar 373428	https://www.ncbi.nlm.nih.gov/clinvar/variation/373428	Homo sapiens, human, clinical
		β64	I64V	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Uncertain significance, tubulin beta-3	Ile64Val	ClinVar 212499	https://www.ncbi.nlm.nih.gov/clinvar/variation/212499	Homo sapiens, human, clinical
		β64	V64I	P68371	https://www.uniprot.org/uniprotkb/P68371/entry	H. sapiens	Invasive lobular, low grade; no treatment, also contains E45D, N48S	Val64Ile	Wang et al. 2017. Protoplasma 254:1163-1173	https://pubmed.ncbi.nlm.nih.gov/27943021/	Homo sapiens, human, clinical	Tubulin beta-4B chain
		β64	V64I	Q13885	https://www.uniprot.org/uniprotkb/Q13885/entry	H. sapiens	Invasive ductal, low grade; no treatment, also contains E45D, N48S, V170M, C201S, A296S, V316I	Val64Ile	Wang et al. 2017. Protoplasma 254:1163-1173	https://pubmed.ncbi.nlm.nih.gov/27943021/	Homo sapiens, human, clinical	Tubulin beta-2A chain
		β64	V64I	P12456	https://www.uniprot.org/uniprotkb/P12456/entry	C. elegans	No defects, mec-7	Val64Ile	Zheng et al. 2017 Mol Biol Cell 28: 2786-2801	https://pubmed.ncbi.nlm.nih.gov/28835377/	Caenorhabditis elegans, nematode, roundworm	also see Lee et al. 2021. Mol Biol Cell. 15:331-347 (PMID 33378215)
		β64	V64L	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:10534 / stomach cancer	Val64Leu	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β65	L65M	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:1324 / lung cancer	Leu65Met	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β65	L65M	Q13885	https://www.uniprot.org/uniprotkb/Q13885/entry	H. sapiens	TBB2A SNP, DOID:3571 / liver cancer	Leu65Met	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13885	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β65	L65P	Q13885	https://www.uniprot.org/uniprotkb/Q13885/entry	H. sapiens	TBB2A SNP, DOID:11054 / urinary bladder cancer	Leu65Pro	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13885	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β66	V66A	Q9D6F9	https://www.uniprot.org/uniprotkb/Q9D6F9/entry	M. musculus	Tubb4a, viable heterozygote	Val66Ala	Mutagenetix	https://mutagenetix.utsouthwestern.edu/incidental/incidental_rec.cfm?mid=29317	Mus musculus, mouse, tubulin beta-4A	Wang et al. 2015. PNAS 112:E440-449 (PMID 25605905)
		β66	V66A	Q922F4	https://www.uniprot.org/uniprotkb/Q922F4/entry	M. musculus	Tubb6, viable heterozygote	Val66Ala	Mutagenetix	https://mutagenetix.utsouthwestern.edu/incidental/incidental_rec.cfm?mid=685804	Mus musculus, mouse, tubulin beta-6	Wang et al. 2015. PNAS 112:E440-449 (PMID 25605905)
		β66	V66G	Q9BUF5	https://www.uniprot.org/uniprotkb/Q9BUF5/entry	H. sapiens	TBB6 SNP, DOID:1612 / breast cancer	Val66Gly	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BUF5	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β67	D67A	A2AQ07	https://www.uniprot.org/uniprotkb/A2AQ07/entry	M. musculus	Tubb1, viable heterozygote	Asp67Ala	Mutagenetix	https://mutagenetix.utsouthwestern.edu/incidental/incidental_rec.cfm?mid=186512	Mus musculus, mouse, tubulin beta-1	Wang et al. 2015. PNAS 112:E440-449 (PMID 25605905)
		β67	D67A	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Wild-type, with E69A, TUB2p	Asp67Ala	Reijo et al. 1994. Mol Biol Cell 5:29-43	https://pubmed.ncbi.nlm.nih.gov/8186463/	Saccharomyces cerevisiae, budding yeast, fungus
		β67	D67A	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Wild-type, with E69A, G71W, TUB2p	Asp67Ala	Reijo et al. 1994. Mol Biol Cell 5:29-43	https://pubmed.ncbi.nlm.nih.gov/8186463/	Saccharomyces cerevisiae, budding yeast, fungus
		β67	D67N	P32882	https://www.uniprot.org/uniprotkb/P32882/entry	G. gallus	GTP binding site mutation, in vitro synthesis in reticulocyte lysates	Asp67Asn	Farr & Sternlicht. 1992. J Mol Biol 227:307-21	https://pubmed.ncbi.nlm.nih.gov/1522595/	Gallus gallus, red junglefowl, chicken, bird
		β67	D67Y	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:3571 / liver cancer	Asp67Tyr	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β68	L68P	P68371	https://www.uniprot.org/uniprotkb/P68371/entry	H. sapiens	TBB4B SNP, DOID:3963 / thyroid carcinoma	Leu68Pro	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P68371	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β69	E69A	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Wild-type, with E67A, TUB2p	Glu69Ala	Reijo et al. 1994. Mol Biol Cell 5:29-43	https://pubmed.ncbi.nlm.nih.gov/8186463/	Saccharomyces cerevisiae, budding yeast, fungus
		β69	E69A	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Wild-type, with E67A, G71W, TUB2p	Glu69Ala	Reijo et al. 1994. Mol Biol Cell 5:29-43	https://pubmed.ncbi.nlm.nih.gov/8186463/	Saccharomyces cerevisiae, budding yeast, fungus
		β69	E69G	Q18817	https://www.uniprot.org/uniprotkb/Q18817/entry	C. elegans	Benzimidazole resistant (ben-1, tbb-5)	Glu69Gly	Hahnel et al. 2018. PLoS Pathog 14:e1007226	https://pubmed.ncbi.nlm.nih.gov/30372484/	Caenorhabditis elegans, nematode, roundworm
		β69	E69K	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:2531 / hematologic cancer	Glu69Lys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β69	E69K	Q13885	https://www.uniprot.org/uniprotkb/Q13885/entry	H. sapiens	TBB2A SNP, DOID:1324 / lung cancer	Glu69Lys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13885	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β69	E69K	P12456	https://www.uniprot.org/uniprotkb/P12456/entry	C. elegans	Antimorph, shortened TRN neurites, mec-7	Glu69Lys	Lee et al. 2021. Mol Biol Cell. 15:331-347	https://pubmed.ncbi.nlm.nih.gov/33378215/	Caenorhabditis elegans, nematode, roundworm
		β69	E75K	P08841	https://www.uniprot.org/uniprotkb/P08841/entry	D. melanogaster	Dominant bristle defects (Pin 1 Allele, β-tubulin60D)	Glu75Lys	Krishnan et al. 2022. Front. Cell Dev. Biol. 9:787976.	https://pubmed.ncbi.nlm.nih.gov/35111755/	Drosophila, fruitfly
		β69	E69Q	P32882	https://www.uniprot.org/uniprotkb/P32882/entry	G. gallus	GTP binding site mutation, in vitro synthesis in reticulocyte lysates	Glu69Gln	Farr & Sternlicht. 1992. J Mol Biol 227:307-21	https://pubmed.ncbi.nlm.nih.gov/1522595/	Gallus gallus, red junglefowl, chicken, bird
		β70	G70C	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	Likely pathogenic, with G142C, G162C, G98C, tubulin beta	Gly70Cys	ClinVar 916073	https://www.ncbi.nlm.nih.gov/clinvar/variation/916073	Homo sapiens, human, clinical
		β70	G70S	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Likely pathogenic, with G142S, tubulin beta-3	Gly70Ser	ClinVar 430312	https://www.ncbi.nlm.nih.gov/clinvar/variation/430312	Homo sapiens, human, clinical
		β70	P70L	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Infertility due to arrest in oocyte maturation, tubulin beta-8	P70Leu	Chen et al. 2017. Hum Reprod 32:457-464.	https://pubmed.ncbi.nlm.nih.gov/27989988/	Homo sapiens, human, clinical
		β70	P70Q	Q9BVA1	https://www.uniprot.org/uniprotkb/Q9BVA1/entry	H. sapiens	TBB2B SNP, DOID:1324 / lung cancer	Pro70Gln	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BVA1	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β70	P70Q	Q9BVA1	https://www.uniprot.org/uniprotkb/Q9BVA1/entry	H. sapiens	TBB2B SNP, DOID:3571 / liver cancer	Pro70Gln	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BVA1	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β70	P70S	Q9BUF5	https://www.uniprot.org/uniprotkb/Q9BUF5/entry	H. sapiens	TBB6 SNP, DOID:363 / uterine cancer	Pro70Ser	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BUF5	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β71	G71C	Q9BUF5	https://www.uniprot.org/uniprotkb/Q9BUF5/entry	H. sapiens	TBB6 SNP, DOID:1909 / melanoma	Gly71Cys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BUF5	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β71	G71E	Q18817	https://www.uniprot.org/uniprotkb/Q18817/entry	C. elegans	Albendazole resistance, ben-1	Gly71Glu	Pallotto et al. 2022. Genetics 221:iyac093	https://pubmed.ncbi.nlm.nih.gov/35731216/	Caenorhabditis elegans, nematode, roundworm
		β71	G71R	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:0070003 / blastoma	Gly71Arg	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β71	G71R	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:2394 / ovarian cancer	Gly71Arg	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β71	G71R	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Fibrosis of extraocular muscles, cortical malformations, tubulin beta-3	Gly71Arg	Whitman et al.2016. Am J Med Genet A 170A:297-305	https://pubmed.ncbi.nlm.nih.gov/26639658/	Homo sapiens, human, clinical
		β71	G71R	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Congenital fibrosis of the extraocular muscles, with G91R, tubulin beta-3	Gly71Arg	ClinVar 219255	https://www.ncbi.nlm.nih.gov/clinvar/variation/219255	Homo sapiens, human, clinical
		β71	G71S	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:363 / uterine cancer	Gly71Ser	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β71	G71S	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:1909 / melanoma	Gly71Ser	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β71	G71S	Q9BUF5	https://www.uniprot.org/uniprotkb/Q9BUF5/entry	H. sapiens	TBB6 SNP, DOID:11934 / head and neck cancer	Gly71Ser	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BUF5	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β71	G71V	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:1324 / lung cancer	Gly71Val	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β71	G71W	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Wild-type, with D67A, E69A, TUB2p	Gly71Trp	Reijo et al. 1994. Mol Biol Cell 5:29-43	https://pubmed.ncbi.nlm.nih.gov/8186463/	Saccharomyces cerevisiae, budding yeast, fungus
		β71	G71W	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Recessive lethal, with D74A, R77A, TUB2p	Gly71Trp	Reijo et al. 1994. Mol Biol Cell 5:29-43	https://pubmed.ncbi.nlm.nih.gov/8186463/	Saccharomyces cerevisiae, budding yeast, fungus
		β72	T72A	Q922F4	https://www.uniprot.org/uniprotkb/Q922F4/entry	M. musculus	Tubb6, viable heterozygote	Thr72Ala	Mutagenetix	https://mutagenetix.utsouthwestern.edu/incidental/incidental_rec.cfm?mid=272197	Mus musculus, mouse, tubulin beta-6	Wang et al. 2015. PNAS 112:E440-449 (PMID 25605905)
		β72	T72I	Q13885	https://www.uniprot.org/uniprotkb/Q13885/entry	H. sapiens	TBB2A SNP, DOID:363 / uterine cancer	Thr72Ile	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13885	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β72	T72I	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:1909 / melanoma	Thr72Ile	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β72	T72M	Q9BVA1	https://www.uniprot.org/uniprotkb/Q9BVA1/entry	H. sapiens	TBB2B SNP, DOID:10534 / stomach cancer	Thr72Met	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BVA1	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β73	M73I	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:3571 / liver cancer	Met73Ile	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β73	M73I	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:1793 / pancreatic cancer	Met73Ile	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β73	M73I	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:11934 / head and neck cancer	Met73Ile	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β73	M73K	Q9BUF5	https://www.uniprot.org/uniprotkb/Q9BUF5/entry	H. sapiens	TBB6 SNP, DOID:3571 / liver cancer	Met73Lys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BUF5	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β73	M73T	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	Circumferential skin creases Kunze type, microcephaly, TUBB	Met73Thr	Dentici et al. 2018. Clinical Genetics, 93:223-28	https://pubmed.ncbi.nlm.nih.gov/29427453/	Homo sapiens, human, clinical
		β73	M73T	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	Microcephaly, corpus callosum agenesis, , tubulin beta	Met73Thr	Sferra et al. 2020. Int J Mol Sci 21:1385	https://pubmed.ncbi.nlm.nih.gov/32085672/	Homo sapiens, human, clinical
		β73	Q73R	Q4HZS8	https://www.uniprot.org/uniprotkb/Q4HZS8/entry	G. zeae	Benzimidazole resistant, with E198L, tub2	Gln73Arg	Chen et al. 2009. Phytopathology 99:1403-11	https://pubmed.ncbi.nlm.nih.gov/19900007/	Gibberella zeae, Fusarium graminearum, fungus
		β74	D74A	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Recessive lethal, with G71W, R77A, TUB2p	Asp74Ala	Reijo et al. 1994. Mol Biol Cell 5:29-43	https://pubmed.ncbi.nlm.nih.gov/8186463/	Saccharomyces cerevisiae, budding yeast, fungus
		β74	D74A	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Wild-type, with R77A, TUB2p	Asp74Ala	Reijo et al. 1994. Mol Biol Cell 5:29-43	https://pubmed.ncbi.nlm.nih.gov/8186463/	Saccharomyces cerevisiae, budding yeast, fungus
		β74	D74G	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Uncertain significance, with D2G, tubulin beta-3	Asp74Gly	ClinVar 872055	https://www.ncbi.nlm.nih.gov/clinvar/variation/872055	Homo sapiens, human, clinical
		β74	D74N	P68371	https://www.uniprot.org/uniprotkb/P68371/entry	H. sapiens	TBB4B SNP, DOID:363 / uterine cancer	Asp74Asn	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P68371	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β74	D74N	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:1909 / melanoma	Asp74Asn	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β74	D74N	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:1612 / breast cancer	Asp74Asn	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β75	S75C	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	TUBB SNP, DOID:4159 / skin cancer	Ser75Cys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P07437	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β75	S75I	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:3571 / liver cancer	Ser75Ile	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β75	S75I	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:3070 / malignant glioma	Ser75Ile	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β75	S75L	Q9BVA1	https://www.uniprot.org/uniprotkb/Q9BVA1/entry	H. sapiens	TBB2B SNP, DOID:363 / uterine cancer	Ser75Leu	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BVA1	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β75	S75L	Q9BVA1	https://www.uniprot.org/uniprotkb/Q9BVA1/entry	H. sapiens	TBB2B SNP, DOID:1909 / melanoma	Ser75Leu	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BVA1	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β75	S75L	Q9BVA1	https://www.uniprot.org/uniprotkb/Q9BVA1/entry	H. sapiens	TBB2B SNP, DOID:9256 / colorectal cancer	Ser75Leu	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BVA1	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β75	S75L	Q9BVA1	https://www.uniprot.org/uniprotkb/Q9BVA1/entry	H. sapiens	TBB2B SNP, DOID:11054 / urinary bladder cancer	Ser75Leu	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BVA1	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β75	S75Y	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:363 / uterine cancer	Ser75Tyr	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β76	F76V	Q25024	https://www.uniprot.org/uniprotkb/Q25024/entry	H. contortus	Benzimidazole resistant (association), isotype not specified	Phe76Val	Kwa et al. 1994. Mol Biochem Parasitol 63:299-303	https://pubmed.ncbi.nlm.nih.gov/7911975/	Haemonchus contortus (Barber pole worm), parasite
		β76	V76A	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:1324 / lung cancer	Val76Ala	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β76	V76D	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	Symmetrical circular skin fold Kunze type, complex brain malformation, TUBB	Val76Asp	Niu et al. 2020. Chinese J Med Genet 37:1413–1414	http://www.zhyxycx.life/index.php/cjmg/issue/archive	Homo sapiens, human, clinical
		β76	V76F	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:3571 / liver cancer	Val76Phe	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β76	V76F	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:0070003 / blastoma	Val76Phe	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β76	V76F	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:3571 / liver cancer	Val76Phe	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β77	D77A	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Recessive lethal, with G71W, D74A, TUB2p	Asp77Ala	Reijo et al. 1994. Mol Biol Cell 5:29-43	https://pubmed.ncbi.nlm.nih.gov/8186463/	Saccharomyces cerevisiae, budding yeast, fungus
		β77	D77A	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Wild-type, with D74A, TUB2p	Asp77Ala	Reijo et al. 1994. Mol Biol Cell 5:29-43	https://pubmed.ncbi.nlm.nih.gov/8186463/	Saccharomyces cerevisiae, budding yeast, fungus
		β77	R77C	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:1909 / melanoma	Arg77Cys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β77	R77C	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:0070003 / blastoma	Arg77Cys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β77	R77C	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:2531 / hematologic cancer	Arg77Cys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β77	R77C	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:363 / uterine cancer	Arg77Cys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β77	R77C	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:10534 / stomach cancer	Arg77Cys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β77	R77H	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:363 / uterine cancer	Arg77His	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β77	R77H	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:1324 / lung cancer	Arg77His	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β77	R77Q	Q9BUF5	https://www.uniprot.org/uniprotkb/Q9BUF5/entry	H. sapiens	TBB6 SNP, DOID:10534 / stomach cancer	Arg77Gln	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BUF5	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β77	R77Q	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:363 / uterine cancer	Arg77Gln	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β77	R77Q	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:9256 / colorectal cancer	Arg77Gln	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β77	R77T	Q13885	https://www.uniprot.org/uniprotkb/Q13885/entry	H. sapiens	TBB2A SNP, DOID:0070003 / blastoma	Arg77Thr	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13885	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β78	L78F	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	Cortical dysplasia, other brain malformations, with L150F, L170F, L106F, tubulin beta	Leu78Phe	ClinVar 807517	https://www.ncbi.nlm.nih.gov/clinvar/variation/807517	Homo sapiens, human, clinical
		β78	S78T	Q9BVA1	https://www.uniprot.org/uniprotkb/Q9BVA1/entry	H. sapiens	TBB2B SNP, DOID:1909 / melanoma	Ser78Thr	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BVA1	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β78	S78Y	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:363 / uterine cancer	Ser78Tyr	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β79	G79R	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:1909 / melanoma	Gly79Arg	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β79	S79K	Q9UV72	https://www.uniprot.org/uniprotkb/Q9UV72/entry	Pestalotiopsis sp.	Carbendazim-resistant, beta tubulin	Ser79Lys	Kummanid et al. 2017 J Phytopathol 165:515-21	https://onlinelibrary.wiley.com/doi/abs/10.1111/jph.12588	Ascomycete fungus
		β80	A80T	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:3371 / chondrosarcoma	Ala80Thr	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β80	P80H	Q13885	https://www.uniprot.org/uniprotkb/Q13885/entry	H. sapiens	TBB2A SNP, DOID:3571 / liver cancer	Pro80His	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13885	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β80	P80L	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:1324 / lung cancer	Pro80Leu	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β80	P80L	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:3571 / liver cancer	Pro80Leu	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β80	P80L	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:1115 / sarcoma	Pro80Leu	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β80	P80L	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Likely benign, with P131L, P8L, P125L, tubulin beta-4A	Pro80Leu	ClinVar 623922	https://www.ncbi.nlm.nih.gov/clinvar/variation/623922	Homo sapiens, human, clinical
		β80	P80S	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:8618 / oral cavity cancer	Pro80Ser	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β80	P80S	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	TUBB SNP, DOID:1909 / melanoma	Pro80Ser	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P07437	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β80	P80S	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	TUBB SNP, DOID:11054 / urinary bladder cancer	Pro80Ser	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P07437	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β80	P80S	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Torsion dystonia, with P125S, P131S, P8S, tubulin beta-4A	Pro80Ser	ClinVar 692150	https://www.ncbi.nlm.nih.gov/clinvar/variation/692150	Homo sapiens, human, clinical
		β81	F81I	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:10534 / stomach cancer	Phe81Ile	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β82	G82D	P10878	https://www.uniprot.org/uniprotkb/P10878/entry	T. gondii	Suppressor of F52Y α1-tubulin defects, β1-tubulin	Gly82Asp	Ma et al. 2008. Genetics 180:845-56	https://pubmed.ncbi.nlm.nih.gov/18780736/	Toxoplasma gondii, parasite, protozoan
		β82	G82R	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Malformation of cortical development, tubulin beta-3	Gly82Arg	Poirier et al. 2010. Hum Mol Genet 19:4462-73	https://pubmed.ncbi.nlm.nih.gov/20829227/	Homo sapiens, human, clinical
		β82	G82R	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Inhibited axonal transport of vesicles and mitochondria, tubulin beta-3	Gly82Arg	Niwa et al. 2013. EMBO J 32:1352-64	https://pubmed.ncbi.nlm.nih.gov/23503589/	Homo sapiens, human, clinical	Model for MCD
		β82	G82V	Q9BVA1	https://www.uniprot.org/uniprotkb/Q9BVA1/entry	H. sapiens	Cortical malformations, tubulin beta-2B	Gly82Val	Cabet 2021. Ultrasound Obstet Gynecol 57: 493 – 497	https://pubmed.ncbi.nlm.nih.gov/32149430/	Homo sapiens, human, clinical
		β82	G82W	P68371	https://www.uniprot.org/uniprotkb/P68371/entry	H. sapiens	TBB4B SNP, DOID:363 / uterine cancer	Gly82Trp	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P68371	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β83	Q83H	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:263 / kidney cancer	Gln83His	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β83	Q83K	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:3571 / liver cancer	Gln83Lys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β83	Q83K	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:0070003 / blastoma	Gln83Lys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β83	I84N	P68371	https://www.uniprot.org/uniprotkb/P68371/entry	H. sapiens	TBB4B SNP, DOID:1324 / lung cancer	Ile84Asn	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P68371	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β83	L84P	Q9BUF5	https://www.uniprot.org/uniprotkb/Q9BUF5/entry	H. sapiens	TBB6 SNP, DOID:1115 / sarcoma	Leu84Pro	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BUF5	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β84	R84L	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with R156L, R207L, R201L, tubulin beta-4A	Arg84Leu	ClinVar 135659	https://www.ncbi.nlm.nih.gov/clinvar/variation/135659	Homo sapiens, human, clinical
		β84	V84F	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:1793 / pancreatic cancer	Val84Phe	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β84	V84I	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:0070003 / blastoma	Val84Ile	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β84	V84I	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:3571 / liver cancer	Val84Ile	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β85	F85L	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:3571 / liver cancer	Phe85Leu	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β85	F85L	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:1115 / sarcoma	Phe85Leu	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β85	F85L	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:4362 / cervical cancer	Phe85Leu	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β85	F85L	Q9BVA1	https://www.uniprot.org/uniprotkb/Q9BVA1/entry	H. sapiens	TBB2B SNP, DOID:3963 / thyroid carcinoma	Phe85Leu	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BVA1	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β85	F85L	P10878	https://www.uniprot.org/uniprotkb/P10878/entry	T. gondii	Suppressor of G142S α1-tubulin defects, β1-tubulin	Phe85Leu	Ma et al. 2008. Genetics 180:845-56	https://pubmed.ncbi.nlm.nih.gov/18780736/	Toxoplasma gondii, parasite, protozoan
		β85	F85L	P69893	https://www.uniprot.org/uniprotkb/P69893/entry	C. griseus	With D39G, paclitaxel resistant, CHO cell line, tubulin beta-5	Phe85Leu	Yin et al. 2012. Pharm Res 29:2994-3006	https://pubmed.ncbi.nlm.nih.gov/22669706/	Cricetulus griseus, chinese hamster, rodent
		β85	F85S	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:2394 / ovarian cancer	Phe85Ser	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β85	F85S	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:2994 / germ cell cancer	Phe85Ser	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β86	R86A	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Wild-type, with D88A, TUB2p	Arg86Ala	Reijo et al. 1994. Mol Biol Cell 5:29-43	https://pubmed.ncbi.nlm.nih.gov/8186463/	Saccharomyces cerevisiae, budding yeast, fungus
		β86	R86C	P12456	https://www.uniprot.org/uniprotkb/P12456/entry	C. elegans	Weak neomorph, overextended PLM-PN, mec-7	Arg86Cys	Lee et al. 2021. Mol Biol Cell. 15:331-347	https://pubmed.ncbi.nlm.nih.gov/33378215/	Caenorhabditis elegans, nematode, roundworm
		β86	R86I	Q13885	https://www.uniprot.org/uniprotkb/Q13885/entry	H. sapiens	TBB2A SNP, DOID:363 / uterine cancer	Arg86Ile	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13885	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β86	R86L	P68371	https://www.uniprot.org/uniprotkb/P68371/entry	H. sapiens	TBB4B SNP, DOID:0070003 / blastoma	Arg86Leu	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P68371	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β86	R86L	P68371	https://www.uniprot.org/uniprotkb/P68371/entry	H. sapiens	TBB4B SNP, DOID:3571 / liver cancer	Arg86Leu	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P68371	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β86	R86Q	Q9BUF5	https://www.uniprot.org/uniprotkb/Q9BUF5/entry	H. sapiens	TBB6 SNP, DOID:9256 / colorectal cancer	Arg86Gln	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BUF5	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β86	R86W	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:9256 / colorectal cancer	Arg86Trp	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β87	P87L	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Female infertility, tubulin beta-8	Pro87Leu	Zhao et al. 2020. J Assist Reprod Genet 37:1837-47.	https://pubmed.ncbi.nlm.nih.gov/32524331/	Homo sapiens, human, clinical
		β87	P87Q	Q9BVA1	https://www.uniprot.org/uniprotkb/Q9BVA1/entry	H. sapiens	Malformation of cortical development, tubulin beta-2B	Pro87Gln	Jimenez et al. 2019. Neuroradiol J 32:148-150	https://pubmed.ncbi.nlm.nih.gov/30704335/	Homo sapiens, human, clinical
		β88	D88A	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Wild-type, with R86A, TUB2p	Asp88Ala	Reijo et al. 1994. Mol Biol Cell 5:29-43	https://pubmed.ncbi.nlm.nih.gov/8186463/	Saccharomyces cerevisiae, budding yeast, fungus
		β88	D88E	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:3963 / thyroid carcinoma	Asp88Glu	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β88	D88H	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:2531 / hematologic cancer	Asp88His	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β88	D88N	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:5041 / esophageal cancer	Asp88Asn	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β88	D88N	Q18817	https://www.uniprot.org/uniprotkb/Q18817/entry	C. elegans	Albendazole resistance, ben-1	Asp88Asn	Pallotto et al. 2022. Genetics 221:iyac093	https://pubmed.ncbi.nlm.nih.gov/35731216/	Caenorhabditis elegans, nematode, roundworm
		β89	N89K	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:363 / uterine cancer	Asn89Lys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β89	N89K	Q13885	https://www.uniprot.org/uniprotkb/Q13885/entry	H. sapiens	Tubulinopathy, brain malformations, tubulin beta-2A	Asn89Lys	Brock et al. 2021. J Med Genet 58:33-40	https://pubmed.ncbi.nlm.nih.gov/32571897/	Homo sapiens, human, clinical
		β89	N89S	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	TUBB SNP, DOID:363 / uterine cancer	Asn89Ser	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P07437	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β89	N89T	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	Cortical dysplasia, other brain malformations, with N45T, N109T, N17T, tubulin beta	Asn89Thr	ClinVar 802193	https://www.ncbi.nlm.nih.gov/clinvar/variation/802193	Homo sapiens, human, clinical
		β89	S89N	A2AQ07	https://www.uniprot.org/uniprotkb/A2AQ07/entry	M. musculus	Tubb1, viable heterozygote	Ser89Asn	Mutagenetix	https://mutagenetix.utsouthwestern.edu/incidental/incidental_rec.cfm?mid=210492	Mus musculus, mouse, tubulin beta-1	Wang et al. 2015. PNAS 112:E440-449 (PMID 25605905)
		β90	F90L	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:11934 / head and neck cancer	Phe90Leu	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β90	F90S	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:3963 / thyroid carcinoma	Phe90Ser	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β91	G91R	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Congenital fibrosis of the extraocular muscles, with G71R, tubulin beta-3	Gly91Arg	ClinVar 219255	https://www.ncbi.nlm.nih.gov/clinvar/variation/219255	Homo sapiens, human, clinical
		β91	V91G	A0A8E5HT31	https://www.uniprot.org/uniprotkb/A0A8E5HT31/entry	U. virens	Carbendazin resistance, Uvβ1Tub	Val91Gly	Song et al. 2022. J Fungi 8:1311	https://pubmed.ncbi.nlm.nih.gov/36547644/	Ustilaginoidea, fungus, rice false smut
		β91	V91M	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:3070 / malignant glioma	Val91Met	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β91	V91M	Q9BVA1	https://www.uniprot.org/uniprotkb/Q9BVA1/entry	H. sapiens	TBB2B SNP, DOID:1324 / lung cancer	Val91Met	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BVA1	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β91	V91M	Q9BVA1	https://www.uniprot.org/uniprotkb/Q9BVA1/entry	H. sapiens	TBB2B SNP, DOID:10534 / stomach cancer	Val91Met	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BVA1	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β91	V91M	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with V142M, V136M, V19M, tubulin beta-4A	Val91Met	ClinVar 847763	https://www.ncbi.nlm.nih.gov/clinvar/variation/847763	Homo sapiens, human, clinical
		β92	F92L	Q9BUF5	https://www.uniprot.org/uniprotkb/Q9BUF5/entry	H. sapiens	TBB6 SNP, DOID:363 / uterine cancer	Phe92Leu	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BUF5	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β93	G93S	P68371	https://www.uniprot.org/uniprotkb/P68371/entry	H. sapiens	TBB4B SNP, DOID:1909 / melanoma	Gly93Ser	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P68371	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β93	G93V	P68371	https://www.uniprot.org/uniprotkb/P68371/entry	H. sapiens	TBB4B SNP, DOID:3571 / liver cancer	Gly93Val	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P68371	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β93	G93V	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:363 / uterine cancer	Gly93Val	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β93	T93M	Q13885	https://www.uniprot.org/uniprotkb/Q13885/entry	H. sapiens	Pathogenic, with T178M, tubulin beta-2A	Thr93Met	ClinVar 265284	https://www.ncbi.nlm.nih.gov/clinvar/variation/265284	Homo sapiens, human, clinical
		β94	Q94E	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:363 / uterine cancer	Gln94Glu	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β94	Q94H	P68371	https://www.uniprot.org/uniprotkb/P68371/entry	H. sapiens	TBB4B SNP, DOID:11054 / urinary bladder cancer	Gln94His	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P68371	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β94	Q94H	P68371	https://www.uniprot.org/uniprotkb/P68371/entry	H. sapiens	TBB4B SNP, DOID:4362 / cervical cancer	Gln94His	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P68371	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β94	Q94H	Q13885	https://www.uniprot.org/uniprotkb/Q13885/entry	H. sapiens	TBB2A SNP, DOID:1324 / lung cancer	Gln94His	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13885	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β95	S96F	P12411	https://www.uniprot.org/uniprotkb/P12411/entry	A. thaliana	Twisting, TUB1	Ser96Phe	Ishida et al. 2007. PNAS 104:8544-9	https://pubmed.ncbi.nlm.nih.gov/17488810/	Arabidopsis thaliana, plant
		β95	S95F	P24636	https://www.uniprot.org/uniprotkb/P24636/entry	A. thaliana	Twisting, TUB4	Ser95Phe	Ishida et al. 2007. PNAS 104:8544-9	https://pubmed.ncbi.nlm.nih.gov/17488810/	Arabidopsis thaliana, plant
		β95	S95I	Q13885	https://www.uniprot.org/uniprotkb/Q13885/entry	H. sapiens	TBB2A SNP, DOID:2394 / ovarian cancer	Ser95Ile	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13885	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β95	S95N	Q13885	https://www.uniprot.org/uniprotkb/Q13885/entry	H. sapiens	TBB2A SNP, DOID:1909 / melanoma	Ser95Gln	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13885	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β95	T95M	Q9BUF5	https://www.uniprot.org/uniprotkb/Q9BUF5/entry	H. sapiens	TBB6 SNP, DOID:1909 / melanoma	Thr95Met	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BUF5	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β95	T95M	Q922F4	https://www.uniprot.org/uniprotkb/Q922F4/entry	M. musculus	Tubb6, viable heterozygote	Thr95Met	Mutagenetix	https://mutagenetix.utsouthwestern.edu/incidental/incidental_rec.cfm?mid=375259	Mus musculus, mouse, tubulin beta-6	Wang et al. 2015. PNAS 112:E440-449 (PMID 25605905)
		β96	G96D	P24636	https://www.uniprot.org/uniprotkb/P24636/entry	A. thaliana	Twisting, TUB4	Gly96Asp	Ishida et al. 2007. PNAS 104:8544-9	https://pubmed.ncbi.nlm.nih.gov/17488810/	Arabidopsis thaliana, plant
		β96	G96E	P61857	https://www.uniprot.org/uniprotkb/P61857/entry	D. melanogaster	B2t mutation, testes specific tubulin	Gly96Glu	Fackenthal et al. 1995. Genetics 139:267-86	https://pubmed.ncbi.nlm.nih.gov/7705629/	Drosophila, fruitfly
		β96	G96R	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Hypomyelinating leukodystrophy, tubulin beta-4A	Gly96Arg	Lu et al. 2017. Hum Genome Var 4:17035	https://pubmed.ncbi.nlm.nih.gov/28791129/	Homo sapiens, human, clinical
		β96	G96R	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Infertility, oocyte maturation arrest, tubulin beta-8	Gly96Arg	Yao et al. 2022. J Ovar Research 15:38	https://pubmed.ncbi.nlm.nih.gov/35354490/	Homo sapiens, human, clinical
		β96	G96R	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Adult-onset dystonia with late-onset epilepsy, TUBB4A	Gly96Arg	Sarkar et al. 2022. Ann Indian Acad Neurol 25:562-565	https://pubmed.ncbi.nlm.nih.gov/35936629/	Homo sapiens, human, clinical
		β96	G96R	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Adolescent-onset hypomyelinating leukodystrophy, TUBB4A	Gly96Arg	Ying et al. 2023. Chin J Med Genet 40: 390-394	https://pubmed.ncbi.nlm.nih.gov/36972930/	Homo sapiens, human, clinical
		β96	G96R	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Pathogenic, with G147R, G141R, G24R, tubulin beta-4A	Gly96Arg	ClinVar 429952	https://www.ncbi.nlm.nih.gov/clinvar/variation/429952	Homo sapiens, human, clinical
		β97	A97D	Q9BVA1	https://www.uniprot.org/uniprotkb/Q9BVA1/entry	H. sapiens	TBB2B SNP, DOID:1324 / lung cancer	Ala97Asp	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BVA1	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β97	A97T	Q922F4	https://www.uniprot.org/uniprotkb/Q922F4/entry	M. musculus	Tubb6, viable heterozygote	Ala97Thr	Mutagenetix	https://mutagenetix.utsouthwestern.edu/incidental/incidental_rec.cfm?mid=213487	Mus musculus, mouse, tubulin beta-6	Wang et al. 2015. PNAS 112:E440-449 (PMID 25605905)
		β97	A97V	Q9BVA1	https://www.uniprot.org/uniprotkb/Q9BVA1/entry	H. sapiens	TBB2B SNP, DOID:10534 / stomach cancer	Ala97Val	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BVA1	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β97	A97V	P12456	https://www.uniprot.org/uniprotkb/P12456/entry	C. elegans	Antimorph, short TRN neurites, mec-7	Ala97Val	Zheng et al. 2017 Mol Biol Cell 28: 2786-2801	https://pubmed.ncbi.nlm.nih.gov/28835377/	Caenorhabditis elegans, nematode, roundworm	also see Lee et al. 2021. Mol Biol Cell. 15:331-347 (PMID 33378215)
		β97	A97V	P12456	https://www.uniprot.org/uniprotkb/P12456/entry	C. elegans	Mechanosensitive, mild recessive, mec-7	Ala97Val	Savage et al. 1994. J Cell Sci 107:2165-75	https://pubmed.ncbi.nlm.nih.gov/7983175/	Caenorhabditis elegans, nematode, roundworm
		β98	G98C	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	Likely pathogenic, with G142C, G162C, G70C, tubulin beta	Gly98Cys	ClinVar 916073	https://www.ncbi.nlm.nih.gov/clinvar/variation/916073	Homo sapiens, human, clinical
		β98	G98D	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:2531 / hematologic cancer	Gly98Asp	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β98	G98D	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:3070 / malignant glioma	Gly98Asp	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β98	G98E	P12456	https://www.uniprot.org/uniprotkb/P12456/entry	C. elegans	Loss-of-function, shortened PLM-PN, mec-7	Gly98Glu	Lee et al. 2021. Mol Biol Cell. 15:331-347	https://pubmed.ncbi.nlm.nih.gov/33378215/	Caenorhabditis elegans, nematode, roundworm
		β98	G98R	Q13885	https://www.uniprot.org/uniprotkb/Q13885/entry	H. sapiens	TBB2A SNP, DOID:363 / uterine cancer	Gly98Arg	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13885	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β98	G98R	Q9BVA1	https://www.uniprot.org/uniprotkb/Q9BVA1/entry	H. sapiens	TBB2B SNP, DOID:3963 / thyroid carcinoma	Gly98Arg	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BVA1	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β98	G98R	Q9BVA1	https://www.uniprot.org/uniprotkb/Q9BVA1/entry	H. sapiens	Cortical malformations, tubulin beta-2B	Gly98Arg	Cushion et al. 2013. Brain 136:536-48	https://pubmed.ncbi.nlm.nih.gov/23361065/	Homo sapiens, human, clinical
		β98	G98R	Q9BVA1	https://www.uniprot.org/uniprotkb/Q9BVA1/entry	H. sapiens	Malformation of cortical development, fetal sample, tubulin beta-2B	Gly98Arg	Fallet-Bianco et al. 2014. Acta Neuropathol Commun 2:69	https://pubmed.ncbi.nlm.nih.gov/25059107/	Homo sapiens, human, clinical
		β98	G98R	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Arrest in oocyte maturation, tubulin beta-8	Gly98Arg	Wang et al. 2018. Gynecol Endocrinol	https://pubmed.ncbi.nlm.nih.gov/29671363/	Homo sapiens, human, clinical
		β98	G98R	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Female infertility, tubulin beta-8	Gly98Arg	Chen et al. 2019. Eur J Hum Genet 27:300-307	https://pubmed.ncbi.nlm.nih.gov/30297906/	Homo sapiens, human, clinical
		β98	G98R	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Female infertility, tubulin beta-8	Gly98Arg	Yang et al. 2021. Clin Genet 99:208-214	https://pubmed.ncbi.nlm.nih.gov/33009822/	Homo sapiens, human, clinical
		β98	G98R	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Human oocyte maturation defects and female infertility, TUBB8	Gly98Arg	Lin et al. 2023. Reprod Biomed Online 46(2):244-254	https://pubmed.ncbi.nlm.nih.gov/36463079/	Homo sapiens, human, clinical
		β98	G98R	Q13885	https://www.uniprot.org/uniprotkb/Q13885/entry	H. sapiens	Cortical dysplasia, other brain malformations, with G13R, tubulin beta-2A	Gly98Arg	ClinVar 421739	https://www.ncbi.nlm.nih.gov/clinvar/variation/421739	Homo sapiens, human, clinical
		β98	G98R	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Uncertain significance, with G149R, G143R, G26R, tubulin beta-4A	Gly98Arg	ClinVar 623921	https://www.ncbi.nlm.nih.gov/clinvar/variation/623921	Homo sapiens, human, clinical
		β98	G98S	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:363 / uterine cancer	Gly98Ser	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β98	G98S	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Fibrosis of extraocular muscles, cortical malformations, tubulin beta-3	Gly98Ser	Whitman et al.2016. Am J Med Genet A 170A:297-305	https://pubmed.ncbi.nlm.nih.gov/26639658/	Homo sapiens, human, clinical
		β98	G98S	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Cortical dysplasia, brain malformations, with G26S, tubulin beta-3	Gly98Ser	ClinVar 160191	https://www.ncbi.nlm.nih.gov/clinvar/variation/160191	Homo sapiens, human, clinical
		β98	G98S	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Uncertain significance, with G149S, G143S, G26S, tubulin beta-4A	Gly98Ser	ClinVar 450804	https://www.ncbi.nlm.nih.gov/clinvar/variation/450804	Homo sapiens, human, clinical
		β98	G98D	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Uncertain significance, with G149D, G143D, G26D, tubulin beta-4A	Gly98Asp	ClinVar 499281	https://www.ncbi.nlm.nih.gov/clinvar/variation/499281	Homo sapiens, human, clinical
		β100	A100T	Q13885	https://www.uniprot.org/uniprotkb/Q13885/entry	H. sapiens	Benign, with A185T, tubulin beta-2A	Ala100Thr	ClinVar 218499	https://www.ncbi.nlm.nih.gov/clinvar/variation/218499	Homo sapiens, human, clinical
		β100	N100Y	Q9BVA1	https://www.uniprot.org/uniprotkb/Q9BVA1/entry	H. sapiens	Lissencephaly, tubulin beta-2B	Asn100Tyr	Di Donato et al. 2018. Genet Med 20:1354-1364	https://pubmed.ncbi.nlm.nih.gov/29671837/	Homo sapiens, human, clinical
		β100	V100M	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Cold sensitive mitotic arrest, TUB2p	Val100Met	Pasqualone et al. 1994. J Cell Biol 127:1973-84	https://pubmed.ncbi.nlm.nih.gov/7806575/	Saccharomyces cerevisiae, budding yeast, fungus
		β101	W101L	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:3571 / liver cancer	Trp101Leu	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β101	W101L	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:9256 / colorectal cancer	Trp101Leu	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β101	W101L	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:1909 / melanoma	Trp101Leu	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β101	W101X	P12456	https://www.uniprot.org/uniprotkb/P12456/entry	C. elegans	Mechanosensitive, severe recessive, mec-7	Trp101X	Savage et al. 1994. J Cell Sci 107:2165-75	https://pubmed.ncbi.nlm.nih.gov/7983175/	Caenorhabditis elegans, nematode, roundworm
		β102	A102S	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:11054 / urinary bladder cancer	Ala102Ser	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β102	V102A	Q9UV72	https://www.uniprot.org/uniprotkb/Q9UV72/entry	Pestalotiopsis sp.	Carbendazim-resistant, beta tubulin	Val102Ala	Kummanid et al. 2016 J Phytopathol 165:515-21	https://onlinelibrary.wiley.com/doi/abs/10.1111/jph.12588	Ascomycete fungus
		β103	K103E	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:1793 / pancreatic cancer	Lys103Glu	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β103	K103M	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Reduced GTP hydrolysis & tubulin critical concentration, TUB2p	Lys103Met	Davis et al. 1994. Science 264:839-42	https://pubmed.ncbi.nlm.nih.gov/8171338/	Saccharomyces cerevisiae, budding yeast, fungus
		β103	K103N	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:3963 / thyroid carcinoma	Lys103Asn	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β103	K103R	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:363 / uterine cancer	Lys103Arg	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β103	V103L	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Inborn genetic diseases, with V175L , tubulin beta-3	Val103Leu	ClinVar 520851	https://www.ncbi.nlm.nih.gov/clinvar/variation/520851	Homo sapiens, human, clinical
		β104	G104D	Q18817	https://www.uniprot.org/uniprotkb/Q18817/entry	C. elegans	Albendazole resistance, ben-1	Gly104Asp	Pallotto et al. 2022. Genetics 221:iyac093	https://pubmed.ncbi.nlm.nih.gov/35731216/	Caenorhabditis elegans, nematode, roundworm
		β104	G104S	Q18817	https://www.uniprot.org/uniprotkb/Q18817/entry	C. elegans	Albendazole resistance, ben-1	Gly104Ser	Pallotto et al. 2022. Genetics 221:iyac093	https://pubmed.ncbi.nlm.nih.gov/35731216/	Caenorhabditis elegans, nematode, roundworm
		β105	H105N	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:3571 / liver cancer	His105Asn	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β105	H105R	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:3571 / liver cancer	His105Arg	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β106	L106F	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	Cortical dysplasia, other brain malformations, with L150F, L170F, L78F, tubulin beta	Leu106Phe	ClinVar 807517	https://www.ncbi.nlm.nih.gov/clinvar/variation/807517	Homo sapiens, human, clinical
		β106	T106M	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Cortical dysplasia, brain malformations, with T178M, tubulin beta-3	Thr106Met	ClinVar 265335	https://www.ncbi.nlm.nih.gov/clinvar/variation/265335	Homo sapiens, human, clinical
		β106	T106M	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with T229M, T178M, T223M, tubulin beta-4A	Thr106Met	ClinVar 267774	https://www.ncbi.nlm.nih.gov/clinvar/variation/267774	Homo sapiens, human, clinical
		β106	T106R	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with T178R, T229R, T223R, tubulin beta-4A	Thr106Arg	ClinVar 139453	https://www.ncbi.nlm.nih.gov/clinvar/variation/139453	Homo sapiens, human, clinical
		β106	T106S	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	Likely pathogenic, with T178S, T134S, T198S, tubulin beta	Thr106Ser	ClinVar 376764	https://www.ncbi.nlm.nih.gov/clinvar/variation/376764	Homo sapiens, human, clinical
		β106	Y106D	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:1324 / lung cancer	Tyr106Asp	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β106	Y106X	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	Thyroid dysgenesis, abnormal platelet physiology, tubulin beta-1	Tyr106X	Stoupa et al. 2018. EMBO Mol Med 10:e9569	https://pubmed.ncbi.nlm.nih.gov/30446499/	Homo sapiens, human, clinical
		β107	T107G	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Haploid lethal, enhanced GTP hydrolysis & dynamic instability, TUB2p	Thr107Gly	Davis et al. 1994. Science 264:839-42	https://pubmed.ncbi.nlm.nih.gov/8171338/	Saccharomyces cerevisiae, budding yeast, fungus
		β107	T107K	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Haploid lethal, slowed MT dynamics	Thr107Lys	Sage et al. 1995. Cell Motil Cytoskeleton 30:285-300	https://pubmed.ncbi.nlm.nih.gov/7779783/	Saccharomyces cerevisiae, budding yeast, fungus
		β107	T107K	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Haploid lethal, enhanced GTP hydrolysis & dynamic instability, TUB2p	Thr107Lys	Davis et al. 1994. Science 264:839-42	https://pubmed.ncbi.nlm.nih.gov/8171338/	Saccharomyces cerevisiae, budding yeast, fungus
		β107	T107M	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:363 / uterine cancer	Thr107Met	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β107	T107M	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:1324 / lung cancer	Thr107Met	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β107	T107M	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:1324 / lung cancer	Thr107Met	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β107	T107M	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:1793 / pancreatic cancer	Thr107Met	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β107	T107R	Q9BUF5	https://www.uniprot.org/uniprotkb/Q9BUF5/entry	H. sapiens	TBB6 SNP, DOID:11054 / urinary bladder cancer	Thr107Arg	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BUF5	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β107	T107W	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Haploid lethal, enhanced GTPase & dynamic instability, TUB2p	Thr107Trp	Dougherty et al. 1998. Biochemistry 37:10861-5	https://pubmed.ncbi.nlm.nih.gov/9692978/	Saccharomyces cerevisiae, budding yeast, fungus
		β107	V107A	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Uncertain significance, with V179A, tubulin beta-3	Val107Ala	ClinVar 437132	https://www.ncbi.nlm.nih.gov/clinvar/variation/437132	Homo sapiens, human, clinical
		β107	V107L	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Pathogenic, with V179L, V230L, V224L, tubulin beta-4A	Val107Leu	ClinVar 372789	https://www.ncbi.nlm.nih.gov/clinvar/variation/372789	Homo sapiens, human, clinical
		β108	E108A	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Cold sensitive, benomyl resistant, with E111A, TUB2p	Glu108Ala	Reijo et al. 1994. Mol Biol Cell 5:29-43	https://pubmed.ncbi.nlm.nih.gov/8186463/	Saccharomyces cerevisiae, budding yeast, fungus
		β108	E108K	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Complete cleavage failure in fertilized eggs, tubulin beta-8	Glu108Lys	Yuan et al. 2018. J Assist Reprod Genet	https://pubmed.ncbi.nlm.nih.gov/29704226/	Homo sapiens, human, clinical
		β108	E108K	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Female infertility, tubulin beta-8	Glu108Lys	Chen et al. 2019. Eur J Hum Genet 27:300-307	https://pubmed.ncbi.nlm.nih.gov/30297906/	Homo sapiens, human, clinical
		β108	E108K	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Human oocyte maturation defects and female infertility, TUBB8	Glu108Lys	Lin et al. 2023. Reprod Biomed Online 46(2):244-254	https://pubmed.ncbi.nlm.nih.gov/36463079/	Homo sapiens, human, clinical	2 patients
		β108	E108K	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	Likely pathogenic, with E64K, E128K, E36K, tubulin beta	Glu108Lys	ClinVar 373428	https://www.ncbi.nlm.nih.gov/clinvar/variation/373428	Homo sapiens, human, clinical
		β108	E108V	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:263 / kidney cancer	Glu108Val	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β108	V108M	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Uncertain significance, with V231M, V180M, V225M, tubulin beta-4A	Val108Met	ClinVar 425158	https://www.ncbi.nlm.nih.gov/clinvar/variation/425158	Homo sapiens, human, clinical
		β109	E109K	Q13885	https://www.uniprot.org/uniprotkb/Q13885/entry	H. sapiens	Pathogenic, with E194K, tubulin beta-2A	Glu109Lys	ClinVar 449113	https://www.ncbi.nlm.nih.gov/clinvar/variation/449113	Homo sapiens, human, clinical
		β109	G109D	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:3963 / thyroid carcinoma	Gly109Asp	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β109	G109E	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:1909 / melanoma	Gly109Glu	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β109	G109E	P12456	https://www.uniprot.org/uniprotkb/P12456/entry	C. elegans	Weak antimorph, moderately shortened neurites, mec-7	Gly109Glu	Zheng et al. 2017 Mol Biol Cell 28: 2786-2801	https://pubmed.ncbi.nlm.nih.gov/28835377/	Caenorhabditis elegans, nematode, roundworm	also see Lee et al. 2021. Mol Biol Cell. 15:331-347 (PMID 33378215)
		β109	G109E	P12456	https://www.uniprot.org/uniprotkb/P12456/entry	C. elegans	Mechanosensitive, severe semidominant, mec-7	Gly109Glu	Savage et al. 1994. J Cell Sci 107:2165-75	https://pubmed.ncbi.nlm.nih.gov/7983175/	Caenorhabditis elegans, nematode, roundworm
		β109	G109R	Q18817	https://www.uniprot.org/uniprotkb/Q18817/entry	C. elegans	Albendazole resistance, ben-1	Gly109Arg	Pallotto et al. 2022. Genetics 221:iyac093	https://pubmed.ncbi.nlm.nih.gov/35731216/	Caenorhabditis elegans, nematode, roundworm
		β109	G109V	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:1324 / lung cancer	Gly109Val	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β109	N109T	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	Cortical dysplasia, other brain malformations, with N89T, N45T, N17T, tubulin beta	Asn109Thr	ClinVar 802193	https://www.ncbi.nlm.nih.gov/clinvar/variation/802193	Homo sapiens, human, clinical
		β110	A110S	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:3571 / liver cancer	Ala110Ser	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β110	A110T	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:9256 / colorectal cancer	Ala110Thr	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β110	A110T	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:10534 / stomach cancer	Ala110Thr	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β110	A110V	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:1793 / pancreatic cancer	Ala110Val	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β110	A110V	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:2394 / ovarian cancer	Ala110Val	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β110	A110V	Q13885	https://www.uniprot.org/uniprotkb/Q13885/entry	H. sapiens	TBB2A SNP, DOID:3963 / thyroid carcinoma	Ala110Val	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13885	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β110	A110V	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:9256 / colorectal cancer	Ala110Val	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β110	P110T	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with P233T, P182T, P227T, tubulin beta-4A	Pro110Thr	ClinVar 267775	https://www.ncbi.nlm.nih.gov/clinvar/variation/267775	Homo sapiens, human, clinical
		β111	E111A	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Cold sensitive, benomyl resistant, with E108A, TUB2p	Glu111Ala	Reijo et al. 1994. Mol Biol Cell 5:29-43	https://pubmed.ncbi.nlm.nih.gov/8186463/	Saccharomyces cerevisiae, budding yeast, fungus
		β111	E111K	Q9BVA1	https://www.uniprot.org/uniprotkb/Q9BVA1/entry	H. sapiens	TBB2B SNP, DOID:363 / uterine cancer	Glu111Lys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BVA1	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β111	E111Q	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	TUBB SNP, DOID:1324 / lung cancer	Glu111Gln	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P07437	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β112	L112P	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	Invasive ductal, low grade; no treatment, also contains T351V, A364S, V365S	Leu112Pro	Wang et al. 2017. Protoplasma 254:1163-1173	https://pubmed.ncbi.nlm.nih.gov/27943021/	Homo sapiens, human, clinical	Tubulin beta-1 chain
		β112	L112V	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:1324 / lung cancer	Leu112Val	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β113	I113N	A2AQ07	https://www.uniprot.org/uniprotkb/A2AQ07/entry	M. musculus	Tubb1, viable heterozygote	Ile113Asn	Mutagenetix	https://mutagenetix.utsouthwestern.edu/incidental/incidental_rec.cfm?mid=396557	Mus musculus, mouse, tubulin beta-1	Wang et al. 2015. PNAS 112:E440-449 (PMID 25605905)
		β114	D114A	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Benomyl supersensitive, with D118A, TUB2p	Asp114Ala	Reijo et al. 1994. Mol Biol Cell 5:29-43	https://pubmed.ncbi.nlm.nih.gov/8186463/	Saccharomyces cerevisiae, budding yeast, fungus
		β114	D114N	Q9BUF5	https://www.uniprot.org/uniprotkb/Q9BUF5/entry	H. sapiens	TBB6 SNP, DOID:3070 / malignant glioma	Asp114Asn	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BUF5	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β114	D114N	P61857	https://www.uniprot.org/uniprotkb/P61857/entry	D. melanogaster	B2t mutation, testes specific tubulin	Asp114Asn	Fackenthal et al. 1995. Genetics 139:267-86	https://pubmed.ncbi.nlm.nih.gov/7705629/	Drosophila, fruitfly
		β114	E114V	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:1324 / lung cancer	Glu114Val	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β115	S115L	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:363 / uterine cancer	Ser115Leu	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β115	S115L	Q9BVA1	https://www.uniprot.org/uniprotkb/Q9BVA1/entry	H. sapiens	TBB2B SNP, DOID:1612 / breast cancer	Ser115Leu	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BVA1	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β115	S115Y	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	TUBB SNP, DOID:363 / uterine cancer	Ser115Tyr	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P07437	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β116	S116C	Q13885	https://www.uniprot.org/uniprotkb/Q13885/entry	H. sapiens	Cortical dysplasia, other brain malformations, with S201C, tubulin beta-2A	Ser116Cys	ClinVar 372867	https://www.ncbi.nlm.nih.gov/clinvar/variation/372867	Homo sapiens, human, clinical
		β116	V116G	Q9CWF2	https://www.uniprot.org/uniprotkb/Q9CWF2/entry	M. musculus	Tubb2b, viable heterozygote	Val116Gly	Mutagenetix	https://mutagenetix.utsouthwestern.edu/incidental/incidental_rec.cfm?mid=680666	Mus musculus, mouse, tubulin beta-2B	Wang et al. 2015. PNAS 112:E440-449 (PMID 25605905)
		β117	L117M	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:0070003 / blastoma	Leu117Met	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β117	L117M	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:1793 / pancreatic cancer	Leu117Met	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β117	L117P	Q9BVA1	https://www.uniprot.org/uniprotkb/Q9BVA1/entry	H. sapiens	Symmetric polymicrogyria & pachygyria, tubulin beta-2B	Leu117Pro	Guerrini et al. 2012. Eur J Hum Genet 20:995-8	https://pubmed.ncbi.nlm.nih.gov/22333901/	Homo sapiens, human, clinical
		β117	L117R	Q9BUF5	https://www.uniprot.org/uniprotkb/Q9BUF5/entry	H. sapiens	TBB6 SNP, DOID:5041 / esophageal cancer	Leu117Arg	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BUF5	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β117	M117I	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:363 / uterine cancer	Met117Ile	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β118	D118A	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Benomyl supersensitive, with D114A, TUB2p	Asp118Ala	Reijo et al. 1994. Mol Biol Cell 5:29-43	https://pubmed.ncbi.nlm.nih.gov/8186463/	Saccharomyces cerevisiae, budding yeast, fungus
		β118	D118G	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Female infertility, tubulin beta-8	Asp118Gly	Zhao et al. 2020. J Assist Reprod Genet 37:1837-47.	https://pubmed.ncbi.nlm.nih.gov/32524331/	Homo sapiens, human, clinical
		β118	H118Y	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with H190Y, H241Y, H235Y, tubulin beta-4A	His118Tyr	ClinVar 192383	https://www.ncbi.nlm.nih.gov/clinvar/variation/192383	Homo sapiens, human, clinical
		β119	V119A	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	TUBB SNP, DOID:1612 / breast cancer	Val119Ala	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P07437	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β119	V119E	Q922F4	https://www.uniprot.org/uniprotkb/Q922F4/entry	M. musculus	Tubb6, viable heterozygote	Val119Glu	Mutagenetix	https://mutagenetix.utsouthwestern.edu/incidental/incidental_rec.cfm?mid=514296	Mus musculus, mouse, tubulin beta-6	Wang et al. 2015. PNAS 112:E440-449 (PMID 25605905)
		β119	V119F	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:3963 / thyroid carcinoma	Val119Phe	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β119	V119G	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:1612 / breast cancer	Val119Gly	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β119	V119I	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:10534 / stomach cancer	Val119Ile	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β119	V119I	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:0070003 / blastoma	Val119Ile	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β119	V119M	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	TUBB SNP, DOID:1612 / breast cancer	Val119Met	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P07437	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β119	V119M	Q9BUF5	https://www.uniprot.org/uniprotkb/Q9BUF5/entry	H. sapiens	TBB6 SNP, DOID:1909 / melanoma	Val119Met	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BUF5	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β121	R121A	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Benomyl supersensitive, with R122A, TUB2p	Arg121Ala	Reijo et al. 1994. Mol Biol Cell 5:29-43	https://pubmed.ncbi.nlm.nih.gov/8186463/	Saccharomyces cerevisiae, budding yeast, fungus
		β121	R121K	P12456	https://www.uniprot.org/uniprotkb/P12456/entry	C. elegans	Partial loss-of-function, no PLM synaptic branch, mec-7	Arg121Lys	Lee et al. 2021. Mol Biol Cell. 15:331-347	https://pubmed.ncbi.nlm.nih.gov/33378215/	Caenorhabditis elegans, nematode, roundworm
		β121	R121Q	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:363 / uterine cancer	Arg121Gln	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β121	R121Q	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:9256 / colorectal cancer	Arg121Gln	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β121	R121Q	Q9BUF5	https://www.uniprot.org/uniprotkb/Q9BUF5/entry	H. sapiens	TBB6 SNP, DOID:10534 / stomach cancer	Arg121Gln	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BUF5	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β121	R121T	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:1324 / lung cancer	Arg121Thr	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β121	R121W	Q9BUF5	https://www.uniprot.org/uniprotkb/Q9BUF5/entry	H. sapiens	TBB6 SNP, DOID:1909 / melanoma	Arg121Trp	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BUF5	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β121	R121W	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Laryngeal and cervical dystonia, TUBB4A	Arg121Trp	Bally et al. 2021. Neurology 96: e1887-97	https://pubmed.ncbi.nlm.nih.gov/32943487/	Homo sapiens, human, clinical
		β121	R121W	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with R166W, R49W, R172W, tubulin beta-4A	Arg121Trp	ClinVar 837764	https://www.ncbi.nlm.nih.gov/clinvar/variation/837764	Homo sapiens, human, clinical
		β122	K122E	P10878	https://www.uniprot.org/uniprotkb/P10878/entry	T. gondii	Suppressor of G142S α1-tubulin defects, β1-tubulin	Lys122Glu	Ma et al. 2008. Genetics 180:845-56	https://pubmed.ncbi.nlm.nih.gov/18780736/	Toxoplasma gondii, parasite, protozoan
		β122	R122A	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Benomyl supersensitive, with R121A, TUB2p	Arg122Ala	Reijo et al. 1994. Mol Biol Cell 5:29-43	https://pubmed.ncbi.nlm.nih.gov/8186463/	Saccharomyces cerevisiae, budding yeast, fungus
		β123	E123A	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Cold sensitive, benomyl resistant, TUB2p	Glu123Ala	Reijo et al. 1994. Mol Biol Cell 5:29-43	https://pubmed.ncbi.nlm.nih.gov/8186463/	Saccharomyces cerevisiae, budding yeast, fungus
		β123	E123K	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Female infertility, tubulin beta-8	Glu123Lys	Yang et al. 2021. Clin Genet 99:208-214	https://pubmed.ncbi.nlm.nih.gov/33009822/	Homo sapiens, human, clinical
		β123	E123Q	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:11054 / urinary bladder cancer	Glu123Gln	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β123	E123Q	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	Macrocytopenia, correlation, tubulin beta-1	Glu123QGln	ÇaliŞkaner et al. 2020. Turk J Med Sci	https://pubmed.ncbi.nlm.nih.gov/32892537/	Homo sapiens, human, clinical
		β124	A124G	P68371	https://www.uniprot.org/uniprotkb/P68371/entry	H. sapiens	TBB4B SNP, DOID:3963 / thyroid carcinoma	Ala124Gly	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P68371	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β124	A124V	P68371	https://www.uniprot.org/uniprotkb/P68371/entry	H. sapiens	TBB4B SNP, DOID:9256 / colorectal cancer	Ala124Val	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P68371	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β124	S124G	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:363 / uterine cancer	Ser124Gly	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β124	S124G	A2AQ07	https://www.uniprot.org/uniprotkb/A2AQ07/entry	M. musculus	Tubb1, viable heterozygote	Ser124Gly	Mutagenetix	https://mutagenetix.utsouthwestern.edu/incidental/incidental_rec.cfm?mid=157561	Mus musculus, mouse, tubulin beta-1	Wang et al. 2015. PNAS 112:E440-449 (PMID 25605905)
		β124	S124G	A2AQ07	https://www.uniprot.org/uniprotkb/A2AQ07/entry	M. musculus	Tubb1, viable heterozygote	Ser124Gly	Mutagenetix	https://mutagenetix.utsouthwestern.edu/incidental/incidental_rec.cfm?mid=157561	Mus musculus, mouse, tubulin beta-1	Wang et al. 2015. PNAS 112:E440-449 (PMID 25605905)
		β124	S124G	A2AQ07	https://www.uniprot.org/uniprotkb/A2AQ07/entry	M. musculus	Tubb1, viable heterozygote	Ser124Gly	Mutagenetix	https://mutagenetix.utsouthwestern.edu/incidental/incidental_rec.cfm?mid=193489	Mus musculus, mouse, tubulin beta-1	Wang et al. 2015. PNAS 112:E440-449 (PMID 25605905)
		β124	S124R	A2AQ07	https://www.uniprot.org/uniprotkb/A2AQ07/entry	M. musculus	Tubb1, viable heterozygote	Ser124Arg	Mutagenetix	https://mutagenetix.utsouthwestern.edu/incidental/incidental_rec.cfm?mid=178923	Mus musculus, mouse, tubulin beta-1	Wang et al. 2015. PNAS 112:E440-449 (PMID 25605905)
		β125	E125A	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Wild-type, with D128A, TUB2p	Glu125Ala	Reijo et al. 1994. Mol Biol Cell 5:29-43	https://pubmed.ncbi.nlm.nih.gov/8186463/	Saccharomyces cerevisiae, budding yeast, fungus
		β125	E125D	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:10283 / prostate cancer	Glu125Asp	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β125	E125D	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:1793 / pancreatic cancer	Glu125Asp	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β125	E125G	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	TUBB SNP, DOID:263 / kidney cancer	Glu125Gly	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P07437	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β125	E125K	Q9BUF5	https://www.uniprot.org/uniprotkb/Q9BUF5/entry	H. sapiens	TBB6 SNP, DOID:10283 / prostate cancer	Glu125Lys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BUF5	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β125	E125K	Q9BUF5	https://www.uniprot.org/uniprotkb/Q9BUF5/entry	H. sapiens	TBB6 SNP, DOID:1793 / pancreatic cancer	Glu125Lys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BUF5	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β125	P125L	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Likely benign, with P131L, P8L, P80L, tubulin beta-4A	Pro125Leu	ClinVar 623922	https://www.ncbi.nlm.nih.gov/clinvar/variation/623922	Homo sapiens, human, clinical
		β125	P125S	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Torsion dystonia, with P131S, P80S, P8S, tubulin beta-4A	Pro125Ser	ClinVar 692150	https://www.ncbi.nlm.nih.gov/clinvar/variation/692150	Homo sapiens, human, clinical
		β126	E126E	Q9N2N6	https://www.uniprot.org/uniprotkb/Q9N2N6/entry	E. focardii	Cold stable adaptation (correlation, EFBT3)	Glu126Glu	Chiappori et al. 2012. Proteins 80:1154-60	https://pubmed.ncbi.nlm.nih.gov/22275059/	Euplotes focardii, extremophile, Antarctic ciliate
		β126	S126I	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:363 / uterine cancer	Ser126Ile	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β126	S126R	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:363 / uterine cancer	Ser126Arg	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β127	C127A	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Wild-type, TUB2p	Cys127Ala	Gupta et al. 2001. Cell Motil Cytoskeleton 49:67-77	https://pubmed.ncbi.nlm.nih.gov/11443737/	Saccharomyces cerevisiae, budding yeast, fungus
		β127	C127S	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Wild-type, TUB2p	Cys127Ser	Gupta et al. 2001. Cell Motil Cytoskeleton 49:67-77	https://pubmed.ncbi.nlm.nih.gov/11443737/	Saccharomyces cerevisiae, budding yeast, fungus
		β128	D128A	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Wild-type, with E125A, TUB2p	Asp128Ala	Reijo et al. 1994. Mol Biol Cell 5:29-43	https://pubmed.ncbi.nlm.nih.gov/8186463/	Saccharomyces cerevisiae, budding yeast, fungus
		β128	D128E	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:363 / uterine cancer	Asp128Glu	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β128	D128G	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:263 / kidney cancer	Asp128Gly	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β128	D128G	Q9D6F9	https://www.uniprot.org/uniprotkb/Q9D6F9/entry	M. musculus	Tubb4a, viable heterozygote	Asp128Gly	Mutagenetix	https://mutagenetix.utsouthwestern.edu/incidental/incidental_rec.cfm?mid=581867	Mus musculus, mouse, tubulin beta-4A	Wang et al. 2015. PNAS 112:E440-449 (PMID 25605905)
		β128	D128G	Q9CWF2	https://www.uniprot.org/uniprotkb/Q9CWF2/entry	M. musculus	Tubb2b, viable heterozygote	Asp128Gly	Mutagenetix	https://mutagenetix.utsouthwestern.edu/incidental/incidental_rec.cfm?mid=734415	Mus musculus, mouse, tubulin beta-2B	Wang et al. 2015. PNAS 112:E440-449 (PMID 25605905)
		β128	D128N	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:10534 / stomach cancer	Asp128Asn	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β128	E128K	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	Likely pathogenic, with E108K, E64K, E36K, tubulin beta	Glu128Lys	ClinVar 373428	https://www.ncbi.nlm.nih.gov/clinvar/variation/373428	Homo sapiens, human, clinical
		β129	C129F	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:5041 / esophageal cancer	Cys129Phe	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β129	C129Y	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:10534 / stomach cancer	Cys129Tyr	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β131	P131L	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Likely benign, with P8L, P125L, P80L, tubulin beta-4A	P131Leu	ClinVar 623922	https://www.ncbi.nlm.nih.gov/clinvar/variation/623922	Homo sapiens, human, clinical
		B131	P131S	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Torsion dystonia, with P125S, P80S, P8S, tubulin beta-4A	P131Ser	ClinVar 692150	https://www.ncbi.nlm.nih.gov/clinvar/variation/692150	Homo sapiens, human, clinical
		β131	Q131H	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:3963 / thyroid carcinoma	Gln131His	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β131	Q131H	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:1324 / lung cancer	Gln131His	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β131	Q131K	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:1324 / lung cancer	Gln131Lys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β131	Q131L	Q18817	https://www.uniprot.org/uniprotkb/Q18817/entry	C. elegans	Benzimidazole resistant (ben-1, tbb-5)	Gln131Leu	Hahnel et al. 2018. PLoS Pathog 14:e1007226	https://pubmed.ncbi.nlm.nih.gov/30372484/	Caenorhabditis elegans, nematode, roundworm
		β132	G132C	P68371	https://www.uniprot.org/uniprotkb/P68371/entry	H. sapiens	TBB4B SNP, DOID:3963 / thyroid carcinoma	Gly132Cys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P68371	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β132	G132C	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Female infertility, tubulin beta-8	Gly132Cys	Yang et al. 2021. Clin Genet 99:208-214	https://pubmed.ncbi.nlm.nih.gov/33009822/	Homo sapiens, human, clinical
		β132	G132D	Q9BUF5	https://www.uniprot.org/uniprotkb/Q9BUF5/entry	H. sapiens	TBB6 SNP, DOID:10534 / stomach cancer	Gly132Asp	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BUF5	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β132	G132S	Q13885	https://www.uniprot.org/uniprotkb/Q13885/entry	H. sapiens	Likely pathogenic, with G47S, tubulin beta-2A	Gly132Ser	ClinVar 421613	https://www.ncbi.nlm.nih.gov/clinvar/variation/421613	Homo sapiens, human, clinical
		β133	E133A	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Likely pathogenic, with E205A, tubulin beta-3	Glu133Ala	ClinVar 373761	https://www.ncbi.nlm.nih.gov/clinvar/variation/373761	Homo sapiens, human, clinical
		β133	E133K	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Cortical dysplasia, other brain malformations, with E205K, tubulin beta-3	Glu133Lys	ClinVar 30274	https://www.ncbi.nlm.nih.gov/clinvar/variation/30274	Homo sapiens, human, clinical
		β134	Q134X	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Female infertility, tubulin beta-8	Gln134X	Zhao et al. 2020. J Assist Reprod Genet 37:1837-47.	https://pubmed.ncbi.nlm.nih.gov/32524331/	Homo sapiens, human, clinical
		β134	Q134H	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:1612 / breast cancer	Gln134His	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β134	Q134H	P04690	https://www.uniprot.org/uniprotkb/P04690/entry	C. reinhardtii	Propyzamide resistant, tub2	Gln134His	Kato-Minoura et al. 2020. PLoS One 15(11):e0242694	https://pubmed.ncbi.nlm.nih.gov/33227038/	Chlamydomonas reinhardtii, green alga
		β134	Q134K	F9X1J1	https://www.uniprot.org/uniprotkb/F9X1J1/entry	Z. tritici	Carbendazim resistant, with F265L, beta tubulin	Gln134Lys	Matsuzaki et al. 2020. Pest Manag Sci 76:1393-1401	https://pubmed.ncbi.nlm.nih.gov/31622533/	Zymoseptoria, fungus, plant pathogen, septoria leaf blotch	Numbering may need to be adjusted
		β134	Q134L	P68371	https://www.uniprot.org/uniprotkb/P68371/entry	H. sapiens	TBB4B SNP, DOID:1324 / lung cancer	Gln134Leu	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P68371	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β134	Q134R	Q13885	https://www.uniprot.org/uniprotkb/Q13885/entry	H. sapiens	TBB2A SNP, DOID:3963 / thyroid carcinoma	Gln134Arg	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13885	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β134	T134S	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	Likely pathogenic, with T178S, T106S, T198S, tubulin beta	Thr134Ser	ClinVar 376764	https://www.ncbi.nlm.nih.gov/clinvar/variation/376764	Homo sapiens, human, clinical
		β135	L135M	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:3963 / thyroid carcinoma	Leu135Met	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β136	T136I	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:3963 / thyroid carcinoma	Thr136Ile	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β136	V136M	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with V142M, V91M, V19M, tubulin beta-4A	Val136Met	ClinVar 847763	https://www.ncbi.nlm.nih.gov/clinvar/variation/847763	Homo sapiens, human, clinical
		β137	H137Q	Q9BUF5	https://www.uniprot.org/uniprotkb/Q9BUF5/entry	H. sapiens	TBB6 SNP, DOID:363 / uterine cancer	His137Gln	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BUF5	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β137	H137Y	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	TUBB SNP, DOID:3070 / malignant glioma	His137Tyr	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P07437	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β138	S138L	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:1909 / melanoma	Ser138Leu	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β138	S138L	Q9BUF5	https://www.uniprot.org/uniprotkb/Q9BUF5/entry	H. sapiens	TBB6 SNP, DOID:1909 / melanoma	Ser138Leu	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BUF5	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β138	S138P	Q922F4	https://www.uniprot.org/uniprotkb/Q922F4/entry	M. musculus	Tubb6, viable heterozygote	Ser138Pro	Mutagenetix	https://mutagenetix.utsouthwestern.edu/incidental/incidental_rec.cfm?mid=699223	Mus musculus, mouse, tubulin beta-6	Wang et al. 2015. PNAS 112:E440-449 (PMID 25605905)
		β139	C139R	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Fibrosis of extraocular muscles, with C211R, tubulin beta-3	Cys139Arg	ClinVar 617613	https://www.ncbi.nlm.nih.gov/clinvar/variation/617613	Homo sapiens, human, clinical
		β139	L139M	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:1793 / pancreatic cancer	Leu139Met	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β140	G140A	Q9BVA1	https://www.uniprot.org/uniprotkb/Q9BVA1/entry	H. sapiens	Microcephaly, tubulin beta-2B, with Leu361_Lys362delinsHisLeuGln	Gly140Ala	Romaniello et al. 2014. Dev Med Child Neurol 56:354-60	https://pubmed.ncbi.nlm.nih.gov/24392928/	Homo sapiens, human, clinical
		β140	G140A	Q9BVA1	https://www.uniprot.org/uniprotkb/Q9BVA1/entry	H. sapiens	Cerebellar dysplasia, tubulin beta-2B	Gly140Ala	Romaniello et al. 2017. Eur Radiol 27:5080-5092	https://pubmed.ncbi.nlm.nih.gov/28677066/	Homo sapiens, human, clinical
		β140	G140C	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:1324 / lung cancer	Gly140Cys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β140	G140S	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:1790 / malignant mesothelioma	Gly140Ser	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β140	G140W	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:1324 / lung cancer	Gly140Trp	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β141	G141A	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Female infertility, tubulin beta-8	Gly141Ala	Yang et al. 2021. Clin Genet 99:208-214	https://pubmed.ncbi.nlm.nih.gov/33009822/	Homo sapiens, human, clinical
		β141	G141D	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:1324 / lung cancer	Gly141Asp	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β141	G141E	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:1909 / melanoma	Gly141Glu	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β141	G141E	P52275	https://www.uniprot.org/uniprotkb/P52275/entry	C. elegans	Misplaced mitotic spindle, beta tubulin 2	Gly141Glu	Ellis et al. 2004. J Cell Sci 117:457-64	https://pubmed.ncbi.nlm.nih.gov/14702387/	Caenorhabditis elegans, nematode, roundworm
		β141	G141E	P12456	https://www.uniprot.org/uniprotkb/P12456/entry	C. elegans	Loss-of-function, short PLM-PN, mec-7	Gly141Glu	Zheng et al. 2017 Mol Biol Cell 28: 2786-2801	https://pubmed.ncbi.nlm.nih.gov/28835377/	Caenorhabditis elegans, nematode, roundworm	also see Lee et al. 2021. Mol Biol Cell. 15:331-347 (PMID 33378215)
		β141	G141E	P12456	https://www.uniprot.org/uniprotkb/P12456/entry	C. elegans	Mechanosensitive, severe recessive, mec-7	Gly141Glu	Savage et al. 1994. J Cell Sci 107:2165-75	https://pubmed.ncbi.nlm.nih.gov/7983175/	Caenorhabditis elegans, nematode, roundworm
		β141	G141E	A2AQ07	https://www.uniprot.org/uniprotkb/A2AQ07/entry	M. musculus	Folding mutant, cannot polymerize, reticulocyte lysate expression	Gly141Glu	Zabala et al. 1996. J Cell Sci 109:1471-8	https://pubmed.ncbi.nlm.nih.gov/8799834/	Mus musculus, mouse
		β141	G141R	P12456	https://www.uniprot.org/uniprotkb/P12456/entry	C. elegans	Loss-of-function, shortened PLM-PN, mec-7	Gly141Arg	Zheng et al. 2017 Mol Biol Cell 28: 2786-2801	https://pubmed.ncbi.nlm.nih.gov/28835377/	Caenorhabditis elegans, nematode, roundworm	also see Lee et al. 2021. Mol Biol Cell. 15:331-347 (PMID 33378215)
		β141	G141R	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Pathogenic, with G147R, G96R, G24R, tubulin beta-4A	Gly141Arg	ClinVar 429952	https://www.ncbi.nlm.nih.gov/clinvar/variation/429952	Homo sapiens, human, clinical
		β141	G141V	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:1324 / lung cancer	Gly141Val	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β142	G142C	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:1324 / lung cancer	Gly142Cys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β142	G142C	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	Likely pathogenic, with G162C, G70C, G98C, tubulin beta	Gly142Cys	ClinVar 916073	https://www.ncbi.nlm.nih.gov/clinvar/variation/916073	Homo sapiens, human, clinical
		β142	G142D	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:3963 / thyroid carcinoma	Gly142Asp	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β142	G142E	Q18817	https://www.uniprot.org/uniprotkb/Q18817/entry	C. elegans	Albendazole resistance, ben-1	Gly142Glu	Pallotto et al. 2022. Genetics 221:iyac093	https://pubmed.ncbi.nlm.nih.gov/35731216/	Caenorhabditis elegans, nematode, roundworm
		β142	G142R	Q18817	https://www.uniprot.org/uniprotkb/Q18817/entry	C. elegans	Albendazole resistance, ben-1	Gly142Arg	Pallotto et al. 2022. Genetics 221:iyac093	https://pubmed.ncbi.nlm.nih.gov/35731216/	Caenorhabditis elegans, nematode, roundworm
		β142	G142S	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Likely pathogenic, with G70S, tubulin beta-3	Gly142Ser	ClinVar 430312	https://www.ncbi.nlm.nih.gov/clinvar/variation/430312	Homo sapiens, human, clinical
		β142	V142M	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with V91M, V136M, V19M, tubulin beta-4A	Val142Met	ClinVar 847763	https://www.ncbi.nlm.nih.gov/clinvar/variation/847763	Homo sapiens, human, clinical
		β143	G143D	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Uncertain significance, with G149D, G98D, G26D, tubulin beta-4A	Gly143Asp	ClinVar 499281	https://www.ncbi.nlm.nih.gov/clinvar/variation/499281	Homo sapiens, human, clinical
		β143	G143R	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Uncertain significance, with G149R, G26R, G98R, tubulin beta-4A	Gly143Arg	ClinVar 623921	https://www.ncbi.nlm.nih.gov/clinvar/variation/623921	Homo sapiens, human, clinical
		β143	G143S	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Uncertain significance, with G149S, G98S, G26S, tubulin beta-4A	Gly143Ser	ClinVar 450804	https://www.ncbi.nlm.nih.gov/clinvar/variation/450804	Homo sapiens, human, clinical
		β143	T143A	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:1324 / lung cancer	Thr143Ala	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β143	T143G	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Reduced GTP affinity, decreased GTPase, stable microtubules, TUB2p	Thr143Gly	Dougherty et al. 1998. Biochemistry 37:10861-5	https://pubmed.ncbi.nlm.nih.gov/9692978/	Saccharomyces cerevisiae, budding yeast, fungus
		β143	T143X	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Female infertility, tubulin beta-8	Thr143X	Chen et al. 2019. Eur J Hum Genet 27:300-307	https://pubmed.ncbi.nlm.nih.gov/30297906/	Homo sapiens, human, clinical
		β143	ΔT143	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Defects in oocyte meiosis, tubulin beta-8	ΔThr143	Feng et al. 2016. J Med Genet 53:662-71	https://pubmed.ncbi.nlm.nih.gov/27273344/	Homo sapiens, human, clinical
		β144	K144R	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	Likely pathogenic, with K216R, K236R, K172R, tubulin beta	Lys144Arg	ClinVar 545082	https://www.ncbi.nlm.nih.gov/clinvar/variation/545082	Homo sapiens, human, clinical
		β145	S145A	A0A179HPA9	https://www.uniprot.org/uniprotkb/A0A179HPA9/entry	P. lilacinus	Carbendazim resistant, with T185A, F200Y	Ser145Ala	Yang et al. 2015. Eur J Plant Pathol 143:57-68	https://link.springer.com/article/10.1007/s10658-015-0665-0	Paecilomyces lilacinus, fungus
		β145	S145F	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	TUBB SNP, DOID:1909 / melanoma	Ser145Phe	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P07437	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β145	S145F	Q18817	https://www.uniprot.org/uniprotkb/Q18817/entry	C. elegans	Benzimidazole resistant (ben-1, tbb-5)	Ser145Phe	Hahnel et al. 2018. PLoS Pathog 14:e1007226	https://pubmed.ncbi.nlm.nih.gov/30372484/	Caenorhabditis elegans, nematode, roundworm
		β145	S145F	P12456	https://www.uniprot.org/uniprotkb/P12456/entry	C. elegans	Loss-of-function, shortened PLM-PN, mec-7	Ser145Phe	Lee et al. 2021. Mol Biol Cell. 15:331-347	https://pubmed.ncbi.nlm.nih.gov/33378215/	Caenorhabditis elegans, nematode, roundworm
		β145	S145Y	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:263 / kidney cancer	Ser145Tyr	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β146	G146C	Q9BUF5	https://www.uniprot.org/uniprotkb/Q9BUF5/entry	H. sapiens	TBB6 SNP, DOID:1324 / lung cancer	Gly146Cys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BUF5	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β146	G146C	A2AQ07	https://www.uniprot.org/uniprotkb/A2AQ07/entry	M. musculus	Folding mutant, cannot polymerize, reticulocyte lysate expression	Gly146Cys	Zabala et al. 1996. J Cell Sci 109:1471-8	https://pubmed.ncbi.nlm.nih.gov/8799834/	Mus musculus, mouse
		β146	G146D	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:363 / uterine cancer	Gly146Asp	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β146	G146E	P12456	https://www.uniprot.org/uniprotkb/P12456/entry	C. elegans	Loss-of-function, shortened PLM-PN, mec-7	Gly146Glu	Lee et al. 2021. Mol Biol Cell. 15:331-347	https://pubmed.ncbi.nlm.nih.gov/33378215/	Caenorhabditis elegans, nematode, roundworm
		β146	G146R	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:1324 / lung cancer	Gly146Arg	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β146	G146R	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:363 / uterine cancer	Gly146Arg	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β146	G146R	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	Glanzmann thrombasthenia & macrothrombocytopenia, tubulin beta-1	Gly146Arg	Guillet et al. 2019. J Thromb Haemost 17:2211-2215	https://pubmed.ncbi.nlm.nih.gov/31565851/	Homo sapiens, human, clinical
		β146	G146R	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	Computational prediction, nsSNP causes protein destablization	Gly146Arg	Hussain et al. 2022. J Biomol Struct Dyn 11:1-11.	https://pubmed.ncbi.nlm.nih.gov/36218086/	Computational modeling, clinical
		β146	G146V	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:1324 / lung cancer	Gly146Val	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β146	T178T	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	Variant, not associated with macrothrombocytopenia, tubulin beta-1	Thr178Thr	Guillet et al. 2019. J Thromb Haemost 17:2211-2215	https://pubmed.ncbi.nlm.nih.gov/31565851/	Homo sapiens, human, clinical
		β147	G147R	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Pathogenic, with G96R, G141R, G24R, tubulin beta-4A	Gly147Arg	ClinVar 429952	https://www.ncbi.nlm.nih.gov/clinvar/variation/429952	Homo sapiens, human, clinical
		β147	M147F	A2AQ07	https://www.uniprot.org/uniprotkb/A2AQ07/entry	M. musculus	Folding mutant, cannot polymerize, lysate expression, with G148T	Met147Phe	Zabala et al. 1996. J Cell Sci 109:1471-8	https://pubmed.ncbi.nlm.nih.gov/8799834/	Mus musculus, mouse
		β147	M147K	A2AQ07	https://www.uniprot.org/uniprotkb/A2AQ07/entry	M. musculus	Folding mutant, cannot polymerize, reticulocyte lysate expression	Met147Lys	Zabala et al. 1996. J Cell Sci 109:1471-8	https://pubmed.ncbi.nlm.nih.gov/8799834/	Mus musculus, mouse
		β147	M147R	Q9BVA1	https://www.uniprot.org/uniprotkb/Q9BVA1/entry	H. sapiens	TBB2B SNP, DOID:11054 / urinary bladder cancer	Met147Arg	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BVA1	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β147	M147T	Q9BUF5	https://www.uniprot.org/uniprotkb/Q9BUF5/entry	H. sapiens	TBB6 SNP, DOID:9256 / colorectal cancer	Met147Thr	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BUF5	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β147	M147V	P68371	https://www.uniprot.org/uniprotkb/P68371/entry	H. sapiens	TBB4B SNP, DOID:9256 / colorectal cancer	Met147Val	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P68371	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β148	G148A	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:1324 / lung cancer	Gly148Ala	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β148	G148C	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:1324 / lung cancer	Gly148Cys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β148	G148D	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:2394 / ovarian cancer	Gly148Asp	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β148	G148R	P12456	https://www.uniprot.org/uniprotkb/P12456/entry	C. elegans	Loss-of-function, short PLM-PN, mec-7	Gly148Arg	Zheng et al. 2017 Mol Biol Cell 28: 2786-2801	https://pubmed.ncbi.nlm.nih.gov/28835377/	Caenorhabditis elegans, nematode, roundworm	also see Lee et al. 2021. Mol Biol Cell. 15:331-347 (PMID 33378215)
		β148	G148R	P12456	https://www.uniprot.org/uniprotkb/P12456/entry	C. elegans	Mechanosensitive, severe recessive, mec-7	Gly148Arg	Savage et al. 1994. J Cell Sci 107:2165-75	https://pubmed.ncbi.nlm.nih.gov/7983175/	Caenorhabditis elegans, nematode, roundworm
		β148	G148S	Q9BVA1	https://www.uniprot.org/uniprotkb/Q9BVA1/entry	H. sapiens	TBB2B SNP, DOID:363 / uterine cancer	Gly148Ser	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BVA1	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β148	G148S	A2AQ07	https://www.uniprot.org/uniprotkb/A2AQ07/entry	M. musculus	Folding mutant, cannot polymerize, reticulocyte lysate expression	Gly148Ser	Zabala et al. 1996. J Cell Sci 109:1471-8	https://pubmed.ncbi.nlm.nih.gov/8799834/	Mus musculus, mouse
		β148	G148T	A2AQ07	https://www.uniprot.org/uniprotkb/A2AQ07/entry	M. musculus	Folding mutant, cannot polymerize, reticulocyte lysate expression, with M147F	Gly148Thr	Zabala et al. 1996. J Cell Sci 109:1471-8	https://pubmed.ncbi.nlm.nih.gov/8799834/	Mus musculus, mouse
		β149	G149D	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Uncertain significance, with G98D, G143D, G26D, tubulin beta-4A	Gly149Asp	ClinVar 499281	https://www.ncbi.nlm.nih.gov/clinvar/variation/499281	Homo sapiens, human, clinical
		β149	G149R	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Uncertain significance, with G143R, G26R, G98R, tubulin beta-4A	Gly149Arg	ClinVar 623921	https://www.ncbi.nlm.nih.gov/clinvar/variation/623921	Homo sapiens, human, clinical
		β149	G149S	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Uncertain significance, with G98S, G143S, G26S, tubulin beta-4A	Gly149Ser	ClinVar 450804	https://www.ncbi.nlm.nih.gov/clinvar/variation/450804	Homo sapiens, human, clinical
		β149	T149I	P12456	https://www.uniprot.org/uniprotkb/P12456/entry	C. elegans	Neomorph, increased MT stability, ectopic neurites, mec-7	Thr149Ile	Zheng et al. 2017 Mol Biol Cell 28: 2786-2801	https://pubmed.ncbi.nlm.nih.gov/28835377/	Caenorhabditis elegans, nematode, roundworm	also see Lee et al. 2021. Mol Biol Cell. 15:331-347 (PMID 33378215)
		β149	T149I	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	Cortical dysplasia, brain malformations, with T221I, T177I, T241I, tubulin beta	Thr149Ile	ClinVar 235892	https://www.ncbi.nlm.nih.gov/clinvar/variation/235892	Homo sapiens, human, clinical
		β149	T149M	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:1909 / melanoma	Thr149Met	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β149	T149M	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:363 / uterine cancer	Thr149Met	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β149	T149M	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:10534 / stomach cancer	Thr149Met	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β149	T149P	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	Thrombocytopenia, tubulin beta	Thr149Pro	Matsumura et al. 2019. Br J Haematol 185:888-902	https://pubmed.ncbi.nlm.nih.gov/30854628/	Homo sapiens, human, clinical
		β150	L150F	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	Cortical dysplasia, brain malformations, with L170F, L78F, L106F, tubulin beta	Leu150Phe	ClinVar 807517	https://www.ncbi.nlm.nih.gov/clinvar/variation/807517	Homo sapiens, human, clinical
		β150	L150V	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:1324 / lung cancer	Leu150Val	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β150	Y150F	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	Symmetric circumferential skin creases, with Y222F, Y178F, Y242F, tubulin beta	Tyr150Phe	ClinVar 218926	https://www.ncbi.nlm.nih.gov/clinvar/variation/218926	Homo sapiens, human, clinical
		β151	G151R	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Likely benign, with G223R, G274R, G268R, tubulin beta-4A	Gly151Arg	ClinVar 212501	https://www.ncbi.nlm.nih.gov/clinvar/variation/212501	Homo sapiens, human, clinical
		β151	V151I	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	Cortical dysplasia, brain malformations, with V353I, V281I, V309I, V373I, tubulin beta	Val151Ile	ClinVar 127190	https://www.ncbi.nlm.nih.gov/clinvar/variation/127190	Homo sapiens, human, clinical
		β152	I152F	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Cold sensitive, with K154A, R156A, TUB2p	Ile152Phe	Reijo et al. 1994. Mol Biol Cell 5:29-43	https://pubmed.ncbi.nlm.nih.gov/8186463/	Saccharomyces cerevisiae, budding yeast, fungus
		β152	I152F	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Recessive lethal, with R156K, E157A, E158A, TUB2p	Ile152Phe	Reijo et al. 1994. Mol Biol Cell 5:29-43	https://pubmed.ncbi.nlm.nih.gov/8186463/	Saccharomyces cerevisiae, budding yeast, fungus
		β152	I152T	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	Invasive ductal, low grade; no treatment, also contains C239L, L240P, R241P, L273P	Ile152Thr	Wang et al. 2017. Protoplasma 254:1163-1173	https://pubmed.ncbi.nlm.nih.gov/27943021/	Homo sapiens, human, clinical	Tubulin beta-1 chain
		β152	L152I	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:4159 / skin cancer	Leu152Ile	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β152	L152I	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:9256 / colorectal cancer	Leu152Ile	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β153	L153F	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with L225F, L276F, L270F, tubulin beta-4A	Leu153Phe	ClinVar 578590	https://www.ncbi.nlm.nih.gov/clinvar/variation/578590	Homo sapiens, human, clinical
		β153	S153C	Q9BUF5	https://www.uniprot.org/uniprotkb/Q9BUF5/entry	H. sapiens	TBB6 SNP, DOID:1324 / lung cancer	Ser153Cys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BUF5	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β154	K154A	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Cold sensitive, with I152F, R156A, TUB2p	Ile152Phe	Reijo et al. 1994. Mol Biol Cell 5:29-43	https://pubmed.ncbi.nlm.nih.gov/8186463/	Saccharomyces cerevisiae, budding yeast, fungus
		β154	K154A	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Recessive lethal, with R156A, TUB2p	Lys154Ala	Reijo et al. 1994. Mol Biol Cell 5:29-43	https://pubmed.ncbi.nlm.nih.gov/8186463/	Saccharomyces cerevisiae, budding yeast, fungus
		β154	K154M	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:1909 / melanoma	Lys154Met	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β154	K154Q	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:11054 / urinary bladder cancer	Lys154Gln	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β155	I155V	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	Invasive mixed, low grade; no treatment, also contains K324R, L331H	Ile155Val	Wang et al. 2017. Protoplasma 254:1163-1173	https://pubmed.ncbi.nlm.nih.gov/27943021/	Homo sapiens, human, clinical	Tubulin beta-1 chain
		β155	I155V	Q9CWF2	https://www.uniprot.org/uniprotkb/Q9CWF2/entry	M. musculus	Tubb2b, viable heterozygote	Ile155Val	Mutagenetix	https://mutagenetix.utsouthwestern.edu/incidental/incidental_rec.cfm?mid=5946	Mus musculus, mouse, tubulin beta-2B	Wang et al. 2015. PNAS 112:E440-449 (PMID 25605905)
		β156	L156V	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	Likely pathogenic, with L228V, L184V, L248V, tubulin beta	Leu156Val	ClinVar 392956	https://www.ncbi.nlm.nih.gov/clinvar/variation/392956	Homo sapiens, human, clinical
		β156	R156A	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Cold sensitive, with I152F & K154A, TUB2p	Arg156Ala	Reijo et al. 1994. Mol Biol Cell 5:29-43	https://pubmed.ncbi.nlm.nih.gov/8186463/	Saccharomyces cerevisiae, budding yeast, fungus
		β156	R156A	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Recessive lethal, with K154A, TUB2p	Arg156Ala	Reijo et al. 1994. Mol Biol Cell 5:29-43	https://pubmed.ncbi.nlm.nih.gov/8186463/	Saccharomyces cerevisiae, budding yeast, fungus
		β156	R156C	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:1793 / pancreatic cancer	Arg156Cys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β156	R156C	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:9256 / colorectal cancer	Arg156Cys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β156	R156H	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:10534 / stomach cancer	Arg156His	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β156	R156H	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:10534 / stomach cancer	Arg156His	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β156	R156H	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:9256 / colorectal cancer	Arg156His	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β156	R156K	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Recessive lethal, with I152F, E157A, E158A, TUB2p	Arg156Lys	Reijo et al. 1994. Mol Biol Cell 5:29-43	https://pubmed.ncbi.nlm.nih.gov/8186463/	Saccharomyces cerevisiae, budding yeast, fungus
		β156	R156K	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Benomyl supersensitive, with E157A, TUB2p	Arg156Lys	Reijo et al. 1994. Mol Biol Cell 5:29-43	https://pubmed.ncbi.nlm.nih.gov/8186463/	Saccharomyces cerevisiae, budding yeast, fungus
		β156	R156L	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Static hypomyelinating leukodystrophy, tubulin beta-4A	Arg156Leu	Purnell et al. 2014. Pediatr Neurol 50:608-11	https://pubmed.ncbi.nlm.nih.gov/24742798/	Homo sapiens, human, clinical
		β156	R156L	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with R207L, R201L, R84L, tubulin beta-4A	Arg156Leu	ClinVar 135659	https://www.ncbi.nlm.nih.gov/clinvar/variation/135659+F191	Homo sapiens, human, clinical
		β156	R156Q	Q9BVA1	https://www.uniprot.org/uniprotkb/Q9BVA1/entry	H. sapiens	TBB2B SNP, DOID:1612 / breast cancer	Arg156Gln	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BVA1	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β156	R156W	Q13885	https://www.uniprot.org/uniprotkb/Q13885/entry	H. sapiens	TBB2A SNP, DOID:363 / uterine cancer	Arg156Trp	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13885	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β157	E157A	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Recessive lethal, with I152F, E157A, E158A, TUB2p	Glu157Ala	Reijo et al. 1994. Mol Biol Cell 5:29-43	https://pubmed.ncbi.nlm.nih.gov/8186463/	Saccharomyces cerevisiae, budding yeast, fungus
		β157	E157A	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Benomyl supersensitive, with E156K, TUB2p	Glu157Ala	Reijo et al. 1994. Mol Biol Cell 5:29-43	https://pubmed.ncbi.nlm.nih.gov/8186463/	Saccharomyces cerevisiae, budding yeast, fungus
		β157	E157A	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Recessive lethal, with E158A, TUB2p	Glu157Ala	Reijo et al. 1994. Mol Biol Cell 5:29-43	https://pubmed.ncbi.nlm.nih.gov/8186463/	Saccharomyces cerevisiae, budding yeast, fungus
		β157	E157K	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:0060119 / pharynx cancer	Glu157Lys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β157	E157K	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:1793 / pancreatic cancer	Glu157Lys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β157	E157K	Q9BUF5	https://www.uniprot.org/uniprotkb/Q9BUF5/entry	H. sapiens	TBB6 SNP, DOID:1612 / breast cancer	Glu157Lys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BUF5	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β157	F157L	Q13885	https://www.uniprot.org/uniprotkb/Q13885/entry	H. sapiens	Likely pathogenic, with F242L, tubulin beta-2A	Phe157Leu	ClinVar 432097	https://www.ncbi.nlm.nih.gov/clinvar/variation/432097	Homo sapiens, human, clinical
		β157	V157A	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with V229A, V280A, V274A, tubulin beta-4A	Val157Ala	ClinVar 580978	https://www.ncbi.nlm.nih.gov/clinvar/variation/580978	Homo sapiens, human, clinical
		β158	E158A	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Recessive lethal, with I152F, E157A, E158A, TUB2p	Glu158Ala	Reijo et al. 1994. Mol Biol Cell 5:29-43	https://pubmed.ncbi.nlm.nih.gov/8186463/	Saccharomyces cerevisiae, budding yeast, fungus
		β158	E158A	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Recessive lethal, with E157A, TUB2p	Glu158Ala	Reijo et al. 1994. Mol Biol Cell 5:29-43	https://pubmed.ncbi.nlm.nih.gov/8186463/	Saccharomyces cerevisiae, budding yeast, fungus
		β158	S158L	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Pathogenic, with S230L, tubulin beta-3	Ser158Leu	ClinVar 280212	https://www.ncbi.nlm.nih.gov/clinvar/variation/280212	Homo sapiens, human, clinical
		β159	G159A	Q13885	https://www.uniprot.org/uniprotkb/Q13885/entry	H. sapiens	Likely pathogenic, with G244A, tubulin beta-2A	Gly159Ala	ClinVar 384308	https://www.ncbi.nlm.nih.gov/clinvar/variation/384308	Homo sapiens, human, clinical
		β159	Y159H	P68371	https://www.uniprot.org/uniprotkb/P68371/entry	H. sapiens	TBB4B SNP, DOID:3571 / liver cancer	Tyr159His	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P68371	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β159	Y159H	P99024	https://www.uniprot.org/uniprotkb/P99024/entry	M. musculus	Tubb5, viable heterozygote	Tyr159His	Mutagenetix	https://mutagenetix.utsouthwestern.edu/incidental/incidental_rec.cfm?mid=516944	Mus musculus, mouse, tubulin beta-5	Wang et al. 2015. PNAS 112:E440-449 (PMID 25605905)
		β160	P160L	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	Thyroid dysgenesis, abnormal platelet physiology, tubulin beta-1	Pro160Leu	Stoupa et al. 2018. EMBO Mol Med 10:e9569	https://pubmed.ncbi.nlm.nih.gov/30446499/	Homo sapiens, human, clinical
		β160	P160Q	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:1324 / lung cancer	Pro160Gln	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β160	P160Q	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:1909 / melanoma	Pro160Gln	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β161	D161A	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Benomyl supersensitive, with R162A, TUB2p	Asp161Ala	Reijo et al. 1994. Mol Biol Cell 5:29-43	https://pubmed.ncbi.nlm.nih.gov/8186463/	Saccharomyces cerevisiae, budding yeast, fungus
		β161	D161H	P68371	https://www.uniprot.org/uniprotkb/P68371/entry	H. sapiens	TBB4B SNP, DOID:1324 / lung cancer	Asp161His	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P68371	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β161	D161N	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:5041 / esophageal cancer	Asp161Asn	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β161	D161N	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:1909 / melanoma	Asp161Asn	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β162	G162C	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	Likely pathogenic, with G142C, G70C, G98C, tubulin beta	Gly162Cys	ClinVar 916073	https://www.ncbi.nlm.nih.gov/clinvar/variation/916073	Homo sapiens, human, clinical
		β162	N162K	Q13885	https://www.uniprot.org/uniprotkb/Q13885/entry	H. sapiens	Cortical dysplasia, brain malformations, with N247K, tubulin beta-2A	Asn162Lys	ClinVar 127100	https://www.ncbi.nlm.nih.gov/clinvar/variation/127100	Homo sapiens, human, clinical
		β162	R162A	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Benomyl supersensitive, with D161A, TUB2p	Arg162Ala	Reijo et al. 1994. Mol Biol Cell 5:29-43	https://pubmed.ncbi.nlm.nih.gov/8186463/	Saccharomyces cerevisiae, budding yeast, fungus
		β162	R162C	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:9256 / colorectal cancer	Arg162Cys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β162	R162C	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:10534 / stomach cancer	Arg162Cys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β162	R162C	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:9256 / colorectal cancer	Arg162Cys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β162	R162C	Q9BVA1	https://www.uniprot.org/uniprotkb/Q9BVA1/entry	H. sapiens	TBB2B SNP, DOID:363 / uterine cancer	Arg162Cys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BVA1	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β162	R162Q	P12456	https://www.uniprot.org/uniprotkb/P12456/entry	C. elegans	Neomorph, ectopic ALM-PN, mec-7	Arg162Gln	Zheng et al. 2017 Mol Biol Cell 28: 2786-2801	https://pubmed.ncbi.nlm.nih.gov/28835377/	Caenorhabditis elegans, nematode, roundworm	also see Lee et al. 2021. Mol Biol Cell. 15:331-347 (PMID 33378215)
		β163	A163V	Q13885	https://www.uniprot.org/uniprotkb/Q13885/entry	H. sapiens	Cortical dysplasia, brain malformations, with A248V, tubulin beta-2A	Ala163Val	ClinVar 127101	https://www.ncbi.nlm.nih.gov/clinvar/variation/127101	Homo sapiens, human, clinical
		β163	G163R	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with G280R, G286R, G235R, tubulin beta-4A	Gly163Arg	ClinVar 643798	https://www.ncbi.nlm.nih.gov/clinvar/variation/643798	Homo sapiens, human, clinical
		β163	I163V	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:10534 / stomach cancer	Ile163Val	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β163	I163V	Q9D6F9	https://www.uniprot.org/uniprotkb/Q9D6F9/entry	M. musculus	Tubb4a, viable heterozygote	Ile163Val	Mutagenetix	https://mutagenetix.utsouthwestern.edu/incidental/incidental_rec.cfm?mid=15781	Mus musculus, mouse, tubulin beta-4A	Wang et al. 2015. PNAS 112:E440-449 (PMID 25605905)
		β163	I163V	Q9D6F9	https://www.uniprot.org/uniprotkb/Q9D6F9/entry	M. musculus	Tubb4a, viable heterozygote	Ile163Val	Mutagenetix	https://mutagenetix.utsouthwestern.edu/incidental/incidental_rec.cfm?mid=289174	Mus musculus, mouse, tubulin beta-4A	Wang et al. 2015. PNAS 112:E440-449 (PMID 25605905)
		β163	M163I	A0A411NQ56	https://www.uniprot.org/uniprotkb/A0A411NQ56/entry	C. cassiicola	Benzimidazole resistant, with E198A	Met163Ile	Duan et al. 2019. Pestic Biochem Physiol 153:95-105	https://pubmed.ncbi.nlm.nih.gov/30744902/	Corynespora, fungus, plant pathogen
		β163	M163I	A0A411NQ78	https://www.uniprot.org/uniprotkb/A0A411NQ78/entry	C. cassiicola	High resistance to carbendazim, benomyl, with E198A	Met163Ile	Mao et al. 2022. J Agric Food Chem 70:15046-56	https://pubs.acs.org/doi/10.1021/acs.jafc.2c05912	Corynespora, fungus, plant pathogen
		β164	M164I	Q9BUF5	https://www.uniprot.org/uniprotkb/Q9BUF5/entry	H. sapiens	TBB6 SNP, DOID:1793 / pancreatic cancer	Met164Ile	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BUF5	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β164	M164I	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:1612 / breast cancer	Met164Ile	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β164	M164T	Q9ERD7	https://www.uniprot.org/uniprotkb/Q9ERD7/entry	M. musculus	Tubb3, viable heterozygote	Met164Thr	Mutagenetix	https://mutagenetix.utsouthwestern.edu/incidental/incidental_rec.cfm?mid=286508	Mus musculus, mouse, tubulin beta-3	Wang et al. 2015. PNAS 112:E440-449 (PMID 25605905)
		β165	A165V	P10653	https://www.uniprot.org/uniprotkb/P10653/entry	A. nidulans	Benomyl resistant, tubulin beta-1	Ala165Val	Jung et al. 1990. Cell Motil Cytoskeleton 17:87-94	https://pubmed.ncbi.nlm.nih.gov/1423663/	Aspergillus nidulans, fungus
		β165	C165Y	A0A650DFF5	https://www.uniprot.org/uniprotkb/A0A650DFF5/entry	P. sojae	Ethaboxam resistant	Cys165Tyr	Peng et al. 2019. Phytopathology 109:2096-2106	https://pubmed.ncbi.nlm.nih.gov/31559903/	Phytophthora sojae, oomycete, fungus, plant pathogen
		β165	E165K	P33188	https://www.uniprot.org/uniprotkb/P33188/entry	P. tetraurelia	Nocodazole resistant, enhancer of sm-19 (eta/zeta-tubulin), bPT2	Glu165Lys	Ruiz et al. 2004. Eukaryot Cell 3:212-20	https://pubmed.ncbi.nlm.nih.gov/14871951/	Paramecium tetraurelia, ciliate, protozoa
		β165	N165H	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:363 / uterine cancer	Asn165His	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β166	R166W	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with R121W, R49W, R172W, tubulin beta-4A	Arg166Trp	ClinVar 837764	https://www.ncbi.nlm.nih.gov/clinvar/variation/837764	Homo sapiens, human, clinical
		β166	T166A	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Invasive ductal, low grade; taxane treatment, also contains I189V, S239C, T315A, A332N, I333V, S335N, V351T	Thr166Ala	Wang et al. 2017. Protoplasma 254:1163-1173	https://pubmed.ncbi.nlm.nih.gov/27943021/	Homo sapiens, human, clinical	Tubulin beta-3 chain
		β166	T166S	Q922F4	https://www.uniprot.org/uniprotkb/Q922F4/entry	M. musculus	Tubb6, viable heterozygote	Thr166Ser	Mutagenetix	https://mutagenetix.utsouthwestern.edu/incidental/incidental_rec.cfm?mid=664782	Mus musculus, mouse, tubulin beta-6	Wang et al. 2015. PNAS 112:E440-449 (PMID 25605905)
		β166	T166S	Q922F4	https://www.uniprot.org/uniprotkb/Q922F4/entry	M. musculus	Tubb6, viable heterozygote	Thr166Ser	Mutagenetix	https://mutagenetix.utsouthwestern.edu/incidental/incidental_rec.cfm?mid=668150	Mus musculus, mouse, tubulin beta-6	Wang et al. 2015. PNAS 112:E440-449 (PMID 25605905)
		β167	C167F	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with C290F, C239F, C284F, tubulin beta-4A	Cys167Phe	ClinVar 267776	https://www.ncbi.nlm.nih.gov/clinvar/variation/267776	Homo sapiens, human, clinical
		β167	F167L	P68371	https://www.uniprot.org/uniprotkb/P68371/entry	H. sapiens	TBB4B SNP, DOID:0060119 / pharynx cancer	Phe167Leu	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P68371	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β167	F167Y	Q4HZS8	https://www.uniprot.org/uniprotkb/Q4HZS8/entry	G. zeae	Benzimidazole resistant	Phe167Tyr	Chen et al. 2009. Phytopathology 99:1403-11	https://pubmed.ncbi.nlm.nih.gov/19900007/	Gibberella zeae, Fusarium graminearum, fungus
		β167	F167Y	P05220	https://www.uniprot.org/uniprotkb/P05220/entry	N. crassa	Benomyl resistant, beta tubulin	Phe167Tyr	Orbach et al. 1986. Mol Cell Biol 6:2452-61	https://pubmed.ncbi.nlm.nih.gov/2946938/	Neurospora crassa, fungus, red bread mold
		β167	F167Y	Q18817	https://www.uniprot.org/uniprotkb/Q18817/entry	C. elegans	Benzimidazole resistant (ben-1, tbb-5)	Phe167Tyr	Hahnel et al. 2018. PLoS Pathog 14:e1007226	https://pubmed.ncbi.nlm.nih.gov/30372484/	Caenorhabditis elegans, nematode, roundworm
		β167	F167Y	A0A411NQ56	https://www.uniprot.org/uniprotkb/A0A411NQ56/entry	C. cassiicola	Benzimidazole resistant, with E198A	Phe167Tyr	Duan et al. 2019. Pestic Biochem Physiol 153:95-105	https://pubmed.ncbi.nlm.nih.gov/30744902/	Corynespora, fungus, plant pathogen
		β167	F167Y	B5AX19	https://www.uniprot.org/uniprotkb/B5AX19/entry	A. caninum	Fenbendazole resistant, tbb-iso-1	Phe167Tyr	Kitchen et al. 2019. Int J Parasitol 49:397-406	https://pubmed.ncbi.nlm.nih.gov/30771359/	Hookworm, parasite
		β167	F167Y	Q18817	https://www.uniprot.org/uniprotkb/Q18817/entry	C. elegans	Thiabendazole resistant, ben-1	Phe167Tyr	Kitchen et al. 2019. Int J Parasitol 49:397-406	https://pubmed.ncbi.nlm.nih.gov/30771359/	Caenorhabditis elegans, nematode, roundworm
		β167	F167Y	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Benzimidazole resistant, benomyl supersensitive, cold sensitive, TUB2p	Phe167Tyr	Li et al. 1996. FEBS Lett 385:7-10	https://pubmed.ncbi.nlm.nih.gov/8641470/	Saccharomyces cerevisiae, budding yeast, fungus
		β167	F167Y	A0A411NQ78	https://www.uniprot.org/uniprotkb/A0A411NQ78/entry	C. cassiicola	High resistance to carbendazim, benomyl, with E198A	Phe167Tyr	Mao et al. 2022. J Agric Food Chem 70:15046-56	https://pubs.acs.org/doi/10.1021/acs.jafc.2c05912	Corynespora, fungus, plant pathogen
		β167	F167Y	A0A411NQ78	https://www.uniprot.org/uniprotkb/A0A411NQ78/entry	C. cassiicola	Moderate resistance to carbendazim, benomyl	Phe167Tyr	Mao et al. 2022. J Agric Food Chem 70:15046-56	https://pubs.acs.org/doi/10.1021/acs.jafc.2c05912	Corynespora, fungus, plant pathogen
		β167	S167F	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Uncertain significance, with S239F, tubulin beta-3	Ser167Phe	ClinVar 546125	https://www.ncbi.nlm.nih.gov/clinvar/variation/546125	Homo sapiens, human, clinical
		β168	S168C	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:2994 / germ cell cancer	Ser168Cys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β168	S168C	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:2394 / ovarian cancer	Ser168Cys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β168	S168G	P68371	https://www.uniprot.org/uniprotkb/P68371/entry	H. sapiens	TBB4B SNP, DOID:1909 / melanoma	Ser168Gly	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P68371	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β168	S168N	Q9BVA1	https://www.uniprot.org/uniprotkb/Q9BVA1/entry	H. sapiens	TBB2B SNP, DOID:9256 / colorectal cancer	Ser168Asn	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BVA1	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β168	S168R	Q13885	https://www.uniprot.org/uniprotkb/Q13885/entry	H. sapiens	TBB2A SNP, DOID:0070003 / blastoma	Ser168Arg	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13885	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β168	S168R	Q13885	https://www.uniprot.org/uniprotkb/Q13885/entry	H. sapiens	TBB2A SNP, DOID:3571 / liver cancer	Ser168Arg	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13885	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β168	S168R	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:1612 / breast cancer	Ser168Arg	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β169	I169M	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:11934 / head and neck cancer	Ile169Met	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β169	V169A	A2AQ07	https://www.uniprot.org/uniprotkb/A2AQ07/entry	M. musculus	Tubb1, viable heterozygote	Val169Ala	Mutagenetix	https://mutagenetix.utsouthwestern.edu/incidental/incidental_rec.cfm?mid=575712	Mus musculus, mouse, tubulin beta-1	Wang et al. 2015. PNAS 112:E440-449 (PMID 25605905)
		β169	V169F	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:1324 / lung cancer	Val169Phe	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β169	V169I	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:11054 / urinary bladder cancer	Val169Ile	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β169	V169I	Q9BVA1	https://www.uniprot.org/uniprotkb/Q9BVA1/entry	H. sapiens	TBB2B SNP, DOID:263 / kidney cancer	Val169Ile	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BVA1	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β169	V169I	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:363 / uterine cancer	Val169Ile	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β169	V169L	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:1909 / melanoma	Val169Leu	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β169	V169L	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:9256 / colorectal cancer	Val169Leu	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β169	V169M	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:0070003 / blastoma	Val169Met	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β169	V169M	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:1793 / pancreatic cancer	Val169Met	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β170	L170F	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	Cortical dysplasia, brain malformations, with L150F, L78F, L106F, tubulin beta	Leu170Phe	ClinVar 807517	https://www.ncbi.nlm.nih.gov/clinvar/variation/807517	Homo sapiens, human, clinical
		β170	M170I	Q13885	https://www.uniprot.org/uniprotkb/Q13885/entry	H. sapiens	TBB2A SNP, DOID:363 / uterine cancer	Met170Ile	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13885	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β170	V170L	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:1324 / lung cancer	Val170Leu	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β170	V170M	P68371	https://www.uniprot.org/uniprotkb/P68371/entry	H. sapiens	TBB4B SNP, DOID:9256 / colorectal cancer	Val170Met	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P68371	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β170	V170M	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:363 / uterine cancer	Val170Met	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β170	V170M	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Invasive ductal, low grade; no treatment	Val170Met	Wang et al. 2017. Protoplasma 254:1163-1173	https://pubmed.ncbi.nlm.nih.gov/27943021/	Homo sapiens, human, clinical	Tubulin beta-3 chain
		β170	V170M	Q13885	https://www.uniprot.org/uniprotkb/Q13885/entry	H. sapiens	Invasive ductal, low grade; no treatment, also contains E45D, N48S, V64I, C201S, A296S, V316I	Val170Met	Wang et al. 2017. Protoplasma 254:1163-1173	https://pubmed.ncbi.nlm.nih.gov/27943021/	Homo sapiens, human, clinical	Tubulin beta-2A chain
		β171	P171H	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:363 / uterine cancer	Pro171His	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β171	P171L	P68371	https://www.uniprot.org/uniprotkb/P68371/entry	H. sapiens	Invasive ductal, low grade; taxane treatment, also contains C239R	Pro171Leu	Wang et al. 2017. Protoplasma 254:1163-1173	https://pubmed.ncbi.nlm.nih.gov/27943021/	Homo sapiens, human, clinical	Tubulin beta-4B chain
		β171	P171L	P12456	https://www.uniprot.org/uniprotkb/P12456/entry	C. elegans	Antimorph, short TRN neurites, mec-7	Pro171Leu	Zheng et al. 2017 Mol Biol Cell 28: 2786-2801	https://pubmed.ncbi.nlm.nih.gov/28835377/	Caenorhabditis elegans, nematode, roundworm	also see Lee et al. 2021. Mol Biol Cell. 15:331-347 (PMID 33378215)
		β171	P171L	P12456	https://www.uniprot.org/uniprotkb/P12456/entry	C. elegans	Mechanosensitive, severe semidominant, mec-7	Pro171Leu	Savage et al. 1994. J Cell Sci 107:2165-75	https://pubmed.ncbi.nlm.nih.gov/7983175/	Caenorhabditis elegans, nematode, roundworm
		β171	P171L	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Cortical dysplasia, brain malformations, with P243L, tubulin beta-3	Pro171Leu	ClinVar 160195	https://www.ncbi.nlm.nih.gov/clinvar/variation/160195	Homo sapiens, human, clinical
		β171	P171S	Q9BUF5	https://www.uniprot.org/uniprotkb/Q9BUF5/entry	H. sapiens	TBB6 SNP, DOID:3070 / malignant glioma	Pro171Ser	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BUF5	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β171	P171S	P12456	https://www.uniprot.org/uniprotkb/P12456/entry	C. elegans	Reduced MT stability, antimorph, shortened TRN neurites, mec-7	Pro171Ser	Zheng et al. 2017 Mol Biol Cell 28: 2786-2801	https://pubmed.ncbi.nlm.nih.gov/28835377/	Caenorhabditis elegans, nematode, roundworm	also see Lee et al. 2021. Mol Biol Cell. 15:331-347 (PMID 33378215)
		β172	G172D	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with G295D, G244D, G289D, tubulin beta-4A	Gly172Asp	ClinVar 267778	https://www.ncbi.nlm.nih.gov/clinvar/variation/267778	Homo sapiens, human, clinical
		β172	G172R	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with G244R, G289R, G295R, tubulin beta-4A	Gly172Arg	ClinVar 803516	https://www.ncbi.nlm.nih.gov/clinvar/variation/803516	Homo sapiens, human, clinical
		β172	G172S	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with G244S, G295S, G289S, tubulin beta-4A	Gly172Ser	ClinVar 267772	https://www.ncbi.nlm.nih.gov/clinvar/variation/267772	Homo sapiens, human, clinical
		β172	G172V	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with G295V, G244V, G289V, tubulin beta-4A	Gly172Val	ClinVar 267777	https://www.ncbi.nlm.nih.gov/clinvar/variation/267777	Homo sapiens, human, clinical
		β172	K172R	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	Likely pathogenic, with K216R, K236R, K144R, tubulin beta	Ly172Arg	ClinVar 545082	https://www.ncbi.nlm.nih.gov/clinvar/variation/545082	Homo sapiens, human, clinical
		β172	R172W	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with R121W, R166W, R49W, tubulin beta-4A	Arg172Trp	ClinVar 837764	https://www.ncbi.nlm.nih.gov/clinvar/variation/837764	Homo sapiens, human, clinical
		β172	S172A	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	HTI-286 (hemiasterlin derivative) resistant, tubulin beta	Ser172Ala	Poruchynsky et al. 2004. Biochemistry 43:13944-54	https://pubmed.ncbi.nlm.nih.gov/15518543/	Homo sapiens, human, clinical
		β172	S172A	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Cold & benomyl sensitive, synthetic lethal with Bik1, Bim1 or Kar3, TUB2p	Ser172Ala	Caudron et al. 2010. PLoS One 5	https://pubmed.ncbi.nlm.nih.gov/21042413/	Saccharomyces cerevisiae, budding yeast, fungus
		β172	S172E	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Cold & benomyl sensitive, synthetic lethal with Bik1, Bim1 or Kar3, TUB2p	Ser172Glu	Caudron et al. 2010. PLoS One 5	https://pubmed.ncbi.nlm.nih.gov/21042413/	Saccharomyces cerevisiae, budding yeast, fungus
		β172	S172L	Q9BUF5	https://www.uniprot.org/uniprotkb/Q9BUF5/entry	H. sapiens	TBB6 SNP, DOID:11934 / head and neck cancer	Ser172Leu	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BUF5	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β172	S172P	Q9BVA1	https://www.uniprot.org/uniprotkb/Q9BVA1/entry	H. sapiens	Polymicrogyria, tubulin beta-2B	Ser172Pro	Jaglin et al. 2009. Nat Genet 41:746-52	https://pubmed.ncbi.nlm.nih.gov/19465910/	Homo sapiens, human, clinical
		β172	S172P	Q13885	https://www.uniprot.org/uniprotkb/Q13885/entry	H. sapiens	Inhibited axonal transport of vesicles and mitochondria, tubulin beta-2A	Ser172Pro	Niwa et al. 2013. EMBO J 32:1352-64	https://pubmed.ncbi.nlm.nih.gov/23503589/	Homo sapiens, human, clinical	Model for polymicrogyria
		β172	S172P	Q9BVA1	https://www.uniprot.org/uniprotkb/Q9BVA1/entry	H. sapiens	Polymicrogyria, tubulin beta-2B	Ser172Pro	Fallet-Bianco et al. 2014. Acta Neuropathol Commun 2:69	https://pubmed.ncbi.nlm.nih.gov/25059107/	Homo sapiens, human, clinical
		β172	S172P	P12456	https://www.uniprot.org/uniprotkb/P12456/entry	C. elegans	Loss-of-function, shortened PLM-PN, mec-7	Ser172Pro	Zheng et al. 2017 Mol Biol Cell 28: 2786-2801	https://pubmed.ncbi.nlm.nih.gov/28835377/	Caenorhabditis elegans, nematode, roundworm	also see Lee et al. 2021. Mol Biol Cell. 15:331-347 (PMID 33378215)
		β173	L173L	Q9N2N6	https://www.uniprot.org/uniprotkb/Q9N2N6/entry	E. focardii	Cold stable adaptation (correlation, EFBT3)	Leu173Leu	Chiappori et al. 2012. Proteins 80:1154-60	https://pubmed.ncbi.nlm.nih.gov/22275059/	Euplotes focardii, extremophile, Antarctic ciliate
		β173	P173A	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	Taxol and epothilone resistant HeLa cell line, tubulin beta	Pro173Ala	He et al. 2001. Mol Cancer Ther 1:3-10	https://pubmed.ncbi.nlm.nih.gov/12467233/	Homo sapiens, human, clinical
		β173	P173L	Q9BUF5	https://www.uniprot.org/uniprotkb/Q9BUF5/entry	H. sapiens	TBB6 SNP, DOID:1909 / melanoma	Pro173Leu	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BUF5	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β173	P173L	Q9BVA1	https://www.uniprot.org/uniprotkb/Q9BVA1/entry	H. sapiens	Malformation of cortical development, fetal sample, tubulin beta-2B	Pro173Leu	Fallet-Bianco et al. 2014. Acta Neuropathol Commun 2:69	https://pubmed.ncbi.nlm.nih.gov/25059107/	Homo sapiens, human, clinical
		β173	P173L	P12456	https://www.uniprot.org/uniprotkb/P12456/entry	C. elegans	No defects, mec-7	Pro173Leu	Zheng et al. 2017 Mol Biol Cell 28: 2786-2801	https://pubmed.ncbi.nlm.nih.gov/28835377/	Caenorhabditis elegans, nematode, roundworm	also see Lee et al. 2021. Mol Biol Cell. 15:331-347 (PMID 33378215)
		β174	K174A	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Cold sensitive, benomyl supersensitive, with D177A, TUB2p	Lys174Ala	Reijo et al. 1994. Mol Biol Cell 5:29-43	https://pubmed.ncbi.nlm.nih.gov/8186463/	Saccharomyces cerevisiae, budding yeast, fungus
		β174	K174T	P68371	https://www.uniprot.org/uniprotkb/P68371/entry	H. sapiens	TBB4B SNP, DOID:0060119 / pharynx cancer	Lys174Thr	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P68371	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β175	N175S	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Cortical dysplasia, brain malformations, with N247S, tubulin beta-3	Asn175Ser	ClinVar 160196	https://www.ncbi.nlm.nih.gov/clinvar/variation/160196	Homo sapiens, human, clinical
		β175	T175R	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Blocked polymerization, with V179R, TUB2p	Thr175Arg	Johnson et al. 2011. Biochemistry:8636-44	https://pubmed.ncbi.nlm.nih.gov/21888381/	Saccharomyces cerevisiae, budding yeast, fungus
		β175	V175L	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:263 / kidney cancer	Val175Leu	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β175	V175L	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:9256 / colorectal cancer	Val175Leu	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β175	V175L	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Hydrocephalus & Walker–Warburg Syndrome, tubulin beta-3	Val175Leu	Powis et al. 2018. Pediatr Dev Pathol 21:319-323	https://pubmed.ncbi.nlm.nih.gov/29187032/	Homo sapiens, human, clinical
		β175	V175L	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Inborn genetic diseases, with V103L, tubulin beta-3	Val175Leu	ClinVar 520851	https://www.ncbi.nlm.nih.gov/clinvar/variation/520851	Homo sapiens, human, clinical
		β175	V175M	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:10283 / prostate cancer	Val175Met	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β175	V175M	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Female infertility, tubulin beta-8	Val175Met	Chen et al. 2019. Eur J Hum Genet 27:300-307	https://pubmed.ncbi.nlm.nih.gov/30297906/	Homo sapiens, human, clinical
		β176	S176F	P12456	https://www.uniprot.org/uniprotkb/P12456/entry	C. elegans	Antimorph, short TRN neurites, mec-7	Ser176Phe	Zheng et al. 2017 Mol Biol Cell 28: 2786-2801	https://pubmed.ncbi.nlm.nih.gov/28835377/	Caenorhabditis elegans, nematode, roundworm	also see Lee et al. 2021. Mol Biol Cell. 15:331-347 (PMID 33378215)
		β176	S176F	P12456	https://www.uniprot.org/uniprotkb/P12456/entry	C. elegans	Mechanosensitive, severe semidominant, mec-7	Ser176Phe	Savage et al. 1994. J Cell Sci 107:2165-75	https://pubmed.ncbi.nlm.nih.gov/7983175/	Caenorhabditis elegans, nematode, roundworm
		β176	S176L	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:1909 / melanoma	Ser176Leu	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β176	S176L	Q9BUF5	https://www.uniprot.org/uniprotkb/Q9BUF5/entry	H. sapiens	TBB6 SNP, DOID:1612 / breast cancer	Ser176Leu	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BUF5	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β176	S176L	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:5041 / esophageal cancer	Ser176Leu	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β176	S176L	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Defects in oocyte meiosis, tubulin beta-8	Ser176Leu	Feng et al. 2016. N Engl J Med 374:223-32	https://pubmed.ncbi.nlm.nih.gov/26789871/	Homo sapiens, human, clinical
		β176	S176L	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Defects in oocyte meiosis, tubulin beta-8, new occurance (previously observed)	Ser176Leu	Feng et al. 2016. J Med Genet 53:662-71	https://pubmed.ncbi.nlm.nih.gov/27273344/	Homo sapiens, human, clinical
		β176	S176L	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Female infertility, tubulin beta-8	Ser176Leu	Chen et al. 2019. Eur J Hum Genet 27:300-307	https://pubmed.ncbi.nlm.nih.gov/30297906/	Homo sapiens, human, clinical
		β176	S176L	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Female infertility, tubulin beta-8	Ser176Leu	Yang et al. 2021. Clin Genet 99:208-214	https://pubmed.ncbi.nlm.nih.gov/33009822/	Homo sapiens, human, clinical
		β176	S176L	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Oocyte maturation arrest, tubulin beta-8	Ser176Leu	Zhu et al. 2022. Front. Endocrinol. 13:1016563.	https://pubmed.ncbi.nlm.nih.gov/36440233/	Homo sapiens, human, clinical
		β176	S176L	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Oocyte maturation defect, tubulin beta-8	Ser176Leu	ClinVar 221268	https://www.ncbi.nlm.nih.gov/clinvar/variation/223143	Homo sapiens, human, clinical
		β176	S176P	Q9D6F9	https://www.uniprot.org/uniprotkb/Q9D6F9/entry	M. musculus	Tubb4a, viable heterozygote	Ser176Pro	Mutagenetix	https://mutagenetix.utsouthwestern.edu/incidental/incidental_rec.cfm?mid=23402	Mus musculus, mouse, tubulin beta-4A	Wang et al. 2015. PNAS 112:E440-449 (PMID 25605905)
		β176	S176P	Q9ERD7	https://www.uniprot.org/uniprotkb/Q9ERD7/entry	M. musculus	Tubb3, viable heterozygote	Ser176Pro	Mutagenetix	https://mutagenetix.utsouthwestern.edu/incidental/incidental_rec.cfm?mid=641914	Mus musculus, mouse, tubulin beta-3	Wang et al. 2015. PNAS 112:E440-449 (PMID 25605905)
		β176	S176W	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Oocyte maturation arrest and infertility, TUBB8	Ser176Trp	Yu et al. 2023. Reprod Sci 30:1376-82	https://pubmed.ncbi.nlm.nih.gov/36197634/	Homo sapiens, human, clinical
		β177	D177A	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Cold sensitive, benomyl supersensitive, with K174A, TUB2p	Asp177Ala	Reijo et al. 1994. Mol Biol Cell 5:29-43	https://pubmed.ncbi.nlm.nih.gov/8186463/	Saccharomyces cerevisiae, budding yeast, fungus
		β177	D177G	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	Invasive mixed, low grade; no treatment, also contains C239R	Asp177Gly	Wang et al. 2017. Protoplasma 254:1163-1173	https://pubmed.ncbi.nlm.nih.gov/27943021/	Homo sapiens, human, clinical	Tubulin beta-1 chain
		β177	D177G	P69893	https://www.uniprot.org/uniprotkb/P69893/entry	C. griseus	Paclitaxel resistant, tubulin beta-5	Asp177Gly	Yin et al. 2012. Pharm Res 29:2994-3006	https://pubmed.ncbi.nlm.nih.gov/22669706/	Cricetulus griseus, chinese hamster, rodent
		β177	D177H	P68371	https://www.uniprot.org/uniprotkb/P68371/entry	H. sapiens	TBB4B SNP, DOID:1324 / lung cancer	Asp177His	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P68371	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β177	D177N	P32882	https://www.uniprot.org/uniprotkb/P32882/entry	G. gallus	GTP binding site mutation, in vitro synthesis in reticulocyte lysates	Asp177Asn	Farr & Sternlicht. 1992. J Mol Biol 227:307-21	https://pubmed.ncbi.nlm.nih.gov/1522595/	Gallus gallus, red junglefowl, chicken, bird
		β177	D177N	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with D249N, D300N, D294N, tubulin beta-4A	Asp177Asn	ClinVar 50985	https://www.ncbi.nlm.nih.gov/clinvar/variation/50985	Homo sapiens, human, clinical
		β177	D177N	P69893	https://www.uniprot.org/uniprotkb/P69893/entry	C. griseus	Paclitaxel resistant, tubulin beta-5	Asp177Asn	Yin et al. 2012. Pharm Res 29:2994-3006	https://pubmed.ncbi.nlm.nih.gov/22669706/	Cricetulus griseus, chinese hamster, rodent
		β177	T177I	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	Cortical dysplasia, brain malformations, with T221I, T149I, T241I, tubulin beta	Thr177Ile	ClinVar 235892	https://www.ncbi.nlm.nih.gov/clinvar/variation/235892	Homo sapiens, human, clinical
		β178	T178A	P69893	https://www.uniprot.org/uniprotkb/P69893/entry	C. griseus	Paclitaxel resistant, with N416D, CHO cell line, tubulin beta-5	Thr178Ala	Yin et al. 2012. Pharm Res 29:2994-3006	https://pubmed.ncbi.nlm.nih.gov/22669706/	Cricetulus griseus, chinese hamster, rodent
		β178	T178I	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:1909 / melanoma	Thr178Ile	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β178	T178I	P24636	https://www.uniprot.org/uniprotkb/P24636/entry	A. thaliana	Twisting, TUB4	Thr178Ile	Ishida et al. 2007. PNAS 104:8544-9	https://pubmed.ncbi.nlm.nih.gov/17488810/	Arabidopsis thaliana, plant
		β178	T178M	Q13885	https://www.uniprot.org/uniprotkb/Q13885/entry	H. sapiens	TBB2A SNP, DOID:10534 / stomach cancer	Thr178Met	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13885	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β178	T178M	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Malformation of cortical development, tubulin beta-3	Thr178Met	Poirier et al. 2010. Hum Mol Genet 19:4462-73	https://pubmed.ncbi.nlm.nih.gov/20829227/	Homo sapiens, human, clinical
		β178	T178M	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Inhibited axonal transport of vesicles and mitochondria, tubulin beta-3	Thr178Met	Niwa et al. 2013. EMBO J 32:1352-64	https://pubmed.ncbi.nlm.nih.gov/23503589/	Homo sapiens, human, clinical	Model for MCD
		β178	T178M	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Hypomyelinating leukodystrophy, TUBB4A	Thr178Met	Tonduti et al. 2016. Eur J Paediatr Neurol 20:323-30	https://pubmed.ncbi.nlm.nih.gov/26643067/	Homo sapiens, human, clinical
		β178	T178M	Q13885	https://www.uniprot.org/uniprotkb/Q13885/entry	H. sapiens	Pathogenic, with T93M, tubulin beta-2A	Thr178Met	ClinVar 265284	https://www.ncbi.nlm.nih.gov/clinvar/variation/265284	Homo sapiens, human, clinical
		β178	T178M	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Cortical dysplasia, brain malformations, with T106M, tubulin beta-3	Thr178Met	ClinVar 265335	https://www.ncbi.nlm.nih.gov/clinvar/variation/265335	Homo sapiens, human, clinical
		β178	T178M	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with T229M, T106M, T223M, tubulin beta-4A	Thr178Met	ClinVar 267774	https://www.ncbi.nlm.nih.gov/clinvar/variation/267774	Homo sapiens, human, clinical
		β178	T178R	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Hypomyelinating leukoencephalopathy, tubulin beta-4A	Thr178Arg	Miyatake et al. 2014. Neurology 82:2230-7	https://pubmed.ncbi.nlm.nih.gov/24850488/	Homo sapiens, human, clinical
		β178	T178R	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Hypomyelination, basal ganglia & cerebellum atrophy, tubulin beta-4A	Thr178Arg	Joyal et al. 2019. J Neuropathol Exp Neurol 78:3-9	https://pubmed.ncbi.nlm.nih.gov/30476126/	Homo sapiens, human, clinical
		β178	T178R	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with T229R, T223R, T106R, tubulin beta-4A	Thr178Arg	ClinVar 139453	https://www.ncbi.nlm.nih.gov/clinvar/variation/139453	Homo sapiens, human, clinical
		β178	T178S	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	Likely pathogenic, with T106S, T134S, T198S, tubulin beta	Thr178Ser	ClinVar 376764	https://www.ncbi.nlm.nih.gov/clinvar/variation/376764	Homo sapiens, human, clinical
		β178	Y178F	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	Symmetric circumferential skin creases, with Y222F, Y150F, Y242F, tubulin beta	Tyr178Phe	ClinVar 218926	https://www.ncbi.nlm.nih.gov/clinvar/variation/218926	Homo sapiens, human, clinical
		β179	V179A	P12456	https://www.uniprot.org/uniprotkb/P12456/entry	C. elegans	Antimorph, short TRN neurites, mec-7	Val179Ala	Zheng et al. 2017 Mol Biol Cell 28: 2786-2801	https://pubmed.ncbi.nlm.nih.gov/28835377/	Caenorhabditis elegans, nematode, roundworm	also see Lee et al. 2021. Mol Biol Cell. 15:331-347 (PMID 33378215)
		β179	V179A	P12456	https://www.uniprot.org/uniprotkb/P12456/entry	C. elegans	Mechanosensitive, severe semidominant, mec-7	Val179Ala	Savage et al. 1994. J Cell Sci 107:2165-75	https://pubmed.ncbi.nlm.nih.gov/7983175/	Caenorhabditis elegans, nematode, roundworm
		β179	V179A	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Uncertain significance, with V107A, tubulin beta-3	Val179Ala	ClinVar 437132	https://www.ncbi.nlm.nih.gov/clinvar/variation/437132	Homo sapiens, human, clinical
		β179	V179L	Q9ERD7	https://www.uniprot.org/uniprotkb/Q9ERD7/entry	M. musculus	Tubb3, viable heterozygote	Val179Leu	Mutagenetix	https://mutagenetix.utsouthwestern.edu/incidental/incidental_rec.cfm?mid=284579	Mus musculus, mouse, tubulin beta-3	Wang et al. 2015. PNAS 112:E440-449 (PMID 25605905)
		β179	V179L	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Pathogenic, with V230L, V224L, V107L, tubulin beta-4A	Val179Leu	ClinVar 372789	https://www.ncbi.nlm.nih.gov/clinvar/variation/372789	Homo sapiens, human, clinical
		β179	V179M	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:2531 / hematologic cancer	Val179Met	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β179	V179M	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:1612 / breast cancer	Val179Met	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β179	V179M	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:263 / kidney cancer	Val179Met	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β179	V179M	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:363 / uterine cancer	Val179Met	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β179	V179M	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:1793 / pancreatic cancer	Val179Met	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β179	V179M	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:9256 / colorectal cancer	Val179Met	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β179	V179M	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:363 / uterine cancer	Val179Met	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β179	V179M	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Female infertility, tubulin beta-8	Val179Met	Yang et al. 2021. Clin Genet 99:208-214	https://pubmed.ncbi.nlm.nih.gov/33009822/	Homo sapiens, human, clinical
		β179	V179R	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Blocked polymerization, with T175R, TUB2p	Val179Arg	Johnson et al. 2011. Biochemistry:8636-44	https://pubmed.ncbi.nlm.nih.gov/21888381/	Saccharomyces cerevisiae, budding yeast, fungus
		β180	S188X	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Human oocyte maturation defects and female infertility, TUBB8	Ser188X	Lin et al. 2023. Reprod Biomed Online 46(2):244-254	https://pubmed.ncbi.nlm.nih.gov/36463079/	Homo sapiens, human, clinical
		β180	V180A	Q9ERD7	https://www.uniprot.org/uniprotkb/Q9ERD7/entry	M. musculus	Tubb3, viable heterozygote	Val180Ala	Mutagenetix	https://mutagenetix.utsouthwestern.edu/incidental/incidental_rec.cfm?mid=390712	Mus musculus, mouse, tubulin beta-3	Wang et al. 2015. PNAS 112:E440-449 (PMID 25605905)
		β180	V180A	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Invasive ductal, high grade; doxorubicin treatment, also contains T315A, A332N, I333V, S335N, V351T, S365A, I374T	Val180Ala	Wang et al. 2017. Protoplasma 254:1163-1173	https://pubmed.ncbi.nlm.nih.gov/27943021/	Homo sapiens, human, clinical	Tubulin beta-3 chain
		β180	V180A	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Female infertility, tubulin beta-8	Val180Ala	Yang et al. 2021. Clin Genet 99:208-214	https://pubmed.ncbi.nlm.nih.gov/33009822/	Homo sapiens, human, clinical
		β180	V180M	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:9256 / colorectal cancer	Val180Met	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β180	V180M	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Oocyte maturation arrest and infertility, TUBB8	Val180Met	Yu et al. 2023. Reprod Sci 30:1376-82	https://pubmed.ncbi.nlm.nih.gov/36197634/	Homo sapiens, human, clinical
		β180	V180M	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Uncertain significance, with V231M, V108M, V225M, tubulin beta-4A	Val180Met	ClinVar 425158	https://www.ncbi.nlm.nih.gov/clinvar/variation/425158	Homo sapiens, human, clinical
		β180	V180X	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Human oocyte maturation defects and female infertility, TUBB8	Val180X	Lin et al. 2023. Reprod Biomed Online 46(2):244-254	https://pubmed.ncbi.nlm.nih.gov/36463079/	Homo sapiens, human, clinical
		β181	A181A	Q9N2N6	https://www.uniprot.org/uniprotkb/Q9N2N6/entry	E. focardii	Cold stable adaptation (correlation, EFBT3)	Ala181Ala	Chiappori et al. 2012. Proteins 80:1154-60	https://pubmed.ncbi.nlm.nih.gov/22275059/	Euplotes focardii, extremophile, Antarctic ciliate
		β181	E181A	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Wild-type, TUB2p	Glu181Ala	Reijo et al. 1994. Mol Biol Cell 5:29-43	https://pubmed.ncbi.nlm.nih.gov/8186463/	Saccharomyces cerevisiae, budding yeast, fungus
		β181	E181D	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:363 / uterine cancer	Glu181Asp	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β182	P182H	Q9BUF5	https://www.uniprot.org/uniprotkb/Q9BUF5/entry	H. sapiens	TBB6 SNP, DOID:3571 / liver cancer	Pro182His	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BUF5	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β182	P182S	Q13885	https://www.uniprot.org/uniprotkb/Q13885/entry	H. sapiens	TBB2A SNP, DOID:11934 / head and neck cancer	Pro182Ser	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13885	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β182	P182S	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:0070003 / blastoma	Pro182Ser	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β182	P182S	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:1793 / pancreatic cancer	Pro182Ser	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β182	P182S	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Female infertility, tubulin beta-8	Pro182Ser	Yang et al. 2021. Clin Genet 99:208-214	https://pubmed.ncbi.nlm.nih.gov/33009822/	Homo sapiens, human, clinical
		β182	P182T	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Hypomyelinating leukodystrophy, TUBB4A	Pro182Thr	Tonduti et al. 2016. Eur J Paediatr Neurol 20:323-30	https://pubmed.ncbi.nlm.nih.gov/26643067/	Homo sapiens, human, clinical
		β182	P182T	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with P233T, P227T, P110T, tubulin beta-4A	Pro182Thr	ClinVar 267775	https://www.ncbi.nlm.nih.gov/clinvar/variation/267775	Homo sapiens, human, clinical
		β183	T183T	Q9N2N6	https://www.uniprot.org/uniprotkb/Q9N2N6/entry	E. focardii	Cold stable adaptation (correlation, EFBT3)	Thr183Thr	Chiappori et al. 2012. Proteins 80:1154-60	https://pubmed.ncbi.nlm.nih.gov/22275059/	Euplotes focardii, extremophile, Antarctic ciliate
		β183	V183I	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with V255I, V306I, V300I, tubulin beta-4A	Val183Ile	ClinVar 217025	https://www.ncbi.nlm.nih.gov/clinvar/variation/217025	Homo sapiens, human, clinical
		β183	V183I	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Likely pathogenic, with V255I, tubulin beta-3	Val183Ile	ClinVar 372654	https://www.ncbi.nlm.nih.gov/clinvar/variation/372654	Homo sapiens, human, clinical
		β183	Y183C	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:1324 / lung cancer	Tyr183Cys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β183	Y183F	Q9CWF2	https://www.uniprot.org/uniprotkb/Q9CWF2/entry	M. musculus	Tubb2b, viable heterozygote	Tyr183Phe	Mutagenetix	https://mutagenetix.utsouthwestern.edu/incidental/incidental_rec.cfm?mid=227163	Mus musculus, mouse, tubulin beta-2B	Wang et al. 2015. PNAS 112:E440-449 (PMID 25605905)
		β183	Y183H	Q9BUF5	https://www.uniprot.org/uniprotkb/Q9BUF5/entry	H. sapiens	TBB6 SNP, DOID:10534 / stomach cancer	Tyr183His	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BUF5	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β184	L184V	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	Likely pathogenic, with L228V, L156V, L248V, tubulin beta	Leu184Val	ClinVar 392956	https://www.ncbi.nlm.nih.gov/clinvar/variation/392956	Homo sapiens, human, clinical
		β184	N184D	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Female infertility, tubulin beta-8	Asn184Asp	Yang et al. 2021. Clin Genet 99:208-214	https://pubmed.ncbi.nlm.nih.gov/33009822/	Homo sapiens, human, clinical
		β184	N184K	Q13885	https://www.uniprot.org/uniprotkb/Q13885/entry	H. sapiens	TBB2A SNP, DOID:3571 / liver cancer	Gln184Lys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13885	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β184	N184K	Q9BVA1	https://www.uniprot.org/uniprotkb/Q9BVA1/entry	H. sapiens	TBB2B SNP, DOID:1324 / lung cancer	Asn184Lys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BVA1	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β184	N184S	Q9BVA1	https://www.uniprot.org/uniprotkb/Q9BVA1/entry	H. sapiens	TBB2B SNP, DOID:3571 / liver cancer	Asn184Ser	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BVA1	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β184	N184Y	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Uncertain significance, with N256Y, tubulin beta-3	Asn184Tyr	ClinVar 423464	https://www.ncbi.nlm.nih.gov/clinvar/variation/423464	Homo sapiens, human, clinical
		β185	A185P	Q18817	https://www.uniprot.org/uniprotkb/Q18817/entry	C. elegans	Benzimidazole resistant, 2 strains (ben-1, tbb-5)	Ala185Pro	Hahnel et al. 2018. PLoS Pathog 14:e1007226	https://pubmed.ncbi.nlm.nih.gov/30372484/	Caenorhabditis elegans, nematode, roundworm
		β185	A185T	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:1909 / melanoma	Ala185Thr	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β185	A185T	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:9256 / colorectal cancer	Ala185Thr	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β185	A185T	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:2394 / ovarian cancer	Ala185Thr	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β185	A185T	P68371	https://www.uniprot.org/uniprotkb/P68371/entry	H. sapiens	TBB4B SNP, DOID:363 / uterine cancer	Ala185Thr	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P68371	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β185	A185T	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:9256 / colorectal cancer	Ala185Thr	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β185	A185T	Q13885	https://www.uniprot.org/uniprotkb/Q13885/entry	H. sapiens	TBB2A SNP, DOID:9256 / colorectal cancer	Ala185Thr	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13885	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β185	A185T	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:9256 / colorectal cancer	Ala185Thr	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β185	A185T	Q9BVA1	https://www.uniprot.org/uniprotkb/Q9BVA1/entry	H. sapiens	TBB2B SNP, DOID:9256 / colorectal cancer	Ala185Thr	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BVA1	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β185	A185T	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	Paclitaxel resistant, tubulin beta-1	Ala185Thr	Yin et al. 2010. Mol Cancer Ther 9:327-35	https://pubmed.ncbi.nlm.nih.gov/20103599/	Homo sapiens, human, clinical
		β185	A185T	Q13885	https://www.uniprot.org/uniprotkb/Q13885/entry	H. sapiens	Benign, with A100T, tubulin beta-2A	Ala185Thr	ClinVar 218499	https://www.ncbi.nlm.nih.gov/clinvar/variation/218499	Homo sapiens, human, clinical
		β185	A185V	Q9BVA1	https://www.uniprot.org/uniprotkb/Q9BVA1/entry	H. sapiens	TBB2B SNP, DOID:10283 / prostate cancer	Ala185Val	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BVA1	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β185	M185L	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with M257L, M308L, M302L, tubulin beta-4A	Met185Leu	ClinVar 537237	https://www.ncbi.nlm.nih.gov/clinvar/variation/537237	Homo sapiens, human, clinical
		β185	T185A	A0A179HPA9	https://www.uniprot.org/uniprotkb/A0A179HPA9/entry	P. lilacinus	Carbendazim resistant, with S145A, F200Y	Thr185A	Yang et al. 2015. Eur J Plant Pathol 143:57-68	https://link.springer.com/article/10.1007/s10658-015-0665-0	Paecilomyces lilacinus, fungus
		β186	T186M	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:1909 / melanoma	Thr186Met	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β186	T186M	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:9256 / colorectal cancer	Thr186Met	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β186	T186M	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Autosomal dominant hereditaryspastic paraplegia, TUBB4A	Thr186Met	Monteiro et al. 2020. Clin Genet 98:416-417	https://pubmed.ncbi.nlm.nih.gov/32720309/	Homo sapiens, human, clinical
		β187	L187R	P69893	https://www.uniprot.org/uniprotkb/P69893/entry	C. griseus	Revertant of D45Y, CHO cell line, tubulin beta-5	Leu187Arg	Wang et al. 2006. J Biol Chem 281:13628-35	https://pubmed.ncbi.nlm.nih.gov/16554299/	Cricetulus griseus, chinese hamster, rodent
		β188	S188F	Q13885	https://www.uniprot.org/uniprotkb/Q13885/entry	H. sapiens	TBB2A SNP, DOID:363 / uterine cancer	Ser188Phe	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13885	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β188	S188F	P12456	https://www.uniprot.org/uniprotkb/P12456/entry	C. elegans	Loss-of-function, short PLM-PN, mec-7	Ser188Phe	Zheng et al. 2017 Mol Biol Cell 28: 2786-2801	https://pubmed.ncbi.nlm.nih.gov/28835377/	Caenorhabditis elegans, nematode, roundworm	also see Lee et al. 2021. Mol Biol Cell. 15:331-347 (PMID 33378215)
		β188	S188F	P12456	https://www.uniprot.org/uniprotkb/P12456/entry	C. elegans	Mechanosensitive, severe semidominant, mec-7	Ser188Phe	Savage et al. 1994. J Cell Sci 107:2165-75	https://pubmed.ncbi.nlm.nih.gov/7983175/	Caenorhabditis elegans, nematode, roundworm
		β188	S188L	Q9BUF5	https://www.uniprot.org/uniprotkb/Q9BUF5/entry	H. sapiens	TBB6 SNP, DOID:363 / uterine cancer	Ser188Leu	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BUF5	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β188	S188L	Q9BVA1	https://www.uniprot.org/uniprotkb/Q9BVA1/entry	H. sapiens	TBB2B SNP, DOID:9256 / colorectal cancer	Ser188Leu	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BVA1	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β189	I189T	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:0070003 / blastoma	Ile189Thr	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β189	I189V	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Invasive ductal, high grade; taxane treatment, also contains A218T, A275S, Q291R, K297R, R320P, S364A, T386S	Ile189Val	Wang et al. 2017. Protoplasma 254:1163-1173	https://pubmed.ncbi.nlm.nih.gov/27943021/	Homo sapiens, human, clinical	Tubulin beta-3 chain
		β189	I189V	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Invasive ductal, low grade; taxane treatment, also contains T166A, S239C, T315A, A332N, I333V, S335N, V351T	Ile189Val	Wang et al. 2017. Protoplasma 254:1163-1173	https://pubmed.ncbi.nlm.nih.gov/27943021/	Homo sapiens, human, clinical	Tubulin beta-3 chain
		β190	H190R	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:1612 / breast cancer	His190Arg	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β190	H190R	Q922F4	https://www.uniprot.org/uniprotkb/Q922F4/entry	M. musculus	Tubb6, viable heterozygote	His190Arg	Mutagenetix	https://mutagenetix.utsouthwestern.edu/incidental/incidental_rec.cfm?mid=727549	Mus musculus, mouse, tubulin beta-6	Wang et al. 2015. PNAS 112:E440-449 (PMID 25605905)
		β190	H190R	Q922F4	https://www.uniprot.org/uniprotkb/Q922F4/entry	M. musculus	Tubb6, viable heterozygote	His190Arg	Mutagenetix	https://mutagenetix.utsouthwestern.edu/incidental/incidental_rec.cfm?mid=731187	Mus musculus, mouse, tubulin beta-6	Wang et al. 2015. PNAS 112:E440-449 (PMID 25605905)
		β190	H190Y	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Complicated hereditary spastic paraplegia, TUBB4A	His190Tyr	Kancheva et al. 2015. Mov Disord 30:854-8	https://pubmed.ncbi.nlm.nih.gov/25772097/	Homo sapiens, human, clinical
		β190	H190Y	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Congenital-onset spastic paraplegia, TUBB4A	His190Tyr	Nicita et al. 2016. J Neurol Sci 368:145-6	https://pubmed.ncbi.nlm.nih.gov/27538619/	Homo sapiens, human, clinical
		β190	H190Y	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with H241Y, H235Y, H118Y, tubulin beta-4A	His190Tyr	ClinVar 192383	https://www.ncbi.nlm.nih.gov/clinvar/variation/192383	Homo sapiens, human, clinical
		β190	P190P	Q9N2N6	https://www.uniprot.org/uniprotkb/Q9N2N6/entry	E. focardii	Cold stable adaptation (correlation, EFBT4)	Pro190Pro	Chiappori et al. 2012. Proteins 80:1154-60	https://pubmed.ncbi.nlm.nih.gov/22275059/	Euplotes focardii, extremophile, Antarctic ciliate
		β190	R190C	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Fibrosis of extraocular muscles, with R262C, tubulin beta-3	Arg190Cyr	ClinVar 6963	https://www.ncbi.nlm.nih.gov/clinvar/variation/6963	Homo sapiens, human, clinical
		β190	R190H	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Congenital fibrosis of the extraocular muscles, with R262H, tubulin beta-3	Arg190His	ClinVar 219256	https://www.ncbi.nlm.nih.gov/clinvar/variation/219256	Homo sapiens, human, clinical
		β190	R190H	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with R262H, R313H, R307H, tubulin beta-4A	Arg190His	ClinVar 265314	https://www.ncbi.nlm.nih.gov/clinvar/variation/265314	Homo sapiens, human, clinical
		β191	Q191H	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:0070003 / blastoma	Gln191His	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β193	V193A	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	TUBB SNP, DOID:1324 / lung cancer	Val193Ala	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P07437	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β193	V193E	Q9BUF5	https://www.uniprot.org/uniprotkb/Q9BUF5/entry	H. sapiens	TBB6 SNP, DOID:0070003 / blastoma	Val193Glu	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BUF5	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β193	V193E	Q9BUF5	https://www.uniprot.org/uniprotkb/Q9BUF5/entry	H. sapiens	TBB6 SNP, DOID:3571 / liver cancer	Val193Glu	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BUF5	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β193	V193L	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:1324 / lung cancer	Val193Leu	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β193	V193M	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:363 / uterine cancer	Val193Met	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β194	E194A	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Benomyl resistant, with H195A, E198A, TUB2p	Glu194Ala	Reijo et al. 1994. Mol Biol Cell 5:29-43	https://pubmed.ncbi.nlm.nih.gov/8186463/	Saccharomyces cerevisiae, budding yeast, fungus
		β194	E194A	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Benomyl resistant, with D197A, TUB2p	Glu194Ala	Reijo et al. 1994. Mol Biol Cell 5:29-43	https://pubmed.ncbi.nlm.nih.gov/8186463/	Saccharomyces cerevisiae, budding yeast, fungus
		β194	E194D	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	TUBB SNP, DOID:9256 / colorectal cancer	Glu194Asp	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P07437	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β194	E194K	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:1909 / melanoma	Glu194Lys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β194	E194K	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Infertility due to arrest in oocyte maturation, with M415I, tubulin beta-8	Glu194Lys	Chen et al. 2017. Hum Reprod 32:457-464.	https://pubmed.ncbi.nlm.nih.gov/27989988/	Homo sapiens, human, clinical
		β194	E194K	P61857	https://www.uniprot.org/uniprotkb/P61857/entry	D. melanogaster	B2t mutation, testes specific tubulin	Glu194Lys	Fackenthal et al. 1995. Genetics 139:267-86	https://pubmed.ncbi.nlm.nih.gov/7705629/	Drosophila, fruitfly
		β194	E194K	Q13885	https://www.uniprot.org/uniprotkb/Q13885/entry	H. sapiens	Pathogenic, with E109K, tubulin beta-2A	Glu194Lys	ClinVar 449113	https://www.ncbi.nlm.nih.gov/clinvar/variation/449113	Homo sapiens, human, clinical
		β194	E194Q	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	TUBB SNP, DOID:11054 / urinary bladder cancer	Glu194Gln	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P07437	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β194	E194Q	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	TUBB SNP, DOID:4362 / cervical cancer	Glu194Gln	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P07437	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β195	H195A	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Benomyl resistant, with E194A, E198A, TUB2p	His195Ala	Reijo et al. 1994. Mol Biol Cell 5:29-43	https://pubmed.ncbi.nlm.nih.gov/8186463/	Saccharomyces cerevisiae, budding yeast, fungus
		β195	N195D	Q9CWF2	https://www.uniprot.org/uniprotkb/Q9CWF2/entry	M. musculus	Tubb2b, viable heterozygote	Asn195Asp	Mutagenetix	https://mutagenetix.utsouthwestern.edu/incidental/incidental_rec.cfm?mid=248777	Mus musculus, mouse, tubulin beta-2B	Wang et al. 2015. PNAS 112:E440-449 (PMID 25605905)
		β195	N195S	A2AQ07	https://www.uniprot.org/uniprotkb/A2AQ07/entry	M. musculus	Tubb1, viable heterozygote	Asn195Ser	Mutagenetix	https://mutagenetix.utsouthwestern.edu/incidental/incidental_rec.cfm?mid=250023	Mus musculus, mouse, tubulin beta-1	Wang et al. 2015. PNAS 112:E440-449 (PMID 25605905)
		β196	A196S	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:3963 / thyroid carcinoma	Ala196Ser	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β196	A196T	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:3963 / thyroid carcinoma	Ala196Thr	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β196	A196V	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:3070 / malignant glioma	Ala196Val	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β196	T196A	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Possible agenesis of the corpus callosum, tubulin beta-3, error?	Thr196Ala	Brar et al. 2022. Prenatal Diagnosis 42:1686–1693	https://pubmed.ncbi.nlm.nih.gov/36403095/	Homo sapiens, human, clinical	Annotation may be wrong 586G>A
		β197	D197A	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Benomyl resistant, with E194A, TUB2p	Asp197Ala	Reijo et al. 1994. Mol Biol Cell 5:29-43	https://pubmed.ncbi.nlm.nih.gov/8186463/	Saccharomyces cerevisiae, budding yeast, fungus
		β197	D197G	Q9ERD7	https://www.uniprot.org/uniprotkb/Q9ERD7/entry	M. musculus	Tubb3, viable heterozygote	Asp197Gly	Mutagenetix	https://mutagenetix.utsouthwestern.edu/incidental/incidental_rec.cfm?mid=344518	Mus musculus, mouse, tubulin beta-3	Wang et al. 2015. PNAS 112:E440-449 (PMID 25605905)
		β197	D197H	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:1324 / lung cancer	Asp197His	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β197	D197N	P32882	https://www.uniprot.org/uniprotkb/P32882/entry	G. gallus	GTP binding site mutation, in vitro synthesis in reticulocyte lysates	Asp197Asn	Farr & Sternlicht. 1992. J Mol Biol 227:307-21	https://pubmed.ncbi.nlm.nih.gov/1522595/	Gallus gallus, red junglefowl, chicken, bird
		β197	D197N	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	Indanocine & 2-Methoxyestradiol resistant, MDA-MB-435 line, tubulin beta	Asp197Asn	Gökmen-Polar et al. 2005. Cancer Res 65:9406-14	https://pubmed.ncbi.nlm.nih.gov/16230404/	Homo sapiens, human, clinical
		β197	D197N	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	2-Methoxyestradiol resistant, tubulin beta	Asp197Asn	Liaw et al. 2008. Mol Cancer Ther 7:3150-9	https://pubmed.ncbi.nlm.nih.gov/18852118/	Homo sapiens, human, clinical
		β198	A198S	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:11934 / head and neck cancer	Ala198Ser	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β198	E198A	P53373	https://www.uniprot.org/uniprotkb/P53373/entry	B. cinerea	Resistant to procymidone & zoxamide, correlation, beta-tubulin	Glu198Ala	Adnan et al. 2019. Phytopathol Res 1:17	https://phytopatholres.biomedcentral.com/articles/10.1186/s42483-019-0024-8	Botrytis cinerea, fungus, plant pathogen
		β198	E198A	Q7Z7U2	https://www.uniprot.org/uniprotkb/Q7Z7U2/entry	M. fructicola	Benomyl resistant	Glu198Ala	Ma et al. 2003. Appl Environ Microbiol 69:7145-52	https://pubmed.ncbi.nlm.nih.gov/14660360/	Monilinia fructicola, fungus
		β198	E198A	A2TF56	https://www.uniprot.org/uniprotkb/A2TF56/entry	H. contortus	Thiabendazole and albendazole resistant	Glu198Ala	Ghisi et al. 2007. Vet Parasitol 144:313-20.	https://pubmed.ncbi.nlm.nih.gov/17101226/	Haemonchus contortus (Barber pole worm), parasite
		β198	E198A	Q7Z9J7	https://www.uniprot.org/uniprotkb/Q7Z9J7/entry	F. asiaticum	Benzimidazole resistant	Glu198Ala	Yang et al. 2018. Pest Biochem Physiol 145:15-21	https://pubmed.ncbi.nlm.nih.gov/29482727/	Gibberella zeae, Fusarium graminearum, fungus
		β198	E198A	Q18817	https://www.uniprot.org/uniprotkb/Q18817/entry	C. elegans	Benzimidazole resistant (ben-1, tbb-5)	Glu198Ala	Hahnel et al. 2018. PLoS Pathog 14:e1007226	https://pubmed.ncbi.nlm.nih.gov/30372484/	Caenorhabditis elegans, nematode, roundworm
		β198	E198A	W5S7W6	https://www.uniprot.org/uniprotkb/W5S7W6/entry	C. homoeocarpa	Thiophanate-methyl resistant, beta-tubulin	Glu198Ala	Hu et al. 2018. Pestic Biochem Physiol 152:84-89	https://pubmed.ncbi.nlm.nih.gov/30497716/	Clarireedia , AKA Sclerotinia homeocarpa, fungus, plant pathogen
		β198	E198A	P53373	https://www.uniprot.org/uniprotkb/P53373/entry	B. cinerera	Zoxamide resistant, correlation, beta-tubulin	Glu198Ala	Adnan et al. 2018. Plant Disease 102:1299-1306	https://pubmed.ncbi.nlm.nih.gov/30673571/	Botrytis cinerea, fungus, plant pathogen
		β198	E198A	A0A411NQ56	https://www.uniprot.org/uniprotkb/A0A411NQ56/entry	C. cassiicola	Benzimidazole resistant	Glu198Ala	Duan et al. 2019. Pestic Biochem Physiol 153:95-105	https://pubmed.ncbi.nlm.nih.gov/30744902/	Corynespora, fungus, plant pathogen
		β198	E198A	A0A411NQ56	https://www.uniprot.org/uniprotkb/A0A411NQ56/entry	C. cassiicola	Benzimidazole resistant, with M163I	Glu198Ala	Duan et al. 2019. Pestic Biochem Physiol 153:95-105	https://pubmed.ncbi.nlm.nih.gov/30744902/	Corynespora, fungus, plant pathogen
		β198	E198A	A0A411NQ56	https://www.uniprot.org/uniprotkb/A0A411NQ56/entry	C. cassiicola	Benzimidazole resistant, with F167Y	Glu198Ala	Duan et al. 2019. Pestic Biochem Physiol 153:95-105	https://pubmed.ncbi.nlm.nih.gov/30744902/	Corynespora, fungus, plant pathogen
		β198	E198A	A0A411NQ56	https://www.uniprot.org/uniprotkb/A0A411NQ56/entry	C. cassiicola	Benzimidazole resistant, with F200S	Glu198Ala	Duan et al. 2019. Pestic Biochem Physiol 153:95-105	https://pubmed.ncbi.nlm.nih.gov/30744902/	Corynespora, fungus, plant pathogen
		β198	E198A	A0A2P1E6I7	https://www.uniprot.org/uniprotkb/A0A2P1E6I7/entry	B. theobromae	Carbendazim resistant, tubulin beta	Glu198A	Yang et al. 2019. Plant Dis 103:2076-2082	https://pubmed.ncbi.nlm.nih.gov/31194616/	Lasiodiplodia theobromae aka Botryodiplodia
		β198	E198A	A0A2S1FHI6	https://www.uniprot.org/uniprotkb/A0A2S1FHI6/entry	C. siamense	Thiophanate-methyl resistant, beta-tubulin	Glu198Ala	Chechi et al. 2019. Pest Biochem Physiol 158:18-24	https://pubmed.ncbi.nlm.nih.gov/31378355/	Colletotrichum gloeosporioides, collectotrichum siamense, fungus
		β198	E198A	F9X1J1	https://www.uniprot.org/uniprotkb/F9X1J1/entry	Z. tritici	Carbendazim resistant, beta tubulin, beta tubulin	Glu198Ala	Matsuzaki et al. 2020. Pest Manag Sci 76:1393-1401	https://pubmed.ncbi.nlm.nih.gov/31622533/	Zymoseptoria, fungus, plant pathogen, septoria leaf blotch	Numbering may need to be adjusted
		β198	E198A	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Benomyl resistant, with E194A, H195A, TUB2p	Glu198Ala	Reijo et al. 1994. Mol Biol Cell 5:29-43	https://pubmed.ncbi.nlm.nih.gov/8186463/	Saccharomyces cerevisiae, budding yeast, fungus
		β198	E198A	A0A411NQ78	https://www.uniprot.org/uniprotkb/A0A411NQ78/entry	C. cassiicola	High resistance to carbendazim, benomyl	Glu198Ala	Mao et al. 2022. J Agric Food Chem 70:15046-56	https://pubs.acs.org/doi/10.1021/acs.jafc.2c05912	Corynespora, fungus, plant pathogen
		β198	E198A	A0A411NQ78	https://www.uniprot.org/uniprotkb/A0A411NQ78/entry	C. cassiicola	High resistance to carbendazim, benomyl, M163I	Glu198Ala	Mao et al. 2022. J Agric Food Chem 70:15046-56	https://pubs.acs.org/doi/10.1021/acs.jafc.2c05912	Corynespora, fungus, plant pathogen
		β198	E198A	A0A411NQ78	https://www.uniprot.org/uniprotkb/A0A411NQ78/entry	C. cassiicola	High resistance to carbendazim, benomyl,with F167Y	Glu198Ala	Mao et al. 2022. J Agric Food Chem 70:15046-56	https://pubs.acs.org/doi/10.1021/acs.jafc.2c05912	Corynespora, fungus, plant pathogen
		β198	E198A	A0A411NQ78	https://www.uniprot.org/uniprotkb/A0A411NQ78/entry	C. cassiicola	High resistance to carbendazim, benomyl, with F200S	Glu198Ala	Mao et al. 2022. J Agric Food Chem 70:15046-56	https://pubs.acs.org/doi/10.1021/acs.jafc.2c05912	Corynespora, fungus, plant pathogen
		β198	E198A	P53373	https://www.uniprot.org/uniprotkb/P53373/entry	B. cinerea	Benomyl resistant, benA	Glu198Ala	Yarden. 1993. Phyotopathology 83	https://scholar.google.com/scholar_lookup?journal=Phytopathology&title=Mutations+leading+to+substitutions+at+amino+acids+198+&+200+of+beta-tubulin+that+correlate+with+benomyl-resistance+phenotypes+of+field+strains+of+Botrytis+cinerea&author=O.+Yarden&author=T.+Katan&volume=83&publication_year=1993&pages=1478-1483&	Botrytis cinerea, fungus, plant pathogen
		β198	E198D	P10653	https://www.uniprot.org/uniprotkb/P10653/entry	A. nidulans	Benomyl resistant, tubulin beta-1	Glu198Asp	Jung et al. 1992. Cell Motil Cytoskeleton 22:170-4	https://pubmed.ncbi.nlm.nih.gov/1423663/	Aspergillus nidulans, fungus
		β198	E198D	F9X1J1	https://www.uniprot.org/uniprotkb/F9X1J1/entry	Z. tritici	Carbendazim resistant, beta tubulin, beta tubulin	Glu198Asp	Matsuzaki et al. 2020. Pest Manag Sci 76:1393-1401	https://pubmed.ncbi.nlm.nih.gov/31622533/	Zymoseptoria, fungus, plant pathogen, septoria leaf blotch	Numbering may need to be adjusted
		β198	E198D	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Female infertility, tubulin beta-8	Glu198Asp	Yang et al. 2021. Clin Genet 99:208-214	https://pubmed.ncbi.nlm.nih.gov/33009822/	Homo sapiens, human, clinical
		β198	E198G	P05220	https://www.uniprot.org/uniprotkb/P05220/entry	N. crassa	Carbendazim resistant, diethofencarb supersensitive	Glu198Gly	Fujimura et al. 1992. Curr Genet 21:399-404	https://pubmed.ncbi.nlm.nih.gov/1388107/	Neurospora crassa, fungus, red bread mold
		β198	E198G	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	Taxol resistant, tubulin beta	Glu198Gly	Wiesen et al. 2007. Cancer Lett 257:227-35	https://pubmed.ncbi.nlm.nih.gov/17869412/	Homo sapiens, human, clinical
		β198	E198G	F9X1J1	https://www.uniprot.org/uniprotkb/F9X1J1/entry	Z. tritici	Carbendazim resistant, beta tubulin, beta tubulin	Glu198Gly	Matsuzaki et al. 2020. Pest Manag Sci 76:1393-1401	https://pubmed.ncbi.nlm.nih.gov/31622533/	Zymoseptoria, fungus, plant pathogen, septoria leaf blotch	Numbering may need to be adjusted
		β198	E198I	A2TF56	https://www.uniprot.org/uniprotkb/A2TF56/entry	H. contortus	Albendazole resistant variant, tubulin beta-1	Glu198Ile	Mohammedsalih et al. 2020. Parasit Vectors 13:114	https://pubmed.ncbi.nlm.nih.gov/32122383/	Haemonchus contortus (Barber pole worm), parasite
		β198	E198I	Q18817	https://www.uniprot.org/uniprotkb/Q18817/entry	C. elegans	Benzimidazole resistant, correlation (ben-1, tbb-5)	Glu198Ile	Dilks et al. 2020. Int J Parasitol Drugs Drug Resist 14:28-36	https://pubmed.ncbi.nlm.nih.gov/32858477/	Caenorhabditis elegans, nematode, roundworm
		β198	E198K	Q9BUF5	https://www.uniprot.org/uniprotkb/Q9BUF5/entry	H. sapiens	TBB6 SNP, DOID:363 / uterine cancer	Glu198Lys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BUF5	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β198	E198K	Q9BUF5	https://www.uniprot.org/uniprotkb/Q9BUF5/entry	H. sapiens	TBB6 SNP, DOID:11054 / urinary bladder cancer	Glu198Lys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BUF5	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β198	E198K	P53373	https://www.uniprot.org/uniprotkb/P53373/entry	B. cinerea	Resistant to procymidone & zoxamide, with T351I, correlation, beta-tubulin	Glu198Lys	Adnan et al. 2019. Phytopathol Res 1:17	https://phytopatholres.biomedcentral.com/articles/10.1186/s42483-019-0024-8	Botrytis cinerea, fungus, plant pathogen
		β198	E198K	P52275	https://www.uniprot.org/uniprotkb/P52275/entry	C. elegans	Disrupted spindle orientation, benomyl resistance, tbb-2	Glu198Lys	Wright & Hunter. 2003. Mol Biol Cell 14:4512-25	https://pubmed.ncbi.nlm.nih.gov/12937270/	Caenorhabditis elegans, nematode, roundworm
		β198	E198K	P10653	https://www.uniprot.org/uniprotkb/P10653/entry	A. nidulans	Benomyl resistant, tubulin beta-1	Glu198Lys	Jung et al. 1992. Cell Motil Cytoskeleton 22:170-4	https://pubmed.ncbi.nlm.nih.gov/1423663/	Aspergillus nidulans, fungus
		β198	E198K	Q7Z9J7	https://www.uniprot.org/uniprotkb/Q7Z9J7/entry	G. zeae	Carbendazim resistant, β2-tubulin (no accession number)	Glu198Lys	Qiu et al. 2011. Pest Man Sci 67:191-8	https://pubmed.ncbi.nlm.nih.gov/21077124/	Gibberella zeae, Fusarium graminearum, fungus
		β198	E198K	W5S7W6	https://www.uniprot.org/uniprotkb/W5S7W6/entry	C. homoeocarpa	Thiophanate-methyl resistant, beta-tubulin	Glu198Lys	Hu et al. 2018. Pestic Biochem Physiol 152:84-89	https://pubmed.ncbi.nlm.nih.gov/30497716/	Fungus, plant pathogen
		β198	E198K	P53373	https://www.uniprot.org/uniprotkb/P53373/entry	B. cinerera	Zoxamide resistant, correlation, beta-tubulin, with T351I	Glu198Lys	Adnan et al. 2018. Plant Disease 102:1299-1306	https://pubmed.ncbi.nlm.nih.gov/30673571/	Botrytis cinerea, fungus, plant pathogen
		β198	E198K	A2TF56	https://www.uniprot.org/uniprotkb/A2TF56/entry	H. contortus	Albendazole resistant variant, tubulin beta-1	Glu198Lys	Mohammedsalih et al. 2020. Parasit Vectors 13:114	https://pubmed.ncbi.nlm.nih.gov/32122383/	Haemonchus contortus (Barber pole worm), parasite
		β198	E198K	Q18817	https://www.uniprot.org/uniprotkb/Q18817/entry	C. elegans	Benzimidazole resistant, correlation (ben-1, tbb-5)	Glu198Lys	Dilks et al. 2020. Int J Parasitol Drugs Drug Resist 14:28-36	https://pubmed.ncbi.nlm.nih.gov/32858477/	Caenorhabditis elegans, nematode, roundworm
		β198	E198K	P04690	https://www.uniprot.org/uniprotkb/P04690/entry	C. reinhardtii	Propyzamide resistant, tub1	Glu198Lys	Kato-Minoura et al. 2020. PLoS One 15(11):e0242694	https://pubmed.ncbi.nlm.nih.gov/33227038/	Chlamydomonas reinhardtii, green alga
		β198	E198K	P04690	https://www.uniprot.org/uniprotkb/P04690/entry	C. reinhardtii	Propyzamide resistant, tub2	Glu198Lys	Kato-Minoura et al. 2020. PLoS One 15(11):e0242694	https://pubmed.ncbi.nlm.nih.gov/33227038/	Chlamydomonas reinhardtii, green alga
		β198	E198K	Q18817	https://www.uniprot.org/uniprotkb/Q18817/entry	C. elegans	Albendazole resistance, ben-1	Glu198Lys	Pallotto et al. 2022. Genetics 221:iyac093	https://pubmed.ncbi.nlm.nih.gov/35731216/	Caenorhabditis elegans, nematode, roundworm
		β198	E198K	P40904	https://www.uniprot.org/uniprotkb/P40904/entry	C. gloeosporioides	Benomyl resistant, correlation, TUB2	Glu198Lys	Buhr et al. 1994. Appl Environ Microbiol 60:4155-9	https://pubmed.ncbi.nlm.nih.gov/7993097/	Colletotrichum gloeosporioides, anthracnose, fungus
		β198	E198K	P53373	https://www.uniprot.org/uniprotkb/P53373/entry	B. cinerea	Benomyl resistant, benA	Glu198Lys	Yarden. 1993. Phyotopathology 83	https://scholar.google.com/scholar_lookup?journal=Phytopathology&title=Mutations+leading+to+substitutions+at+amino+acids+198+&+200+of+beta-tubulin+that+correlate+with+benomyl-resistance+phenotypes+of+field+strains+of+Botrytis+cinerea&author=O.+Yarden&author=T.+Katan&volume=83&publication_year=1993&pages=1478-1483&	Botrytis cinerea, fungus, plant pathogen
		β198	E198L	Q4HZS8	https://www.uniprot.org/uniprotkb/Q4HZS8/entry	G. zeae	Benzimidazole resistant, with Q73R, tub2	Glu198Leu	Chen et al. 2009. Phytopathology 99:1403-11	https://pubmed.ncbi.nlm.nih.gov/19900007/	Gibberella zeae, Fusarium graminearum, fungus
		β198	E198L	A2TF56	https://www.uniprot.org/uniprotkb/A2TF56/entry	H. contortus	Albendazole resistant variant, tubulin beta-1	Glu198Leu	Mohammedsalih et al. 2020. Parasit Vectors 13:114	https://pubmed.ncbi.nlm.nih.gov/32122383/	Haemonchus contortus (Barber pole worm), parasite
		β198	E198L	Q18817	https://www.uniprot.org/uniprotkb/Q18817/entry	C. elegans	Benzimidazole resistant, correlation (ben-1, tbb-5)	Glu198Leu	Dilks et al. 2020. Int J Parasitol Drugs Drug Resist 14:28-36	https://pubmed.ncbi.nlm.nih.gov/32858477/	Caenorhabditis elegans, nematode, roundworm
		β198	E198Q	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	TUBB SNP, DOID:11934 / head and neck cancer	Glu198Gln	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P07437	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β198	E198Q	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	TUBB SNP, DOID:5041 / esophageal cancer	Glu198Gln	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P07437	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β198	E198Q	P10653	https://www.uniprot.org/uniprotkb/P10653/entry	A. nidulans	Benomyl resistant, tubulin beta-1	Glu198Gln	Jung et al. 1992. Cell Motil Cytoskeleton 22:170-4	https://pubmed.ncbi.nlm.nih.gov/1423663/	Aspergillus nidulans, fungus
		β198	E198Q	Q7Z9J7	https://www.uniprot.org/uniprotkb/Q7Z9J7/entry	G. zeae	Carbendazim resistant, β2-tubulin (no accession number)	Glu198Gln	Qiu et al. 2011. Pest Man Sci 67:191-8	https://pubmed.ncbi.nlm.nih.gov/21077124/	Gibberella zeae, Fusarium graminearum, fungus
		β198	E198V	A2TF56	https://www.uniprot.org/uniprotkb/A2TF56/entry	H. contortus	Albendazole resistant variant, tubulin beta-1	Glu198Val	Mohammedsalih et al. 2020. Parasit Vectors 13:114	https://pubmed.ncbi.nlm.nih.gov/32122383/	Haemonchus contortus (Barber pole worm), parasite
		β198	E198V	Q18817	https://www.uniprot.org/uniprotkb/Q18817/entry	C. elegans	Benzimidazole resistant, correlation (ben-1, tbb-5)	Glu198Val	Dilks et al. 2020. Int J Parasitol Drugs Drug Resist 14:28-36	https://pubmed.ncbi.nlm.nih.gov/32858477/	Caenorhabditis elegans, nematode, roundworm
		β198	E198V	P53373	https://www.uniprot.org/uniprotkb/P53373/entry	B. cinerea	Benomyl resistant, benA	Glu198Val	Yarden. 1993. Phyotopathology 83	https://scholar.google.com/scholar_lookup?journal=Phytopathology&title=Mutations+leading+to+substitutions+at+amino+acids+198+&+200+of+beta-tubulin+that+correlate+with+benomyl-resistance+phenotypes+of+field+strains+of+Botrytis+cinerea&author=O.+Yarden&author=T.+Katan&volume=83&publication_year=1993&pages=1478-1483&	Botrytis cinerea, fungus, plant pathogen
		β198	E198X	A2TF56	https://www.uniprot.org/uniprotkb/A2TF56/entry	H. contortus	Albendazole resistant variant, tubulin beta-1	Glu198X	Mohammedsalih et al. 2020. Parasit Vectors 13:114	https://pubmed.ncbi.nlm.nih.gov/32122383/	Haemonchus contortus (Barber pole worm), parasite
		β198	E198X	Q18817	https://www.uniprot.org/uniprotkb/Q18817/entry	C. elegans	Benzimidazole resistant, correlation (ben-1, tbb-5)	Glu198X	Dilks et al. 2020. Int J Parasitol Drugs Drug Resist 14:28-36	https://pubmed.ncbi.nlm.nih.gov/32858477/	Caenorhabditis elegans, nematode, roundworm
		β198	T198S	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	Likely pathogenic, with T178S, T106S, T134S, tubulin beta	Thr198Ser	ClinVar 376764	https://www.ncbi.nlm.nih.gov/clinvar/variation/376764	Homo sapiens, human, clinical
		β199	A199T	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Torsion dystonia, with A271T, A322T, A316T, tubulin beta-4A	Ala199Thr	ClinVar 92111	https://www.ncbi.nlm.nih.gov/clinvar/variation/92111	Homo sapiens, human, clinical
		B199	E199K	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	Cortical dysplasia, brain malformations, with E401K, E357K, E329K, E421K, tubulin beta	Glu199Lys	ClinVar 127191	https://www.ncbi.nlm.nih.gov/clinvar/variation/127191	Homo sapiens, human, clinical
		β200	E200K	P53373	https://www.uniprot.org/uniprotkb/P53373/entry	B. cinerea	Benomyl resistant, benA	Glu200Lys	Yarden. 1993. Phyotopathology 83	https://scholar.google.com/scholar_lookup?journal=Phytopathology&title=Mutations+leading+to+substitutions+at+amino+acids+198+&+200+of+beta-tubulin+that+correlate+with+benomyl-resistance+phenotypes+of+field+strains+of+Botrytis+cinerea&author=O.+Yarden&author=T.+Katan&volume=83&publication_year=1993&pages=1478-1483&	Botrytis cinerea, fungus, plant pathogen
		β200	F202F	P36221	https://www.uniprot.org/uniprotkb/P36221/entry	N. coriiceps	Cold stable adaptation (correlation, NcTbB1, L08013)	Phe202Phe	Detrich et al. 2000. J Biol Chem 275:37038-47	https://pubmed.ncbi.nlm.nih.gov/10956651/	Notothenia coriiceps, extremophile, icefish
		β200	F202F	Q78C12	https://www.uniprot.org/uniprotkb/Q78C12/entry	N. coriiceps	Cold stable adaptation (correlation, NcTbB2, AF255553)	Phe202Phe	Detrich et al. 2000. J Biol Chem 275:37038-47	https://pubmed.ncbi.nlm.nih.gov/10956651/	Notothenia coriiceps, extremophile, icefish
		β200	F202F	Q9DFT5	https://www.uniprot.org/uniprotkb/Q9DFT5/entry	N. coriiceps	Cold stable adaptation (correlation, NcTbB4, AF255555)	Phe202Phe	Detrich et al. 2000. J Biol Chem 275:37038-47	https://pubmed.ncbi.nlm.nih.gov/10956651/	Notothenia coriiceps, extremophile, icefish
		β200	F202F	Q9DFT6	https://www.uniprot.org/uniprotkb/Q9DFT6/entry	N. coriiceps	Cold stable adaptation (correlation, NcTbB3, AF255554)	Phe202Phe	Detrich et al. 2000. J Biol Chem 275:37038-47	https://pubmed.ncbi.nlm.nih.gov/10956651/	Notothenia coriiceps, extremophile, icefish
		β200	F200L	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Female infertility, tubulin beta-8	Phe200Leu	Chen et al. 2019. Eur J Hum Genet 27:300-307	https://pubmed.ncbi.nlm.nih.gov/30297906/	Homo sapiens, human, clinical
		β200	F200L	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Female infertility, uncertain significance, tubulin beta-8	Phe200Leu	ClinVar 522599	https://www.ncbi.nlm.nih.gov/clinvar/variation/522599	Homo sapiens, human, clinical
		β200	F200S	A0A411NQ56	https://www.uniprot.org/uniprotkb/A0A411NQ56/entry	C. cassiicola	Benzimidazole resistant, with E198A	Phe200Ser	Duan et al. 2019. Pestic Biochem Physiol 153:95-105	https://pubmed.ncbi.nlm.nih.gov/30744902/	Corynespora, fungus, plant pathogen
		β200	F200S	A0A411NQ78	https://www.uniprot.org/uniprotkb/A0A411NQ78/entry	C. cassiicola	High resistance to carbendazim, benomyl, with E198A	Phe200Ser	Mao et al. 2022. J Agric Food Chem 70:15046-56	https://pubs.acs.org/doi/10.1021/acs.jafc.2c05912	Corynespora, fungus, plant pathogen
		β200	F200S	A0A411NQ78	https://www.uniprot.org/uniprotkb/A0A411NQ78/entry	C. cassiicola	Moderate resistance to carbendazim, benomyl	Phe200Ser	Mao et al. 2022. J Agric Food Chem 70:15046-56	https://pubs.acs.org/doi/10.1021/acs.jafc.2c05912	Corynespora, fungus, plant pathogen
		β200	F200Y	A0A179HPA9	https://www.uniprot.org/uniprotkb/A0A179HPA9/entry	P. lilacinus	Carbendazim resistant, with S145A, T185A	Phe200Tyr	Yang et al. 2015. Eur J Plant Pathol 143:57-68	https://link.springer.com/article/10.1007/s10658-015-0665-0	Paecilomyces lilacinus, fungus
		β200	F200Y	Q26901	https://www.uniprot.org/uniprotkb/Q26901/entry	T. circumcincta	Benomyl resistant, isotype accession not specified	Phe200Tyr	Elard et al. 1999. Parasitol Res 85:452-6	https://pubmed.ncbi.nlm.nih.gov/10344538/	Teladorsagia circumcincta, nematode
		β200	F200Y	P10653	https://www.uniprot.org/uniprotkb/P10653/entry	A. nidulans	Benomyl resistant, tubulin beta-1	Phe200Tyr	Jung et al. 1992. Cell Motil Cytoskeleton 22:170-4	https://pubmed.ncbi.nlm.nih.gov/1423663/	Aspergillus nidulans, fungus
		β200	F200Y	P05219	https://www.uniprot.org/uniprotkb/P05219/entry	S. pombe	Increased microtubule stability, delayed mitotic exit, nda-3 beta tubulin	Phe200Tyr	Paluh et al. 2004. Mol Biol Chem 15:1160-71	https://pubmed.ncbi.nlm.nih.gov/14657251/	Schizosaccharomyces pombe, fission yeast, fungus
		β200	F200Y	A2TF56	https://www.uniprot.org/uniprotkb/A2TF56/entry	H. contortus	Thiabendazole and albendazole resistant	Phe200Tyr	Ghisi et al. 2007. Vet Parasitol 144:313-20.	https://pubmed.ncbi.nlm.nih.gov/17101226/	Haemonchus contortus (Barber pole worm), parasite
		β200	F200Y	Q4HZS8	https://www.uniprot.org/uniprotkb/Q4HZS8/entry	G. zeae	Benzimidazole resistant	Phe200Tyr	Chen et al. 2009. Phytopathology 99:1403-11	https://pubmed.ncbi.nlm.nih.gov/19900007/	Gibberella zeae, Fusarium graminearum, fungus
		β200	F200Y	Q2QJK8	https://www.uniprot.org/uniprotkb/Q2QJK8/entry	A. caninum	Benzimidazole resistant, beta tubulin-1	Phe200Tyr	Furtado et al. 2014. Vet Parasitol 206:313-6	https://pubmed.ncbi.nlm.nih.gov/25468029/	Ancylostoma caninum, nematode, hookworm
		β200	F200Y	Unavailable		N. battus	Benzimidazole resistant	Phe200Tyr	Morrison et al. 2014. Vet Res 45:116	https://pubmed.ncbi.nlm.nih.gov/25487605/	Nematodirosis battus, roundworm
		β200	F200Y	P05220	https://www.uniprot.org/uniprotkb/P05220/entry	N. crassa	Benomyl resistant, beta tubulin	Phe200Tyr	Orbach et al. 1986. Mol Cell Biol 6:2452-61	https://pubmed.ncbi.nlm.nih.gov/2946938/	Neurospora crassa, fungus, red bread mold
		β200	F200Y	Q18817	https://www.uniprot.org/uniprotkb/Q18817/entry	C. elegans	Benzimidazole resistant, 6 strains (ben-1, tbb-5)	Phe200Tyr	Hahnel et al. 2018. PLoS Pathog 14:e1007226	https://pubmed.ncbi.nlm.nih.gov/30372484/	Caenorhabditis elegans, nematode, roundworm
		β200	F200Y	W5S7W6	https://www.uniprot.org/uniprotkb/W5S7W6/entry	C. homoeocarpa	Thiophanate-methyl resistant, beta-tubulin	Phe200Tyr	Hu et al. 2018. Pestic Biochem Physiol 152:84-89	https://pubmed.ncbi.nlm.nih.gov/30497716/	Fungus, plant pathogen
		β200	F200Y	A0A2P1E6I7	https://www.uniprot.org/uniprotkb/A0A2P1E6I7/entry	B. theobromae	Carbendazim resistant, tubulin beta	Phe200Tyr	Yang et al. 2019. Plant Dis 103:2076-2082	https://pubmed.ncbi.nlm.nih.gov/31194616/	Lasiodiplodia theobromae aka Botryodiplodia
		β200	F200Y	Q25024	https://www.uniprot.org/uniprotkb/Q25024/entry	H. contortus	Benzimidazole resistant (association), isotype not specified	Phe200Tyr	Kwa et al. 1994. Mol Biochem Parasitol 63:299-303	https://pubmed.ncbi.nlm.nih.gov/7911975/	Haemonchus contortus (Barber pole worm), parasite
		β200	F200Y	F9X1J1	https://www.uniprot.org/uniprotkb/F9X1J1/entry	Z. tritici	Carbendazim resistant, beta tubulin, beta tubulin	Phe200Tyr	Matsuzaki et al. 2020. Pest Manag Sci 76:1393-1401	https://pubmed.ncbi.nlm.nih.gov/31622533/	Zymoseptoria, fungus, plant pathogen, septoria leaf blotch	Numbering may need to be adjusted
		β201	C201A	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Benomyl supersensitive, TUB2p	Cys201Ala	Gupta et al. 2001. Cell Motil Cytoskeleton 49:67-77	https://pubmed.ncbi.nlm.nih.gov/11443737/	Saccharomyces cerevisiae, budding yeast, fungus
		β201	C201R	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:1612 / breast cancer	Cys201Arg	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β201	C201S	Q9BUF5	https://www.uniprot.org/uniprotkb/Q9BUF5/entry	H. sapiens	TBB6 SNP, DOID:1324 / lung cancer	Cys201Ser	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BUF5	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β201	C201S	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Benomyl supersensitive, TUB2p	Cys201Ser	Gupta et al. 2001. Cell Motil Cytoskeleton 49:67-77	https://pubmed.ncbi.nlm.nih.gov/11443737/	Saccharomyces cerevisiae, budding yeast, fungus
		β201	C201S	Q13885	https://www.uniprot.org/uniprotkb/Q13885/entry	H. sapiens	Invasive ductal, low grade; no treatment, also contains E45D, N48S, V64I, V170M, A296S, V316I	Cys201Ser	Wang et al. 2017. Protoplasma 254:1163-1173	https://pubmed.ncbi.nlm.nih.gov/27943021/	Homo sapiens, human, clinical	Tubulin beta-2A chain
		β201	C201W	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:3070 / malignant glioma	Cys201Trp	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β201	R201L	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with R156L, R207L, R84L, tubulin beta-4A	Arg201Leu	ClinVar 135659	https://www.ncbi.nlm.nih.gov/clinvar/variation/135659	Homo sapiens, human, clinical
		β201	S201C	Q13885	https://www.uniprot.org/uniprotkb/Q13885/entry	H. sapiens	TBB2A SNP, DOID:4362 / cervical cancer	Ser201Cys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13885	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β201	S201C	Q13885	https://www.uniprot.org/uniprotkb/Q13885/entry	H. sapiens	TBB2A SNP, DOID:1612 / breast cancer	Ser201Cys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13885	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β201	S201C	Q13885	https://www.uniprot.org/uniprotkb/Q13885/entry	H. sapiens	Cortical dysplasia, other brain malformations, with S116C, tubulin beta-2A	Ser201Cys	ClinVar 372867	https://www.ncbi.nlm.nih.gov/clinvar/variation/372867	Homo sapiens, human, clinical
		β202	F202F	Q9DD57	https://www.uniprot.org/uniprotkb/Q9DD57/entry	C. rastrospinosus	Cold stable adaptation (correlation, CrTbB2, AF255954)	Phe202Phe	Detrich et al. 2000. J Biol Chem 275:37038-47	https://pubmed.ncbi.nlm.nih.gov/10956651/	Chionodraco rastrospinosus, extremophile, icefish
		β202	F202F	Q9DFS7	https://www.uniprot.org/uniprotkb/Q9DFS7/entry	C. rastrospinosus	Cold stable adaptation (correlation, CrTbB5, AF255955)	Phe202Phe	Detrich et al. 2000. J Biol Chem 275:37038-47	https://pubmed.ncbi.nlm.nih.gov/10956651/	Chionodraco rastrospinosus, extremophile, icefish
		β202	I202N	Q9CWF2	https://www.uniprot.org/uniprotkb/Q9CWF2/entry	M. musculus	Tubb2b, viable heterozygote	Ile202Asn	Mutagenetix	https://mutagenetix.utsouthwestern.edu/incidental/incidental_rec.cfm?mid=378125	Mus musculus, mouse, tubulin beta-2B	Wang et al. 2015. PNAS 112:E440-449 (PMID 25605905)
		β202	I202V	Q9BVA1	https://www.uniprot.org/uniprotkb/Q9BVA1/entry	H. sapiens	TBB2B SNP, DOID:363 / uterine cancer	Ile202Val	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BVA1	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β203	D203A	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Cold sensitive, benomyl supersensitive, with E205A, TUB2p	Asp203Ala	Reijo et al. 1994. Mol Biol Cell 5:29-43	https://pubmed.ncbi.nlm.nih.gov/8186463/	Saccharomyces cerevisiae, budding yeast, fungus
		β203	D203G	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Female infertility, tubulin beta-8	Asp203Gly	Zhao et al. 2020. J Assist Reprod Genet 37:1837-47.	https://pubmed.ncbi.nlm.nih.gov/32524331/	Homo sapiens, human, clinical
		β203	D203H	Q13885	https://www.uniprot.org/uniprotkb/Q13885/entry	H. sapiens	TBB2A SNP, DOID:10534 / stomach cancer	Asp203His	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13885	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β203	D203N	Q13885	https://www.uniprot.org/uniprotkb/Q13885/entry	H. sapiens	TBB2A SNP, DOID:11054 / urinary bladder cancer	Asp203Gln	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13885	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β203	D203N	P32882	https://www.uniprot.org/uniprotkb/P32882/entry	G. gallus	GTP binding site mutation, in vitro synthesis in reticulocyte lysates	Asp203Asn	Farr & Sternlicht. 1992. J Mol Biol 227:307-21	https://pubmed.ncbi.nlm.nih.gov/1522595/	Gallus gallus, red junglefowl, chicken, bird
		β203	D203S	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Mutation to the GTP binding site, non-viable as haploid	Asp203Ser	Sage et al. 1995. Biochemistry 34:7409-19	https://pubmed.ncbi.nlm.nih.gov/7779783/	Saccharomyces cerevisiae, budding yeast, fungus
		β203	D203V	P12456	https://www.uniprot.org/uniprotkb/P12456/entry	C. elegans	Loss-of-function, shortened PLM-PN, mec-7	Asp203Val	Lee et al. 2021. Mol Biol Cell. 15:331-347	https://pubmed.ncbi.nlm.nih.gov/33378215/	Caenorhabditis elegans, nematode, roundworm
		β203	D203Y	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:2531 / hematologic cancer	Asp203Tyr	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β204	N204I	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:10534 / stomach cancer	Asn204Ile	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β204	N204K	Q9CWF2	https://www.uniprot.org/uniprotkb/Q9CWF2/entry	M. musculus	Tubb2b, viable heterozygote	Asn204Lys	Mutagenetix	https://mutagenetix.utsouthwestern.edu/incidental/incidental_rec.cfm?mid=448673	Mus musculus, mouse, tubulin beta-2B	Wang et al. 2015. PNAS 112:E440-449 (PMID 25605905)
		β204	N204S	Q9BUF5	https://www.uniprot.org/uniprotkb/Q9BUF5/entry	H. sapiens	TBB6 SNP, DOID:363 / uterine cancer	Asn204Ser	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BUF5	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β205	E205A	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Cold sensitive, benomyl supersensitive, with D203A, TUB2p	Glu205Ala	Reijo et al. 1994. Mol Biol Cell 5:29-43	https://pubmed.ncbi.nlm.nih.gov/8186463/	Saccharomyces cerevisiae, budding yeast, fungus
		β205	E205A	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Likely pathogenic, with E133A, tubulin beta-3	Glu205Ala	ClinVar 373761	https://www.ncbi.nlm.nih.gov/clinvar/variation/373761	Homo sapiens, human, clinical
		β205	E205K	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:1909 / melanoma	Glu205Lys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β205	E205K	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:9256 / colorectal cancer	Glu205Lys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β205	E205K	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:3070 / malignant glioma	Glu205Lys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β205	E205K	Q9BUF5	https://www.uniprot.org/uniprotkb/Q9BUF5/entry	H. sapiens	TBB6 SNP, DOID:11934 / head and neck cancer	Glu205Lys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BUF5	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β205	E205K	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Malformation of cortical development, tubulin beta-3, 2 patients	Glu205Lys	Poirier et al. 2010. Hum Mol Genet 19:4462-73	https://pubmed.ncbi.nlm.nih.gov/20829227/	Homo sapiens, human, clinical
		β205	E205K	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Infertility due to arrest in oocyte maturation, tubulin beta-8	Glu205Lys	Chen et al. 2017. Hum Reprod 32:457-464.	https://pubmed.ncbi.nlm.nih.gov/27989988/	Homo sapiens, human, clinical
		β205	E205K	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Female infertility, tubulin beta-8	Glu205Lys	Yang et al. 2021. Clin Genet 99:208-214	https://pubmed.ncbi.nlm.nih.gov/33009822/	Homo sapiens, human, clinical
		β205	E205K	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Cortical dysplasia, other brain malformations, with E133K, tubulin beta-3	Glu205Lys	ClinVar 30274	https://www.ncbi.nlm.nih.gov/clinvar/variation/30274	Homo sapiens, human, clinical
		β206	Q206P	Q13885	https://www.uniprot.org/uniprotkb/Q13885/entry	H. sapiens	Cortical dysplasia, brain malformations, with Q291P, tubulin beta-2A	Gln206Pro	ClinVar 217024	https://www.ncbi.nlm.nih.gov/clinvar/variation/217024	Homo sapiens, human, clinical
		β206	S206R	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Likely pathogenic, with S278R, tubulin beta-3	Ser206Arg	ClinVar 427208	https://www.ncbi.nlm.nih.gov/clinvar/variation/427208	Homo sapiens, human, clinical
		β207	L207I	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:1324 / lung cancer	Leu207Ile	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β207	L207M	Q13885	https://www.uniprot.org/uniprotkb/Q13885/entry	H. sapiens	TBB2A SNP, DOID:1909 / melanoma	Leu207Met	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13885	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β207	L207M	Q13885	https://www.uniprot.org/uniprotkb/Q13885/entry	H. sapiens	TBB2A SNP, DOID:9256 / colorectal cancer	Leu207Met	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13885	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β207	L207P	Q9BVA1	https://www.uniprot.org/uniprotkb/Q9BVA1/entry	H. sapiens	Cortical malformations, tubulin beta-2B	Leu207Pro	Cushion et al. 2013. Brain 136:536-48	https://pubmed.ncbi.nlm.nih.gov/23361065/	Homo sapiens, human, clinical
		β207	R207L	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with R156L, R201L, R84L, tubulin beta-4A	Arg207Leu	ClinVar 135659	https://www.ncbi.nlm.nih.gov/clinvar/variation/135659	Homo sapiens, human, clinical
		β208	E208D	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	Likely pathogenic, with E410D, E338D, E430D, E366D, tubulin beta	Glu208Asp	ClinVar 426178	https://www.ncbi.nlm.nih.gov/clinvar/variation/426178	Homo sapiens, human, clinical
		β208	Y208H	Q9BUF5	https://www.uniprot.org/uniprotkb/Q9BUF5/entry	H. sapiens	TBB6 SNP, DOID:263 / kidney cancer	Tyr208His	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BUF5	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β208	Y208H	F9X1J1	https://www.uniprot.org/uniprotkb/F9X1J1/entry	Z. tritici	Pyridachlometyl resistant, beta tubulin	Tyr208His	Matsuzaki et al. 2020. Pest Manag Sci 76:1393-1401	https://pubmed.ncbi.nlm.nih.gov/31622533/	Zymoseptoria, fungus, plant pathogen, septoria leaf blotch	Numbering may need to be adjusted
		β208	Y208X	Q9CWF2	https://www.uniprot.org/uniprotkb/Q9CWF2/entry	M. musculus	Tubb2b, viable heterozygote	Tyr208X	Mutagenetix	https://mutagenetix.utsouthwestern.edu/incidental/incidental_rec.cfm?mid=381039	Mus musculus, mouse, tubulin beta-2B	Wang et al. 2015. PNAS 112:E440-449 (PMID 25605905)
		β209	D209A	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Wild-type, TUB2p	Asp209Ala	Reijo et al. 1994. Mol Biol Cell 5:29-43	https://pubmed.ncbi.nlm.nih.gov/8186463/	Saccharomyces cerevisiae, budding yeast, fungus
		B209	D209N	P32882	https://www.uniprot.org/uniprotkb/P32882/entry	G. gallus	GTP binding site mutation, in vitro synthesis in reticulocyte lysates	Asp209Asn	Farr & Sternlicht. 1992. J Mol Biol 227:307-21	https://pubmed.ncbi.nlm.nih.gov/1522595/	Gallus gallus, red junglefowl, chicken, bird
		β210	I210K	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Female infertility, tubulin beta-8	Ile210Lys	Yang et al. 2021. Clin Genet 99:208-214	https://pubmed.ncbi.nlm.nih.gov/33009822/	Homo sapiens, human, clinical
		β210	I210L	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Oocyte maturation arrest and infertility, TUBB8	Ile210Leu	Yu et al. 2023. Reprod Sci 30:1376-82	https://pubmed.ncbi.nlm.nih.gov/36197634/	Homo sapiens, human, clinical
		β210	I210N	Q9BVA1	https://www.uniprot.org/uniprotkb/Q9BVA1/entry	H. sapiens	Epileptic encephalopathy, tubulin beta-2B	Ile210Asn	Hung et al. 2022. Children 9: 1105	https://pubmed.ncbi.nlm.nih.gov/35892608/	Homo sapiens, human, clinical
		β210	I210S	Q9BVA1	https://www.uniprot.org/uniprotkb/Q9BVA1/entry	H. sapiens	TBB2B SNP, DOID:1612 / breast cancer	Ile210Ser	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BVA1	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β210	I210T	Q9BVA1	https://www.uniprot.org/uniprotkb/Q9BVA1/entry	H. sapiens	Polymicrogyria, tubulin beta-2B	Ile210Thr	Jaglin et al. 2009. Nat Genet 41:746-52	https://pubmed.ncbi.nlm.nih.gov/19465910/	Homo sapiens, human, clinical
		β210	I210T	Q13885	https://www.uniprot.org/uniprotkb/Q13885/entry	H. sapiens	Inhibited axonal transport of vesicles and mitochondria, tubulin beta-2A	Ile210Thr	Niwa et al. 2013. EMBO J 32:1352-64	https://pubmed.ncbi.nlm.nih.gov/23503589/	Homo sapiens, human, clinical	Model for polymicrogyria
		β210	I210T	Q9BVA1	https://www.uniprot.org/uniprotkb/Q9BVA1/entry	H. sapiens	Cerebellar dysplasia, tubulin beta-2B	Ile210Thr	Romaniello et al. 2017. Eur Radiol 27:5080-5092	https://pubmed.ncbi.nlm.nih.gov/28677066/	Homo sapiens, human, clinical
		β210	I210T	P69893	https://www.uniprot.org/uniprotkb/P69893/entry	C. griseus	Paclitaxel resistant, tubulin beta-5	Ile210Thr	Yin et al. 2012. Pharm Res 29:2994-3006	https://pubmed.ncbi.nlm.nih.gov/22669706/	Cricetulus griseus, chinese hamster, rodent
		β210	I210V	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:5041 / esophageal cancer	Ile210Val	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β210	I210V	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Defects in oocyte meiosis, tubulin beta-8	Ile210Val	Feng et al. 2016. J Med Genet 53:662-71	https://pubmed.ncbi.nlm.nih.gov/27273344/	Homo sapiens, human, clinical
		β210	R210P	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with R333P, R282P, R327P, tubulin beta-4A	Arg210Pro	ClinVar 267779	https://www.ncbi.nlm.nih.gov/clinvar/variation/267779	Homo sapiens, human, clinical
		β210	R210P	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Likely pathogenic, with R282P, tubulin beta-3	Arg210Pro	ClinVar 421587	https://www.ncbi.nlm.nih.gov/clinvar/variation/421587	Homo sapiens, human, clinical
		β210	R210Q	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	Uncertain significance, with R282Q, R238Q, R302Q, tubulin beta	Arg210Gln	ClinVar 498257	https://www.ncbi.nlm.nih.gov/clinvar/variation/498257	Homo sapiens, human, clinical
		β211	C211A	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Benomyl supersensitive, TUB2p	Cys211Ala	Gupta et al. 2001. Cell Motil Cytoskeleton 49:67-77	https://pubmed.ncbi.nlm.nih.gov/11443737/	Saccharomyces cerevisiae, budding yeast, fungus
		β211	C211F	P69893	https://www.uniprot.org/uniprotkb/P69893/entry	C. griseus	Colcimid & vinblastine resistant, CHO cell line, tubulin beta-5	Cys211Phe	Hari et al. 2003. Mol Cancer Therap 2:597-605	https://pubmed.ncbi.nlm.nih.gov/12883031/	Cricetulus griseus, chinese hamster, rodent
		β211	C211R	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Fibrosis of extraocular muscles, with C139R, tubulin beta-3	Cys211Arg	ClinVar 617613	https://www.ncbi.nlm.nih.gov/clinvar/variation/617613	Homo sapiens, human, clinical
		β211	C211S	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Wild-type, TUB2p	Cys211Ser	Gupta et al. 2001. Cell Motil Cytoskeleton 49:67-77	https://pubmed.ncbi.nlm.nih.gov/11443737/	Saccharomyces cerevisiae, budding yeast, fungus
		β212	F212L	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:0070003 / blastoma	Phe212Leu	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β212	Q212Q	Q7XYS0	https://www.uniprot.org/uniprotkb/Q7XYS0/entry	C. caldarium	Heat stable adaptation (correlation)	Gln212Gln	Arnold MS thesis (VPI)	https://vtechworks.lib.vt.edu/h&le/10919/9745?show=full	Cyanidium caldarium, extremophile, algae
		β212	Q212Q	A0A125YTB7	https://www.uniprot.org/uniprotkb/A0A125YTB7/entry	C. merolae	Heat stable adaptation (correlation)	Gln212Gln	Arnold MS thesis (VPI)	https://vtechworks.lib.vt.edu/h&le/10919/9745?show=full	Cyanidioschyzon merolae, extremophile, algae
		β213	K213R	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:9256 / colorectal cancer	Lys213Arg	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β213	R213A	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Benomyl supersensitive, with K216A, TUB2p	Arg213Ala	Reijo et al. 1994. Mol Biol Cell 5:29-43	https://pubmed.ncbi.nlm.nih.gov/8186463/	Saccharomyces cerevisiae, budding yeast, fungus
		β213	R213C	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:11934 / head and neck cancer	Arg213Cys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β213	R213C	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:10283 / prostate cancer	Arg213Cys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β213	R213C	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:0070003 / blastoma	Arg213Cys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β213	R213C	Q13885	https://www.uniprot.org/uniprotkb/Q13885/entry	H. sapiens	TBB2A SNP, DOID:10534 / stomach cancer	Arg213Cys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13885	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β213	R213C	Q9ERD7	https://www.uniprot.org/uniprotkb/Q9ERD7/entry	M. musculus	Tubb3, viable heterozygote	Arg213Cys	Mutagenetix	https://mutagenetix.utsouthwestern.edu/incidental/incidental_rec.cfm?mid=89868	Mus musculus, mouse, tubulin beta-3	Wang et al. 2015. PNAS 112:E440-449 (PMID 25605905)
		β213	R213H	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:363 / uterine cancer	Arg213His	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β213	R213H	Q13885	https://www.uniprot.org/uniprotkb/Q13885/entry	H. sapiens	TBB2A SNP, DOID:10534 / stomach cancer	Arg213His	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13885	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β213	R213H	Q13885	https://www.uniprot.org/uniprotkb/Q13885/entry	H. sapiens	TBB2A SNP, DOID:9256 / colorectal cancer	Arg213His	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13885	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β213	R213H	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:4362 / cervical cancer	Arg213His	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β213	R213S	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:363 / uterine cancer	Arg213Ser	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β214	T214I	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	TUBB SNP, DOID:363 / uterine cancer	Thr214Ile	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P07437	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β214	T214I	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:1909 / melanoma	Thr214Ile	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β214	T214N	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	TUBB SNP, DOID:1324 / lung cancer	Thr214Asn	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P07437	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β214	T214N	Q13885	https://www.uniprot.org/uniprotkb/Q13885/entry	H. sapiens	TBB2A SNP, DOID:3571 / liver cancer	Thr214Gln	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13885	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β214	T214P	P12456	https://www.uniprot.org/uniprotkb/P12456/entry	C. elegans	Loss-of-function, short PLM-PN, mec-7	Thr214Pro	Zheng et al. 2017 Mol Biol Cell 28: 2786-2801	https://pubmed.ncbi.nlm.nih.gov/28835377/	Caenorhabditis elegans, nematode, roundworm	also see Lee et al. 2021. Mol Biol Cell. 15:331-347 (PMID 33378215)
		β214	T214P	P12456	https://www.uniprot.org/uniprotkb/P12456/entry	C. elegans	Mechanosensitive, severe semidominant, mec-7	Thr214Pro	Savage et al. 1994. J Cell Sci 107:2165-75	https://pubmed.ncbi.nlm.nih.gov/7983175/	Caenorhabditis elegans, nematode, roundworm
		β214	V214M	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Likely benign, with V286M, tubulin beta-3	Val214Met	ClinVar 437134	https://www.ncbi.nlm.nih.gov/clinvar/variation/437134	Homo sapiens, human, clinical
		β215	L215F	P69893	https://www.uniprot.org/uniprotkb/P69893/entry	C. griseus	Taxol resistant, CHO cell line, tubulin beta-5 chain	Leu215Phe	Gonzalez-Garray et al. 1999. J Biol Chem 274:23875-82	https://pubmed.ncbi.nlm.nih.gov/10446152/	Cricetulus griseus, chinese hamster, rodent
		β215	L215H	P69893	https://www.uniprot.org/uniprotkb/P69893/entry	C. griseus	Taxol resistant, CHO cell line, tubulin beta-5 chain	Leu215His	Gonzalez-Garray et al. 1999. J Biol Chem 274:23875-82	https://pubmed.ncbi.nlm.nih.gov/10446152/	Cricetulus griseus, chinese hamster, rodent
		β215	L215H	P69893	https://www.uniprot.org/uniprotkb/P69893/entry	C. griseus	Paclitaxel resistant, CHO cell line, tubulin beta-5	Leu215His	Yin et al. 2012. Pharm Res 29:2994-3006	https://pubmed.ncbi.nlm.nih.gov/22669706/	Cricetulus griseus, chinese hamster, rodent
		β215	L215P	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:10534 / stomach cancer	Leu215Pro	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β215	L215R	P69893	https://www.uniprot.org/uniprotkb/P69893/entry	C. griseus	Taxol resistant, CHO cell line, tubulin beta-5 chain	Leu215Arg	Gonzalez-Garray et al. 1999. J Biol Chem 274:23875-82	https://pubmed.ncbi.nlm.nih.gov/10446152/	Cricetulus griseus, chinese hamster, rodent
		β215	L215V	Q9BUF5	https://www.uniprot.org/uniprotkb/Q9BUF5/entry	H. sapiens	TBB6 SNP, DOID:10534 / stomach cancer	Leu215Val	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BUF5	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β215	P215L	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	Cortical dysplasia, brain malformation, with P287L, P307L, P243L, tubulin beta	Pro215Leu	ClinVar 438586	https://www.ncbi.nlm.nih.gov/clinvar/variation/438586	Homo sapiens, human, clinical
		β216	E216K	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Cortical dysplasia, other brain malformations, with E288K, tubulin beta-3	Glu216Lys	ClinVar 384329	https://www.ncbi.nlm.nih.gov/clinvar/variation/384329	Homo sapiens, human, clinical
		β216	K216A	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Benomyl supersensitive, with R213A, TUB2p	Lys216Ala	Reijo et al. 1994. Mol Biol Cell 5:29-43	https://pubmed.ncbi.nlm.nih.gov/8186463/	Saccharomyces cerevisiae, budding yeast, fungus
		β216	K216E	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:363 / uterine cancer	Lys216Glu	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β216	K216R	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	Likely pathogenic, with K236R, K144R, K172R, tubulin beta	Lys216Arg	ClinVar 545082	https://www.ncbi.nlm.nih.gov/clinvar/variation/545082	Homo sapiens, human, clinical
		β217	L217N	P69893	https://www.uniprot.org/uniprotkb/P69893/entry	C. griseus	Paclitaxel resistant, CHO cell line, tubulin beta-5	Leu217Asn	Yin et al. 2012. Pharm Res 29:2994-3006	https://pubmed.ncbi.nlm.nih.gov/22669706/	Cricetulus griseus, chinese hamster, rodent
		β217	L217P	P69893	https://www.uniprot.org/uniprotkb/P69893/entry	C. griseus	Paclitaxel resistant, CHO cell line, tubulin beta-5	Leu217Pro	Yin et al. 2012. Pharm Res 29:2994-3006	https://pubmed.ncbi.nlm.nih.gov/22669706/	Cricetulus griseus, chinese hamster, rodent
		β217	L217R	P69893	https://www.uniprot.org/uniprotkb/P69893/entry	C. griseus	Taxol resistant, CHO cell line, tubulin beta-5 chain	Leu217Arg	Gonzalez-Garray et al. 1999. J Biol Chem 274:23875-82	https://pubmed.ncbi.nlm.nih.gov/10446152/	Cricetulus griseus, chinese hamster, rodent
		β218	A218T	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Invasive ductal, high grade; taxane treatment, also contains I189V, A275S, Q291R, K297R, R320P, S364A, T386S	Ala218Thr	Wang et al. 2017. Protoplasma 254:1163-1173	https://pubmed.ncbi.nlm.nih.gov/27943021/	Homo sapiens, human, clinical	Tubulin beta-3 chain
		β218	T218M	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:1324 / lung cancer	Thr218Met	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β219	N219K	F9X1J1	https://www.uniprot.org/uniprotkb/F9X1J1/entry	Z. tritici	Pyridachlometyl resistant, beta tubulin	Asn219Lys	Matsuzaki et al. 2020. Pest Manag Sci 76:1393-1401	https://pubmed.ncbi.nlm.nih.gov/31622533/	Zymoseptoria, fungus, plant pathogen, septoria leaf blotch	Numbering may need to be adjusted
		β219	T219A	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	TUBB SNP, DOID:3070 / malignant glioma	Thr219Ala	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P07437	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β220	P220C	P69893	https://www.uniprot.org/uniprotkb/P69893/entry	C. griseus	Colcimid & vinblastine resistant, CHO cell line, tubulin beta-5	Pro220Cys	Yin et al. 2007. Mol Cancer Ther 6:2798-806	https://pubmed.ncbi.nlm.nih.gov/17938271/	Cricetulus griseus, chinese hamster, rodent
		β220	P220L	P69893	https://www.uniprot.org/uniprotkb/P69893/entry	C. griseus	Paclitaxel resistant, CHO cell line, tubulin beta-5	Pro220Leu	Yin et al. 2007. Mol Cancer Ther 6:2798-806	https://pubmed.ncbi.nlm.nih.gov/17938271/	Cricetulus griseus, chinese hamster, rodent
		β220	P220S	P24636	https://www.uniprot.org/uniprotkb/P24636/entry	A. thaliana	Twisting, TUB4	Pro220Ser	Ishida et al. 2007. PNAS 104:8544-9	https://pubmed.ncbi.nlm.nih.gov/17488810/	Arabidopsis thaliana, plant
		β220	P220S	P69893	https://www.uniprot.org/uniprotkb/P69893/entry	C. griseus	Colcimid & vinblastine resistant, CHO cell line, tubulin beta-5	Pro220Ser	Yin et al. 2007. Mol Cancer Ther 6:2798-806	https://pubmed.ncbi.nlm.nih.gov/17938271/	Cricetulus griseus, chinese hamster, rodent
		β220	P220S	P12456	https://www.uniprot.org/uniprotkb/P12456/entry	C. elegans	Increased microtubule stability, ectopic neurites, mec-7	Pro220Ser	Kirszenblat et al. 2013. Mol Biol Chem 24:285-96	https://pubmed.ncbi.nlm.nih.gov/23223572/	Caenorhabditis elegans, nematode, roundworm
		β220	P220S	P12456	https://www.uniprot.org/uniprotkb/P12456/entry	C. elegans	Neomorph, ectopic ALM-PN, mec-7	Pro220Ser	Zheng et al. 2017 Mol Biol Cell 28: 2786-2801	https://pubmed.ncbi.nlm.nih.gov/28835377/	Caenorhabditis elegans, nematode, roundworm	also see Lee et al. 2021. Mol Biol Cell. 15:331-347 (PMID 33378215)
		β220	P220T	P69893	https://www.uniprot.org/uniprotkb/P69893/entry	C. griseus	Colcimid & vinblastine resistant, CHO cell line, tubulin beta-5	Pro220Thr	Yin et al. 2007. Mol Cancer Ther 6:2798-806	https://pubmed.ncbi.nlm.nih.gov/17938271/	Cricetulus griseus, chinese hamster, rodent
		β220	P220V	P69893	https://www.uniprot.org/uniprotkb/P69893/entry	C. griseus	Paclitaxel resistant, CHO cell line, tubulin beta-5	Pro220Val	Yin et al. 2007. Mol Cancer Ther 6:2798-806	https://pubmed.ncbi.nlm.nih.gov/17938271/	Cricetulus griseus, chinese hamster, rodent
		β220	Q220K	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with Q343K, Q292K, Q337K, tubulin beta-4A	Gln220Lys	ClinVar 267780	https://www.ncbi.nlm.nih.gov/clinvar/variation/267780	Homo sapiens, human, clinical
		β221	S221P	F9X1J1	https://www.uniprot.org/uniprotkb/F9X1J1/entry	Z. tritici	Pyridachlometyl resistant, beta tubulin	Ser221Pro	Matsuzaki et al. 2020. Pest Manag Sci 76:1393-1401	https://pubmed.ncbi.nlm.nih.gov/31622533/	Zymoseptoria, fungus, plant pathogen, septoria leaf blotch	Numbering may need to be adjusted
		β221	T221I	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:263 / kidney cancer	Thr221Ile	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β221	T221I	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Female infertility, tubulin beta-8	Thr221Ile	Zhao et al. 2020. J Assist Reprod Genet 37:1837-47.	https://pubmed.ncbi.nlm.nih.gov/32524331/	Homo sapiens, human, clinical
		β221	T221I	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	Cortical dysplasia, brain malformations, with T149I, T177I, T241I, tubulin beta	Thr221Ile	ClinVar 235892	https://www.ncbi.nlm.nih.gov/clinvar/variation/235892	Homo sapiens, human, clinical
		β221	T221I	Q9CWF2	https://www.uniprot.org/uniprotkb/Q9CWF2/entry	M. musculus	Tubb2b, viable heterozygote	Thr221Ile	Mutagenetix	https://mutagenetix.utsouthwestern.edu/incidental/incidental_rec.cfm?mid=152158	Mus musculus, mouse, tubulin beta-2B	Wang et al. 2015. PNAS 112:E440-449 (PMID 25605905)
		β222	Y222F	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	Microcephaly phenotypes, tubulin beta	Tyr221Phe	Ulucan. 2013. Clin Dysmorphol 22:87-90	https://pubmed.ncbi.nlm.nih.gov/23324645/	Homo sapiens, human, clinical	Michelin tire baby syndrome
		β222	Y222F	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	Circumferential skin creases, Kunze Type, tubulin beta	Tyr222Phe	Isrie et al. 2015. Am J Hum Genet. 97:790-800	https://pubmed.ncbi.nlm.nih.gov/26637975/	Homo sapiens, human, clinical
		β222	Y222F	Q24560	https://www.uniprot.org/uniprotkb/Q24560/entry	D. melanogaster	Accellerated MT nucleation, betaTub56D	Tyr222Phe	Ayukawa et al. 2021. J Cell Biol 220:e202007033	https://pubmed.ncbi.nlm.nih.gov/33544140/	Drosophila, fruitfly
		β222	Y222F	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	Symmetric circumferential skin creases, with Y178F, Y150F, Y242F, tubulin beta	Tyr222Phe	ClinVar 218926	https://www.ncbi.nlm.nih.gov/clinvar/variation/218926	Homo sapiens, human, clinical
		β222	Y222H	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:5041 / esophageal cancer	Tyr222His	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β222	Y222H	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:1324 / lung cancer	Tyr222His	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β222	Y222N	F9X1J1	https://www.uniprot.org/uniprotkb/F9X1J1/entry	Z. tritici	Pyridachlometyl resistant, beta tubulin	Tyr222Asn	Matsuzaki et al. 2020. Pest Manag Sci 76:1393-1401	https://pubmed.ncbi.nlm.nih.gov/31622533/	Zymoseptoria, fungus, plant pathogen, septoria leaf blotch	Numbering may need to be adjusted
		β222	Y222S	F9X1J1	https://www.uniprot.org/uniprotkb/F9X1J1/entry	Z. tritici	Pyridachlometyl resistant, beta tubulin	Tyr222Ser	Matsuzaki et al. 2020. Pest Manag Sci 76:1393-1401	https://pubmed.ncbi.nlm.nih.gov/31622533/	Zymoseptoria, fungus, plant pathogen, septoria leaf blotch	Numbering may need to be adjusted
		β223	G223E	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:1324 / lung cancer	Gly223Glu	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β223	G223E	P12456	https://www.uniprot.org/uniprotkb/P12456/entry	C. elegans	Weak neomorph, overextended PLM-PN, mec-7	Gly223Glu	Lee et al. 2021. Mol Biol Cell. 15:331-347	https://pubmed.ncbi.nlm.nih.gov/33378215/	Caenorhabditis elegans, nematode, roundworm
		β223	G223R	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:1909 / melanoma	Gly223Arg	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β223	G223R	Q9BVA1	https://www.uniprot.org/uniprotkb/Q9BVA1/entry	H. sapiens	TBB2B SNP, DOID:5041 / esophageal cancer	Gly223Arg	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BVA1	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β223	G223R	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Likely benign, with G274R, G151R, G268R, tubulin beta-4A	Gly223Arg	ClinVar 212501	https://www.ncbi.nlm.nih.gov/clinvar/variation/212501	Homo sapiens, human, clinical
		β223	T223M	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with T229M, T178M, T106M, tubulin beta-4A	Thr223Met	ClinVar 267774	https://www.ncbi.nlm.nih.gov/clinvar/variation/267774	Homo sapiens, human, clinical
		β223	T223R	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with T178R, T229R, T106R, tubulin beta-4A	Thr223Arg	ClinVar 139453	https://www.ncbi.nlm.nih.gov/clinvar/variation/139453	Homo sapiens, human, clinical
		β224	D224N	P69893	https://www.uniprot.org/uniprotkb/P69893/entry	C. griseus	Colcimid & vinblastine resistant, CHO cell line, tubulin beta-5	Asp224Asn	Hari et al. 2003. Mol Cancer Therap 2:597-605	https://pubmed.ncbi.nlm.nih.gov/12883031/	Cricetulus griseus, chinese hamster, rodent
		β224	D224N	P32882	https://www.uniprot.org/uniprotkb/P32882/entry	G. gallus	GTP binding site mutation, in vitro synthesis in reticulocyte lysates	Asp224Asn	Farr & Sternlicht. 1992. J Mol Biol 227:307-21	https://pubmed.ncbi.nlm.nih.gov/1522595/	Gallus gallus, red junglefowl, chicken, bird
		β224	D224V	Q9BUF5	https://www.uniprot.org/uniprotkb/Q9BUF5/entry	H. sapiens	TBB6 SNP, DOID:10534 / stomach cancer	Asp224Val	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BUF5	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β224	D224Y	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:10534 / stomach cancer	Asp224Tyr	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β224	V224L	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Pathogenic, with V179L, V230L, V107L, tubulin beta-4A	Val224Leu	ClinVar 372789	https://www.ncbi.nlm.nih.gov/clinvar/variation/372789	Homo sapiens, human, clinical
		β225	L225F	P12456	https://www.uniprot.org/uniprotkb/P12456/entry	C. elegans	Antimorph, shortened TRN neurites, mec-7	Leu225Phe	Lee et al. 2021. Mol Biol Cell. 15:331-347	https://pubmed.ncbi.nlm.nih.gov/33378215/	Caenorhabditis elegans, nematode, roundworm
		β225	L225F	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with L276F, L153F, L270F, tubulin beta-4A	Leu225Phe	ClinVar 578590	https://www.ncbi.nlm.nih.gov/clinvar/variation/578590	Homo sapiens, human, clinical
		β225	L225P	Q13885	https://www.uniprot.org/uniprotkb/Q13885/entry	H. sapiens	TBB2A SNP, DOID:9256 / colorectal cancer	Leu225Pro	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13885	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β225	L225P	Q9CWF2	https://www.uniprot.org/uniprotkb/Q9CWF2/entry	M. musculus	Tubb2b, viable heterozygote	Leu225Pro	Mutagenetix	https://mutagenetix.utsouthwestern.edu/incidental/incidental_rec.cfm?mid=591946	Mus musculus, mouse, tubulin beta-2B	Wang et al. 2015. PNAS 112:E440-449 (PMID 25605905)
		β225	L225V	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:1324 / lung cancer	Leu225Val	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β225	L225V	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Human oocyte maturation defects and female infertility, TUBB8	Leu225Val	Lin et al. 2023. Reprod Biomed Online 46(2):244-254	https://pubmed.ncbi.nlm.nih.gov/36463079/	Homo sapiens, human, clinical
		β225	V225M	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Uncertain significance, with V231M, V180M, V108M, tubulin beta-4A	Val225Met	ClinVar 425158	https://www.ncbi.nlm.nih.gov/clinvar/variation/425158	Homo sapiens, human, clinical
		β226	D226Y	P12456	https://www.uniprot.org/uniprotkb/P12456/entry	C. elegans	Mechanosensitive, mild semidominant, mec-7	Asn226Tyr	Savage et al. 1994. J Cell Sci 107:2165-75	https://pubmed.ncbi.nlm.nih.gov/7983175/	Caenorhabditis elegans, nematode, roundworm
		β226	N226Y	P12456	https://www.uniprot.org/uniprotkb/P12456/entry	C. elegans	Antimorph, short TRN neurites, mec-7	Asn226Tyr	Zheng et al. 2017 Mol Biol Cell 28: 2786-2801	https://pubmed.ncbi.nlm.nih.gov/28835377/	Caenorhabditis elegans, nematode, roundworm	also see Lee et al. 2021. Mol Biol Cell. 15:331-347 (PMID 33378215)
		β227	H227L	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:3571 / liver cancer	His227Leu	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β227	H227R	Q9ERD7	https://www.uniprot.org/uniprotkb/Q9ERD7/entry	M. musculus	Tubb3, viable heterozygote	His227Arg	Mutagenetix	https://mutagenetix.utsouthwestern.edu/incidental/incidental_rec.cfm?mid=309507	Mus musculus, mouse, tubulin beta-3	Wang et al. 2015. PNAS 112:E440-449 (PMID 25605905)
		β227	M227L	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Uncertain significance, with M299L, M350L, M344L, tubulin beta-4A	Met227Leu	ClinVar 429972	https://www.ncbi.nlm.nih.gov/clinvar/variation/429972	Homo sapiens, human, clinical
		β227	M227V	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	Cortical dysplasia, brain malformations, with M299V, M255V, M319V, tubulin beta	Met227Val	ClinVar 127189	https://www.ncbi.nlm.nih.gov/clinvar/variation/127189	Homo sapiens, human, clinical
		β227	N227H	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Required for Taxol binding, TUB2p	Asn227His	Gupta et al. 2003. PNAS 100:6394-7	https://pubmed.ncbi.nlm.nih.gov/12740436/	Saccharomyces cerevisiae, budding yeast, fungus
		β227	P227T	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with P233T, P182T, P110T, tubulin beta-4A	Pro227Thr	ClinVar 267775	https://www.ncbi.nlm.nih.gov/clinvar/variation/267775	Homo sapiens, human, clinical
		β228	L228F	P69893	https://www.uniprot.org/uniprotkb/P69893/entry	C. griseus	Taxol resistant, CHO cell line, tubulin beta-5 chain	Leu228Phe	Gonzalez-Garray et al. 1999. J Biol Chem 274:23875-82	https://pubmed.ncbi.nlm.nih.gov/10446152/	Cricetulus griseus, chinese hamster, rodent
		β228	L228H	P69893	https://www.uniprot.org/uniprotkb/P69893/entry	C. griseus	Taxol resistant, CHO cell line, tubulin beta-5 chain	Leu228His	Gonzalez-Garray et al. 1999. J Biol Chem 274:23875-82	https://pubmed.ncbi.nlm.nih.gov/10446152/	Cricetulus griseus, chinese hamster, rodent
		β228	L228P	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:1909 / melanoma	Leu228Pro	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β228	L228P	Q9BVA1	https://www.uniprot.org/uniprotkb/Q9BVA1/entry	H. sapiens	Polymicrogyria, tubulin beta-2B	Leu228Pro	Jaglin et al. 2009. Nat Genet 41:746-52	https://pubmed.ncbi.nlm.nih.gov/19465910/	Homo sapiens, human, clinical
		β228	L228P	Q13885	https://www.uniprot.org/uniprotkb/Q13885/entry	H. sapiens	Inhibited axonal transport of vesicles and mitochondria, tubulin beta-2A	Leu228Pro	Niwa et al. 2013. EMBO J 32:1352-64	https://pubmed.ncbi.nlm.nih.gov/23503589/	Homo sapiens, human, clinical	Model for polymicrogyria
		β228	L228Q	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:0070003 / blastoma	Leu228Gln	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β228	L228Q	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:3571 / liver cancer	Leu228Gln	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β228	L228V	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	Likely pathogenic, with L156V, L184V, L248V, tubulin beta	Leu228Val	ClinVar 392956	https://www.ncbi.nlm.nih.gov/clinvar/variation/392956	Homo sapiens, human, clinical
		β228	M228I	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with M351I, M300I, M345I, tubulin beta-4A	Met228Ile	ClinVar 267782	https://www.ncbi.nlm.nih.gov/clinvar/variation/267782	Homo sapiens, human, clinical
		β228	L228P	Q9BVA1	https://www.uniprot.org/uniprotkb/Q9BVA1/entry	H. sapiens	Cerebellar dysplasia, tubulin beta-2B	Leu228Pro	Romaniello et al. 2017. Eur Radiol 27:5080-5092	https://pubmed.ncbi.nlm.nih.gov/28677066/	Homo sapiens, human, clinical
		β229	T229M	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with T178M, T106M, T223M, tubulin beta-4A	Thr229Met	ClinVar 267774	https://www.ncbi.nlm.nih.gov/clinvar/variation/267774	Homo sapiens, human, clinical
		β229	T229R	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with T178R, T223R, T106R, tubulin beta-4A	Thr229Arg	ClinVar 139453	https://www.ncbi.nlm.nih.gov/clinvar/variation/139453	Homo sapiens, human, clinical
		β229	V229A	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Defects in oocyte meiosis, tubulin beta-8	Val229Ala	Feng et al. 2016. N Engl J Med 374:223-32	https://pubmed.ncbi.nlm.nih.gov/26789871/	Homo sapiens, human, clinical
		β229	V229A	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Oocyte maturation defect, tubulin beta-8	Val229Ala	ClinVar 221268	https://www.ncbi.nlm.nih.gov/clinvar/variation/221268	Homo sapiens, human, clinical
		β229	V229A	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with V280A, V157A, V274A, tubulin beta-4A	Val229Ala	ClinVar 580978	https://www.ncbi.nlm.nih.gov/clinvar/variation/580978	Homo sapiens, human, clinical
		β229	V229L	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:1324 / lung cancer	Val229Leu	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β230	A230T	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Fibrosis of extraocular muscles, with A302T, tubulin beta-3	Ala230Thr	ClinVar 6964	https://www.ncbi.nlm.nih.gov/clinvar/variation/6964	Homo sapiens, human, clinical
		β230	A230V	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Cortical dysplasia, other brain malformations, with A302V, tubulin beta-3	Ala230Val	ClinVar 30275	https://www.ncbi.nlm.nih.gov/clinvar/variation/30275	Homo sapiens, human, clinical
		β230	S230F	Q9BUF5	https://www.uniprot.org/uniprotkb/Q9BUF5/entry	H. sapiens	TBB6 SNP, DOID:1909 / melanoma	Ser230Phe	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BUF5	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β230	S230F	Q18817	https://www.uniprot.org/uniprotkb/Q18817/entry	C. elegans	Albendazole resistance, ben-1	Ser230Phe	Pallotto et al. 2022. Genetics 221:iyac093	https://pubmed.ncbi.nlm.nih.gov/35731216/	Caenorhabditis elegans, nematode, roundworm
		β230	S230L	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Motor impairment, intellectual disability & epilepsy, tubulin beta-3	Ser230Leu	Romaniello et al. 2019. Cells 8:669	https://pubmed.ncbi.nlm.nih.gov/31269740/	Homo sapiens, human, clinical
		β230	S230L	Q13885	https://www.uniprot.org/uniprotkb/Q13885/entry	H. sapiens	Tubulinopathy, brain malformations, tubulin beta-2A	Ser230Leu	Brock et al. 2021. J Med Genet 58:33-40	https://pubmed.ncbi.nlm.nih.gov/32571897/	Homo sapiens, human, clinical
		β230	S230L	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Pathogenic, with S158L, tubulin beta-3	Ser230Leu	ClinVar 280212	https://www.ncbi.nlm.nih.gov/clinvar/variation/280212	Homo sapiens, human, clinical
		β230	V230L	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Pathogenic, with V179L, V224L, V107L, tubulin beta-4A	Val230Leu	ClinVar 372789	https://www.ncbi.nlm.nih.gov/clinvar/variation/372789	Homo sapiens, human, clinical
		β231	A231T	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	Decreased microtubule stability, desoxyepothilone B resistance, tubulin beta	Ala231Thr	Verrills et al. 2003. Chem Biol 10:597-607	https://pubmed.ncbi.nlm.nih.gov/12890533/	Homo sapiens, human, clinical
		β231	Q292E	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	Desoxyepothilone B resistant, with A231T, tubulin beta	Gln292Glu	Verrills et al. 2003. Chem Biol 10:597-607	https://pubmed.ncbi.nlm.nih.gov/12890533/	Homo sapiens, human, clinical
		β231	V231M	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Uncertain significance, with V180M, V108M, V225M, tubulin beta-4A	Val231Met	ClinVar 425158	https://www.ncbi.nlm.nih.gov/clinvar/variation/425158	Homo sapiens, human, clinical
		β232	T232I	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:263 / kidney cancer	Thr232Ile	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β232	V232V	Q9N2N6	https://www.uniprot.org/uniprotkb/Q9N2N6/entry	E. focardii	Cold stable adaptation (correlation, EFBT2)	Val232Val	Chiappori et al. 2012. Proteins 80:1154-60	https://pubmed.ncbi.nlm.nih.gov/22275059/	Euplotes focardii, extremophile, Antarctic ciliate
		β232	V232V	Q9N2N6	https://www.uniprot.org/uniprotkb/Q9N2N6/entry	E. focardii	Cold stable adaptation (correlation, EFBT3)	Val232Val	Chiappori et al. 2012. Proteins 80:1154-60	https://pubmed.ncbi.nlm.nih.gov/22275059/	Euplotes focardii, extremophile, Antarctic ciliate
		β232	V232V	Q9N2N6	https://www.uniprot.org/uniprotkb/Q9N2N6/entry	E. focardii	Cold stable adaptation (correlation, EFBT4)	Val232Val	Chiappori et al. 2012. Proteins 80:1154-60	https://pubmed.ncbi.nlm.nih.gov/22275059/	Euplotes focardii, extremophile, Antarctic ciliate
		β233	M233I	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	TUBB SNP, DOID:1612 / breast cancer	Met233Ile	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P07437	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β233	M233I	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:1909 / melanoma	Met233Ile	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β233	M233T	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:1909 / melanoma	Met233Thr	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β233	M233T	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:9256 / colorectal cancer	Met233Thr	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β233	M233V	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Cold sensitive microtubules, with Y242C, Q245L, TUB2p	Met233Val	Huffaker et al. 1988. J Cell Biol 106:1997-2010	https://pubmed.ncbi.nlm.nih.gov/3290223/	Saccharomyces cerevisiae, budding yeast, fungus
		β233	P233T	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with P182T, P227T, P110T, tubulin beta-4A	Pro233Thr	ClinVar 267775	https://www.ncbi.nlm.nih.gov/clinvar/variation/267775	Homo sapiens, human, clinical
		β234	S234G	Q9ERD7	https://www.uniprot.org/uniprotkb/Q9ERD7/entry	M. musculus	Tubb3, viable heterozygote	Ser234Gly	Mutagenetix	https://mutagenetix.utsouthwestern.edu/incidental/incidental_rec.cfm?mid=655415	Mus musculus, mouse, tubulin beta-3	Wang et al. 2015. PNAS 112:E440-449 (PMID 25605905)
		β234	S234G	P69893	https://www.uniprot.org/uniprotkb/P69893/entry	C. griseus	Paclitaxel resistant, CHO cell line, tubulin beta-5	Ser234Gly	Yin et al. 2012. Pharm Res 29:2994-3006	https://pubmed.ncbi.nlm.nih.gov/22669706/	Cricetulus griseus, chinese hamster, rodent
		β234	S234N	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:10534 / stomach cancer	Ser234Asn	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β234	S234N	P69893	https://www.uniprot.org/uniprotkb/P69893/entry	C. griseus	Colcimid & vinblastine resistant, CHO cell line, tubulin beta-5	Ser234Asn	Hari et al. 2003. Mol Cancer Therap 2:597-605	https://pubmed.ncbi.nlm.nih.gov/12883031/	Cricetulus griseus, chinese hamster, rodent
		β234	S234R	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:3070 / malignant glioma	Ser234Arg	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β234	S234T	Q9BUF5	https://www.uniprot.org/uniprotkb/Q9BUF5/entry	H. sapiens	TBB6 SNP, DOID:10534 / stomach cancer	Ser234Thr	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BUF5	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β235	G235R	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with G280R, G286R, G163R, tubulin beta-4A	Gly235Arg	ClinVar 643798	https://www.ncbi.nlm.nih.gov/clinvar/variation/643798	Homo sapiens, human, clinical
		β235	G235S	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:1324 / lung cancer	Gly235Ser	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β235	G235S	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	Likely benign, with G437S, G365S, G457S, G393S, tubulin beta	Gly235Ser	ClinVar 382889	https://www.ncbi.nlm.nih.gov/clinvar/variation/382889	Homo sapiens, human, clinical
		β235	H235Y	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with H190Y, H241Y, H118Y, tubulin beta-4A	His235Tyr	ClinVar 192383	https://www.ncbi.nlm.nih.gov/clinvar/variation/192383	Homo sapiens, human, clinical
		β236	I236Nb	P04690	https://www.uniprot.org/uniprotkb/P04690/entry	C. reinhardtii	Propyzamide resistant	Ile236Asn	Kato-Minoura et al. 2020. PLoS One 15(11):e0242694	https://pubmed.ncbi.nlm.nih.gov/33227038/	Chlamydomonas reinhardtii, green alga
		β236	K236R	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	Likely pathogenic, with K216R, K144R, K172R, tubulin beta	Lys236Arg	ClinVar 545082	https://www.ncbi.nlm.nih.gov/clinvar/variation/545082	Homo sapiens, human, clinical
		β237	A165V	P05220	https://www.uniprot.org/uniprotkb/P05220/entry	N. crassa	Carbendazim & diethofencarb resistant,	Ala165Val	Fujimura et al. 1994. Curr Genet 25:418-22	https://pubmed.ncbi.nlm.nih.gov/8082187/	Neurospora crassa, fungus, red bread mold
		β237	T237A	P05220	https://www.uniprot.org/uniprotkb/P05220/entry	N. crassa	Carbendazim & diethofencarb resistant	Thr237Ala	Fujimura et al. 1994. Curr Genet 25:418-22	https://pubmed.ncbi.nlm.nih.gov/8082187/	Neurospora crassa, fungus, red bread mold
		β237	T237H	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	Invasive ductal, low grade; no treatment, also contains C239L, T237H, T238H, L240P, R241P	Thr237His	Wang et al. 2017. Protoplasma 254:1163-1173	https://pubmed.ncbi.nlm.nih.gov/27943021/	Homo sapiens, human, clinical	Tubulin beta-1 chain
		β238	R238Q	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	Uncertain significance, with R282Q, R210Q, R302Q, tubulin beta	Arg238Gln	ClinVar 498257	https://www.ncbi.nlm.nih.gov/clinvar/variation/498257	Homo sapiens, human, clinical
		β238	T238A	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Reduces microtubule catastrophe, TUB2p	Thr238Ala	Geyer et al. 2015. eLife 4: e10113	https://pubmed.ncbi.nlm.nih.gov/26439009/	Saccharomyces cerevisiae, budding yeast, fungus	Ye et al.2020. Protein Sci 29:1429-143
		β238	T238A	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Cerebellar dysplasia, tubulin beta-3	Thr238Ala	Romaniello et al. 2017. Eur Radiol 27:5080-5092	https://pubmed.ncbi.nlm.nih.gov/28677066/	Homo sapiens, human, clinical
		β238	T238A	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Increased microtubule assembly (slower shrinking), tubulin beta-3	Thr238Ala	Ye et al.2020. Protein Sci 29:1429-143	https://pubmed.ncbi.nlm.nih.gov/32077153/	Homo sapiens, human, clinical
		β238	T238A	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Slow microtubule catastrophe, recombinant protein, tubulin beta-3	Thr238Ala	Ye et al.2020. Protein Sci 29:1429-143	https://pubmed.ncbi.nlm.nih.gov/32077153/	Homo sapiens, human, clinical
		β238	T238A	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	Resistant to benzamide covalent modification	Thr238Ala	Povedano et al. 2020. J Med Chem 63:14054-14066	https://pubmed.ncbi.nlm.nih.gov/33180487/	Homo sapiens, human, clinical
		β238	T238A	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Spindle elongation defect, TUB2p	Thr238Ala	Machin et al. 1995. Mol Biol Cell 6:1241-59	https://pubmed.ncbi.nlm.nih.gov/8534919/	Saccharomyces cerevisiae, budding yeast, fungus
		β238	T238H	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	Invasive ductal, low grade; no treatment, also contains C239L, T237H, T238H, L240P, R241P	Thr238His	Wang et al. 2017. Protoplasma 254:1163-1173	https://pubmed.ncbi.nlm.nih.gov/27943021/	Homo sapiens, human, clinical	Tubulin beta-1 chain
		β238	T238H	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	Invasive mucinous, low grade; doxorubicin treatment, also contains C239L, L240P, R241P	Thr238His	Wang et al. 2017. Protoplasma 254:1163-1173	https://pubmed.ncbi.nlm.nih.gov/27943021/	Homo sapiens, human, clinical	Tubulin beta-1 chain
		β238	T238M	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Defects in oocyte meiosis, tubulin beta-8	Thr238Met	Feng et al. 2016. J Med Genet 53:662-71	https://pubmed.ncbi.nlm.nih.gov/27273344/	Homo sapiens, human, clinical
		β238	T238M	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Female infertility, tubulin beta-8	Thr238Met	Yang et al. 2021. Clin Genet 99:208-214	https://pubmed.ncbi.nlm.nih.gov/33009822/	Homo sapiens, human, clinical
		β238	T238M	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Oocyte maturation defect, pathogenic, tubulin beta-8	Thr238Met	ClinVar 378059	https://www.ncbi.nlm.nih.gov/clinvar/variation/378059	Homo sapiens, human, clinical
		β238	T238N	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	TUBB SNP, DOID:2531 / hematologic cancer	Thr238Asn	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P07437	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β238	T238N	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	TUBB SNP, DOID:2994 / germ cell cancer	Thr238Asn	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P07437	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β238	T238P	P68371	https://www.uniprot.org/uniprotkb/P68371/entry	H. sapiens	TBB4B SNP, DOID:1612 / breast cancer	Thr238Pro	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P68371	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β239	C239F	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Hypomyelination, atrophy of basal ganglia & cerebellum, tubulin beta-4A	Cys239Phe	Ferreira et al. 2014. Am J Med Genet A 164A:1802-7.	https://pubmed.ncbi.nlm.nih.gov/24706558/	Homo sapiens, human, clinical
		β239	C239F	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Hypomyelination, basal ganglia & cerebellum atrophy, tubulin beta-4A	Cys239Phe	Hamilton et al. 2014. Brain 137:1921-30	https://pubmed.ncbi.nlm.nih.gov/24785942/	Homo sapiens, human, clinical
		β239	C239F	Q9BVA1	https://www.uniprot.org/uniprotkb/Q9BVA1/entry	H. sapiens	Malformation of cortical development, fetal sample, tubulin beta-2B	Cys239Phe	Fallet-Bianco et al. 2014. Acta Neuropathol Commun 2:69	https://pubmed.ncbi.nlm.nih.gov/25059107/	Homo sapiens, human, clinical
		β239	C239F	Q9BVA1	https://www.uniprot.org/uniprotkb/Q9BVA1/entry	H. sapiens	Microlissencephaly with fetal akinesia, tubulin beta-2B	Cys239Phe	Laquerriere et al. 2016. Eur J Med Genet 59:249-56	https://pubmed.ncbi.nlm.nih.gov/26732629/	Homo sapiens, human, clinical
		β239	C239F	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with C290F, C284F, C167F, tubulin beta-4A	Cys239Phe	ClinVar 267776	https://www.ncbi.nlm.nih.gov/clinvar/variation/267776	Homo sapiens, human, clinical
		β239	C239L	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	Invasive ductal, low grade; no treatment, also contains I152T, L240P, R241P, L273P	Cys239Leu	Wang et al. 2017. Protoplasma 254:1163-1173	https://pubmed.ncbi.nlm.nih.gov/27943021/	Homo sapiens, human, clinical	Tubulin beta-1 chain
		β239	C239L	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	Invasive ductal, low grade; no treatment, also contains C239L, T237H, T238H, L240P, R241P	Cys239Leu	Wang et al. 2017. Protoplasma 254:1163-1173	https://pubmed.ncbi.nlm.nih.gov/27943021/	Homo sapiens, human, clinical	Tubulin beta-1 chain
		β239	C239L	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	Invasive mucinous, low grade; doxorubicin treatment, also contains T238H, L240P, R241P	Cys239Leu	Wang et al. 2017. Protoplasma 254:1163-1173	https://pubmed.ncbi.nlm.nih.gov/27943021/	Homo sapiens, human, clinical	Tubulin beta-1 chain
		β239	C239L	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	Invasive lobular, low grade; doxorubicin treatment, also contains L240P, R241P	Cys239Leu	Wang et al. 2017. Protoplasma 254:1163-1173	https://pubmed.ncbi.nlm.nih.gov/27943021/	Homo sapiens, human, clinical	Tubulin beta-1 chain
		β239	C239P	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	Invasive ductal, low grade; no treatment, also contains L240P, R241P	Cys239Pro	Wang et al. 2017. Protoplasma 254:1163-1173	https://pubmed.ncbi.nlm.nih.gov/27943021/	Homo sapiens, human, clinical	Tubulin beta-1 chain
		β239	C239R	P68371	https://www.uniprot.org/uniprotkb/P68371/entry	H. sapiens	Invasive ductal, low grade; taxane treatment, also contains P171L	Cys239Arg	Wang et al. 2017. Protoplasma 254:1163-1173	https://pubmed.ncbi.nlm.nih.gov/27943021/	Homo sapiens, human, clinical	Tubulin beta-4B chain
		β239	C239R	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	Invasive mixed, low grade; no treatment, also contains D177G	Cys239Arg	Wang et al. 2017. Protoplasma 254:1163-1173	https://pubmed.ncbi.nlm.nih.gov/27943021/	Homo sapiens, human, clinical	Tubulin beta-1 chain
		β239	C239S	Q698C8	https://www.uniprot.org/uniprotkb/Q698C8/entry	P. aphanidermatum	Ethaboxam insensitive, tubulin beta	Cys239Ser	Noel et al. 2019. Phytopathology 109:2087-2095	https://pubmed.ncbi.nlm.nih.gov/31070989/	Pythium, fungus, plant pathogen
		β239	C239S	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	Resistant to Withaferin A covalent modification, tubulin beta	Cys239Ser	Yang et al. 2019. Mol Pharmacol 96:711-719	https://pubmed.ncbi.nlm.nih.gov/31585985/	Homo sapiens, human, clinical
		β239	C239S	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Female infertility, tubulin beta-8	Cys239Ser	Zhao et al. 2020. J Assist Reprod Genet 37:1837-47.	https://pubmed.ncbi.nlm.nih.gov/32524331/	Homo sapiens, human, clinical
		β239	C239Y	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:3963 / thyroid carcinoma	Cys239Tyr	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β239	C239Y	Q56YW9	https://www.uniprot.org/uniprotkb/Q56YW9/entry	A. thaliana	Twisting, TUB2	Cys239Tyr	Ishida et al. 2007. PNAS 104:8544-9	https://pubmed.ncbi.nlm.nih.gov/17488810/	Arabidopsis thaliana, plant
		β239	C239Y	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	Invasive ductal, low grade; no treatment	Cys239Tyr	Wang et al. 2017. Protoplasma 254:1163-1173	https://pubmed.ncbi.nlm.nih.gov/27943021/	Homo sapiens, human, clinical	Tubulin beta-1 chain
		β239	S239C	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Invasive ductal, low grade; taxane treatment, also contains T166A, I189V, T315A, A332N, I333V, S335N, V351T	Ser239Cys	Wang et al. 2017. Protoplasma 254:1163-1173	https://pubmed.ncbi.nlm.nih.gov/27943021/	Homo sapiens, human, clinical	Tubulin beta-3 chain
		β239	S239F	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Uncertain significance, with S167F, tubulin beta-3	Ser239Phe	ClinVar 546125	https://www.ncbi.nlm.nih.gov/clinvar/variation/546125	Homo sapiens, human, clinical
		β239	S239Y	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	Colchicine‑resistant familial Mediterranean fever, tubulin beta	Ser239Tyr	Sahakyan et al. 2019. PLoS One 14:e0221532	https://pubmed.ncbi.nlm.nih.gov/31442266/	Computational modeling, clinical	Model of colchicine binding to variants
		β240	F240A	Q4HZS8	https://www.uniprot.org/uniprotkb/Q4HZS8/entry	F. graminearum	Carbendazim hypersensitive, β2-tubulin (no accession number)	Phe240Ala	Zhu et al. 2020. Phytopathology 110:1522-1529	https://pubmed.ncbi.nlm.nih.gov/32352861/	Gibberella zeae, Fusarium graminearum, fungus
		β240	F240E	Q4HZS8	https://www.uniprot.org/uniprotkb/Q4HZS8/entry	F. graminearum	Carbendazim hypersensitive, β2-tubulin (no accession number)	Phe240Glu	Zhu et al. 2020. Phytopathology 110:1522-1529	https://pubmed.ncbi.nlm.nih.gov/32352861/	Gibberella zeae, Fusarium graminearum, fungus
		β240	F240G	Q4HZS8	https://www.uniprot.org/uniprotkb/Q4HZS8/entry	F. graminearum	Carbendazim resistant, β2-tubulin (no accession number)	Phe240Gly	Zhu et al. 2020. Phytopathology 110:1522-1529	https://pubmed.ncbi.nlm.nih.gov/32352861/	Gibberella zeae, Fusarium graminearum, fungus
		β240	F240I	Q4HZS8	https://www.uniprot.org/uniprotkb/Q4HZS8/entry	F. graminearum	Carbendazim hypersensitive, β2-tubulin (no accession number)	Phe240Ile	Zhu et al. 2020. Phytopathology 110:1522-1529	https://pubmed.ncbi.nlm.nih.gov/32352861/	Gibberella zeae, Fusarium graminearum, fungus
		β240	F240L	Q4HZS8	https://www.uniprot.org/uniprotkb/Q4HZS8/entry	F. graminearum	Carbendazim hypersensitive, β2-tubulin (no accession number)	Phe240Leu	Zhu et al. 2020. Phytopathology 110:1522-1529	https://pubmed.ncbi.nlm.nih.gov/32352861/	Gibberella zeae, Fusarium graminearum, fungus
		β240	F240Y	Q4HZS8	https://www.uniprot.org/uniprotkb/Q4HZS8/entry	F. graminearum	Carbendazim hypersensitive, β2-tubulin (no accession number)	Phe240YTyr	Zhu et al. 2020. Phytopathology 110:1522-1529	https://pubmed.ncbi.nlm.nih.gov/32352861/	Gibberella zeae, Fusarium graminearum, fungus
		β240	L240F	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	Rigosertib resistant, tubulin beta	Leu240Phe	Jost et al. 2020. Mol Cell 79:191-198	https://pubmed.ncbi.nlm.nih.gov/32619469/	Homo sapiens, human, clinical
		β240	L240I	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	Vinca resistant, tubulin beta	Leu240Ile	Kavallaris et al. 2001. Cancer Res 61:5803-9	https://pubmed.ncbi.nlm.nih.gov/11479219/	Homo sapiens, human, clinical
		β240	L240P	P68371	https://www.uniprot.org/uniprotkb/P68371/entry	H. sapiens	TBB4B SNP, DOID:263 / kidney cancer	Leu240Pro	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P68371	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β240	L240P	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	Invasive ductal, low grade; no treatment, also contains C239L, I152T, R241P, L273P	Leu240Pro	Wang et al. 2017. Protoplasma 254:1163-1173	https://pubmed.ncbi.nlm.nih.gov/27943021/	Homo sapiens, human, clinical	Tubulin beta-1 chain
		β240	L240P	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	Invasive ductal, low grade; no treatment, also contains C239L, T237H, T238H, L240P, R241P	Leu240Pro	Wang et al. 2017. Protoplasma 254:1163-1173	https://pubmed.ncbi.nlm.nih.gov/27943021/	Homo sapiens, human, clinical	Tubulin beta-1 chain
		β240	L240P	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	Invasive ductal, low grade; no treatment, also contains C239P, R241P	Leu240Pro	Wang et al. 2017. Protoplasma 254:1163-1173	https://pubmed.ncbi.nlm.nih.gov/27943021/	Homo sapiens, human, clinical	Tubulin beta-1 chain
		β240	L240P	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	Invasive mucinous, low grade; doxorubicin treatment, also contains T238H, C239L, R241P	Leu240Pro	Wang et al. 2017. Protoplasma 254:1163-1173	https://pubmed.ncbi.nlm.nih.gov/27943021/	Homo sapiens, human, clinical	Tubulin beta-1 chain
		β240	L240P	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	Invasive lobular, low grade; doxorubicin treatment, also contains C239L, R241P	Leu240Pro	Wang et al. 2017. Protoplasma 254:1163-1173	https://pubmed.ncbi.nlm.nih.gov/27943021/	Homo sapiens, human, clinical	Tubulin beta-1 chain
		β241	H241Y	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with H190Y, H235Y, H118Y, tubulin beta-4A	His241Tyr	ClinVar 192383	https://www.ncbi.nlm.nih.gov/clinvar/variation/192383	Homo sapiens, human, clinical
		β241	R241C	P68371	https://www.uniprot.org/uniprotkb/P68371/entry	H. sapiens	TBB4B SNP, DOID:3571 / liver cancer	Arg241Cys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P68371	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β241	R241C	P68371	https://www.uniprot.org/uniprotkb/P68371/entry	H. sapiens	TBB4B SNP, DOID:0070003 / blastoma	Arg241Cys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P68371	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β241	R241C	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:1612 / breast cancer	Arg241Cys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β241	R241C	Q9BUF5	https://www.uniprot.org/uniprotkb/Q9BUF5/entry	H. sapiens	TBB6 SNP, DOID:3963 / thyroid carcinoma	Arg241Cys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BUF5	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β241	R241C	Q9BUF5	https://www.uniprot.org/uniprotkb/Q9BUF5/entry	H. sapiens	TBB6 SNP, DOID:1324 / lung cancer	Arg241Cys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BUF5	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β241	R241C	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Female infertility, tubulin beta-8	Arg241Cys	Chen et al. 2019. Eur J Hum Genet 27:300-307	https://pubmed.ncbi.nlm.nih.gov/30297906/	Homo sapiens, human, clinical
		β241	R241H	Q9BUF5	https://www.uniprot.org/uniprotkb/Q9BUF5/entry	H. sapiens	TBB6 SNP, DOID:363 / uterine cancer	Arg241His	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BUF5	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β241	R241H	Q9BVA1	https://www.uniprot.org/uniprotkb/Q9BVA1/entry	H. sapiens	Myoclonus-dystonia, tubulin beta-2B	Arg241His	Geiger et al. 2017. Case Rep Neurol 9: 216-221	https://pubmed.ncbi.nlm.nih.gov/28966590/	Homo sapiens, human, clinical
		β241	R241H	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Benomyl resistant, cold sensitive, TUB2p	Arg241His	Thomas et al. 1985. Genetics 111:715-34.	https://pubmed.ncbi.nlm.nih.gov/2998923/	Saccharomyces cerevisiae, budding yeast, fungus
		β241	R241H	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Female infertility, tubulin beta-8	Arg241His	Chen et al. 2019. Eur J Hum Genet 27:300-307	https://pubmed.ncbi.nlm.nih.gov/30297906/	Homo sapiens, human, clinical
		β241	R241H	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Female infertility, tubulin beta-8	Arg241His	Yang et al. 2021. Clin Genet 99:208-214	https://pubmed.ncbi.nlm.nih.gov/33009822/	Homo sapiens, human, clinical
		β241	R241H	Q18817	https://www.uniprot.org/uniprotkb/Q18817/entry	C. elegans	Albendazole resistance, ben-1	Arg241His	Pallotto et al. 2022. Genetics 221:iyac093	https://pubmed.ncbi.nlm.nih.gov/35731216/	Caenorhabditis elegans, nematode, roundworm
		β241	R241P	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	Invasive ductal, low grade; no treatment, also contains C239L, I152T, L240P, L273P	Arg241Pro	Wang et al. 2017. Protoplasma 254:1163-1173	https://pubmed.ncbi.nlm.nih.gov/27943021/	Homo sapiens, human, clinical	Tubulin beta-1 chain
		β241	R241P	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	Invasive ductal, low grade; no treatment, also contains C239L, T237H, T238H, L240P, R241P	Arg241Pro	Wang et al. 2017. Protoplasma 254:1163-1173	https://pubmed.ncbi.nlm.nih.gov/27943021/	Homo sapiens, human, clinical	Tubulin beta-1 chain
		β241	R241P	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	Invasive ductal, low grade; no treatment, also contains C239P, L240P	Arg241Pro	Wang et al. 2017. Protoplasma 254:1163-1173	https://pubmed.ncbi.nlm.nih.gov/27943021/	Homo sapiens, human, clinical	Tubulin beta-1 chain
		β241	R241P	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	Invasive mucinous, low grade; doxorubicin treatment, also contains T238H, C239L, L240P	Arg241Pro	Wang et al. 2017. Protoplasma 254:1163-1173	https://pubmed.ncbi.nlm.nih.gov/27943021/	Homo sapiens, human, clinical	Tubulin beta-1 chain
		β241	R241P	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	Invasive lobular, low grade; doxorubicin treatment, also contains C239L, L240P	Arg241Pro	Wang et al. 2017. Protoplasma 254:1163-1173	https://pubmed.ncbi.nlm.nih.gov/27943021/	Homo sapiens, human, clinical	Tubulin beta-1 chain
		β241	R241S	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:1324 / lung cancer	Arg241Ser	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β241	T241I	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	Cortical dysplasia, brain malformations, with T221I, T149I, T177I, tubulin beta	Thr241Ile	ClinVar 235892	https://www.ncbi.nlm.nih.gov/clinvar/variation/235892	Homo sapiens, human, clinical
		β242	A242V	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Conflicting interpretations, with A365V, A314V, A359V, tubulin beta-4A	Ala242Val	ClinVar 267783	https://www.ncbi.nlm.nih.gov/clinvar/variation/267783	Homo sapiens, human, clinical
		β242	F242L	Q13885	https://www.uniprot.org/uniprotkb/Q13885/entry	H. sapiens	Likely pathogenic, with F157L, tubulin beta-2A	Phe242Leu	ClinVar 432097	https://www.ncbi.nlm.nih.gov/clinvar/variation/432097	Homo sapiens, human, clinical
		β242	Y242C	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Cold sensitive microtubules, with M233V, Q245L, TUB2p	Tyr242Cys	Huffaker et al. 1988. J Cell Biol 106:1997-2010	https://pubmed.ncbi.nlm.nih.gov/3290223/	Saccharomyces cerevisiae, budding yeast, fungus
		β242	Y242F	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	Symmetric circumferential skin creases, with Y222F, Y178F, Y150F, tubulin beta	Tyr242Phe	ClinVar 218926	https://www.ncbi.nlm.nih.gov/clinvar/variation/218926	Homo sapiens, human, clinical
		β243	P243L	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:9256 / colorectal cancer	Pro243Leu	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β243	P243L	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:1324 / lung cancer	Pro243Leu	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β243	P243L	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:1909 / melanoma	Pro243Leu	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β243	P243L	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:9256 / colorectal cancer	Pro243Leu	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β243	P243L	Q9BUF5	https://www.uniprot.org/uniprotkb/Q9BUF5/entry	H. sapiens	TBB6 SNP, DOID:0060119 / pharynx cancer	Pro243Leu	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BUF5	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β243	P243L	P12456	https://www.uniprot.org/uniprotkb/P12456/entry	C. elegans	Antimorph, short TRN neurites, mec-7	Pro243Leu	Zheng et al. 2017 Mol Biol Cell 28: 2786-2801	https://pubmed.ncbi.nlm.nih.gov/28835377/	Caenorhabditis elegans, nematode, roundworm	also see Lee et al. 2021. Mol Biol Cell. 15:331-347 (PMID 33378215)
		β243	P243L	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Cortical malformations, tubulin beta-3	Pro243Leu	Reches et al. 2018. J Perinatol 38:1301-1308	https://pubmed.ncbi.nlm.nih.gov/30108342/	Homo sapiens, human, clinical
		β243	P243L	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Motor impairment, intellectual disability & epilepsy, tubulin beta-3	Pro243Leu	Romaniello et al. 2019. Cells 8:669	https://pubmed.ncbi.nlm.nih.gov/31269740/	Homo sapiens, human, clinical
		β243	P243L	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Dysgyria, cortical malformations, tubulin beta-3	Pro243Leu	Blumkin et al. 2020. Eur J Paediatr Neurol 26:46-60	https://pubmed.ncbi.nlm.nih.gov/32169460/	Homo sapiens, human, clinical
		β243	P243L	Q13885	https://www.uniprot.org/uniprotkb/Q13885/entry	H. sapiens	Infantile-onset epilepsy & global developmental delay, tubulin beta-2A	Pro243Leu	Cai et al. 2020. J Hum Genet 65:601-608	https://pubmed.ncbi.nlm.nih.gov/32203252/	Homo sapiens, human, clinical
		β243	P243L	Q9BVA1	https://www.uniprot.org/uniprotkb/Q9BVA1/entry	H. sapiens	Cortical dysplasia, tubulin beta-2B	Pro243Leu	Çitli et al. 2020. Fetal Pediatr Pathol 13:1-11	https://pubmed.ncbi.nlm.nih.gov/32281916/	Homo sapiens, human, clinical
		β243	P243L	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Female infertility, tubulin beta-8	Pro243Leu	Zhao et al. 2020. J Assist Reprod Genet 37:1837-47.	https://pubmed.ncbi.nlm.nih.gov/32524331/	Homo sapiens, human, clinical
		β243	P243L	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Female infertility, tubulin beta-8	Pro243Leu	Yang et al. 2021. Clin Genet 99:208-214	https://pubmed.ncbi.nlm.nih.gov/33009822/	Homo sapiens, human, clinical
		β243	P243L	P12456	https://www.uniprot.org/uniprotkb/P12456/entry	C. elegans	Mechanosensitive, dominant, mec-7	Pro243Leu	Savage et al. 1994. J Cell Sci 107:2165-75	https://pubmed.ncbi.nlm.nih.gov/7983175/	Caenorhabditis elegans, nematode, roundworm
		β243	P243L	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Cortical dysplasia, brain malformations, with P171L, tubulin beta-3	Pro243Leu	ClinVar 160195	https://www.ncbi.nlm.nih.gov/clinvar/variation/160195	Homo sapiens, human, clinical
		β243	P243L	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	Cortical dysplasia, brain malformation, with P287L, P307L, P215L, tubulin beta	Pro243Leu	ClinVar 438586	https://www.ncbi.nlm.nih.gov/clinvar/variation/438586	Homo sapiens, human, clinical
		β243	P243L	Q13885	https://www.uniprot.org/uniprotkb/Q13885/entry	H. sapiens	Pathogenic, with P158L, tubulin beta-2A	Pro243Leu	ClinVar 546138	https://www.ncbi.nlm.nih.gov/clinvar/variation/546138	Homo sapiens, human, clinical
		β243	P243L	Q13885	https://www.uniprot.org/uniprotkb/Q13885/entry	H. sapiens	Pathogenic, with P158L, tubulin beta-2A	Pro243Leu	ClinVar 546138	https://www.ncbi.nlm.nih.gov/clinvar/variation/546138	Homo sapiens, human, clinical
		β243	P243Q	Q9BUF5	https://www.uniprot.org/uniprotkb/Q9BUF5/entry	H. sapiens	TBB6 SNP, DOID:10283 / prostate cancer	Pro243Gln	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BUF5	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β243	P243S	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:1909 / melanoma	Pro243Ser	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β243	P243S	P12456	https://www.uniprot.org/uniprotkb/P12456/entry	C. elegans	Loss-of-function, short PLM-PN, mec-7	Pro243Ser	Zheng et al. 2017 Mol Biol Cell 28: 2786-2801	https://pubmed.ncbi.nlm.nih.gov/28835377/	Caenorhabditis elegans, nematode, roundworm	also see Lee et al. 2021. Mol Biol Cell. 15:331-347 (PMID 33378215)
		β244	G244A	Q13885	https://www.uniprot.org/uniprotkb/Q13885/entry	H. sapiens	Likely pathogenic, with G159A, tubulin beta-2A	Gly244Ala	ClinVar 384308	https://www.ncbi.nlm.nih.gov/clinvar/variation/384308	Homo sapiens, human, clinical
		β244	G244C	Q9BUF5	https://www.uniprot.org/uniprotkb/Q9BUF5/entry	H. sapiens	TBB6 SNP, DOID:9256 / colorectal cancer	Gly244Cys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BUF5	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β244	G244C	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Ventriculomegaly & agenesis of the corpus callosum, tubulin beta-3	Gly244Cys	Guduru et al. 2020. Radiol Case Rep 16:381-383	https://pubmed.ncbi.nlm.nih.gov/33318778/	Homo sapiens, human, clinical	Personal communication with A. Beavers
		β244	G244D	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:2531 / hematologic cancer	Gly244Asp	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β244	G244D	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Hypomyelinating leukodystrophy, TUBB4A	Gly244Asp	Tonduti et al. 2016. Eur J Paediatr Neurol 20:323-30	https://pubmed.ncbi.nlm.nih.gov/26643067/	Homo sapiens, human, clinical	In 3 patients
		β244	G244D	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with G295D, G172D, G289D, tubulin beta-4A	Gly244Asp	ClinVar 267778	https://www.ncbi.nlm.nih.gov/clinvar/variation/267778	Homo sapiens, human, clinical
		β244	G245E	P12411	https://www.uniprot.org/uniprotkb/P12411/entry	A. thaliana	Twisting, TUB1	Gly245Glu	Ishida et al. 2007. PNAS 104:8544-9	https://pubmed.ncbi.nlm.nih.gov/17488810/	Arabidopsis thaliana, plant
		β244	G244R	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with G172R, G289R, G295R, tubulin beta-4A	Gly244Arg	ClinVar 803516	https://www.ncbi.nlm.nih.gov/clinvar/variation/803516	Homo sapiens, human, clinical
		β244	G244S	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Hypomyelination, basal ganglia & cerebellum atrophy, tubulin beta-4A, 3 patients	Gly244Ser	Hamilton et al. 2014. Brain 137:1921-30	https://pubmed.ncbi.nlm.nih.gov/24785942/	Homo sapiens, human, clinical
		β244	G244S	P12456	https://www.uniprot.org/uniprotkb/P12456/entry	C. elegans	Antimorph, short TRN neurites, mec-7	Gly244Ser	Zheng et al. 2017 Mol Biol Cell 28: 2786-2801	https://pubmed.ncbi.nlm.nih.gov/28835377/	Caenorhabditis elegans, nematode, roundworm	also see Lee et al. 2021. Mol Biol Cell. 15:331-347 (PMID 33378215)
		β244	G244S	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Human oocyte maturation arrest and female infertility, TUBB8	Gly244Ser	Li et al. 2022. Eur J Obstet Gynecol Reprod Biol 279:132-139	https://pubmed.ncbi.nlm.nih.gov/36335766/	Homo sapiens, human, clinical
		β244	G244S	P12456	https://www.uniprot.org/uniprotkb/P12456/entry	C. elegans	Mechanosensitive, dominant, mec-7	Gly244Ser	Savage et al. 1994. J Cell Sci 107:2165-75	https://pubmed.ncbi.nlm.nih.gov/7983175/	Caenorhabditis elegans, nematode, roundworm
		β244	G244S	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with G295S, G289S, G172S, tubulin beta-4A	Gly244Ser	ClinVar 267772	https://www.ncbi.nlm.nih.gov/clinvar/variation/267772	Homo sapiens, human, clinical
		β244	G244V	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Hypomyelination, basal ganglia & cerebellum atrophy, tubulin beta-4A	Gly244Val	Hamilton et al. 2014. Brain 137:1921-30	https://pubmed.ncbi.nlm.nih.gov/24785942/	Homo sapiens, human, clinical
		β244	G244V	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Hypomyelinating leukodystrophy, TUBB4A	Gly244Val	Tonduti et al. 2016. Eur J Paediatr Neurol 20:323-30	https://pubmed.ncbi.nlm.nih.gov/26643067/	Homo sapiens, human, clinical
		β244	G244V	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with G295V, G172V, G289V, tubulin beta-4A	Gly244Val	ClinVar 267777	https://www.ncbi.nlm.nih.gov/clinvar/variation/267777	Homo sapiens, human, clinical
		β244	V244M	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Uncertain significance, with V316M, tubulin beta-3	Val244Met	ClinVar 212500	https://www.ncbi.nlm.nih.gov/clinvar/variation/212500	Homo sapiens, human, clinical
		β245	Q245H	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Female infertility, tubulin beta-8	Gln245His	Chen et al. 2019. Eur J Hum Genet 27:300-307	https://pubmed.ncbi.nlm.nih.gov/30297906/	Homo sapiens, human, clinical
		β245	Q245H	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Female infertility, tubulin beta-8	Gln245His	Lanuza-López et al. 2020. Gynecol Endocrinol 36:829-834	https://pubmed.ncbi.nlm.nih.gov/32063091/	Homo sapiens, human, clinical
		β245	Q245H	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Oocyte maturation defect, tubulin beta-8	Gln245His	ClinVar 684762	https://www.ncbi.nlm.nih.gov/clinvar/variation/684762	Homo sapiens, human, clinical
		β245	Q245L	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Cold sensitive microtubules, with M233V, Y242C, TUB2p	Gln245Leu	Huffaker et al. 1988. J Cell Biol 106:1997-2010	https://pubmed.ncbi.nlm.nih.gov/3290223/	Saccharomyces cerevisiae, budding yeast, fungus
		β245	Q245R	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:1612 / breast cancer	Gln245Arg	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β247	N247I	P12456	https://www.uniprot.org/uniprotkb/P12456/entry	C. elegans	Antimorph, short TRN neurites, mec-7	Asn247Ile	Zheng et al. 2017 Mol Biol Cell 28: 2786-2801	https://pubmed.ncbi.nlm.nih.gov/28835377/	Caenorhabditis elegans, nematode, roundworm	also see Lee et al. 2021. Mol Biol Cell. 15:331-347 (PMID 33378215)
		β247	N247I	P12456	https://www.uniprot.org/uniprotkb/P12456/entry	C. elegans	Mechanosensitive, dominant, mec-7	Asn247Ile	Savage et al. 1994. J Cell Sci 107:2165-75	https://pubmed.ncbi.nlm.nih.gov/7983175/	Caenorhabditis elegans, nematode, roundworm
		β247	N247K	Q13885	https://www.uniprot.org/uniprotkb/Q13885/entry	H. sapiens	Simplified gyral patterning, infantile-onset epilepsy, tubulin beta-2A	Asn247Lys	Cushion et al. 2014. Am J Hum Genet 94:634-41	https://pubmed.ncbi.nlm.nih.gov/24702957/	Homo sapiens, human, clinical
		β247	N247K	Q13885	https://www.uniprot.org/uniprotkb/Q13885/entry	H. sapiens	Cortical dysplasia, brain malformations, with N162K, tubulin beta-2A	Asn247Lys	ClinVar 127100	https://www.ncbi.nlm.nih.gov/clinvar/variation/127100	Homo sapiens, human, clinical
		β247	N247S	Q9CWF2	https://www.uniprot.org/uniprotkb/Q9CWF2/entry	M. musculus	Hippocampal disorganization, tubulin beta-2B	Asn247Ser	Stottmann et al. 2013. Hum Mol Genet 22:4053-63	https://pubmed.ncbi.nlm.nih.gov/23727838/	Mus musculus, mouse	Also see Stottmann et al. 2017. Genes Brain Behav 16:250-259
		β247	N247S	Q9CWF2	https://www.uniprot.org/uniprotkb/Q9CWF2/entry	M. musculus	Hippocampal disorganization, tubulin beta-2B	Asn247Ser	Stottmann et al. 2013. Hum Mol Genet 22:4053-63	https://pubmed.ncbi.nlm.nih.gov/23727838/	Mus musculus, mouse	Also see Stottmann et al. 2017. Genes Brain Behav 16:250-259
		β247	N247S	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Cortical dysplasia, brain malformations, with N175S, tubulin beta-3	Asn247Ser	ClinVar 160196	https://www.ncbi.nlm.nih.gov/clinvar/variation/160196	Homo sapiens, human, clinical
		β248	A248T	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:363 / uterine cancer	Ala248Thr	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, clinical	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β248	A248T	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	2-methoxyestradiol resistant, tubulin beta	Ala248Thr	Liaw et al. 2008. Mol Cancer Ther 7:3150-9	https://pubmed.ncbi.nlm.nih.gov/18852118/	Homo sapiens, human, clinical
		β248	A248T	Q9BVA1	https://www.uniprot.org/uniprotkb/Q9BVA1/entry	H. sapiens	Malformation of cortical development, fetal sample, tubulin beta-2B	Ala248Thr	Fallet-Bianco et al. 2014. Acta Neuropathol Commun 2:69	https://pubmed.ncbi.nlm.nih.gov/25059107/	Homo sapiens, human, clinical
		β248	A248T	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	Colchicine‑resistant familial Mediterranean fever, tubulin beta	Ala248Thr	Sahakyan et al. 2019. PLoS One 14:e0221532	https://pubmed.ncbi.nlm.nih.gov/31442266/	Computational modeling, clinical	Model of colchicine binding to variants
		β248	A248T	Q9BVA1	https://www.uniprot.org/uniprotkb/Q9BVA1/entry	H. sapiens	Cortical malformations, tubulin beta-2B	Ala248Thr	Cabet 2021. Ultrasound Obstet Gynecol 57: 493 – 497	https://pubmed.ncbi.nlm.nih.gov/32149430/	Homo sapiens, human, clinical
		β248	A248V	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:3571 / liver cancer	Ala248Val	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β248	A248V	Q9BVA1	https://www.uniprot.org/uniprotkb/Q9BVA1/entry	H. sapiens	TBB2B SNP, DOID:1612 / breast cancer	Ala248Val	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BVA1	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β248	A248V	Q9BVA1	https://www.uniprot.org/uniprotkb/Q9BVA1/entry	H. sapiens	TBB2B SNP, DOID:3571 / liver cancer	Ala248Val	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BVA1	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β248	A248V	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	Paclitaxel resistant, tubulin beta-1	Ala248Val	Yin et al. 2010. Mol Cancer Ther 9:327-35	https://pubmed.ncbi.nlm.nih.gov/20103599/	Homo sapiens, human, clinical
		β248	A248V	Q13885	https://www.uniprot.org/uniprotkb/Q13885/entry	H. sapiens	Simplified gyral patterning, infantile-onset epilepsy, tubulin beta-2A	Ala248Val	Cushion et al. 2014. Am J Hum Genet 94:634-41	https://pubmed.ncbi.nlm.nih.gov/24702957/	Homo sapiens, human, clinical
		β248	A248V	Q13885	https://www.uniprot.org/uniprotkb/Q13885/entry	H. sapiens	Anterior temporal pachygyria, tubulin beta-2A	Ala248Val	Rodan et al. 2017. J Child Neurol 32:127-131	https://pubmed.ncbi.nlm.nih.gov/27770045/	Homo sapiens, human, clinical
		β248	A248V	Q13885	https://www.uniprot.org/uniprotkb/Q13885/entry	H. sapiens	Infantile-onset epilepsy & global developmental delay, tubulin beta-2A	Ala248Val	Cai et al. 2020. J Hum Genet 65:601-608	https://pubmed.ncbi.nlm.nih.gov/32203252/	Homo sapiens, human, clinical
		β248	A248V	Q13885	https://www.uniprot.org/uniprotkb/Q13885/entry	H. sapiens	Tubulinopathy, brain malformations, 3 patients, tubulin beta-2A	Ala248Val	Brock et al. 2021. J Med Genet 58:33-40	https://pubmed.ncbi.nlm.nih.gov/32571897/	Homo sapiens, human, clinical	3 unrelated patients
		β248	A248V	Q13885	https://www.uniprot.org/uniprotkb/Q13885/entry	H. sapiens	Intellectual disability and seizures, tubulin beta-2A	Ala248Val	Ragoussis et al. 2022. J Med Genet 59:366–9.	https://pubmed.ncbi.nlm.nih.gov/33547136/	Homo sapiens, human, clinical
		β248	A248V	Q13885	https://www.uniprot.org/uniprotkb/Q13885/entry	H. sapiens	Cortical dysplasia, brain malformations, with A163V, tubulin beta-2A	Ala248Val	ClinVar 127101	https://www.ncbi.nlm.nih.gov/clinvar/variation/127101	Homo sapiens, human, clinical
		β248	F248S	Q9BUF5	https://www.uniprot.org/uniprotkb/Q9BUF5/entry	H. sapiens	Facial palsy, ptosis & velopharyngeal dysfunction, with F394S, F322S, F329S, F357S, tubulin beta-6	Phe248Ser	ClinVar 444894	https://www.ncbi.nlm.nih.gov/clinvar/variation/444894	Homo sapiens, human, clinical
		β248	L248V	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	Likely pathogenic, with L228V, L156V, L184V, tubulin beta	Leu248Val	ClinVar 392956	https://www.ncbi.nlm.nih.gov/clinvar/variation/392956	Homo sapiens, human, clinical
		β248	S248P	A0A1S4C3U3	https://www.uniprot.org/uniprotkb/A0A1S4C3U3/entry#function	N. plumbaginifolia	Dinitroaniline resistant, beta isotype not specified	Ser248Pro	Emets et al. 2009. Tsitol Genet 43:69-76	https://pubmed.ncbi.nlm.nih.gov/20458969/	Nicotiana plumbaginifolia, tobacco plant
		β249	D249A	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Recessive lethal, with R251A, K252A, TUB2p	Asp249Ala	Reijo et al. 1994. Mol Biol Cell 5:29-43	https://pubmed.ncbi.nlm.nih.gov/8186463/	Saccharomyces cerevisiae, budding yeast, fungus
		β249	D249E	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Invasive mucinous, low grade; no treatment, also contains M293V, T315A, A332N, I333V, S335N, V351T, A352V, S364A, S365V	Asp249Glu	Wang et al. 2017. Protoplasma 254:1163-1173	https://pubmed.ncbi.nlm.nih.gov/27943021/	Homo sapiens, human, clinical	Tubulin beta-3 chain
		β249	D249E	Q9BVA1	https://www.uniprot.org/uniprotkb/Q9BVA1/entry	H. sapiens	Lissencephaly, tubulin beta-2B	Asp249Glu	Di Donato et al. 2018. Genet Med 20:1354-1364	https://pubmed.ncbi.nlm.nih.gov/29671837/	Homo sapiens, human, clinical
		β249	D249N	A0A8C0T7N2	https://www.uniprot.org/uniprotkb/A0A8C0T7N2/entry	C. familiaris	Macrothrombocytopenia, tubulin-beta-1	Asp249Asn	Davis et al. 2008. J Vet Intern Med 22:540-5	https://pubmed.ncbi.nlm.nih.gov/18466252/	Canis familiaris, dog
		β249	D249N	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Hypomyelination, basal ganglia & cerebellum atrophy, tubulin beta-4A	Asp249Asn	Simons et al. 2013. Am J Hum Genet 92:767-73	https://pubmed.ncbi.nlm.nih.gov/23582646/	Homo sapiens, human, clinical
		β249	D249N	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Hypomyelination, basal ganglia & cerebellum atrophy, tubulin beta-4A, 25 patients	Asp249Asn	Hamilton et al. 2014. Brain 137:1921-30	https://pubmed.ncbi.nlm.nih.gov/24785942/	Homo sapiens, human, clinical
		β249	D249N	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Hypomyelination, basal ganglia & cerebellum atrophy, tubulin beta-4A, 2 patients	Asp249Asn	Miyatake et al. 2014. Neurology 82:2230-7	https://pubmed.ncbi.nlm.nih.gov/24850488/	Homo sapiens, human, clinical
		β249	D249N	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Severe generalized dystonia, TUBB4A	Asp249Asn	Erro et al. 2015. Mov Disord 30:828-33	https://pubmed.ncbi.nlm.nih.gov/25545912/	Homo sapiens, human, clinical
		β249	D249N	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Hypomyelinating leukodystrophy, TUBB4A	Asp249Asn	Tonduti et al. 2016. Eur J Paediatr Neurol 20:323-30	https://pubmed.ncbi.nlm.nih.gov/26643067/	Homo sapiens, human, clinical	In 5 patients
		β249	D249N	P12456	https://www.uniprot.org/uniprotkb/P12456/entry	C. elegans	Antimorph, short TRN neurites, mec-7	Asp249Asn	Zheng et al. 2017 Mol Biol Cell 28: 2786-2801	https://pubmed.ncbi.nlm.nih.gov/28835377/	Caenorhabditis elegans, nematode, roundworm	also see Lee et al. 2021. Mol Biol Cell. 15:331-347 (PMID 33378215)
		β249	D249N	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Hypomyelination, basal ganglia & cerebellum atrophy, slowed microtubule growth, tubulin beta-4A	Asp249Asn	Curiel et al. 2017. Hum Mol Genet 26:4506-4518	https://pubmed.ncbi.nlm.nih.gov/28973395/	Homo sapiens, human, clinical
		β249	D249N	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Hypomyelination, basal ganglia & cerebellum atrophy, tubulin beta-4A	Asp249Asn	Delgado et al. 2018. Neuropediatrics 49:76-77	https://pubmed.ncbi.nlm.nih.gov/29076120/	Homo sapiens, human, clinical
		β249	D249N	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	M. musculus	Glial & neuronal degeneration, tubulin beta-4A	Asp249Asn	Sase et al. 2020. Elife 9:e52986. doi: 10.7554/eLife.52986	https://pubmed.ncbi.nlm.nih.gov/32463361/	Mus musculus, mouse	Tubulinopathy model
		β249	D249N	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Hypomyelination& atrophy of basal ganglia & cerebellum, tubulin beta-4A	Asp249Asn	Lopez-Juarez et al. 2021. J Comp Neurol 529:957-968	https://pubmed.ncbi.nlm.nih.gov/32681585/	Homo sapiens, human, clinical
		β249	D249N	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Perturbed micicrotubule polymerization, tubulin beta-4A	Asp249Asn	Krajka et al. 2022. Sci. Adv. 8:eabj9229.	https://pubmed.ncbi.nlm.nih.gov/35275727/	Homo sapiens, human, clinical
		β249	D249N	P12456	https://www.uniprot.org/uniprotkb/P12456/entry	C. elegans	Mechanosensitive, dominant, mec-7	Asp249Asn	Savage et al. 1994. J Cell Sci 107:2165-75	https://pubmed.ncbi.nlm.nih.gov/7983175/	Caenorhabditis elegans, nematode, roundworm
		β249	D249N	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with D300N, D177N, D294N, tubulin beta-4A	Asp249Asn	ClinVar 50985	https://www.ncbi.nlm.nih.gov/clinvar/variation/50985	Homo sapiens, human, clinical
		β249	D249V	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	Inherited bone marrow failure, TUBB	Asp249Val	Shah et al. 2023. Br J Haematol 200:222–228	https://pubmed.ncbi.nlm.nih.gov/36207145/	Homo sapiens, human, clinical
		β250	L250F	P24636	https://www.uniprot.org/uniprotkb/P24636/entry	A. thaliana	Twisting, TUB4	Leu250Phe	Ishida et al. 2007. PNAS 104:8544-9	https://pubmed.ncbi.nlm.nih.gov/17488810/	Arabidopsis thaliana, plant
		β250	L250F	P05220	https://www.uniprot.org/uniprotkb/P05220/entry	N. crassa	Carbendazim & diethofencarb resistant	Leu250Phe	Fujimura et al. 1994. Curr Genet 25:418-22	https://pubmed.ncbi.nlm.nih.gov/8082187/	Neurospora crassa, fungus, red bread mold
		β250	L250F	Q18817	https://www.uniprot.org/uniprotkb/Q18817/entry	C. elegans	Albendazole resistance, ben-1	Leu250Phe	Pallotto et al. 2022. Genetics 221:iyac093	https://pubmed.ncbi.nlm.nih.gov/35731216/	Caenorhabditis elegans, nematode, roundworm
		β250	L250M	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:9256 / colorectal cancer	Leu250Met	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β251	M251R	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with M374R, M323R, M368R, tubulin beta-4A	M251Arg	ClinVar 267784	https://www.ncbi.nlm.nih.gov/clinvar/variation/267784	Homo sapiens, human, clinical
		β251	M251V	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Cortical dysplasia, other brain malformations, with M323V, tubulin beta-3	Met251Val	ClinVar 30272	https://www.ncbi.nlm.nih.gov/clinvar/variation/30272	Homo sapiens, human, clinical
		β251	R251A	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Recessive lethal, with D249A, K252A, TUB2p	Arg251Ala	Reijo et al. 1994. Mol Biol Cell 5:29-43	https://pubmed.ncbi.nlm.nih.gov/8186463/	Saccharomyces cerevisiae, budding yeast, fungus
		β251	R251C	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:3070 / malignant glioma	Arg251Cys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β251	R251C	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:9256 / colorectal cancer	Arg251Cys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β251	R251C	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	TUBB SNP, DOID:363 / uterine cancer	Arg251Cys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P07437	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β251	R251C	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:1793 / pancreatic cancer	Arg251Cys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β251	R251C	Q9BUF5	https://www.uniprot.org/uniprotkb/Q9BUF5/entry	H. sapiens	TBB6 SNP, DOID:9256 / colorectal cancer	Arg251Cys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BUF5	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β251	R251C	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:363 / uterine cancer	Arg251Cys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β251	R251H	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:363 / uterine cancer	Arg251His	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β251	R251H	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:1324 / lung cancer	Arg251His	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β251	R251H	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:10534 / stomach cancer	Arg251His	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β251	R251H	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	Thrombocytopenia, tubulin beta	Arg251His	Matsumura et al. 2019. Br J Haematol 185:888-902	https://pubmed.ncbi.nlm.nih.gov/30854628/	Homo sapiens, human, clinical
		β251	R251Q	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:9256 / colorectal cancer	Arg251Gln	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β251	R251Q	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:363 / uterine cancer	Arg251Gln	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β251	R251Q	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:1324 / lung cancer	Arg251Gln	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β251	R251Q	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Infertility, oocyte maturation arrest, tubulin beta-8	Arg251Gln	Yao et al. 2022. J Ovar Research 15:38	https://pubmed.ncbi.nlm.nih.gov/35354490/	Homo sapiens, human, clinical
		β251	R251W	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:363 / uterine cancer	Arg251Trp	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β252	K252A	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	Acetylation mimetic, reduced polymerization, tubulin beta	Lys252Ala	Chu et al. 2011. Mol Biol Cell 22:448-56	https://pubmed.ncbi.nlm.nih.gov/21177827/	Homo sapiens, human, clinical
		β252	K252A	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Acetylation mimetic, reduced polymerization, tubulin beta-3	Lys252Ala	Chu et al. 2011. Mol Biol Cell 22:448-56	https://pubmed.ncbi.nlm.nih.gov/21177827/	Homo sapiens, human, clinical
		β252	K252A	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Recessive lethal, with D249A, R251A, TUB2p	Lys252Ala	Reijo et al. 1994. Mol Biol Cell 5:29-43	https://pubmed.ncbi.nlm.nih.gov/8186463/	Saccharomyces cerevisiae, budding yeast, fungus
		β252	K252N	P68371	https://www.uniprot.org/uniprotkb/P68371/entry	H. sapiens	TBB4B SNP, DOID:2994 / germ cell cancer	Lys252Asn	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P68371	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β252	K252N	P68371	https://www.uniprot.org/uniprotkb/P68371/entry	H. sapiens	TBB4B SNP, DOID:1790 / malignant mesothelioma	Lys252Asn	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P68371	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β252	K252N	P68371	https://www.uniprot.org/uniprotkb/P68371/entry	H. sapiens	TBB4B SNP, DOID:1612 / breast cancer	Lys252Asn	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P68371	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β252	K252N	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:2994 / germ cell cancer	Lys252Asn	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β252	K252Q	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	Acetylation mimetic, reduced polymerization, tubulin beta	Lys252Gln	Chu et al. 2011. Mol Biol Cell 22:448-56	https://pubmed.ncbi.nlm.nih.gov/21177827/	Homo sapiens, human, clinical
		β252	K252Q	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Acetylation mimetic, reduced polymerization, tubulin beta-3	Lys252Gln	Chu et al. 2011. Mol Biol Cell 22:448-56	https://pubmed.ncbi.nlm.nih.gov/21177827/	Homo sapiens, human, clinical
		β253	L253P	Q9BVA1	https://www.uniprot.org/uniprotkb/Q9BVA1/entry	H. sapiens	Cortical malformations, tubulin beta-2B	Leu253Pro	Accogli et al. 2020. Seizure 80:145-152	https://pubmed.ncbi.nlm.nih.gov/32570172/	Homo sapiens, human, clinical
		β253	L253V	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	Colchicine‑resistant familial Mediterranean fever, tubulin beta	Leu253Val	Sahakyan et al. 2019. PLoS One 14:e0221532	https://pubmed.ncbi.nlm.nih.gov/31442266/	Computational modeling, clinical	Model of colchicine binding to variants
		β254	A254D	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:363 / uterine cancer	Ala254Asp	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β254	A254G	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:11054 / urinary bladder cancer	Ala254Gly	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β254	A254S	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:1324 / lung cancer	Ala254Ser	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β254	A254T	P12456	https://www.uniprot.org/uniprotkb/P12456/entry	C. elegans	Partial loss-of-function, no PLM synaptic branch, mec-7	Ala254Thr	Lee et al. 2021. Mol Biol Cell. 15:331-347	https://pubmed.ncbi.nlm.nih.gov/33378215/	Caenorhabditis elegans, nematode, roundworm
		β254	A254V	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:9256 / colorectal cancer	Ala254Val	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β254	A254V	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:1909 / melanoma	Ala254Val	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β254	A254V	P69893	https://www.uniprot.org/uniprotkb/P69893/entry	C. griseus	Taxol resistant revertant of D45Y, CHO cell line, tubulin beta-5	Ala254Val	Wang et al. 2004. Biochemistry 43:8965-73.	https://pubmed.ncbi.nlm.nih.gov/15248754/	Cricetulus griseus, chinese hamster, rodent
		β255	M255V	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	Cortical dysplasia, brain malformations, with M299V, M227V, M319V, tubulin beta	Met255Val	ClinVar 127189	https://www.ncbi.nlm.nih.gov/clinvar/variation/127189	Homo sapiens, human, clinical
		β255	V255I	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:363 / uterine cancer	Val255Ile	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β255	V255I	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:10534 / stomach cancer	Val255Ile	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β255	V255I	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:1793 / pancreatic cancer	Val255Ile	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β255	V255I	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:363 / uterine cancer	Val255Ile	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β255	V255I	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:10283 / prostate cancer	Val255Ile	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β255	V255I	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Hypomyelination, spastic quadriparesis, reduced microtubule assembly, tubulin beta-4A	Val255Ile	Curiel et al. 2017. Hum Mol Genet 26:4506-4518	https://pubmed.ncbi.nlm.nih.gov/28973395/	Homo sapiens, human, clinical
		β255	V255I	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Developmental delay, epilepsy, mild ophthalmological symptoms, tubulin beta-3	Val255Ile	Xue et al. 2022. J Mol Neurosci 72:37–44.	https://pubmed.ncbi.nlm.nih.gov/34562182/	Homo sapiens, human, clinical
		β255	V255I	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Severe intellectual disability, TUBB3	Val255Ile	de Boer et al.2022. Eur J of Med Gen 65: 104402	https://pubmed.ncbi.nlm.nih.gov/34863918/	Homo sapiens, human, clinical
		β255	V255I	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Isolated hypomyelination, increased microtubule stability, tubulin beta-4A	Val255Ile	Xiao et al. 2022. Mol Neurobiol 59:5056-69	https://pubmed.ncbi.nlm.nih.gov/35668344/	Homo sapiens, human, clinical
		β255	V255I	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Isolated hypomyelination, tubulin beta-4A	Val255Ile	Xiao et al. 2022. Mol Neurobiol 59:5056-69.	https://pubmed.ncbi.nlm.nih.gov/35668344/	Homo sapiens, human, clinical
		β255	V255I	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with V306I, V300I, V183I, tubulin beta-4A	Val255Ile	ClinVar 217025	https://www.ncbi.nlm.nih.gov/clinvar/variation/217025	Homo sapiens, human, clinical
		β255	V255I	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Likely pathogenic, with V183I, tubulin beta-3	Val255Ile	ClinVar 372654	https://www.ncbi.nlm.nih.gov/clinvar/variation/372654	Homo sapiens, human, clinical
		β255	V255L	P69893	https://www.uniprot.org/uniprotkb/P69893/entry	C. griseus	Paclitaxel resistant, CHO cell line, tubulin beta-5	Val255Leu	Yin et al. 2012. Pharm Res 29:2994-3006	https://pubmed.ncbi.nlm.nih.gov/22669706/	Cricetulus griseus, chinese hamster, rodent
		β255	V255M	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:3070 / malignant glioma	Val255Met	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β255	V255M	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:10534 / stomach cancer	Val255Met	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β255	V255M	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Defects in oocyte meiosis, tubulin beta-8	Val255Met	Feng et al. 2016. J Med Genet 53:662-71	https://pubmed.ncbi.nlm.nih.gov/27273344/	Homo sapiens, human, clinical
		β255	V255M	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Female infertility, tubulin beta-8	Val255Met	Chen et al. 2019. Eur J Hum Genet 27:300-307	https://pubmed.ncbi.nlm.nih.gov/30297906/	Homo sapiens, human, clinical
		β255	V255M	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Female infertility, tubulin beta-8	Val255Met	Lanuza-López et al. 2020. Gynecol Endocrinol 36:829-834	https://pubmed.ncbi.nlm.nih.gov/32063091/	Homo sapiens, human, clinical
		β255	V255M	P12456	https://www.uniprot.org/uniprotkb/P12456/entry	C. elegans	Mechanosensitive, mild semidominant, mec-7	Val255Met	Savage et al. 1994. J Cell Sci 107:2165-75	https://pubmed.ncbi.nlm.nih.gov/7983175/	Caenorhabditis elegans, nematode, roundworm
		β255	V255M	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Oocyte maturation defect, tubulin beta-8	Val255Met	ClinVar 694522	https://www.ncbi.nlm.nih.gov/clinvar/variation/694522	Homo sapiens, human, clinical
		β256	E256K	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Cortical dysplasia, other brain malformations, with E328K, tubulin beta-3	Glu256Lys	ClinVar 374309	https://www.ncbi.nlm.nih.gov/clinvar/variation/374309	Homo sapiens, human, clinical
		β256	N256S	Q9BVA1	https://www.uniprot.org/uniprotkb/Q9BVA1/entry	H. sapiens	Symmetric polymicrogyria & pachygyria, tubulin beta-2B	Asn256Ser	Guerrini et al. 2012. Eur J Hum Genet 20:995-8	https://pubmed.ncbi.nlm.nih.gov/22333901/	Homo sapiens, human, clinical
		β256	N256Y	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Uncertain significance, with N184Y, tubulin beta-3	Asn256Tyr	ClinVar 423464	https://www.ncbi.nlm.nih.gov/clinvar/variation/423464	Homo sapiens, human, clinical
		β257	M257I	P68371	https://www.uniprot.org/uniprotkb/P68371/entry	H. sapiens	TBB4B SNP, DOID:3070 / malignant glioma	Met257Ile	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P68371	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β257	M257I	Q18817	https://www.uniprot.org/uniprotkb/Q18817/entry	C. elegans	Benzimidazole resistant, correlation (ben-1, tbb-5)	Met257Ile	Hahnel et al. 2018. PLoS Pathog 14:e1007226	https://pubmed.ncbi.nlm.nih.gov/30372484/	Caenorhabditis elegans, nematode, roundworm
		β257	M257L	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:1909 / melanoma	Met257Leu	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β257	M257L	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with M308L, M185L, M302L, tubulin beta-4A	Met257Leu	ClinVar 537237	https://www.ncbi.nlm.nih.gov/clinvar/variation/537237	Homo sapiens, human, clinical
		β257	M257T	P68371	https://www.uniprot.org/uniprotkb/P68371/entry	H. sapiens	TBB4B SNP, DOID:10534 / stomach cancer	Met257Thr	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P68371	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β257	M257T	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:1324 / lung cancer	Met257Thr	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β257	M257T	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	Colchicine‑resistant familial Mediterranean fever, tubulin beta	Met257Thr	Sahakyan et al. 2019. PLoS One 14:e0221532	https://pubmed.ncbi.nlm.nih.gov/31442266/	Computational modeling, clinical	Model of colchicine binding to variants
		β257	M257T	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	Computational prediction, nsSNP causes protein destablization	Met257Thr	Hussain et al. 2022. J Biomol Struct Dyn 11:1-11.	https://pubmed.ncbi.nlm.nih.gov/36218086/	Computational modeling, clinical
		β257	M257V	Q9BUF5	https://www.uniprot.org/uniprotkb/Q9BUF5/entry	H. sapiens	TBB6 SNP, DOID:363 / uterine cancer	Met257Val	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BUF5	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β257	M257V	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:1909 / melanoma	Met257Val	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β257	M257V	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	Colchicine‑resistant familial Mediterranean fever, tubulin beta	Met257Val	Sahakyan et al. 2019. PLoS One 14:e0221532	https://pubmed.ncbi.nlm.nih.gov/31442266/	Computational modeling, clinical	Model of colchicine binding to variants
		β258	I258V	A0A650DFF5	https://www.uniprot.org/uniprotkb/A0A650DFF5/entry	P. sojae	Ethaboxam & zoxamide resistant	Ile258Val	Peng et al. 2019. Phytopathology 109:2096-2106	https://pubmed.ncbi.nlm.nih.gov/31559903/	Phytophthora sojae, oomycete, fungus, plant pathogen
		β258	V258M	Q9BUF5	https://www.uniprot.org/uniprotkb/Q9BUF5/entry	H. sapiens	TBB6 SNP, DOID:10534 / stomach cancer	Val258Met	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BUF5	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β259	P259L	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	Computational prediction, nsSNP causes protein destablization	Pro259Leu	Hussain et al. 2022. J Biomol Struct Dyn 11:1-11.	https://pubmed.ncbi.nlm.nih.gov/36218086/	Computational modeling, clinical
		β260	F260S	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	Congenital macrothrombocytopenia, tubulin beta-1	Phe260Ser	Kunishima et al. 2014. Eur J Haematol 92:276-82	https://pubmed.ncbi.nlm.nih.gov/24344610/	Homo sapiens, human, clinical
		β260	I260F	Q13885	https://www.uniprot.org/uniprotkb/Q13885/entry	H. sapiens	Cortical dysplasia, brain malformations, with I345F, tubulin beta-2A	Ile260Phe	ClinVar 212495	https://www.ncbi.nlm.nih.gov/clinvar/variation/212495	Homo sapiens, human, clinical
		β261	P261S	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:1909 / melanoma	Pro261Ser	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β261	P261S	P10878	https://www.uniprot.org/uniprotkb/P10878/entry	T. gondii	Suppressor of F52Y α1-tubulin defects, β1-tubulin	Pro261Ser	Ma et al. 2008. Genetics 180:845-56	https://pubmed.ncbi.nlm.nih.gov/18780736/	Toxoplasma gondii, parasite, protozoan
		β262	R262A	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Impaired kinesin activity, in vitro assay, tubulin beta-3	Arg262Ala	Minoura et al. 2016. Nat Commun 7:10058	https://pubmed.ncbi.nlm.nih.gov/26775887/	Homo sapiens, human, clinical
		β262	R262C	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:10534 / stomach cancer	Arg262Cys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β262	R262C	Q9BUF5	https://www.uniprot.org/uniprotkb/Q9BUF5/entry	H. sapiens	TBB6 SNP, DOID:1909 / melanoma	Arg262Cys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BUF5	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β262	R262C	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:1324 / lung cancer	Arg262Cys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β262	R262C	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Extraocular congenital fibrosis syndrome, tubulin beta-3, 11 patients	Arg262Cys	Tischfield et al. 2010. Cell 140:74-87	https://pubmed.ncbi.nlm.nih.gov/20074521/	Homo sapiens, human, clinical
		β262	R262C	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Inhibited axonal transport of vesicles and mitochondria, tubulin beta-3	Arg262Cys	Niwa et al. 2013. EMBO J 32:1352-64	https://pubmed.ncbi.nlm.nih.gov/23503589/	Homo sapiens, human, clinical	Model for CFEOM3
		β262	R262C	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Impaired netrin/DCC signaling, primary mouse neuron expression, tubulin beta-3	Arg262Cys	Huang et al. 2018. Neuroscience 374:155-171	https://pubmed.ncbi.nlm.nih.gov/29382549/	Homo sapiens, human, clinical
		β262	R262C	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Disruption of netrin-1 mediated axonal repulsion, tubulin beta-3, HeLa cells	Arg262Cys	Shao et al. 2019. PLoS One 14:e0218811	https://pubmed.ncbi.nlm.nih.gov/31226147/	Homo sapiens, human, clinical
		β262	R262C	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	Computational prediction, nsSNP causes protein destablization	Arg262Cys	Hussain et al. 2022. J Biomol Struct Dyn 11:1-11.	https://pubmed.ncbi.nlm.nih.gov/36218086/	Computational modeling, clinical
		β262	R262C	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Fibrosis of extraocular muscles, with R190C, tubulin beta-3	Arg262Cys	ClinVar 6963	https://www.ncbi.nlm.nih.gov/clinvar/variation/6963	Homo sapiens, human, clinical
		β262	R262H	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:10283 / prostate cancer	Arg262His	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β262	R262H	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:9256 / colorectal cancer	Arg262His	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β262	R262H	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:9256 / colorectal cancer	Arg262His	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β262	R262H	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Extraocular congenital fibrosis syndrome, tubulin beta-3, 2 patients	Arg262His	Tischfield et al. 2010. Cell 140:74-87	https://pubmed.ncbi.nlm.nih.gov/20074521/	Homo sapiens, human, clinical
		β262	R262H	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Extraocular congenital fibrosis syndrome, tubulin beta-3	Arg262His	MacKinnon et al. 2014. Ophthalmology 121:1461-8	https://pubmed.ncbi.nlm.nih.gov/24612975/	Homo sapiens, human, clinical
		β262	R262H	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Hypomyelination, atrophy of basal ganglia & cerebellum, tubulin beta-4A	Arg262His	Ferreira et al. 2014. Am J Med Genet A 164A:1802-7.	https://pubmed.ncbi.nlm.nih.gov/24706558/	Homo sapiens, human, clinical
		β262	R262H	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Hypomyelination, hypomyelinating leukoencephalopathy, tubulin beta-4A	Arg262His	Miyatake et al. 2014. Neurology 82:2230-7	https://pubmed.ncbi.nlm.nih.gov/24850488/	Homo sapiens, human, clinical
		β262	R262H	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Impaired kinesin activity, in vitro assay, tubulin beta-3	Arg262His	Minoura et al. 2016. Nat Commun 7:10058	https://pubmed.ncbi.nlm.nih.gov/26775887/	Homo sapiens, human, clinical
		β262	R262H	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Decreased microtubule catastrophes & MAP binding, tubulin beta-3	Arg262His	Ti et al. 2016. Dev Cell 37:72-84	https://pubmed.ncbi.nlm.nih.gov/27046833/	Homo sapiens, human, clinical
		β262	R262H	Q13885	https://www.uniprot.org/uniprotkb/Q13885/entry	H. sapiens	Arthrogryposis multiplex congenita, brain abnormalities, tubulin beta-2A	Arg262His	Ejaz et al. 2017. Am J Med Genet A 173:2725-2730	https://pubmed.ncbi.nlm.nih.gov/28840640/	Homo sapiens, human, clinical
		β262	R262H	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Congenital fibrosis of the extraocular muscles, with R190H, tubulin beta-3	Arg262His	ClinVar 219256	https://www.ncbi.nlm.nih.gov/clinvar/variation/219256	Homo sapiens, human, clinical
		β262	R262H	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with R313H, R190H, R307H, tubulin beta-4A	Arg262His	ClinVar 265314	https://www.ncbi.nlm.nih.gov/clinvar/variation/265314	Homo sapiens, human, clinical
		β262	R262H	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Hypomyelination, TUBB4A	Arg262His	Shimojima et al. 2015. Brain Dev 37:281-5	https://pubmed.ncbi.nlm.nih.gov/24974158/	Homo sapiens, human, clinical
		β262	R262P	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	Computational prediction, nsSNP causes protein destablization	Arg262Pro	Hussain et al. 2022. J Biomol Struct Dyn 11:1-11.	https://pubmed.ncbi.nlm.nih.gov/36218086/	Computational modeling, clinical
		β262	R262Q	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Defects in oocyte meiosis, tubulin beta-8	Arg262Gln	Feng et al. 2016. N Engl J Med 374:223-32	https://pubmed.ncbi.nlm.nih.gov/26789871/	Homo sapiens, human, clinical
		β262	R262Q	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Oocyte maturation defect, tubulin beta-8	Arg262Gln	ClinVar 221268	https://www.ncbi.nlm.nih.gov/clinvar/variation/223144	Homo sapiens, human, clinical
		β262	R262W	P68371	https://www.uniprot.org/uniprotkb/P68371/entry	H. sapiens	TBB4B SNP, DOID:10534 / stomach cancer	Arg262Trp	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P68371	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β262	R262W	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:1909 / melanoma	Arg262Trp	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β262	R262W	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Defects in oocyte meiosis, tubulin beta-8	Arg262Trp	Feng et al. 2016. J Med Genet 53:662-71	https://pubmed.ncbi.nlm.nih.gov/27273344/	Homo sapiens, human, clinical
		β262	R262W	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Human oocyte maturation defects and female infertility, TUBB8	Arg262Trp	Lin et al. 2023. Reprod Biomed Online 46(2):244-254	https://pubmed.ncbi.nlm.nih.gov/36463079/	Homo sapiens, human, clinical
		β263	L263M	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:363 / uterine cancer	Leu263Met	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β263	L263P	Q9ERD7	https://www.uniprot.org/uniprotkb/Q9ERD7/entry	M. musculus	Tubb3, viable heterozygote	Leu263Pro	Mutagenetix	https://mutagenetix.utsouthwestern.edu/incidental/incidental_rec.cfm?mid=302846	Mus musculus, mouse, tubulin beta-3	Wang et al. 2015. PNAS 112:E440-449 (PMID 25605905)
		β263	L263Q	P61857	https://www.uniprot.org/uniprotkb/P61857/entry	D. melanogaster	Intragenic suppressor, Glu194Lys B2tD allele	Leu263Gln	Fackenthal et al. 1995. Genetics 139:267-86	https://pubmed.ncbi.nlm.nih.gov/7705629/	Drosophila, fruitfly
		β263	L263V	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:10534 / stomach cancer	Leu263Val	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β264	H264Q	P10878	https://www.uniprot.org/uniprotkb/P10878/entry	T. gondii	Suppressor of G142S α1-tubulin defects, β1-tubulin	His264Gln	Ma et al. 2008. Genetics 180:845-56	https://pubmed.ncbi.nlm.nih.gov/18780736/	Toxoplasma gondii, parasite, protozoan
		β265	F265L	P68371	https://www.uniprot.org/uniprotkb/P68371/entry	H. sapiens	TBB4B SNP, DOID:1612 / breast cancer	Phe265Leu	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P68371	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β265	F265L	Q9D6F9	https://www.uniprot.org/uniprotkb/Q9D6F9/entry	M. musculus	Tubb4a, viable heterozygote	Phe265Leu	Mutagenetix	https://mutagenetix.utsouthwestern.edu/incidental/incidental_rec.cfm?mid=692105	Mus musculus, mouse, tubulin beta-4A	Wang et al. 2015. PNAS 112:E440-449 (PMID 25605905)
		β265	F265L	Q9BVA1	https://www.uniprot.org/uniprotkb/Q9BVA1/entry	H. sapiens	Polymicrogyria, tubulin beta-2B	Phe265Leu	Jaglin et al. 2009. Nat Genet 41:746-52	https://pubmed.ncbi.nlm.nih.gov/19465910/	Homo sapiens, human, clinical
		β265	F265L	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Impairs Bim1-dependent spindle positioning, TUB2p	Phe265Leu	Denarier et al. 2019. Biology Open 8	https://pubmed.ncbi.nlm.nih.gov/30674462/	Saccharomyces cerevisiae, budding yeast, fungus
		β265	F265L	F9X1J1	https://www.uniprot.org/uniprotkb/F9X1J1/entry	Z. tritici	Carbendazim resistant, with Q134K, beta tubulin	Phe265Leu	Matsuzaki et al. 2020. Pest Manag Sci 76:1393-1401	https://pubmed.ncbi.nlm.nih.gov/31622533/	Zymoseptoria, fungus, plant pathogen, septoria leaf blotch	Numbering may need to be adjusted
		β266	F266C	P04690	https://www.uniprot.org/uniprotkb/P04690/entry	C. reinhardtii	Propyzamide resistant, tub1	Phe266Cys	Kato-Minoura et al. 2020. PLoS One 15(11):e0242694	https://pubmed.ncbi.nlm.nih.gov/33227038/	Chlamydomonas reinhardtii, green alga
		β266	F266L	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:1324 / lung cancer	Phe266Leu	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β267	M267I	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:263 / kidney cancer	Met267Ile	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β267	M267I	Q9BUF5	https://www.uniprot.org/uniprotkb/Q9BUF5/entry	H. sapiens	TBB6 SNP, DOID:3070 / malignant glioma	Met267Ile	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BUF5	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β267	M267K	Q9ERD7	https://www.uniprot.org/uniprotkb/Q9ERD7/entry	M. musculus	Tubb3, viable heterozygote	Met267Lys	Mutagenetix	https://mutagenetix.utsouthwestern.edu/incidental/incidental_rec.cfm?mid=639786	Mus musculus, mouse, tubulin beta-3	Wang et al. 2015. PNAS 112:E440-449 (PMID 25605905)
		β267	S267S	Q7XYS0	https://www.uniprot.org/uniprotkb/Q7XYS0/entry	C. caldarium	Heat stable adaptation (correlation)	Ser267Ser	Arnold MS thesis (VPI)	https://vtechworks.lib.vt.edu/h&le/10919/9745?show=full	Cyanidium caldarium, extremophile, algae
		β267	S267S	A0A125YTB7	https://www.uniprot.org/uniprotkb/A0A125YTB7/entry	C. merolae	Heat stable adaptation (correlation)	Ser267Ser	Arnold MS thesis (VPI)	https://vtechworks.lib.vt.edu/h&le/10919/9745?show=full	Cyanidioschyzon merolae, extremophile, algae
		β268	G268R	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Likely benign, with G223R, G274R, G151R, tubulin beta-4A	Gly268Arg	ClinVar 212501	https://www.ncbi.nlm.nih.gov/clinvar/variation/212501	Homo sapiens, human, clinical
		β268	P268S	Q9BUF5	https://www.uniprot.org/uniprotkb/Q9BUF5/entry	H. sapiens	TBB6 SNP, DOID:363 / uterine cancer	Pro268Ser	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BUF5	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β268	P268S	Q9BUF5	https://www.uniprot.org/uniprotkb/Q9BUF5/entry	H. sapiens	TBB6 SNP, DOID:10534 / stomach cancer	Pro268Ser	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BUF5	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β269	G269C	Q13885	https://www.uniprot.org/uniprotkb/Q13885/entry	H. sapiens	TBB2A SNP, DOID:3963 / thyroid carcinoma	Gly269Cys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13885	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β269	G269D	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:3963 / thyroid carcinoma	Gly269Asp	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β269	G269D	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	TUBB SNP, DOID:3963 / thyroid carcinoma	Gly269Asp	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P07437	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β269	G269D	P12456	https://www.uniprot.org/uniprotkb/P12456/entry	C. elegans	Loss-of-function, short PLM-PN, mec-7	Gly269Asp	Zheng et al. 2017 Mol Biol Cell 28: 2786-2801	https://pubmed.ncbi.nlm.nih.gov/28835377/	Caenorhabditis elegans, nematode, roundworm	also see Lee et al. 2021. Mol Biol Cell. 15:331-347 (PMID 33378215)
		β269	G269D	P12456	https://www.uniprot.org/uniprotkb/P12456/entry	C. elegans	Mechanosensitive, severe semidominant, mec-7	Gly269Asp	Savage et al. 1994. J Cell Sci 107:2165-75	https://pubmed.ncbi.nlm.nih.gov/7983175/	Caenorhabditis elegans, nematode, roundworm
		β269	G269S	P68371	https://www.uniprot.org/uniprotkb/P68371/entry	H. sapiens	TBB4B SNP, DOID:1324 / lung cancer	Gly269Ser	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P68371	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β269	G269S	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:363 / uterine cancer	Gly269Ser	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β269	G269V	P10878	https://www.uniprot.org/uniprotkb/P10878/entry	T. gondii	Suppressor of F52Y α1-tubulin defects, β1-tubulin	Gly269Val	Ma et al. 2008. Genetics 180:845-56	https://pubmed.ncbi.nlm.nih.gov/18780736/	Toxoplasma gondii, parasite, protozoan
		β269	S269S	Q7XYS0	https://www.uniprot.org/uniprotkb/Q7XYS0/entry	C. caldarium	Heat stable adaptation (correlation)	Ser269Ser	Arnold MS thesis (VPI)	https://vtechworks.lib.vt.edu/h&le/10919/9745?show=full	Cyanidium caldarium, extremophile, algae
		β269	S269S	A0A125YTB7	https://www.uniprot.org/uniprotkb/A0A125YTB7/entry	C. merolae	Heat stable adaptation (correlation)	Ser269Ser	Arnold MS thesis (VPI)	https://vtechworks.lib.vt.edu/h&le/10919/9745?show=full	Cyanidioschyzon merolae, extremophile, algae
		β270	F270C	P69893	https://www.uniprot.org/uniprotkb/P69893/entry	C. griseus	Paclitaxel resistant, CHO cell line, tubulin beta-5	Leu217Asn	Yin et al. 2012. Pharm Res 29:2994-3006	https://pubmed.ncbi.nlm.nih.gov/22669706/	Cricetulus griseus, chinese hamster, rodent
		β270	F270I	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	Docetaxel resistant, prostate cancer cell line, tubulin beta	Phe270Ile	Hara et al. 2010. Cell Biol Int 34:177-84	https://pubmed.ncbi.nlm.nih.gov/19947927/	Homo sapiens, human, clinical
		β270	F270V	P69893	https://www.uniprot.org/uniprotkb/P69893/entry	C. griseus	Paclitaxel resistant, CHO cell line, tubulin beta-5	Phe270Val	Yin et al. 2012. Pharm Res 29:2994-3006	https://pubmed.ncbi.nlm.nih.gov/22669706/	Cricetulus griseus, chinese hamster, rodent
		β270	F270V	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	Paclitaxel resistant, human ovarian cancer cell line, tubulin beta	Phe270Val	Giannakakou et al. 1997. J Biol Chem 272:17118-25	https://pubmed.ncbi.nlm.nih.gov/9202030/	Homo sapiens, human, clinical
		β270	L270F	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with L225F, L276F, L153F, tubulin beta-4A	Leu270Phe	ClinVar 578590	https://www.ncbi.nlm.nih.gov/clinvar/variation/578590	Homo sapiens, human, clinical
		β270	Y270F	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Required for Taxol binding, TUB2p	Tyr270Phe	Gupta et al. 2003. PNAS 100:6394-7	https://pubmed.ncbi.nlm.nih.gov/12740436/	Saccharomyces cerevisiae, budding yeast, fungus
		β271	A271T	Q9BUF5	https://www.uniprot.org/uniprotkb/Q9BUF5/entry	H. sapiens	TBB6 SNP, DOID:1909 / melanoma	Ala271Thr	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BUF5	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β271	A271T	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Spasmodic dysphonia, tubulin beta-4A	Ala271Thr	Lohmann et al. 2013. Ann Neurol 73:537-45	https://pubmed.ncbi.nlm.nih.gov/23595291/	Homo sapiens, human, clinical
		β271	A271T	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Torsion dystonia, with A322T, A316T, A199T, tubulin beta-4A	Ala271Thr	ClinVar 92111	https://www.ncbi.nlm.nih.gov/clinvar/variation/92111	Homo sapiens, human, clinical
		β272	P272S	Q9BUF5	https://www.uniprot.org/uniprotkb/Q9BUF5/entry	H. sapiens	TBB6 SNP, DOID:363 / uterine cancer	Pro272Ser	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BUF5	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β272	P272T	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:363 / uterine cancer	Pro272Thr	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β272	W272R	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Uncertain significance, with W344R, W395R, W389R, tubulin beta-4A	W272Arg	ClinVar 522029	https://www.ncbi.nlm.nih.gov/clinvar/variation/522029	Homo sapiens, human, clinical
		β273	L273P	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	Invasive ductal, low grade; no treatment, also contains C239L, I152T, L240P, R241P	Leu273Pro	Wang et al. 2017. Protoplasma 254:1163-1173	https://pubmed.ncbi.nlm.nih.gov/27943021/	Homo sapiens, human, clinical	Tubulin beta-1 chain
		β273	L273V	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:0070003 / blastoma	Leu273Val	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β273	L273V	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:3571 / liver cancer	Leu273Val	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β273	L273V	P10878	https://www.uniprot.org/uniprotkb/P10878/entry	T. gondii	Suppressor of F52Y α1-tubulin defects, β1-tubulin	Leu273Val	Ma et al. 2008. Genetics 180:845-56	https://pubmed.ncbi.nlm.nih.gov/18780736/	Toxoplasma gondii, parasite, protozoan
		β273	L225M	P69893	https://www.uniprot.org/uniprotkb/P69893/entry	C. griseus	Paclitaxel resistant, expressed in human KB3 cell line, tubulin beta-5	Leu225Met	Yin et al. 2012. Pharm Res 29:2994-3006	https://pubmed.ncbi.nlm.nih.gov/22669706/	Cricetulus griseus, chinese hamster, rodent
		β273	L273V	P69893	https://www.uniprot.org/uniprotkb/P69893/entry	C. griseus	Paclitaxel resistant, expressed in human KB3 cell line, tubulin beta-5	Leu273Val	Yin et al. 2012. Pharm Res 29:2994-3006	https://pubmed.ncbi.nlm.nih.gov/22669706/	Cricetulus griseus, chinese hamster, rodent
		β274	G274R	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Likely benign, with G223R, G151R, G268R, tubulin beta-4A	Gly274Arg	ClinVar 212501	https://www.ncbi.nlm.nih.gov/clinvar/variation/212501	Homo sapiens, human, clinical
		β274	T274I	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	Epothilone & taxane resistant, ovarian carcinoma line, tubulin beta	Thr274Ile	Giannakakou et al. 2000. PNAS 97:2904-9	https://pubmed.ncbi.nlm.nih.gov/10688884/	Homo sapiens, human, clinical
		β274	T274M	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:1324 / lung cancer	Thr274Met	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β274	T274M	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	Macrocytopenia, correlation, tubulin beta-1	Thr274Met	ÇaliŞkaner et al. 2020. Turk J Med Sci	https://pubmed.ncbi.nlm.nih.gov/32892537/	Homo sapiens, human, clinical
		β274	T274M	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	Colchicine‑resistant familial Mediterranean fever, resistant variant, no correlation	Thr274Met	Akbaba et al. Mol Biol Rep 47:9005-9011	https://pubmed.ncbi.nlm.nih.gov/33161498/	Homo sapiens, human, clinical
		β274	T274S	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:10534 / stomach cancer	Thr274Ser	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β274	V274A	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with V229A, V280A, V157A, tubulin beta-4A	Val274Ala	ClinVar 580978	https://www.ncbi.nlm.nih.gov/clinvar/variation/580978	Homo sapiens, human, clinical
		β275	A275P	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:1909 / melanoma	Ala275Pro	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β275	A275S	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Invasive ductal, high grade; taxane treatment, also contains I189V, A218T, Q291R, K297R, R320P, S364A, T386S	Ala275Ser	Wang et al. 2017. Protoplasma 254:1163-1173	https://pubmed.ncbi.nlm.nih.gov/27943021/	Homo sapiens, human, clinical	Tubulin beta-3 chain
		β275	A275T	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Invasive ductal, high grade; doxorubicin treatment	Ala275Thr	Wang et al. 2017. Protoplasma 254:1163-1173	https://pubmed.ncbi.nlm.nih.gov/27943021/	Homo sapiens, human, clinical	Tubulin beta-3 chain
		β275	S275A	P68371	https://www.uniprot.org/uniprotkb/P68371/entry	H. sapiens	Invasive ductal, high grade; no treatment, also contains L44P, Q292R, A315T, V333I, N332A, N335S, T351V, A365S	Ser275Ala	Wang et al. 2017. Protoplasma 254:1163-1173	https://pubmed.ncbi.nlm.nih.gov/27943021/	Homo sapiens, human, clinical	Tubulin beta-4B chain
		β275	S275C	P69893	https://www.uniprot.org/uniprotkb/P69893/entry	C. griseus	Paclitaxel resistant, with L395D, CHO cell line, tubulin beta-5	Ser275Cys	Yin et al. 2012. Pharm Res 29:2994-3006	https://pubmed.ncbi.nlm.nih.gov/22669706/	Cricetulus griseus, chinese hamster, rodent
		β276	L276F	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with L225F, L153F, L270F, tubulin beta-4A	Leu276Phe	ClinVar 578590	https://www.ncbi.nlm.nih.gov/clinvar/variation/578590	Homo sapiens, human, clinical
		β276	R276H	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	TUBB SNP, DOID:11054 / urinary bladder cancer	Arg276His	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P07437	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β276	R276Q	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:5041 / esophageal cancer	Arg276Gln	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β276	R276Q	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:2531 / hematologic cancer	Arg276Gln	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β276	T276T	Q7XYS0	https://www.uniprot.org/uniprotkb/Q7XYS0/entry	C. caldarium	Heat stable adaptation (correlation)	Thr276Thr	Arnold MS thesis (VPI)	https://vtechworks.lib.vt.edu/h&le/10919/9745?show=full	Cyanidium caldarium, extremophile, algae
		β276	T276T	A0A125YTB7	https://www.uniprot.org/uniprotkb/A0A125YTB7/entry	C. merolae	Heat stable adaptation (correlation)	Thr276Thr	Arnold MS thesis (VPI)	https://vtechworks.lib.vt.edu/h&le/10919/9745?show=full	Cyanidioschyzon merolae, extremophile, algae
		β277	G277E	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	TUBB SNP, DOID:4362 / cervical cancer	Gly277Glu	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P07437	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β277	G277S	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:0070003 / blastoma	Gly277Ser	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β277	G277S	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:3571 / liver cancer	Gly277Ser	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β278	G280G	P36221	https://www.uniprot.org/uniprotkb/P36221/entry	N. coriiceps	Cold stable adaptation (correlation, NcTbB1, L08013)	Gly280Gly	Detrich et al. 2000. J Biol Chem 275:37038-47	https://pubmed.ncbi.nlm.nih.gov/10956651/	Notothenia coriiceps, extremophile, icefish
		β278	K278T	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Uncertain significance, with K395T, K350T, K401T, tubulin beta-4A	Lys278Thr	ClinVar 871906	https://www.ncbi.nlm.nih.gov/clinvar/variation/871906	Homo sapiens, human, clinical
		β278	S278C	Q9ERD7	https://www.uniprot.org/uniprotkb/Q9ERD7/entry	M. musculus	Tubb3, viable heterozygote	Ser278Cys	Mutagenetix	https://mutagenetix.utsouthwestern.edu/incidental/incidental_rec.cfm?mid=590070	Mus musculus, mouse, tubulin beta-3	Wang et al. 2015. PNAS 112:E440-449 (PMID 25605905)
		β278	S278R	Q9BUF5	https://www.uniprot.org/uniprotkb/Q9BUF5/entry	H. sapiens	TBB6 SNP, DOID:1324 / lung cancer	Ser278Arg	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BUF5	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β278	S278R	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Likely pathogenic, with S206R, tubulin beta-3	Ser278Arg	ClinVar 427208	https://www.ncbi.nlm.nih.gov/clinvar/variation/427208	Homo sapiens, human, clinical
		β279	Q279R	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Bilateral ventriculomegaly, tubulin beta-3	Gln279Arg	Brar et al. 2022. Prenatal Diagnosis 42:1686–1693	https://pubmed.ncbi.nlm.nih.gov/36403095/	Homo sapiens, human, clinical	836A>G
		β279	Q279X	P12456	https://www.uniprot.org/uniprotkb/P12456/entry	C. elegans	Mechanosensitive, severe recessive, mec-7	Gln279X	Savage et al. 1994. J Cell Sci 107:2165-75	https://pubmed.ncbi.nlm.nih.gov/7983175/	Caenorhabditis elegans, nematode, roundworm
		β279	T279T	Q7XYS0	https://www.uniprot.org/uniprotkb/Q7XYS0/entry	C. caldarium	Heat stable adaptation (correlation)	Thr279Thr	Arnold MS thesis (VPI)	https://vtechworks.lib.vt.edu/h&le/10919/9745?show=full	Cyanidium caldarium, extremophile, algae
		β279	T279T	A0A125YTB7	https://www.uniprot.org/uniprotkb/A0A125YTB7/entry	C. merolae	Heat stable adaptation (correlation)	Thr279Thr	Arnold MS thesis (VPI)	https://vtechworks.lib.vt.edu/h&le/10919/9745?show=full	Cyanidioschyzon merolae, extremophile, algae
		β280	A280S	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with A397S, A352S, A403S, tubulin beta-4A	Ala280Ser	ClinVar 807519	https://www.ncbi.nlm.nih.gov/clinvar/variation/807519	Homo sapiens, human, clinical
		β280	A280T	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with A403T, A352T, A397T, tubulin beta-4A	Ala280Thr	ClinVar 267785	https://www.ncbi.nlm.nih.gov/clinvar/variation/267785	Homo sapiens, human, clinical
		β280	G280R	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with G286R, G163R, G235R, tubulin beta-4A	Gly280Arg	ClinVar 643798	https://www.ncbi.nlm.nih.gov/clinvar/variation/643798	Homo sapiens, human, clinical
		β280	Q280X	P12456	https://www.uniprot.org/uniprotkb/P12456/entry	C. elegans	Mechanosensitive, severe recessive, mec-7	Gln280X	Savage et al. 1994. J Cell Sci 107:2165-75	https://pubmed.ncbi.nlm.nih.gov/7983175/	Caenorhabditis elegans, nematode, roundworm
		β280	V280A	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with V229A, V157A, V274A, tubulin beta-4A	Val280Ala	ClinVar 580978	https://www.ncbi.nlm.nih.gov/clinvar/variation/580978	Homo sapiens, human, clinical
		β281	C281C	Q9N2N6	https://www.uniprot.org/uniprotkb/Q9N2N6/entry	E. focardii	Cold stable adaptation (correlation, EFBT3)	Cys281Cys	Chiappori et al. 2012. Proteins 80:1154-60	https://pubmed.ncbi.nlm.nih.gov/22275059/	Euplotes focardii, extremophile, Antarctic ciliate
		β281	V281I	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	Cortical dysplasia, brain malformations, with V353I, V309I, V151I, V373I, tubulin beta	Val281Ile	ClinVar 127190	https://www.ncbi.nlm.nih.gov/clinvar/variation/127190	Homo sapiens, human, clinical
		β281	V281M	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Uncertain significance, with V353M, tubulin beta-3	Val281Met	ClinVar 808167	https://www.ncbi.nlm.nih.gov/clinvar/variation/808167	Homo sapiens, human, clinical
		β281	Y281X	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Sarcoma, tubulin beta-8	Tyr281X	ClinVar 805978	https://www.ncbi.nlm.nih.gov/clinvar/variation/805978	Homo sapiens, human, clinical
		β281	Y281H	Q9BUF5	https://www.uniprot.org/uniprotkb/Q9BUF5/entry	H. sapiens	TBB6 SNP, DOID:3963 / thyroid carcinoma	Tyr281His	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BUF5	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β281	Y281H	P69893	https://www.uniprot.org/uniprotkb/P69893/entry	C. griseus	Paclitaxel resistant, with T372A, , CHO cell line, tubulin beta-5	Tyr281His	Yin et al. 2012. Pharm Res 29:2994-3006	https://pubmed.ncbi.nlm.nih.gov/22669706/	Cricetulus griseus, chinese hamster, rodent
		β281	Y281X	Q9D6F9	https://www.uniprot.org/uniprotkb/Q9D6F9/entry	M. musculus	Tubb4a, viable heterozygote	Tyr281X	Mutagenetix	https://mutagenetix.utsouthwestern.edu/incidental/incidental_rec.cfm?mid=25143	Mus musculus, mouse, tubulin beta-4A	Wang et al. 2015. PNAS 112:E440-449 (PMID 25605905)
		β282	C282W	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with C354W, C405W, C399W, tubulin beta-4A	Cys282Trp	ClinVar 453295	https://www.ncbi.nlm.nih.gov/clinvar/variation/453295	Homo sapiens, human, clinical
		β282	C282Y	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with C405Y, C354Y, C399Y, tubulin beta-4A	Cys282Tyr	ClinVar 267786	https://www.ncbi.nlm.nih.gov/clinvar/variation/267786	Homo sapiens, human, clinical
		β282	F282L	Q13885	https://www.uniprot.org/uniprotkb/Q13885/entry	H. sapiens	Cortical dysplasia, other brain malformations, with F367L, tubulin beta-2A	Phe282Leu	ClinVar 813942	https://www.ncbi.nlm.nih.gov/clinvar/variation/813942	Homo sapiens, human, clinical
		β282	R282A	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Cold sensitive, benomyl resistant, with E288A, TUB2p	Arg282Ala	Reijo et al. 1994. Mol Biol Cell 5:29-43	https://pubmed.ncbi.nlm.nih.gov/8186463/	Saccharomyces cerevisiae, budding yeast, fungus
		β282	R282P	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Hypomyelination without basal ganglia abnormalities, TUBB4A	Arg282Pro	Pizzino et al. 2014. Neurology 83:898-902	https://pubmed.ncbi.nlm.nih.gov/25085639/	Homo sapiens, human, clinical	2 patients
		β282	R282P	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Hypomyelination, spastic quadriparesis, reduced microtubule assembly, tubulin beta-4A	Arg282Prp	Curiel et al. 2017. Hum Mol Genet 26:4506-4518	https://pubmed.ncbi.nlm.nih.gov/28973395/	Homo sapiens, human, clinical
		β282	R282P	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Female infertility, tubulin beta-8	Arg282Pro	Lanuza-López et al. 2020. Gynecol Endocrinol 36:829-834	https://pubmed.ncbi.nlm.nih.gov/32063091/	Homo sapiens, human, clinical
		β282	R282P	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with R333P, R327P, R210P, tubulin beta-4A	Arg282Pro	ClinVar 267779	https://www.ncbi.nlm.nih.gov/clinvar/variation/267779	Homo sapiens, human, clinical
		β282	R282P	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Likely pathogenic, with R210P, tubulin beta-3	Arg282Pro	ClinVar 421587	https://www.ncbi.nlm.nih.gov/clinvar/variation/421587	Homo sapiens, human, clinical
		β282	R282P	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Oocyte maturation defect, tubulin beta-8	Arg282Pro	ClinVar 805949	https://www.ncbi.nlm.nih.gov/clinvar/variation/805949	Homo sapiens, human, clinical
		β282	R282Q	P68371	https://www.uniprot.org/uniprotkb/P68371/entry	H. sapiens	TBB4B SNP, DOID:363 / uterine cancer	Arg282Gln	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P68371	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β282	R282Q	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:0070003 / blastoma	Arg282Gln	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β282	R282Q	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:3571 / liver cancer	Arg282Gln	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β282	R282Q	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:10534 / stomach cancer	Arg282Gln	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β282	R282Q	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	Epothilone & taxane resistant, ovarian carcinoma line, tubulin beta	Arg282Gln	Giannakakou et al. 2000. PNAS 97:2904-9	https://pubmed.ncbi.nlm.nih.gov/10688884/	Homo sapiens, human, clinical
		β282	R282Q	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	Uncertain significance, with R210Q, R238Q, R302Q, tubulin beta	Arg282Gln	ClinVar 498257	https://www.ncbi.nlm.nih.gov/clinvar/variation/498257	Homo sapiens, human, clinical
		β282	R282W	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:1909 / melanoma	Arg282Trp	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β283	A283D	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:3963 / thyroid carcinoma	Ala283Asp	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β283	D283E	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with D355E, D400E, D406E, tubulin beta-4A	Asp283Glu	ClinVar 807518	https://www.ncbi.nlm.nih.gov/clinvar/variation/807518	Homo sapiens, human, clinical
		β283	H283H	Q7XYS0	https://www.uniprot.org/uniprotkb/Q7XYS0/entry	C. caldarium	Heat stable adaptation (correlation)	His283His	Arnold MS thesis (VPI)	https://vtechworks.lib.vt.edu/h&le/10919/9745?show=full	Cyanidium caldarium, extremophile, algae
		β283	H283H	A0A125YTB7	https://www.uniprot.org/uniprotkb/A0A125YTB7/entry	C. merolae	Heat stable adaptation (correlation)	His283His	Arnold MS thesis (VPI)	https://vtechworks.lib.vt.edu/h&le/10919/9745?show=full	Cyanidioschyzon merolae, extremophile, algae
		β283	S285S	P36221	https://www.uniprot.org/uniprotkb/P36221/entry	N. coriiceps	Cold stable adaptation (correlation, NcTbB1, L08013)	Ser285Ser	Detrich et al. 2000. J Biol Chem 275:37038-47	https://pubmed.ncbi.nlm.nih.gov/10956651/	Notothenia coriiceps, extremophile, icefish
		β283	S285S	Q9DFT6	https://www.uniprot.org/uniprotkb/Q9DFT6/entry	N. coriiceps	Cold stable adaptation (correlation, NcTbB3, AF255555)	Ser285Ser	Detrich et al. 2000. J Biol Chem 275:37038-47	https://pubmed.ncbi.nlm.nih.gov/10956651/	Notothenia coriiceps, extremophile, icefish
		β284	C284F	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with C290F, C239F, C167F, tubulin beta-4A	Cys284Phe	ClinVar 267776	https://www.ncbi.nlm.nih.gov/clinvar/variation/267776	Homo sapiens, human, clinical
		β284	L284P	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:3963 / thyroid carcinoma	Leu284Pro	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β285	S285F	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:263 / kidney cancer	Ser285Phe	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β285	S285S	Q9DFS7	https://www.uniprot.org/uniprotkb/Q9DFS7/entry	C. rastrospinosus	Cold stable adaptation (correlation, CrTbB5, AF255955)	Ser285Ser	Detrich et al. 2000. J Biol Chem 275:37038-47	https://pubmed.ncbi.nlm.nih.gov/10956651/	Chionodraco rastrospinosus, extremophile, icefish
		β285	T285I	Q9BUF5	https://www.uniprot.org/uniprotkb/Q9BUF5/entry	H. sapiens	TBB6 SNP, DOID:1909 / melanoma	Thr285Ile	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BUF5	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β285	T285M	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:3070 / malignant glioma	Thr285Met	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β285	T285P	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Defects in oocyte meiosis, tubulin beta-8	Thr285Pro	Feng et al. 2016. J Med Genet 53:662-71	https://pubmed.ncbi.nlm.nih.gov/27273344/	Homo sapiens, human, clinical
		β286	G286R	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with G280R, G163R, G235R, tubulin beta-4A	Gly286Arg	ClinVar 643798	https://www.ncbi.nlm.nih.gov/clinvar/variation/643798	Homo sapiens, human, clinical
		β286	V286D	P12456	https://www.uniprot.org/uniprotkb/P12456/entry	C. elegans	Antimorph, short TRN neurites, mec-7	Val286Asp	Zheng et al. 2017 Mol Biol Cell 28: 2786-2801	https://pubmed.ncbi.nlm.nih.gov/28835377/	Caenorhabditis elegans, nematode, roundworm	also see Lee et al. 2021. Mol Biol Cell. 15:331-347 (PMID 33378215)
		β286	V286D	P12456	https://www.uniprot.org/uniprotkb/P12456/entry	C. elegans	Mechanosensitive, dominant, mec-7	Val286Asp	Savage et al. 1994. J Cell Sci 107:2165-75	https://pubmed.ncbi.nlm.nih.gov/7983175/	Caenorhabditis elegans, nematode, roundworm
		β286	V286L	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:1324 / lung cancer	Val286Leu	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β286	V286L	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:1324 / lung cancer	Val286Leu	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β286	V286M	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:363 / uterine cancer	Val286Met	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β286	V286M	P68371	https://www.uniprot.org/uniprotkb/P68371/entry	H. sapiens	TBB4B SNP, DOID:9256 / colorectal cancer	Val286Met	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P68371	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β286	V286M	P68371	https://www.uniprot.org/uniprotkb/P68371/entry	H. sapiens	TBB4B SNP, DOID:3070 / malignant glioma	Val286Met	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P68371	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β286	V286M	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:3571 / liver cancer	Val286Met	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β286	V286M	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Likely benign, with V214M, tubulin beta-3	Val286Met	ClinVar 437134	https://www.ncbi.nlm.nih.gov/clinvar/variation/437134	Homo sapiens, human, clinical
		β287	A287V	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:10283 / prostate cancer	Ala287Val	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β287	P287L	P24636	https://www.uniprot.org/uniprotkb/P24636/entry	A. thaliana	Twisting, TUB4	Pro287Leu	Ishida et al. 2007. PNAS 104:8544-9	https://pubmed.ncbi.nlm.nih.gov/17488810/	Arabidopsis thaliana, plant
		β287	P287L	Q56YW9	https://www.uniprot.org/uniprotkb/Q56YW9/entry	A. thaliana	Twisting, TUB2	Pro287Leu	Ishida et al. 2007. PNAS 104:8544-9	https://pubmed.ncbi.nlm.nih.gov/17488810/	Arabidopsis thaliana, plant
		β287	P287L	Q9ASR0	https://www.uniprot.org/uniprotkb/Q9ASR0/entry	A. thaliana	Twisting, TUB3	Pro287Leu	Ishida et al. 2007. PNAS 104:8544-9	https://pubmed.ncbi.nlm.nih.gov/17488810/	Arabidopsis thaliana, plant
		β287	P287L	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	Lissencephaly, tubulin beta	Pro287Leu	Di Donato et al. 2018. Genet Med 20:1354-1364	https://pubmed.ncbi.nlm.nih.gov/29671837/	Homo sapiens, human, clinical
		β287	P287L	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	Cortical dysplasia, other brain malformation, with P307L, P215L, P243L, tubulin beta	Pro287Leu	ClinVar 438586	https://www.ncbi.nlm.nih.gov/clinvar/variation/438586	Homo sapiens, human, clinical
		β287	P287L	P24636	https://www.uniprot.org/uniprotkb/P24636/entry	A. thaliana	Shade avoidance, tubulin beta-4	Pro287Leu	Yu et al. 2015. J Integr Plant Biol 57:757-69	https://pubmed.ncbi.nlm.nih.gov/25899068/	Arabidopsis thaliana, plant
		β288	E288A	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Cold sensitive, benomyl resistant, with R282A, TUB2p	Glu288Ala	Reijo et al. 1994. Mol Biol Cell 5:29-43	https://pubmed.ncbi.nlm.nih.gov/8186463/	Saccharomyces cerevisiae, budding yeast, fungus
		β288	E288K	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:363 / uterine cancer	Glu288Lys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β288	E288K	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	TUBB SNP, DOID:1324 / lung cancer	Glu288Lys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P07437	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β288	E288K	P68371	https://www.uniprot.org/uniprotkb/P68371/entry	H. sapiens	TBB4B SNP, DOID:363 / uterine cancer	Glu288Lys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P68371	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β288	E288K	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:1793 / pancreatic cancer	Glu288Lys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β288	E288K	P33188	https://www.uniprot.org/uniprotkb/P33188/entry	P. tetraurelia	Suppressor of sm-19 (delta/eta/zeta-tubulin allele), bPT2	Glu288Lys	Ruiz et al. 2004. Eukaryot Cell 3:212-20	https://pubmed.ncbi.nlm.nih.gov/14871951/	Paramecium tetraurelia, ciliate, protozoa
		β288	E288K	P24636	https://www.uniprot.org/uniprotkb/P24636/entry	A. thaliana	Twisting, TUB4	Glu288Lys	Ishida et al. 2007. PNAS 104:8544-9	https://pubmed.ncbi.nlm.nih.gov/17488810/	Arabidopsis thaliana, plant
		β288	E288K	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Supersensitive to benomyl (modest)	Glu288Lys	Praitis et al. 1991. Mol Cell Biol 11:4726-31	https://pubmed.ncbi.nlm.nih.gov/1908555/	Saccharomyces cerevisiae, budding yeast, fungus
		β288	E288K	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Cerebellar dysplasia, tubulin beta-3	Glu288Lys	Oegema et al. 2015. Hum Mol Genet 24:5213-25	https://pubmed.ncbi.nlm.nih.gov/26130693/	Homo sapiens, human, clinical
		β288	E288K	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Cortical malformations with unilateral hypohidrosis, tubulin beta-3	Glu288Lys	Fukumura et al. 2016. Child Neurol Open 3:1-3	https://pubmed.ncbi.nlm.nih.gov/28503613/	Homo sapiens, human, clinical
		β288	E288K	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Cerebellar dysplasia, 2 patients, tubulin beta-3	Glu288Lys	Romaniello et al. 2017. Eur Radiol 27:5080-5092	https://pubmed.ncbi.nlm.nih.gov/28677066/	Homo sapiens, human, clinical
		β288	E288K	P61857	https://www.uniprot.org/uniprotkb/P61857/entry	D. melanogaster	Male sterile, testes specific isoform, betaTub85D (recessive)	Glu288Lys	Rudolph et al. 1987. Mol Cell Biol 7:2231-42	https://pubmed.ncbi.nlm.nih.gov/3037352/	Drosophila, fruitfly
		β288	E288K	Q9BVA1	https://www.uniprot.org/uniprotkb/Q9BVA1/entry	H. sapiens	Pachygyria, tubulin beta-2B	Glu288Lys	Wang et al. 2019. Fetal Pediatr Pathol 38:63-71	https://pubmed.ncbi.nlm.nih.gov/30585108/	Homo sapiens, human, clinical
		β288	E288K	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Cortical malformations, tubulin beta-3	Glu288Lys	Accogli et al. 2020. Seizure 80:145-152	https://pubmed.ncbi.nlm.nih.gov/32570172/	Homo sapiens, human, clinical
		β288	E288K	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Cortical dysplasia, other brain malformations, with E216K, tubulin beta-3	Glu288Lys	ClinVar 384329	https://www.ncbi.nlm.nih.gov/clinvar/variation/384329	Homo sapiens, human, clinical
		β288	E288X	Q9D6F9	https://www.uniprot.org/uniprotkb/Q9D6F9/entry	M. musculus	Tubb4a, viable heterozygote	Glu288X	Mutagenetix	https://mutagenetix.utsouthwestern.edu/incidental/incidental_rec.cfm?mid=298696	Mus musculus, mouse, tubulin beta-4A	Wang et al. 2015. PNAS 112:E440-449 (PMID 25605905)
		β289	G289D	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with G295D, G244D, G172D, tubulin beta-4A	Gly289Asp	ClinVar 267778	https://www.ncbi.nlm.nih.gov/clinvar/variation/267778	Homo sapiens, human, clinical
		β289	G289R	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with G244R, G172R, G295R, tubulin beta-4A	Gly289Arg	ClinVar 803516	https://www.ncbi.nlm.nih.gov/clinvar/variation/803516	Homo sapiens, human, clinical
		β289	G289S	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with G244S, G295S, G172S, tubulin beta-4A	Gly289Ser	ClinVar 267772	https://www.ncbi.nlm.nih.gov/clinvar/variation/267772	Homo sapiens, human, clinical
		β289	G289V	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with G295V, G244V, G172V, tubulin beta-4A	Gly289Val	ClinVar 267777	https://www.ncbi.nlm.nih.gov/clinvar/variation/267777	Homo sapiens, human, clinical
		β289	L289I	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Likely pathogenic, with L361I, tubulin beta-3	Leu289Ile	ClinVar 421147	https://www.ncbi.nlm.nih.gov/clinvar/variation/421147	Homo sapiens, human, clinical
		β289	L289V	P68371	https://www.uniprot.org/uniprotkb/P68371/entry	H. sapiens	TBB4B SNP, DOID:1612 / breast cancer	Leu289Val	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P68371	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β290	C290F	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with C239F, C284F, C167F, tubulin beta-4A	Cys290Phe	ClinVar 267776	https://www.ncbi.nlm.nih.gov/clinvar/variation/267776	Homo sapiens, human, clinical
		β290	T290A	Q9BUF5	https://www.uniprot.org/uniprotkb/Q9BUF5/entry	H. sapiens	TBB6 SNP, DOID:1909 / melanoma	Thr290Ala	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BUF5	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β290	T290I	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:363 / uterine cancer	Thr290Ile	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β290	T290N	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:1324 / lung cancer	Thr290Asn	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β290	T290P	A2AQ07	https://www.uniprot.org/uniprotkb/A2AQ07/entry	M. musculus	Tubb1, viable heterozygote	Thr290Pro	Mutagenetix	https://mutagenetix.utsouthwestern.edu/incidental/incidental_rec.cfm?mid=529484	Mus musculus, mouse, tubulin beta-1	Wang et al. 2015. PNAS 112:E440-449 (PMID 25605905)
		β291	E291X	A0A8E5HT31	https://www.uniprot.org/uniprotkb/A0A8E5HT31/entry	U. virens	Carbendazin resistance, Uvβ1Tub	Glu291X	Song et al. 2022. J Fungi 8:1311	https://pubmed.ncbi.nlm.nih.gov/36547644/	Ustilaginoidea, fungus, rice false smut
		β291	Q291E	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:1324 / lung cancer	Gln291Glu	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β291	Q291E	P10878	https://www.uniprot.org/uniprotkb/P10878/entry	T. gondii	Suppressor of G142S α1-tubulin defects, β1-tubulin	Gln291Glu	Ma et al. 2008. Genetics 180:845-56	https://pubmed.ncbi.nlm.nih.gov/18780736/	Toxoplasma gondii, parasite, protozoan
		β291	Q291H	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:0070003 / blastoma	Gln291His	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β291	Q291H	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:3571 / liver cancer	Gln291His	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β291	Q291K	Q9BVA1	https://www.uniprot.org/uniprotkb/Q9BVA1/entry	H. sapiens	Lissencephaly, tubulin beta-2B	Gln291Lys	Di Donato et al. 2018. Genet Med 20:1354-1364	https://pubmed.ncbi.nlm.nih.gov/29671837/	Homo sapiens, human, clinical
		β291	Q291P	Q13885	https://www.uniprot.org/uniprotkb/Q13885/entry	H. sapiens	Cortical dysplasia, brain malformations, with Q206P, tubulin beta-2A	Gln291Pro	ClinVar 217024	https://www.ncbi.nlm.nih.gov/clinvar/variation/217024	Homo sapiens, human, clinical
		β291	Q291R	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Invasive ductal, high grade; taxane treatment, also contains I189V, A218T, A275S, K297R, R320P, S364A, T386S	Gln291Arg	Wang et al. 2017. Protoplasma 254:1163-1173	https://pubmed.ncbi.nlm.nih.gov/27943021/	Homo sapiens, human, clinical	Tubulin beta-3 chain
		β292	A292D	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with A415D, A364D, A409D, tubulin beta-4A	Ala292Asp	ClinVar 267787	https://www.ncbi.nlm.nih.gov/clinvar/variation/267787	Homo sapiens, human, clinical
		β292	E292H	P69893	https://www.uniprot.org/uniprotkb/P69893/entry	C. griseus	Taxol resistant revertant of D45Y, CHO cell line, tubulin beta-5	Glu292His	Wang et al. 2004. Biochemistry 43:8965-73.	https://pubmed.ncbi.nlm.nih.gov/15248754/	Cricetulus griseus, chinese hamster, rodent
		β292	Q292E	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	Taxol and epothilone resistant A549 cell line, tubulin beta	Gln292Glu	He et al. 2001. Mol Cancer Ther 1:3-10	https://pubmed.ncbi.nlm.nih.gov/12467233/	Homo sapiens, human, clinical
		β292	Q292E	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	A549 human lung carcinoma line EpoB resistance, tubulin beta-1	Gln292Glu	Yang et al. 2005. Mol Cancer Ther 4:987-95	https://pubmed.ncbi.nlm.nih.gov/15956256/	Homo sapiens, human, clinical
		β292	Q292E	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Cerebellar dysplasia, tubulin beta-3	Gln292Glu	Romaniello et al. 2017. Eur Radiol 27:5080-5092	https://pubmed.ncbi.nlm.nih.gov/28677066/	Homo sapiens, human, clinical
		β292	Q292K	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Isolated hypomyelination, increased microtubule stability, tubulin beta-4A	Gln292Lys	Xiao et al. 2022. Mol Neurobiol 59:5056-69	https://pubmed.ncbi.nlm.nih.gov/35668344/	Homo sapiens, human, clinical
		β292	Q292K	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Isolated hypomyelination, tubulin beta-4A	Gln292Lys	Xiao et al. 2022. Mol Neurobiol 59:5056-69.	https://pubmed.ncbi.nlm.nih.gov/35668344/	Homo sapiens, human, clinical
		β292	Q292K	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Oocyte maturation arrest, tubulin beta-8	Gln292Lys	Zhu et al. 2022. Front. Endocrinol. 13:1016563.	https://pubmed.ncbi.nlm.nih.gov/36440233/	Homo sapiens, human, clinical
		β292	Q292K	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with Q343K, Q220K, Q337K, tubulin beta-4A	Gln292Lys	ClinVar 267780	https://www.ncbi.nlm.nih.gov/clinvar/variation/267780	Homo sapiens, human, clinical
		β292	Q292K	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Hypomyelination without basal ganglia abnormalities, TUBB4A	Gln292Lys	Pizzino et al. 2014. Neurology 83:898-902	https://pubmed.ncbi.nlm.nih.gov/25085639/	Homo sapiens, human, clinical
		β292	Q292P	P12456	https://www.uniprot.org/uniprotkb/P12456/entry	C. elegans	Mechanosensitive, severe semidominant, mec-7	Gln292Pro	Savage et al. 1994. J Cell Sci 107:2165-75	https://pubmed.ncbi.nlm.nih.gov/7983175/	Caenorhabditis elegans, nematode, roundworm
		β292	Q292R	P68371	https://www.uniprot.org/uniprotkb/P68371/entry	H. sapiens	Invasive ductal, high grade; no treatment, also contains L44P, S275A, A315T, V333I, N332A, N335S, T351V, A365S	Gln292Arg	Wang et al. 2017. Protoplasma 254:1163-1173	https://pubmed.ncbi.nlm.nih.gov/27943021/	Homo sapiens, human, clinical	Tubulin beta-4B chain
		β293	C239S	A7XGY7	https://www.uniprot.org/uniprotkb/A7XGY7/entry	P. sojae	Zoxamide resistant	Cys239Ser	Cai et al. 2016. Front Microbiol 7:762	https://pubmed.ncbi.nlm.nih.gov/27242773/	Phytophthora sojae, oomycete, fungus, plant pathogen
		β293	C239W	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Infertility, oocyte maturation arrest, tubulin beta-8	Cys239Trp	Yao et al. 2022. J Ovar Research 15:38	https://pubmed.ncbi.nlm.nih.gov/35354490/	Homo sapiens, human, clinical
		β293	M293I	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:1324 / lung cancer	Met293Ile	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β293	M293I	Q922F4	https://www.uniprot.org/uniprotkb/Q922F4/entry	M. musculus	Tubb6, viable heterozygote	Met293Ile	Mutagenetix	https://mutagenetix.utsouthwestern.edu/incidental/incidental_rec.cfm?mid=546163	Mus musculus, mouse, tubulin beta-6	Wang et al. 2015. PNAS 112:E440-449 (PMID 25605905)
		β293	M293K	A2AQ07	https://www.uniprot.org/uniprotkb/A2AQ07/entry	M. musculus	Tubb1, viable heterozygote	Met293Lys	Mutagenetix	https://mutagenetix.utsouthwestern.edu/incidental/incidental_rec.cfm?mid=690446	Mus musculus, mouse, tubulin beta-1	Wang et al. 2015. PNAS 112:E440-449 (PMID 25605905)
		β293	M293V	P68371	https://www.uniprot.org/uniprotkb/P68371/entry	H. sapiens	TBB4B SNP, DOID:10534 / stomach cancer	Met293Val	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P68371	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β293	M293V	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Invasive mucinous, low grade; no treatment, also contains D249E, T315A, A332N, I333V, S335N, V351T, A352V, S364A, S365V	Met293Val	Wang et al. 2017. Protoplasma 254:1163-1173	https://pubmed.ncbi.nlm.nih.gov/27943021/	Homo sapiens, human, clinical	Tubulin beta-3 chain
		β294	D294H	Q9BVA1	https://www.uniprot.org/uniprotkb/Q9BVA1/entry	H. sapiens	Malformation of cortical development, fetal sample, tubulin beta-2B	Asp294His	Fallet-Bianco et al. 2014. Acta Neuropathol Commun 2:69	https://pubmed.ncbi.nlm.nih.gov/25059107/	Homo sapiens, human, clinical
		β294	D294N	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with D249N, D300N, D177N, tubulin beta-4A	Asp294Asn	ClinVar 50985	https://www.ncbi.nlm.nih.gov/clinvar/variation/50985	Homo sapiens, human, clinical
		β295	D295A	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Benomyl resistant, with K297A, TUB2p	Asp295Ala	Reijo et al. 1994. Mol Biol Cell 5:29-43	https://pubmed.ncbi.nlm.nih.gov/8186463/	Saccharomyces cerevisiae, budding yeast, fungus
		β295	D295H	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:1115 / sarcoma	Asp295His	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β295	D295H	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:1909 / melanoma	Asp295His	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β295	D295H	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Female infertility, tubulin beta-8	Asp295His	Chen et al. 2019. Eur J Hum Genet 27:300-307	https://pubmed.ncbi.nlm.nih.gov/30297906/	Homo sapiens, human, clinical
		β295	D295N	Q9BUF5	https://www.uniprot.org/uniprotkb/Q9BUF5/entry	H. sapiens	TBB6 SNP, DOID:1909 / melanoma	Asp295Asn	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BUF5	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β295	D295N	P32882	https://www.uniprot.org/uniprotkb/P32882/entry	G. gallus	GTP binding site mutation, in vitro synthesis in reticulocyte lysates	Asp295Asn	Farr & Sternlicht. 1992. J Mol Biol 227:307-21	https://pubmed.ncbi.nlm.nih.gov/1522595/	Gallus gallus, red junglefowl, chicken, bird
		β295	D295N	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Laryngeal and cervical dystonia, TUBB4A	Asp295Asn	Bally et al. 2021. Neurology 96: e1887-97	https://pubmed.ncbi.nlm.nih.gov/32943487/	Homo sapiens, human, clinical
		β295	D295N	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	DYT4 Dystonia, TUBB4A	Asp295Asn	Bally et al. 2022. Mov Disord Clin Pract 9:659-675	https://pubmed.ncbi.nlm.nih.gov/35844288/	Homo sapiens, human, clinical
		β295	D295N	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	GTP binding site mutation, viable as haploid	Asp295Asn	Sage et al. 1995. Biochemistry 34:7409-19	https://pubmed.ncbi.nlm.nih.gov/7779783/	Saccharomyces cerevisiae, budding yeast, fungus
		β295	F295I	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with F418I, F367I, F412I, tubulin beta-4A	Phe295Ile	ClinVar 267788	https://www.ncbi.nlm.nih.gov/clinvar/variation/267788	Homo sapiens, human, clinical
		β295	F295L	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with F418L, F367L, F412L, tubulin beta-4A	Phe295Leu	ClinVar 267789	https://www.ncbi.nlm.nih.gov/clinvar/variation/267789	Homo sapiens, human, clinical
		β295	G295D	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with G244D, G172D, G289D, tubulin beta-4A	Gly295Asp	ClinVar 267778	https://www.ncbi.nlm.nih.gov/clinvar/variation/267778	Homo sapiens, human, clinical
		β295	G295R	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with G244R, G172R, G289R, tubulin beta-4A	Gly295Arg	ClinVar 803516	https://www.ncbi.nlm.nih.gov/clinvar/variation/803516	Homo sapiens, human, clinical
		β295	G295S	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with G244S, G289S, G172S, tubulin beta-4A	Gly295Ser	ClinVar 267772	https://www.ncbi.nlm.nih.gov/clinvar/variation/267772	Homo sapiens, human, clinical
		β295	G295V	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with G244V, G172V, G289V, tubulin beta-4A	Gly295Val	ClinVar 267777	https://www.ncbi.nlm.nih.gov/clinvar/variation/267777	Homo sapiens, human, clinical
		β296	A296G	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	TUBB SNP, DOID:263 / kidney cancer	Ala296Gly	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P07437	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β296	A296S	Q13885	https://www.uniprot.org/uniprotkb/Q13885/entry	H. sapiens	Invasive ductal, low grade; no treatment, also contains E45D, N48S, V64I, V170M, C201S, V316I	Ala296Ser	Wang et al. 2017. Protoplasma 254:1163-1173	https://pubmed.ncbi.nlm.nih.gov/27943021/	Homo sapiens, human, clinical	Tubulin beta-2A chain
		β296	A296T	P68371	https://www.uniprot.org/uniprotkb/P68371/entry	H. sapiens	TBB4B SNP, DOID:1115 / sarcoma	Ala296Thr	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P68371	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β296	A296T	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	Resistant to peloruside A, human ovarian carcinoma cell line,	Ala296Thr	Kanakkanthara et al. 2011. Mol Cancer Ther 10:1418-29	https://pubmed.ncbi.nlm.nih.gov/21653684/	Homo sapiens, human, clinical
		β296	A296V	Q9BUF5	https://www.uniprot.org/uniprotkb/Q9BUF5/entry	H. sapiens	TBB6 SNP, DOID:363 / uterine cancer	Ala296Val	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BUF5	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β297	K297A	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Benomyl resistant, with D295A, TUB2p	Lys297Ala	Reijo et al. 1994. Mol Biol Cell 5:29-43	https://pubmed.ncbi.nlm.nih.gov/8186463/	Saccharomyces cerevisiae, budding yeast, fungus
		β297	K297N	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:9256 / colorectal cancer	Lys297Asn	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β297	K297R	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Invasive ductal, high grade; taxane treatment, also contains I189V, A218T, A275S, Q291R, R320P, S364A, T386S	Lys297Arg	Wang et al. 2017. Protoplasma 254:1163-1173	https://pubmed.ncbi.nlm.nih.gov/27943021/	Homo sapiens, human, clinical	Tubulin beta-3 chain
		β297	R297K	Q9BUF5	https://www.uniprot.org/uniprotkb/Q9BUF5/entry	H. sapiens	TBB6 SNP, DOID:363 / uterine cancer	Arg297Lys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BUF5	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β297	R297L	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:9256 / colorectal cancer	Arg297Leu	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β297	R297L	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:263 / kidney cancer	Arg297Leu	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β297	R297S	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:1324 / lung cancer	Arg297Ser	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β298	N298D	Q922F4	https://www.uniprot.org/uniprotkb/Q922F4/entry	M. musculus	Tubb6, viable heterozygote	Asn298Asp	Mutagenetix	https://mutagenetix.utsouthwestern.edu/incidental/incidental_rec.cfm?mid=255164	Mus musculus, mouse, tubulin beta-6	Wang et al. 2015. PNAS 112:E440-449 (PMID 25605905)
		β298	N298K	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	GTP binding site mutation, viable as haploid	Asn298Lys	Sage et al. 1995. Biochemistry 34:7409-19	https://pubmed.ncbi.nlm.nih.gov/7779783/	Saccharomyces cerevisiae, budding yeast, fungus
		β298	N298Q	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	GTP binding site mutation, viable as haploid	Asn298Gln	Sage et al. 1995. Biochemistry 34:7409-19	https://pubmed.ncbi.nlm.nih.gov/7779783/	Saccharomyces cerevisiae, budding yeast, fungus
		β298	N298S	P69893	https://www.uniprot.org/uniprotkb/P69893/entry	C. griseus	Paclitaxel resistant, tubulin beta-5	Asn298Ser	Yin et al. 2012. Pharm Res 29:2994-3006	https://pubmed.ncbi.nlm.nih.gov/22669706/	Cricetulus griseus, chinese hamster, rodent
		β298	N298S	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Female infertility, tubulin beta-8	Asn298Ser	Yang et al. 2021. Clin Genet 99:208-214	https://pubmed.ncbi.nlm.nih.gov/33009822/	Homo sapiens, human, clinical
		β299	I299T	A2AQ07	https://www.uniprot.org/uniprotkb/A2AQ07/entry	M. musculus	Tubb1, viable heterozygote	Ile299T hr	Mutagenetix	https://mutagenetix.utsouthwestern.edu/incidental/incidental_rec.cfm?mid=202706	Mus musculus, mouse, tubulin beta-1	Wang et al. 2015. PNAS 112:E440-449 (PMID 25605905)
		β299	I299T	A2AQ07	https://www.uniprot.org/uniprotkb/A2AQ07/entry	M. musculus	Tubb1, viable heterozygote	Ile299Thr	Mutagenetix	https://mutagenetix.utsouthwestern.edu/incidental/incidental_rec.cfm?mid=500333	Mus musculus, mouse, tubulin beta-1	Wang et al. 2015. PNAS 112:E440-449 (PMID 25605905)
		β299	M299I	Q9BUF5	https://www.uniprot.org/uniprotkb/Q9BUF5/entry	H. sapiens	TBB6 SNP, DOID:8618 / oral cavity cancer	Met299Ile	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BUF5	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β299	M299L	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Uncertain significance, with M350L, M227L, M344L, tubulin beta-4A	Met299Leu	ClinVar 429972	https://www.ncbi.nlm.nih.gov/clinvar/variation/429972	Homo sapiens, human, clinical
		β299	M299V	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	Microcephaly, tubulin beta	Met299Val	Breuss et al. 2012. Cell Rep 2:1554-62	https://pubmed.ncbi.nlm.nih.gov/23246003/	Homo sapiens, human, clinical
		β299	M299V	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	Cortical dysplasia, brain malformations, with M227V, M255V, M319V, tubulin beta	Met299Val	ClinVar 127189	https://www.ncbi.nlm.nih.gov/clinvar/variation/127189	Homo sapiens, human, clinical
		β299	T299A	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:10534 / stomach cancer	Thr299Ala	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β299	T299A	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:9256 / colorectal cancer	Thr299Ala	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β299	T299S	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:1612 / breast cancer	Thr299Ser	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β300	D300N	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with D249N, D177N, D294N, tubulin beta-4A	Asp300Asn	ClinVar 50985	https://www.ncbi.nlm.nih.gov/clinvar/variation/50985	Homo sapiens, human, clinical
		β300	M300I	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:1324 / lung cancer	Met300Ile	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β300	M300I	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:11054 / urinary bladder cancer	Met300Ile	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β300	M300I	Q9BUF5	https://www.uniprot.org/uniprotkb/Q9BUF5/entry	H. sapiens	TBB6 SNP, DOID:3571 / liver cancer	Met300Ile	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BUF5	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β300	M300I	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:3571 / liver cancer	Met300Ile	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β300	M300I	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Severe generalized dystonia, TUBB4A	Met300Ile	Erro et al. 2015. Mov Disord 30:828-33	https://pubmed.ncbi.nlm.nih.gov/25545912/	Homo sapiens, human, clinical
		β300	M300I	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Defects in oocyte meiosis, tubulin beta-8	Met300Ile	Feng et al. 2016. N Engl J Med 374:223-32	https://pubmed.ncbi.nlm.nih.gov/26789871/	Homo sapiens, human, clinical
		β300	M300I	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Oocyte maturation defect, tubulin beta-8	Met300Ile	ClinVar 221268	https://www.ncbi.nlm.nih.gov/clinvar/variation/223146	Homo sapiens, human, clinical
		β300	M300I	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with M351I, M345I, M228I, tubulin beta-4A	Met300Ile	ClinVar 267782	https://www.ncbi.nlm.nih.gov/clinvar/variation/267782	Homo sapiens, human, clinical
		β300	M300L	P68371	https://www.uniprot.org/uniprotkb/P68371/entry	H. sapiens	TBB4B SNP, DOID:363 / uterine cancer	Met300Leu	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P68371	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β300	M300T	P12456	https://www.uniprot.org/uniprotkb/P12456/entry	C. elegans	Antimorph, short TRN neurites, mec-7	Met300Thr	Zheng et al. 2017 Mol Biol Cell 28: 2786-2801	https://pubmed.ncbi.nlm.nih.gov/28835377/	Caenorhabditis elegans, nematode, roundworm	also see Lee et al. 2021. Mol Biol Cell. 15:331-347 (PMID 33378215)
		β300	M300T	P12456	https://www.uniprot.org/uniprotkb/P12456/entry	C. elegans	Mechanosensitive, severe semidominant, mec-7	Met300Thr	Savage et al. 1994. J Cell Sci 107:2165-75	https://pubmed.ncbi.nlm.nih.gov/7983175/	Caenorhabditis elegans, nematode, roundworm
		β300	M300V	A2AQ07	https://www.uniprot.org/uniprotkb/A2AQ07/entry	M. musculus	Tubb1, viable heterozygote	Met300Val	Mutagenetix	https://mutagenetix.utsouthwestern.edu/incidental/incidental_rec.cfm?mid=403922	Mus musculus, mouse, tubulin beta-1	Wang et al. 2015. PNAS 112:E440-449 (PMID 25605905)
		β300	M300V	P12456	https://www.uniprot.org/uniprotkb/P12456/entry	C. elegans	Antimorph, short TRN neurites, mec-7	Met300Val	Zheng et al. 2017 Mol Biol Cell 28: 2786-2801	https://pubmed.ncbi.nlm.nih.gov/28835377/	Caenorhabditis elegans, nematode, roundworm	also see Lee et al. 2021. Mol Biol Cell. 15:331-347 (PMID 33378215)
		β300	M300V	P12456	https://www.uniprot.org/uniprotkb/P12456/entry	C. elegans	Mechanosensitive, severe semidominant, mec-7	Met300Val	Savage et al. 1994. J Cell Sci 107:2165-75	https://pubmed.ncbi.nlm.nih.gov/7983175/	Caenorhabditis elegans, nematode, roundworm
		β300	V300I	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with V255I, V306I, V183I, tubulin beta-4A	Val300Ile	ClinVar 217025	https://www.ncbi.nlm.nih.gov/clinvar/variation/217025	Homo sapiens, human, clinical
		β301	A301S	Q9BVA1	https://www.uniprot.org/uniprotkb/Q9BVA1/entry	H. sapiens	TBB2B SNP, DOID:1793 / pancreatic cancer	Ala301Ser	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BVA1	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β301	A301T	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:363 / uterine cancer	Ala301Thr	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β301	A301V	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:363 / uterine cancer	Ala301Val	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β302	A302T	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:363 / uterine cancer	Ala302Thr	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β302	A302T	Q9BUF5	https://www.uniprot.org/uniprotkb/Q9BUF5/entry	H. sapiens	TBB6 SNP, DOID:363 / uterine cancer	Ala302Thr	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BUF5	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β302	A302T	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Extraocular congenital fibrosis syndrome, tubulin beta-3, 3 patients	Ala302Thr	Tischfield et al. 2010. Cell 140:74-87	https://pubmed.ncbi.nlm.nih.gov/20074521/	Homo sapiens, human, clinical
		β302	A302T	P12456	https://www.uniprot.org/uniprotkb/P12456/entry	C. elegans	Antimorph, short TRN neurites, mec-7	Ala302Thr	Zheng et al. 2017 Mol Biol Cell 28: 2786-2801	https://pubmed.ncbi.nlm.nih.gov/28835377/	Caenorhabditis elegans, nematode, roundworm	also see Lee et al. 2021. Mol Biol Cell. 15:331-347 (PMID 33378215)
		β302	A302T	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Disruption of netrin-1 mediated axonal repulsion, tubulin beta-3, HeLa cells	Ala302Thr	Shao et al. 2019. PLoS One 14:e0218811	https://pubmed.ncbi.nlm.nih.gov/31226147/	Homo sapiens, human, clinical
		β302	A302T	B4F7C2	https://www.uniprot.org/uniprotkb/B4F7C2/entry	R. norvegicus	Rat model of H-ABC, tubulin beta	Ala302Thr	Garduno-Robles et al. 2020. Front Neurosci 14: 555	https://pubmed.ncbi.nlm.nih.gov/32581692/	Rattus, tubulinopathy, rat model
		β302	A302T	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Infantile esotropia (eye misalignment), tubulin beta-3	Ala302Thr	Jang et al. 2022. Ophth Genet 43:716–719.	https://pubmed.ncbi.nlm.nih.gov/35765833/	Homo sapiens, human, clinical
		β302	A302T	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Fibrosis of extraocular muscles, with A230T, tubulin beta-3	Ala302Thr	ClinVar 6964	https://www.ncbi.nlm.nih.gov/clinvar/variation/6964	Homo sapiens, human, clinical
		β302	A302V	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:363 / uterine cancer	Ala302Val	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β302	A302V	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:9256 / colorectal cancer	Ala302Val	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β302	A302V	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:3070 / malignant glioma	Ala302Val	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β302	A302V	P68371	https://www.uniprot.org/uniprotkb/P68371/entry	H. sapiens	TBB4B SNP, DOID:363 / uterine cancer	Ala302Val	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P68371	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β302	A302V	P24636	https://www.uniprot.org/uniprotkb/P24636/entry	A. thaliana	Twisting, TUB4	Ala302Val	Ishida et al. 2007. PNAS 104:8544-9	https://pubmed.ncbi.nlm.nih.gov/17488810/	Arabidopsis thaliana, plant
		β302	A302V	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Malformation of cortical development, tubulin beta-3	Ala302Val	Poirier et al. 2010. Hum Mol Genet 19:4462-73	https://pubmed.ncbi.nlm.nih.gov/20829227/	Homo sapiens, human, clinical
		β302	A302V	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Inhibited axonal transport of vesicles and mitochondria, tubulin beta-3	Ala302Val	Niwa et al. 2013. EMBO J 32:1352-64	https://pubmed.ncbi.nlm.nih.gov/23503589/	Homo sapiens, human, clinical	Model for MCD
		β302	A302V	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Impaired netrin/DCC signaling, primary mouse neuron expression, tubulin beta-3	Ala302Val	Huang et al. 2018. Neuroscience 374:155-171	https://pubmed.ncbi.nlm.nih.gov/29382549/	Homo sapiens, human, clinical
		β302	A302V	P12456	https://www.uniprot.org/uniprotkb/P12456/entry	C. elegans	Neomorph, ectopic ALM-PN, mec-7	Ala302Val	Lee et al. 2021. Mol Biol Cell. 15:331-347	https://pubmed.ncbi.nlm.nih.gov/33378215/	Caenorhabditis elegans, nematode, roundworm
		β302	A302V	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Cortical dysplasia, other brain malformations, with A230V, tubulin beta-3	Ala302Val	ClinVar 30275	https://www.ncbi.nlm.nih.gov/clinvar/variation/30275	Homo sapiens, human, clinical
		β302	M302L	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with M257L, M308L, M185L, tubulin beta-4A	Met302Leu	ClinVar 537237	https://www.ncbi.nlm.nih.gov/clinvar/variation/537237	Homo sapiens, human, clinical
		β302	R302Q	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	Uncertain significance, with R282Q, R210Q, R238Q, tubulin beta	Arg302Gln	ClinVar 498257	https://www.ncbi.nlm.nih.gov/clinvar/variation/498257	Homo sapiens, human, clinical
		β303	C303G	Q9ERD7	https://www.uniprot.org/uniprotkb/Q9ERD7/entry	M. musculus	Tubb3, viable heterozygote	Cys303Gly	Mutagenetix	https://mutagenetix.utsouthwestern.edu/incidental/incidental_rec.cfm?mid=257538	Mus musculus, mouse, tubulin beta-3	Wang et al. 2015. PNAS 112:E440-449 (PMID 25605905)
		β303	C303S	P12456	https://www.uniprot.org/uniprotkb/P12456/entry	C. elegans	No defects, mec-7	Cys303Ser	Zheng et al. 2017 Mol Biol Cell 28: 2786-2801	https://pubmed.ncbi.nlm.nih.gov/28835377/	Caenorhabditis elegans, nematode, roundworm	also see Lee et al. 2021. Mol Biol Cell. 15:331-347 (PMID 33378215)
		β303	C303S	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	Sensitive to Withaferin A covalent modification, tubulin beta	Cys303Ser	Yang et al. 2019. Mol Pharmacol 96:711-719	https://pubmed.ncbi.nlm.nih.gov/31585985/	Homo sapiens, human, clinical
		β303	C303Y	P68371	https://www.uniprot.org/uniprotkb/P68371/entry	H. sapiens	TBB4B SNP, DOID:3963 / thyroid carcinoma	Cys303Tyr	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P68371	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β303	C303Y	P12456	https://www.uniprot.org/uniprotkb/P12456/entry	C. elegans	Neomorph, ectopic ALM-PN, mec-7	Cys303Tyr	Zheng et al. 2017 Mol Biol Cell 28: 2786-2801	https://pubmed.ncbi.nlm.nih.gov/28835377/	Caenorhabditis elegans, nematode, roundworm	also see Lee et al. 2021. Mol Biol Cell. 15:331-347 (PMID 33378215)
		β303	C303Y	Q18817	https://www.uniprot.org/uniprotkb/Q18817/entry	C. elegans	Albendazole resistance, ben-1	Cys303Tyr	Pallotto et al. 2022. Genetics 221:iyac093	https://pubmed.ncbi.nlm.nih.gov/35731216/	Caenorhabditis elegans, nematode, roundworm
		β303	C303Y	P12456	https://www.uniprot.org/uniprotkb/P12456/entry	C. elegans	Mechanosensitive, mild semidominant, mec-7	Cys303Tyr	Savage et al. 1994. J Cell Sci 107:2165-75	https://pubmed.ncbi.nlm.nih.gov/7983175/	Caenorhabditis elegans, nematode, roundworm
		β303	M303T	Q13885	https://www.uniprot.org/uniprotkb/Q13885/entry	H. sapiens	Uncertain significance, with M388T, tubulin beta-2A	Met303Thr	ClinVar 437124	https://www.ncbi.nlm.nih.gov/clinvar/variation/437124	Homo sapiens, human, clinical
		β304	D304A	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Benomyl supersensitive, with R306A, TUB2p	Asp304Ala	Reijo et al. 1994. Mol Biol Cell 5:29-43	https://pubmed.ncbi.nlm.nih.gov/8186463/	Saccharomyces cerevisiae, budding yeast, fungus
		β304	D304G	Q9D6F9	https://www.uniprot.org/uniprotkb/Q9D6F9/entry	M. musculus	Tubb4a, viable heterozygote	Asp304Gly	Mutagenetix	https://mutagenetix.utsouthwestern.edu/incidental/incidental_rec.cfm?mid=64235	Mus musculus, mouse, tubulin beta-4A	Wang et al. 2015. PNAS 112:E440-449 (PMID 25605905)
		β304	D304N	P68371	https://www.uniprot.org/uniprotkb/P68371/entry	H. sapiens	TBB4B SNP, DOID:3963 / thyroid carcinoma	Asp304Asn	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P68371	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β305	P305L	Q922F4	https://www.uniprot.org/uniprotkb/Q922F4/entry	M. musculus	Tubb6, viable heterozygote	Pro305Leu	Mutagenetix	https://mutagenetix.utsouthwestern.edu/incidental/incidental_rec.cfm?mid=352813	Mus musculus, mouse, tubulin beta-6	Wang et al. 2015. PNAS 112:E440-449 (PMID 25605905)
		β305	P305S	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	TUBB SNP, DOID:1909 / melanoma	Pro305Ser	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P07437	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β305	P305T	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:1324 / lung cancer	Pro305Thr	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β306	R306A	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Benomyl supersensitive, with D304A, TUB2p	Arg306Ala	Reijo et al. 1994. Mol Biol Cell 5:29-43	https://pubmed.ncbi.nlm.nih.gov/8186463/	Saccharomyces cerevisiae, budding yeast, fungus
		β306	R306C	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:1324 / lung cancer	Arg306Cys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β306	R306C	P68371	https://www.uniprot.org/uniprotkb/P68371/entry	H. sapiens	TBB4B SNP, DOID:9256 / colorectal cancer	Arg306Cys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P68371	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β306	R306C	P68371	https://www.uniprot.org/uniprotkb/P68371/entry	H. sapiens	TBB4B SNP, DOID:263 / kidney cancer	Arg306Cys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P68371	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β306	R306C	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:363 / uterine cancer	Arg306Cys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β306	R306C	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	Taxol resistance, correlation, tubulin beta	Arg306Cys	Hasegawa et al. 2002. Int J Cancer 101:46-51	https://pubmed.ncbi.nlm.nih.gov/12209587/	Homo sapiens, human, clinical
		β306	R306C	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	Taxol resistant, breast cancer samples, tubulin beta	Arg306Cys	Hasegawa et al. 2002. Int J Cancer 101:46-51	https://pubmed.ncbi.nlm.nih.gov/12209587/	Homo sapiens, human, clinical
		β306	R306C	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	Paclitaxel resistant, tubulin beta-1	Arg306Cys	Yin et al. 2010. Mol Cancer Ther 9:327-35	https://pubmed.ncbi.nlm.nih.gov/20103599/	Homo sapiens, human, clinical
		β306	R306C	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	Peloruside A, laulimalide & Taxol resistant	Arg306Cys	Kanakkanthara et al. 2011. Mol Cancer Ther 10:1418-29	https://pubmed.ncbi.nlm.nih.gov/21653684/	Homo sapiens, human, clinical
		β306	R306C	Q13885	https://www.uniprot.org/uniprotkb/Q13885/entry	H. sapiens	Cortical dysplasia, other brain malformations, with R391C, tubulin beta-2A	Arg306Cys	ClinVar 521900	https://www.ncbi.nlm.nih.gov/clinvar/variation/521900	Homo sapiens, human, clinical
		β306	R306G	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:1324 / lung cancer	Arg306Gly	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β306	R306H	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	Resistant to peloruside A & laulimalide	Arg306His	Kanakkanthara et al. 2011. Mol Cancer Ther 10:1418-29	https://pubmed.ncbi.nlm.nih.gov/21653684/	Homo sapiens, human, clinical
		β306	R306H	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	Colchicine‑resistant familial Mediterranean fever, tubulin beta	Arg306His	Sahakyan et al. 2019. PLoS One 14:e0221532	https://pubmed.ncbi.nlm.nih.gov/31442266/	Computational modeling, clinical	Model of colchicine binding to variants
		β306	R306H	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	Colchicine‑resistant familial Mediterranean fever, resistant variant, no correlation	Arg306His	Akbaba et al. Mol Biol Rep 47:9005-9011	https://pubmed.ncbi.nlm.nih.gov/33161498/	Homo sapiens, human, clinical
		β306	R306H	Q13885	https://www.uniprot.org/uniprotkb/Q13885/entry	H. sapiens	Likely pathogenic, with R391H, tubulin beta-2A	Arg306His	ClinVar 382096	https://www.ncbi.nlm.nih.gov/clinvar/variation/382096	Homo sapiens, human, clinical
		β306	R306S	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Infertility, early embryonic developmental arrest, H28Y, , tubulin beta-8	Arg306Serfs	Zhang et al. 2023. J Assist Reprod Genet 40:753-763.	https://pubmed.ncbi.nlm.nih.gov/36735156/	Homo sapiens, human, clinical
		β306	V306I	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with V255I, V300I, V183I, tubulin beta-4A	Val306Ile	ClinVar 217025	https://www.ncbi.nlm.nih.gov/clinvar/variation/217025	Homo sapiens, human, clinical
		β307	H307L	P68371	https://www.uniprot.org/uniprotkb/P68371/entry	H. sapiens	TBB4B SNP, DOID:3070 / malignant glioma	His307Leu	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P68371	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β307	H307Y	P68371	https://www.uniprot.org/uniprotkb/P68371/entry	H. sapiens	TBB4B SNP, DOID:1909 / melanoma	His307Tyr	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P68371	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β307	P307L	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	Cortical dysplasia, other brain malformation, with P287L, P215L, P243L, tubulin beta	Pro307Leu	ClinVar 438586	https://www.ncbi.nlm.nih.gov/clinvar/variation/438586	Homo sapiens, human, clinical
		β307	R307H	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:3571 / liver cancer	Arg307His	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β307	R307H	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	Immune thrombocytopenia treatment failure, association, tubulin beta-1	Arg307His	Basciano et al. 2013. Br J Haematol 160:237-43	https://pubmed.ncbi.nlm.nih.gov/23157319/	Homo sapiens, human, clinical
		β307	R307H	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	Colchicine‑resistant familial Mediterranean fever, tubulin beta	Arg307His	Sahakyan et al. 2019. PLoS One 14:e0221532	https://pubmed.ncbi.nlm.nih.gov/31442266/	Computational modeling, clinical	Model of colchicine binding to variants
		β307	R307H	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	Colchicine‑resistant familial Mediterranean fever, resistant variant, no correlation	Arg307His	Akbaba et al. Mol Biol Rep 47:9005-9011	https://pubmed.ncbi.nlm.nih.gov/33161498/	Homo sapiens, human, clinical
		β307	R307H	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with R262H, R313H, R190H, tubulin beta-4A	Arg307His	ClinVar 265314	https://www.ncbi.nlm.nih.gov/clinvar/variation/265314	Homo sapiens, human, clinical
		β307	R307L	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:0070003 / blastoma	Arg307Leu	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β307	R307L	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:3571 / liver cancer	Arg307Leu	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β308	A308V	Q13885	https://www.uniprot.org/uniprotkb/Q13885/entry	H. sapiens	Cortical dysplasia, other brain malformations, with A393V, tubulin beta-2A	Ala308Val	ClinVar 800924	https://www.ncbi.nlm.nih.gov/clinvar/variation/800924	Homo sapiens, human, clinical
		β308	G308A	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:9256 / colorectal cancer	Gly308Ala	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β308	G308C	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:2394 / ovarian cancer	Gly308Cys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β308	G308C	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:2994 / germ cell cancer	Gly308Cys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β308	G308C	A2AQ07	https://www.uniprot.org/uniprotkb/A2AQ07/entry	M. musculus	Tubb1, viable heterozygote	Gly308Cys	Mutagenetix	https://mutagenetix.utsouthwestern.edu/incidental/incidental_rec.cfm?mid=421534	Mus musculus, mouse, tubulin beta-1	Wang et al. 2015. PNAS 112:E440-449 (PMID 25605905)
		β308	G308S	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:9256 / colorectal cancer	Gly308Ser	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β308	G308S	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:1909 / melanoma	Gly308Ser	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β308	G308V	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:3571 / liver cancer	Gly308Val	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β308	M308L	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with M257L, M185L, M302L, tubulin beta-4A	Met308Leu	ClinVar 537237	https://www.ncbi.nlm.nih.gov/clinvar/variation/537237	Homo sapiens, human, clinical
		β308	R308C	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Congenital fibrosis of the extraocular muscles, with R380C, tubulin beta-3	Arg308Cys	ClinVar 219257	https://www.ncbi.nlm.nih.gov/clinvar/variation/219257	Homo sapiens, human, clinical
		β308	R308H	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Uncertain significance, with R380H, tubulin beta-3	Arg308His	ClinVar 429413	https://www.ncbi.nlm.nih.gov/clinvar/variation/429413	Homo sapiens, human, clinical
		β309	R309A	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Benomyl supersensitive, TUB2p	Arg309Ala	Reijo et al. 1994. Mol Biol Cell 5:29-43	https://pubmed.ncbi.nlm.nih.gov/8186463/	Saccharomyces cerevisiae, budding yeast, fungus
		β309	R309C	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:363 / uterine cancer	Arg309Cys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β309	R309C	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:3070 / malignant glioma	Arg309Cys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β309	R309C	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:363 / uterine cancer	Arg309Cys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β309	R309C	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:263 / kidney cancer	Arg309Cys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β309	R309C	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:1793 / pancreatic cancer	Arg309Cys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β309	R309C	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:0070003 / blastoma	Arg309Cys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β309	R309G	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	Cleft palate, cardiac defects, hemivertebrae, preauricular skin tags, tubulin beta	Arg309Gly	Li et al. 2020. Am J Med Genet A 182:3035-3039	https://pubmed.ncbi.nlm.nih.gov/33016642/	Homo sapiens, human, clinical
		β309	R309H	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:363 / uterine cancer	Arg309His	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β309	V309I	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	Cortical dysplasia, brain malformations, with V353I, V281I, V151I, V373I, tubulin beta	Val309Ile	ClinVar 127190	https://www.ncbi.nlm.nih.gov/clinvar/variation/127190	Homo sapiens, human, clinical
		β311	L311F	P12456	https://www.uniprot.org/uniprotkb/P12456/entry	C. elegans	Partial loss-of-function, no PLM synaptic branch, mec-7	Leu311Phe	Lee et al. 2021. Mol Biol Cell. 15:331-347	https://pubmed.ncbi.nlm.nih.gov/33378215/	Caenorhabditis elegans, nematode, roundworm
		β311	L311Q	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:1324 / lung cancer	Leu311Gln	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β311	Y311Y	Q9N2N6	https://www.uniprot.org/uniprotkb/Q9N2N6/entry	E. focardii	Cold stable adaptation (correlation, EFBT3)	Tyr311Tyr	Chiappori et al. 2012. Proteins 80:1154-60	https://pubmed.ncbi.nlm.nih.gov/22275059/	Euplotes focardii, extremophile, Antarctic ciliate
		β312	T312I	Q9BUF5	https://www.uniprot.org/uniprotkb/Q9BUF5/entry	H. sapiens	TBB6 SNP, DOID:1909 / melanoma	Thr312Ile	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BUF5	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β312	T312I	Q9BUF5	https://www.uniprot.org/uniprotkb/Q9BUF5/entry	H. sapiens	TBB6 SNP, DOID:9256 / colorectal cancer	Thr312Ile	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BUF5	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β312	T312M	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:9256 / colorectal cancer	Thr312Met	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β312	T312M	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:1115 / sarcoma	Thr312Met	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β312	T312M	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:1909 / melanoma	Thr312Met	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β312	T312M	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:10534 / stomach cancer	Thr312Met	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β312	T312M	Q9BVA1	https://www.uniprot.org/uniprotkb/Q9BVA1/entry	H. sapiens	Polymicrogyria, tubulin beta-2B	Thr312Met	Jaglin et al. 2009. Nat Genet 41:746-52	https://pubmed.ncbi.nlm.nih.gov/19465910/	Homo sapiens, human, clinical
		β312	T312M	Q13885	https://www.uniprot.org/uniprotkb/Q13885/entry	H. sapiens	Inhibited axonal transport of vesicles and mitochondria, tubulin beta-2A	Thr312Met	Niwa et al. 2013. EMBO J 32:1352-64	https://pubmed.ncbi.nlm.nih.gov/23503589/	Homo sapiens, human, clinical	Model for polymicrogyria
		β312	T312M	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Dysgyria, cortical malformations, tubulin beta-3	Thr312Met	Blumkin et al. 2020. Eur J Paediatr Neurol 26:46-60	https://pubmed.ncbi.nlm.nih.gov/32169460/	Homo sapiens, human, clinical
		β312	T312N	Q9ERD7	https://www.uniprot.org/uniprotkb/Q9ERD7/entry	M. musculus	Tubb3, viable heterozygote	Thr312Asn	Mutagenetix	https://mutagenetix.utsouthwestern.edu/incidental/incidental_rec.cfm?mid=307946	Mus musculus, mouse, tubulin beta-3	Wang et al. 2015. PNAS 112:E440-449 (PMID 25605905)
		β313	A313V	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Female infertility, tubulin beta-8	Ala313Val	Yang et al. 2021. Clin Genet 99:208-214	https://pubmed.ncbi.nlm.nih.gov/33009822/	Homo sapiens, human, clinical
		β313	A313V	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Infertility, oocyte maturation arrest, tubulin beta-8	Ala313Val	Yao et al. 2022. J Ovar Research 15:38	https://pubmed.ncbi.nlm.nih.gov/35354490/	Homo sapiens, human, clinical
		β313	A313V	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Human oocyte maturation defects and female infertility, TUBB8	Ala313Val	Lin et al. 2023. Reprod Biomed Online 46(2):244-254	https://pubmed.ncbi.nlm.nih.gov/36463079/	Homo sapiens, human, clinical	3 patients
		β313	R313H	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with R262H, R190H, R307H, tubulin beta-4A	Arg313His	ClinVar 265314	https://www.ncbi.nlm.nih.gov/clinvar/variation/265314	Homo sapiens, human, clinical
		β313	V313M	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:10534 / stomach cancer	Val313Met	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β313	V313M	P52275	https://www.uniprot.org/uniprotkb/P52275/entry	C. elegans	Misplaced mitotic spindle, tbb-2	Val313Met	Wright & Hunter. 2003. Mol Biol Cell 14:4512-25	https://pubmed.ncbi.nlm.nih.gov/12937270/	Caenorhabditis elegans, nematode, roundworm
		β314	A314S	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Female infertility, tubulin beta-8	Ala314Ser	Yang et al. 2021. Clin Genet 99:208-214	https://pubmed.ncbi.nlm.nih.gov/33009822/	Homo sapiens, human, clinical
		β314	A314T	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:4362 / cervical cancer	Ala314Thr	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β314	A314T	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:1909 / melanoma	Ala314Thr	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β314	A314V	Q9ERD7	https://www.uniprot.org/uniprotkb/Q9ERD7/entry	M. musculus	Tubb3, viable heterozygote	Ala314Val	Mutagenetix	https://mutagenetix.utsouthwestern.edu/incidental/incidental_rec.cfm?mid=227439	Mus musculus, mouse, tubulin beta-3	Wang et al. 2015. PNAS 112:E440-449 (PMID 25605905)
		β314	A314V	Q9ERD7	https://www.uniprot.org/uniprotkb/Q9ERD7/entry	M. musculus	Tubb3, viable heterozygote	Ala314Val	Mutagenetix	https://mutagenetix.utsouthwestern.edu/incidental/incidental_rec.cfm?mid=227533	Mus musculus, mouse, tubulin beta-3	Wang et al. 2015. PNAS 112:E440-449 (PMID 25605905)
		β314	A314V	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Severe generalized dystonia, TUBB4A	Ala314Val	Erro et al. 2015. Mov Disord 30:828-33	https://pubmed.ncbi.nlm.nih.gov/25545912/	Homo sapiens, human, clinical
		β314	A314V	P12456	https://www.uniprot.org/uniprotkb/P12456/entry	C. elegans	Antimorph, short TRN neurites, mec-7	Ala314Val	Zheng et al. 2017 Mol Biol Cell 28: 2786-2801	https://pubmed.ncbi.nlm.nih.gov/28835377/	Caenorhabditis elegans, nematode, roundworm	also see Lee et al. 2021. Mol Biol Cell. 15:331-347 (PMID 33378215)
		β314	A314V	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	Colchicine‑resistant familial Mediterranean fever, tubulin beta	Ala314Val	Sahakyan et al. 2019. PLoS One 14:e0221532	https://pubmed.ncbi.nlm.nih.gov/31442266/	Computational modeling, clinical	Model of colchicine binding to variants
		β314	A314V	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Conflicting interpretations of pathogenicity, with A365V, A359V, A242V, tubulin beta-4A	Ala314Val	ClinVar 267783	https://www.ncbi.nlm.nih.gov/clinvar/variation/267783	Homo sapiens, human, clinical
		β314	T314S	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Uncertain significance, with T386S, tubulin beta-3	Thr314Ser	ClinVar 872056	https://www.ncbi.nlm.nih.gov/clinvar/variation/872056	Homo sapiens, human, clinical
		β315	A315T	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:1324 / lung cancer	Ala315Thr	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β315	A315T	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:263 / kidney cancer	Ala315Thr	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β315	A315T	P68371	https://www.uniprot.org/uniprotkb/P68371/entry	H. sapiens	TBB4B SNP, DOID:363 / uterine cancer	Ala315Thr	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P68371	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β315	A315T	P68371	https://www.uniprot.org/uniprotkb/P68371/entry	H. sapiens	TBB4B SNP, DOID:10283 / prostate cancer	Ala315Thr	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P68371	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β315	A315T	P68371	https://www.uniprot.org/uniprotkb/P68371/entry	H. sapiens	Invasive ductal, high grade; no treatment, also contains L44P, S275A, Q292R, V333I, N332A, N335S, T351V, A365S	Ala315Thr	Wang et al. 2017. Protoplasma 254:1163-1173	https://pubmed.ncbi.nlm.nih.gov/27943021/	Homo sapiens, human, clinical	Tubulin beta-4B chain
		β315	T315A	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Invasive ductal, high grade; doxorubicin treatment, also contains V180A, A332N, I333V, S335N, V351T, S365A, I374T	Thr315Ala	Wang et al. 2017. Protoplasma 254:1163-1173	https://pubmed.ncbi.nlm.nih.gov/27943021/	Homo sapiens, human, clinical	Tubulin beta-3 chain
		β315	T315A	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Invasive mucinous, low grade; no treatment, also contains D249E, M293V, A332N, I333V, S335N, V351T, A352V, S364A, S365V	Thr315Ala	Wang et al. 2017. Protoplasma 254:1163-1173	https://pubmed.ncbi.nlm.nih.gov/27943021/	Homo sapiens, human, clinical	Tubulin beta-3 chain
		β315	T315A	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Invasive ductal, low grade; taxane treatment, also contains T166A, I189V, S239C, A332N, I333V, S335N, V351T	Thr315Ala	Wang et al. 2017. Protoplasma 254:1163-1173	https://pubmed.ncbi.nlm.nih.gov/27943021/	Homo sapiens, human, clinical	Tubulin beta-3 chain
		β316	A316T	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Torsion dystonia, pathogenic, with A271T, A322T, A199T, tubulin beta-4A	Ala316Thr	ClinVar 92111	https://www.ncbi.nlm.nih.gov/clinvar/variation/92111	Homo sapiens, human, clinical
		β316	I316T	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:10534 / stomach cancer	Ile316Thr	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β316	I316V	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	Colchicine‑resistant familial Mediterranean fever, tubulin beta	Ile316Val	Sahakyan et al. 2019. PLoS One 14:e0221532	https://pubmed.ncbi.nlm.nih.gov/31442266/	Computational modeling, clinical	Model of colchicine binding to variants
		β316	M316I	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with M388I, M439I, M433I, tubulin beta-4A	Met316Ile	ClinVar 209201	https://www.ncbi.nlm.nih.gov/clinvar/variation/209201	Homo sapiens, human, clinical
		β316	M316I	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Microcephaly, cerebellar hypoplasia, hypomyelination, with M439I, M388I, M433I, tubulin beta-4A	Met316Ile	ClinVar 267792	https://www.ncbi.nlm.nih.gov/clinvar/variation/267792	Homo sapiens, human, clinical
		β316	M316T	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with M439T, M388T, M433T, tubulin beta-4A	Met316Thr	ClinVar 267791	https://www.ncbi.nlm.nih.gov/clinvar/variation/267791	Homo sapiens, human, clinical
		β316	M316V	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Cortical dysplasia, other brain malformations, with M388V, tubulin beta-3	Met316Val	ClinVar 236243	https://www.ncbi.nlm.nih.gov/clinvar/variation/236243	Homo sapiens, human, clinical
		β316	M316V	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with M439V, M388V, M433V, tubulin beta-4A	Met316Val	ClinVar 267790	https://www.ncbi.nlm.nih.gov/clinvar/variation/267790	Homo sapiens, human, clinical
		β316	V316D	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	TUBB SNP, DOID:10534 / stomach cancer	Val316Asp	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P07437	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β316	V316D	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	TUBB SNP, DOID:3953 / adrenal gland cancer	Val316Asp	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P07437	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β316	V316D	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	TUBB SNP, DOID:1115 / sarcoma	Val316Asp	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P07437	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β316	V316I	Q13885	https://www.uniprot.org/uniprotkb/Q13885/entry	H. sapiens	Invasive ductal, low grade; no treatment, also contains E45D, N48S, V64I, V170M, C201S, A296S	Val316Ile	Wang et al. 2017. Protoplasma 254:1163-1173	https://pubmed.ncbi.nlm.nih.gov/27943021/	Homo sapiens, human, clinical	Tubulin beta-2A chain
		β316	V316M	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:363 / uterine cancer	Val316Met	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β316	V316M	Q9BUF5	https://www.uniprot.org/uniprotkb/Q9BUF5/entry	H. sapiens	TBB6 SNP, DOID:363 / uterine cancer	Val316Met	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BUF5	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β316	V316M	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Uncertain significance, with V244M, tubulin beta-3	Val316Met	ClinVar 212500	https://www.ncbi.nlm.nih.gov/clinvar/variation/212500	Homo sapiens, human, clinical
		β317	F317I	P12456	https://www.uniprot.org/uniprotkb/P12456/entry	C. elegans	Loss-of-function, short PLM-PN, mec-7	Phe317Ile	Zheng et al. 2017 Mol Biol Cell 28: 2786-2801	https://pubmed.ncbi.nlm.nih.gov/28835377/	Caenorhabditis elegans, nematode, roundworm	also see Lee et al. 2021. Mol Biol Cell. 15:331-347 (PMID 33378215)
		β317	F317I	P12456	https://www.uniprot.org/uniprotkb/P12456/entry	C. elegans	Mechanosensitive, severe semidominant, mec-7	Phe317Ile	Savage et al. 1994. J Cell Sci 107:2165-75	https://pubmed.ncbi.nlm.nih.gov/7983175/	Caenorhabditis elegans, nematode, roundworm
		β317	F317L	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:5041 / esophageal cancer	Phe317Leu	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β317	F317L	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:11934 / head and neck cancer	Phe317Leu	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β317	F317S	A0A1S4C3U3	https://www.uniprot.org/uniprotkb/A0A1S4C3U3/entry#function	N. plumbaginifolia	Dinitroaniline resistant, beta isotype not specified	Phe317Ser	Emets et al. 2009. Tsitol Genet 43:69-76	https://pubmed.ncbi.nlm.nih.gov/20458969/	Nicotiana plumbaginifolia, tobacco plant
		β317	F317V	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Uncertain significance, with F389V, tubulin beta-3	Phe317Val	ClinVar 430430	https://www.ncbi.nlm.nih.gov/clinvar/variation/430430	Homo sapiens, human, clinical
		β318	R318A	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Benomyl resistant, with K320A, TUB2p	Arg318Ala	Reijo et al. 1994. Mol Biol Cell 5:29-43	https://pubmed.ncbi.nlm.nih.gov/8186463/	Saccharomyces cerevisiae, budding yeast, fungus
		β318	R318C	Q9BUF5	https://www.uniprot.org/uniprotkb/Q9BUF5/entry	H. sapiens	TBB6 SNP, DOID:1909 / melanoma	Arg318Cys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BUF5	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β318	R318C	P10878	https://www.uniprot.org/uniprotkb/P10878/entry	T. gondii	Suppressor of G142S α1-tubulin defects, β1-tubulin	Arg318Cys	Ma et al. 2008. Genetics 180:845-56	https://pubmed.ncbi.nlm.nih.gov/18780736/	Toxoplasma gondii, parasite, protozoan
		β318	R318G	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:1324 / lung cancer	Arg318Gly	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β318	R318K	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:1793 / pancreatic cancer	Arg318Lys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β318	R318P	Q9BUF5	https://www.uniprot.org/uniprotkb/Q9BUF5/entry	H. sapiens	TBB6 SNP, DOID:10283 / prostate cancer	Arg318Pro	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BUF5	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β318	R318P	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Uncertain significance, with R390P, tubulin beta-3	Arg318Pro	ClinVar 282046	https://www.ncbi.nlm.nih.gov/clinvar/variation/282046	Homo sapiens, human, clinical
		β318	R318Q	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:363 / uterine cancer	Arg318Gln	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β318	R318Q	P12456	https://www.uniprot.org/uniprotkb/P12456/entry	C. elegans	Loss-of-function, short PLM-PN, mec-7	Arg318Gln	Zheng et al. 2017 Mol Biol Cell 28: 2786-2801	https://pubmed.ncbi.nlm.nih.gov/28835377/	Caenorhabditis elegans, nematode, roundworm	also see Lee et al. 2021. Mol Biol Cell. 15:331-347 (PMID 33378215)
		β318	R318Q	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	Computational prediction, nsSNP causes protein destablization	Arg318Gln	Hussain et al. 2022. J Biomol Struct Dyn 11:1-11.	https://pubmed.ncbi.nlm.nih.gov/36218086/	Computational modeling, clinical
		β318	R318Q	P12456	https://www.uniprot.org/uniprotkb/P12456/entry	C. elegans	Mechanosensitive, severe semidominant, mec-7	Arg318Gln	Savage et al. 1994. J Cell Sci 107:2165-75	https://pubmed.ncbi.nlm.nih.gov/7983175/	Caenorhabditis elegans, nematode, roundworm
		β318	R318S	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:1324 / lung cancer	Arg318Ser	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β318	R318W	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:363 / uterine cancer	Arg318Trp	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β318	R318W	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:10534 / stomach cancer	Arg318Trp	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β318	R318W	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	Macrothrombocytopenia, tubulin-beta-1	Arg318Trp	Kunishima et al. 2009. Blood 113:458-61	https://pubmed.ncbi.nlm.nih.gov/18849486/	Homo sapiens, human, clinical
		β318	R318W	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	Congenital hypothyroidism, thyroid dysgenesis, tubulin beta-1	Arg318Trp	Sun et al. 2019. Zhongguo Dang Dai Er Ke Za Zhi 21:972-976	https://pubmed.ncbi.nlm.nih.gov/31642429/	Homo sapiens, human, clinical
		β318	R318W	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Cold sensitive microtubules, TUB2p	Arg318Trp	Huffaker et al. 1988. J Cell Biol 106:1997-2010	https://pubmed.ncbi.nlm.nih.gov/3290223/	Saccharomyces cerevisiae, budding yeast, fungus
		β318	R318W	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	Congenital macrothrombocytopenia, tubulin beta-1	Arg318Trp	Hou et al. 2021. Platelets 5:1-5	https://pubmed.ncbi.nlm.nih.gov/33400601/	Homo sapiens, human, clinical
		β318	R318W	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	Computational prediction, nsSNP causes protein destablization	Arg318Trp	Hussain et al. 2022. J Biomol Struct Dyn 11:1-11.	https://pubmed.ncbi.nlm.nih.gov/36218086/	Computational modeling, clinical
		β318	R318X	P12456	https://www.uniprot.org/uniprotkb/P12456/entry	C. elegans	Mechanosensitive, severe recessive, mec-7	Arg318X	Savage et al. 1994. J Cell Sci 107:2165-75	https://pubmed.ncbi.nlm.nih.gov/7983175/	Caenorhabditis elegans, nematode, roundworm
		β319	M319V	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	Cortical dysplasia, brain malformations, with M299V, M227V, M255V, tubulin beta	Met319Val	ClinVar 127189	https://www.ncbi.nlm.nih.gov/clinvar/variation/127189	Homo sapiens, human, clinical
		β319	R319H	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with R442H, R391H, R436H, tubulin beta-4A	Arg319His	ClinVar 267793	https://www.ncbi.nlm.nih.gov/clinvar/variation/267793	Homo sapiens, human, clinical
		β319	R319L	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Pathogenic, with R391L, tubulin beta-3	Arg319Leu	ClinVar 265354	https://www.ncbi.nlm.nih.gov/clinvar/variation/265354	Homo sapiens, human, clinical
		β319	R319L	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with R391L, R442L, R436L, tubulin beta-4A	Arg319Leu	ClinVar 419697	https://www.ncbi.nlm.nih.gov/clinvar/variation/419697	Homo sapiens, human, clinical
		β319	S320S	Q7XYS0	https://www.uniprot.org/uniprotkb/Q7XYS0/entry	C. caldarium	Heat stable adaptation (correlation)	Ser320Ser	Arnold MS thesis (VPI)	https://vtechworks.lib.vt.edu/h&le/10919/9745?show=full	Cyanidium caldarium, extremophile, algae
		β319	S320S	A0A125YTB7	https://www.uniprot.org/uniprotkb/A0A125YTB7/entry	C. merolae	Heat stable adaptation (correlation)	Ser320Ser	Arnold MS thesis (VPI)	https://vtechworks.lib.vt.edu/h&le/10919/9745?show=full	Cyanidioschyzon merolae, extremophile, algae
		β320	K320A	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Benomyl resistant, with R318A, TUB2p	Lys320Ala	Reijo et al. 1994. Mol Biol Cell 5:29-43	https://pubmed.ncbi.nlm.nih.gov/8186463/	Saccharomyces cerevisiae, budding yeast, fungus
		β320	R320C	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:10534 / stomach cancer	Arg320Cys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β320	R320C	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:363 / uterine cancer	Arg320Cys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β320	R320C	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:1909 / melanoma	Arg320Cys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β320	R320C	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:9256 / colorectal cancer	Arg320Cys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β320	R320C	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:363 / uterine cancer	Arg320Cys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β320	R320C	P69893	https://www.uniprot.org/uniprotkb/P69893/entry	C. griseus	Paclitaxel resistant, tubulin beta-5	Arg320Cys	Yin et al. 2012. Pharm Res 29:2994-3006	https://pubmed.ncbi.nlm.nih.gov/22669706/	Cricetulus griseus, chinese hamster, rodent
		β320	R320H	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:11934 / head and neck cancer	Arg320His	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β320	R320H	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:169 / neuroendocrine tumor	Arg320His	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β320	R320H	P68371	https://www.uniprot.org/uniprotkb/P68371/entry	H. sapiens	TBB4B SNP, DOID:3070 / malignant glioma	Arg320His	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P68371	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β320	R320H	P68371	https://www.uniprot.org/uniprotkb/P68371/entry	H. sapiens	TBB4B SNP, DOID:363 / uterine cancer	Arg320His	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P68371	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β320	R320H	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:1793 / pancreatic cancer	Arg320His	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β320	R320H	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:1793 / pancreatic cancer	Arg320His	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β320	R320H	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:3070 / malignant glioma	Arg320His	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β320	R320H	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:2394 / ovarian cancer	Arg320His	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β320	R320H	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:4362 / cervical cancer	Arg320His	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β320	R320P	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Invasive ductal, high grade; taxane treatment, also contains I189V, A218T, A275S, Q291R, K297R, S364A, T386S	Arg320Pro	Wang et al. 2017. Protoplasma 254:1163-1173	https://pubmed.ncbi.nlm.nih.gov/27943021/	Homo sapiens, human, clinical	Tubulin beta-3 chain
		β320	R320S	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:0070003 / blastoma	Arg320Ser	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β320	R320S	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:3571 / liver cancer	Arg320Ser	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β320	R320S	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:2531 / hematologic cancer	Arg320Ser	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β320	S230P	Q922F4	https://www.uniprot.org/uniprotkb/Q922F4/entry	M. musculus	Tubb6, viable heterozygote	Ser230Pro	Mutagenetix	https://mutagenetix.utsouthwestern.edu/incidental/incidental_rec.cfm?mid=607694	Mus musculus, mouse, tubulin beta-6	Wang et al. 2015. PNAS 112:E440-449 (PMID 25605905)
		β320	S320S	Q9N2N6	https://www.uniprot.org/uniprotkb/Q9N2N6/entry	E. focardii	Cold stable adaptation (correlation, EFBT3)	Ser320Ser	Chiappori et al. 2012. Proteins 80:1154-60	https://pubmed.ncbi.nlm.nih.gov/22275059/	Euplotes focardii, extremophile, Antarctic ciliate
		β321	M321I	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:10534 / stomach cancer	Met321Ile	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β321	M321L	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	TUBB SNP, DOID:1612 / breast cancer	Met321Leu	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P07437	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β321	M321V	Q9BUF5	https://www.uniprot.org/uniprotkb/Q9BUF5/entry	H. sapiens	TBB6 SNP, DOID:10534 / stomach cancer	Met321Val	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BUF5	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β321	M321V	P99024	https://www.uniprot.org/uniprotkb/P99024/entry	M. musculus	Tubb5, viable heterozygote	Met321Val	Mutagenetix	https://mutagenetix.utsouthwestern.edu/incidental/incidental_rec.cfm?mid=623437	Mus musculus, mouse, tubulin beta-5	Wang et al. 2015. PNAS 112:E440-449 (PMID 25605905)
		β322	A322T	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Torsion dystonia, pathogenic, with A271T, A316T, A199T, tubulin beta-4A	Ala322Thr	ClinVar 92111	https://www.ncbi.nlm.nih.gov/clinvar/variation/92111	Homo sapiens, human, clinical
		β322	F322C	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with F445C, F394C, F439C, tubulin beta-4A	Phe322Cys	ClinVar 267794	https://www.ncbi.nlm.nih.gov/clinvar/variation/267794	Homo sapiens, human, clinical
		β322	F322S	Q9BUF5	https://www.uniprot.org/uniprotkb/Q9BUF5/entry	H. sapiens	Facial palsy, ptosis, velopharyngeal dysfunction, with F394S, F248S, F329S, F357S, tubulin beta-6	Phe322Ser	ClinVar 444894	https://www.ncbi.nlm.nih.gov/clinvar/variation/444894	Homo sapiens, human, clinical
		β322	F322S	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Torsion dystonia, with F445S, F439S, F394S, tubulin beta-4A	Phe322Ser	ClinVar 689794	https://www.ncbi.nlm.nih.gov/clinvar/variation/689794	Homo sapiens, human, clinical
		β322	S322F	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	Computational prediction, nsSNP causes protein destablization	Ser322Phe	Hussain et al. 2022. J Biomol Struct Dyn 11:1-11.	https://pubmed.ncbi.nlm.nih.gov/36218086/	Computational modeling, clinical
		β323	M323R	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Hypomyelination, basal ganglia & cerebellum atrophy, tubulin beta-4A	Met323Arg	Hamilton et al. 2014. Brain 137:1921-30	https://pubmed.ncbi.nlm.nih.gov/24785942/	Homo sapiens, human, clinical
		β323	M323R	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with M374R, M251R, M368R, tubulin beta-4A	Met323Arg	ClinVar 267784	https://www.ncbi.nlm.nih.gov/clinvar/variation/267784	Homo sapiens, human, clinical
		β323	M323V	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Malformation of cortical development, tubulin beta-3	Met323Val	Poirier et al. 2010. Hum Mol Genet 19:4462-73	https://pubmed.ncbi.nlm.nih.gov/20829227/	Homo sapiens, human, clinical
		β323	M323V	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Inhibited axonal transport of vesicles and mitochondria, tubulin beta-3	Met323Val	Niwa et al. 2013. EMBO J 32:1352-64	https://pubmed.ncbi.nlm.nih.gov/23503589/	Homo sapiens, human, clinical	Model for MCD
		β323	M323V	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Disruption of netrin-1 mediated axonal repulsion, tubulin beta-3, HeLa cells	Met323Val	Shao et al. 2019. PLoS One 14:e0218811	https://pubmed.ncbi.nlm.nih.gov/31226147/	Homo sapiens, human, clinical
		β323	M323V	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Cortical dysplasia, other brain malformations, with M251V, tubulin beta-3	Met323Val	ClinVar 30272	https://www.ncbi.nlm.nih.gov/clinvar/variation/30272	Homo sapiens, human, clinical
		β324	K324A	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Heat sensitive, benomyl supersensitive, TUB2p	Lys324Ala	Reijo et al. 1994. Mol Biol Cell 5:29-43	https://pubmed.ncbi.nlm.nih.gov/8186463/	Saccharomyces cerevisiae, budding yeast, fungus
		β324	K324A	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Cold sensitive, benomyl supersensitive, with E325A, TUB2p	Lys324Ala	Reijo et al. 1994. Mol Biol Cell 5:29-43	https://pubmed.ncbi.nlm.nih.gov/8186463/	Saccharomyces cerevisiae, budding yeast, fungus
		β324	K324R	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	Invasive mixed, low grade; no treatment, also contains I155V, L331H	Lys324Arg	Wang et al. 2017. Protoplasma 254:1163-1173	https://pubmed.ncbi.nlm.nih.gov/27943021/	Homo sapiens, human, clinical	Tubulin beta-1 chain
		β324	K324T	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Epilepsy of infancy, migrating focal seizures, 4 patients, tubulin beta-4A	Lys324Thr	Xiao et al. 2022. Mol Neurobiol 59:5056-69	https://pubmed.ncbi.nlm.nih.gov/35668344/	Homo sapiens, human, clinical
		β324	K324T	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Epilepsy of infancy with migrating focal seizures, tubulin beta-4A	Lys324Thr	Xiao et al. 2022. Mol Neurobiol 59:5056-69.	https://pubmed.ncbi.nlm.nih.gov/35668344/	Homo sapiens, human, clinical
		β324	L324L	Q9N2N6	https://www.uniprot.org/uniprotkb/Q9N2N6/entry	E. focardii	Cold stable adaptation (correlation, EFBT3)	Leu324Leu	Chiappori et al. 2012. Proteins 80:1154-60	https://pubmed.ncbi.nlm.nih.gov/22275059/	Euplotes focardii, extremophile, Antarctic ciliate
		β324	Q324Q	Q9N2N6	https://www.uniprot.org/uniprotkb/Q9N2N6/entry	E. focardii	Cold stable adaptation (correlation, EFBT4)	Gln324Gln	Chiappori et al. 2012. Proteins 80:1154-60	https://pubmed.ncbi.nlm.nih.gov/22275059/	Euplotes focardii, extremophile, Antarctic ciliate
		β324	R324K	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:1324 / lung cancer	Arg324Lys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β324	R324K	Q18817	https://www.uniprot.org/uniprotkb/Q18817/entry	C. elegans	Albendazole resistance, ben-1	Arg324Lys	Pallotto et al. 2022. Genetics 221:iyac093	https://pubmed.ncbi.nlm.nih.gov/35731216/	Caenorhabditis elegans, nematode, roundworm
		β325	E325A	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Benomyl supersensitive, TUB2p	Glu325Ala	Reijo et al. 1994. Mol Biol Cell 5:29-43	https://pubmed.ncbi.nlm.nih.gov/8186463/	Saccharomyces cerevisiae, budding yeast, fungus
		β325	E325A	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Cold sensitive, benomyl supersensitive, with K324A, TUB2p	Glu325Ala	Reijo et al. 1994. Mol Biol Cell 5:29-43	https://pubmed.ncbi.nlm.nih.gov/8186463/	Saccharomyces cerevisiae, budding yeast, fungus
		β325	E325K	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:1909 / melanoma	Glu325Lys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β325	E325Q	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:1612 / breast cancer	Glu325Gln	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β325	E325Q	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:1612 / breast cancer	Glu325Gln	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β326	V326A	Q9ERD7	https://www.uniprot.org/uniprotkb/Q9ERD7/entry	M. musculus	Tubb3, viable heterozygote	Val326Ala	Mutagenetix	https://mutagenetix.utsouthwestern.edu/incidental/incidental_rec.cfm?mid=443631	Mus musculus, mouse, tubulin beta-3	Wang et al. 2015. PNAS 112:E440-449 (PMID 25605905)
		β327	D327G	Q9BVA1	https://www.uniprot.org/uniprotkb/Q9BVA1/entry	H. sapiens	Cerebellar dysplasia, tubulin beta-2B	Asp327Gly	Romaniello et al. 2017. Eur Radiol 27:5080-5092	https://pubmed.ncbi.nlm.nih.gov/28677066/	Homo sapiens, human, clinical
		β327	E327A	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Dominant lethal, with D328A, E329A, TUB2p	Glu327Ala	Reijo et al. 1994. Mol Biol Cell 5:29-43	https://pubmed.ncbi.nlm.nih.gov/8186463/	Saccharomyces cerevisiae, budding yeast, fungus
		β327	R327P	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with R333P, R282P, R210P, tubulin beta-4A	Arg327Pro	ClinVar 267779	https://www.ncbi.nlm.nih.gov/clinvar/variation/267779	Homo sapiens, human, clinical
		β327	T327S	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Likely benign, with T399S, tubulin beta-3	Thr327Ser	ClinVar 437133	https://www.ncbi.nlm.nih.gov/clinvar/variation/437133	Homo sapiens, human, clinical
		β328	D328A	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Dominant lethal, with E327, E329A, TUB2p	Asp328Ala	Reijo et al. 1994. Mol Biol Cell 5:29-43	https://pubmed.ncbi.nlm.nih.gov/8186463/	Saccharomyces cerevisiae, budding yeast, fungus
		β328	E328A	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:1909 / melanoma	Glu328Ala	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β328	E328D	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:1612 / breast cancer	Glu328Asp	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β328	E328K	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:10534 / stomach cancer	Glu328Lys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β328	E328K	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Cortical dysplasia, other brain malformations, with E256K, tubulin beta-3	Glu328Lys	ClinVar 374309	https://www.ncbi.nlm.nih.gov/clinvar/variation/374309	Homo sapiens, human, clinical
		β329	E329A	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Dominant lethal, with E327A, D328A, TUB2p	Glu329Ala	Reijo et al. 1994. Mol Biol Cell 5:29-43	https://pubmed.ncbi.nlm.nih.gov/8186463/	Saccharomyces cerevisiae, budding yeast, fungus
		β329	E329K	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	Cortical dysplasia, brain malformations, with E401K, E357K, E421K, E199K, tubulin beta	Glu329Lys	ClinVar 127191	https://www.ncbi.nlm.nih.gov/clinvar/variation/127191	Homo sapiens, human, clinical
		β329	F329S	Q9BUF5	https://www.uniprot.org/uniprotkb/Q9BUF5/entry	H. sapiens	Facial palsy, ptosis, velopharyngeal dysfunction, with F394S, F322S, F248S, F357S, tubulin beta-6	Phe329Ser	ClinVar 444894	https://www.ncbi.nlm.nih.gov/clinvar/variation/444894	Homo sapiens, human, clinical
		β329	N329H	Q13885	https://www.uniprot.org/uniprotkb/Q13885/entry	H. sapiens	Likely pathogenic, with N414H, tubulin beta-2A	Asn329His	ClinVar 372880	https://www.ncbi.nlm.nih.gov/clinvar/variation/372880	Homo sapiens, human, clinical
		β330	M330I	Q9BUF5	https://www.uniprot.org/uniprotkb/Q9BUF5/entry	H. sapiens	TBB6 SNP, DOID:363 / uterine cancer	Met330Ile	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BUF5	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β330	M330I	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Infertility due to arrest in oocyte maturation, tubulin beta-8	Met330Ile	Chen et al. 2017. Hum Reprod 32:457-464.	https://pubmed.ncbi.nlm.nih.gov/27989988/	Homo sapiens, human, clinical
		β331	F331L	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:11054 / urinary bladder cancer	Phe331Leu	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β331	L331H	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	Invasive mixed, low grade; no treatment, also contains I155V, K324R	Leu331His	Wang et al. 2017. Protoplasma 254:1163-1173	https://pubmed.ncbi.nlm.nih.gov/27943021/	Homo sapiens, human, clinical	Tubulin beta-1 chain
		β331	L331I	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	TUBB SNP, DOID:363 / uterine cancer	Leu331Ile	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P07437	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β331	M331I	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Likely pathogenic, with M403I, tubulin beta-3	Met331Ile	ClinVar 429849	https://www.ncbi.nlm.nih.gov/clinvar/variation/429849	Homo sapiens, human, clinical
		β331	N331S	Q13885	https://www.uniprot.org/uniprotkb/Q13885/entry	H. sapiens	Likely pathogenic, with N416S, tubulin beta-2A	Asn331Ser	ClinVar 624121	https://www.ncbi.nlm.nih.gov/clinvar/variation/624121	Homo sapiens, human, clinical
		β332	A332D	Q9BUF5	https://www.uniprot.org/uniprotkb/Q9BUF5/entry	H. sapiens	TBB6 SNP, DOID:10534 / stomach cancer	Ala332Asp	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BUF5	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β332	A332N	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Invasive ductal, high grade; doxorubicin treatment, also contains V180A, T315A, I333V, S335N, V351T, S365A, I374T	Ala332Asn	Wang et al. 2017. Protoplasma 254:1163-1173	https://pubmed.ncbi.nlm.nih.gov/27943021/	Homo sapiens, human, clinical	Tubulin beta-3 chain
		β332	A332N	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Invasive mucinous, low grade; no treatment, also contains D249E, M293V, T315A, I333V, S335N, V351T, A352V, S364A, S365V	Ala332Asn	Wang et al. 2017. Protoplasma 254:1163-1173	https://pubmed.ncbi.nlm.nih.gov/27943021/	Homo sapiens, human, clinical	Tubulin beta-3 chain
		β332	A332N	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Invasive ductal, low grade; taxane treatment, also contains T166A, I189V, S239C, T315A, I333V, S335N, V351T	Ala332Asn	Wang et al. 2017. Protoplasma 254:1163-1173	https://pubmed.ncbi.nlm.nih.gov/27943021/	Homo sapiens, human, clinical	Tubulin beta-3 chain
		β332	K332A	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Recessive lethal, with K336A, TUB2p	Lys332Ala	Reijo et al. 1994. Mol Biol Cell 5:29-43	https://pubmed.ncbi.nlm.nih.gov/8186463/	Saccharomyces cerevisiae, budding yeast, fungus
		β332	K336A	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Recessive lethal, with K332A, TUB2p	Lys332Ala	Reijo et al. 1994. Mol Biol Cell 5:29-43	https://pubmed.ncbi.nlm.nih.gov/8186463/	Saccharomyces cerevisiae, budding yeast, fungus
		β332	N332A	P68371	https://www.uniprot.org/uniprotkb/P68371/entry	H. sapiens	Invasive ductal, high grade; doxorubicin treatment, also contains V333I, N335S, T351V, A365S	Asn332Ala	Wang et al. 2017. Protoplasma 254:1163-1173	https://pubmed.ncbi.nlm.nih.gov/27943021/	Homo sapiens, human, clinical	Tubulin beta-4B chain
		β332	N332A	P68371	https://www.uniprot.org/uniprotkb/P68371/entry	H. sapiens	Invasive ductal, high grade; no treatment, also contains L44P, S275A, Q292R, A315T, V333I, N335S, T351V, A365S	Asn332Ala	Wang et al. 2017. Protoplasma 254:1163-1173	https://pubmed.ncbi.nlm.nih.gov/27943021/	Homo sapiens, human, clinical	Tubulin beta-4B chain
		β333	I333V	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Invasive ductal, high grade; doxorubicin treatment, also contains V180A, T315A, A332N, S335N, V351T, S365A, I374T	Ile333Val	Wang et al. 2017. Protoplasma 254:1163-1173	https://pubmed.ncbi.nlm.nih.gov/27943021/	Homo sapiens, human, clinical	Tubulin beta-3 chain
		β333	I333V	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Invasive mucinous, low grade; no treatment, also contains D249E, M293V, T315A, A332N, S335N, V351T, A352V, S364A, S365V	Ile333Val	Wang et al. 2017. Protoplasma 254:1163-1173	https://pubmed.ncbi.nlm.nih.gov/27943021/	Homo sapiens, human, clinical	Tubulin beta-3 chain
		β333	I333V	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Invasive ductal, low grade; taxane treatment, also contains T166A, I189V, S239C, T315A, A332N, S335N, V351T	Ile333Val	Wang et al. 2017. Protoplasma 254:1163-1173	https://pubmed.ncbi.nlm.nih.gov/27943021/	Homo sapiens, human, clinical	Tubulin beta-3 chain
		β333	R333P	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with R282P, R327P, R210P, tubulin beta-4A	Arg333Pro	ClinVar 267779	https://www.ncbi.nlm.nih.gov/clinvar/variation/267779	Homo sapiens, human, clinical
		β333	V333A	P68371	https://www.uniprot.org/uniprotkb/P68371/entry	H. sapiens	TBB4B SNP, DOID:0070003 / blastoma	Val333Ala	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P68371	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β333	V333A	P68371	https://www.uniprot.org/uniprotkb/P68371/entry	H. sapiens	TBB4B SNP, DOID:3571 / liver cancer	Val333Ala	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P68371	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β333	V333I	P68371	https://www.uniprot.org/uniprotkb/P68371/entry	H. sapiens	Invasive ductal, high grade; doxorubicin treatment, also contains N332A, N335S, T351V, A365S	Val333Ile	Wang et al. 2017. Protoplasma 254:1163-1173	https://pubmed.ncbi.nlm.nih.gov/27943021/	Homo sapiens, human, clinical	Tubulin beta-4B chain
		β333	V333I	P68371	https://www.uniprot.org/uniprotkb/P68371/entry	H. sapiens	Invasive ductal, high grade; no treatment, also contains L44P, S275A, Q292R, A315T, N332A, N335S, T351V, A365S	Val333Ile	Wang et al. 2017. Protoplasma 254:1163-1173	https://pubmed.ncbi.nlm.nih.gov/27943021/	Homo sapiens, human, clinical	Tubulin beta-4B chain
		β333	V333L	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:10534 / stomach cancer	Val333Leu	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β333	V333M	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:0070003 / blastoma	Val333Met	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β333	V333M	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:3571 / liver cancer	Val333Met	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β333	V333M	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:10534 / stomach cancer	Val333Met	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β333	V333M	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:5041 / esophageal cancer	Val333Met	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β334	Q334E	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Female infertility, tubulin beta-8	Gln334Glu	Chen et al. 2019. Eur J Hum Genet 27:300-307	https://pubmed.ncbi.nlm.nih.gov/30297906/	Homo sapiens, human, clinical
		β334	Q334H	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:10283 / prostate cancer	Gln334His	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β334	Q334H	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:1793 / pancreatic cancer	Gln334His	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β334	Q334R	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:3571 / liver cancer	Gln334Arg	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β334	Q334R	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:0070003 / blastoma	Gln334Arg	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β335	N335S	P68371	https://www.uniprot.org/uniprotkb/P68371/entry	H. sapiens	Invasive ductal, high grade; doxorubicin treatment, also contains V333I, N332A, T351V, A365S	Asn335Ser	Wang et al. 2017. Protoplasma 254:1163-1173	https://pubmed.ncbi.nlm.nih.gov/27943021/	Homo sapiens, human, clinical	Tubulin beta-4B chain
		β335	N335S	P68371	https://www.uniprot.org/uniprotkb/P68371/entry	H. sapiens	Invasive ductal, high grade; no treatment, also contains L44P, S275A, Q292R, A315T, V333I, N332A, T351V, A365S	Asn335Ser	Wang et al. 2017. Protoplasma 254:1163-1173	https://pubmed.ncbi.nlm.nih.gov/27943021/	Homo sapiens, human, clinical	Tubulin beta-4B chain
		β335	S335N	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Invasive ductal, high grade; doxorubicin treatment, also contains V180A, T315A, A332N, I333V, V351T, S365A, I374T	Ser335Asn	Wang et al. 2017. Protoplasma 254:1163-1173	https://pubmed.ncbi.nlm.nih.gov/27943021/	Homo sapiens, human, clinical	Tubulin beta-3 chain
		β335	S335N	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Invasive mucinous, low grade; no treatment, also contains D249E, M293V, T315A, A332N, I333V, V351T, A352V, S364A, S365V	Ser335Asn	Wang et al. 2017. Protoplasma 254:1163-1173	https://pubmed.ncbi.nlm.nih.gov/27943021/	Homo sapiens, human, clinical	Tubulin beta-3 chain
		β335	S335N	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Invasive ductal, low grade; taxane treatment, also contains T166A, I189V, S239C, T315A, A332N, I333V, V351T	Ser335Asn	Wang et al. 2017. Protoplasma 254:1163-1173	https://pubmed.ncbi.nlm.nih.gov/27943021/	Homo sapiens, human, clinical	Tubulin beta-3 chain
		β335	T335I	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:3070 / malignant glioma	Thr335Ile	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β336	K336E	P68371	https://www.uniprot.org/uniprotkb/P68371/entry	H. sapiens	TBB4B SNP, DOID:1909 / melanoma	Lys336Glu	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P68371	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β336	K336N	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:363 / uterine cancer	Lys336Asn	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β336	K336R	P68371	https://www.uniprot.org/uniprotkb/P68371/entry	H. sapiens	TBB4B SNP, DOID:3963 / thyroid carcinoma	Lys336Arg	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P68371	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β337	N337T	P10878	https://www.uniprot.org/uniprotkb/P10878/entry	T. gondii	Suppressor of G142S α1-tubulin defects, β1-tubulin	Asn337Thr	Ma et al. 2008. Genetics 180:845-56	https://pubmed.ncbi.nlm.nih.gov/18780736/	Toxoplasma gondii, parasite, protozoan
		β337	N337Y	Q9D6F9	https://www.uniprot.org/uniprotkb/Q9D6F9/entry	M. musculus	Tubb4a, viable heterozygote	Asn337Tyr	Mutagenetix	https://mutagenetix.utsouthwestern.edu/incidental/incidental_rec.cfm?mid=514292	Mus musculus, mouse, tubulin beta-4A	Wang et al. 2015. PNAS 112:E440-449 (PMID 25605905)
		β337	Q337K	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with Q343K, Q292K, Q220K, tubulin beta-4A	Gln337Lys	ClinVar 267780	https://www.ncbi.nlm.nih.gov/clinvar/variation/267780	Homo sapiens, human, clinical
		β338	E338D	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	Likely pathogenic, with E410D, E430D, E366D, E208D, tubulin beta	Glu338Asp	ClinVar 426178	https://www.ncbi.nlm.nih.gov/clinvar/variation/426178	Homo sapiens, human, clinical
		β338	E338K	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with E410K, E461K, E455K, tubulin beta-4A	Glu338Lys	ClinVar 135658	https://www.ncbi.nlm.nih.gov/clinvar/variation/135658	Homo sapiens, human, clinical
		β338	E338K	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Cortical dysplasia, other brain malformations, with E410K, tubulin beta-3	Glu338Lys	ClinVar 6967	https://www.ncbi.nlm.nih.gov/clinvar/variation/6967	Homo sapiens, human, clinical
		β338	S338C	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:1324 / lung cancer	Ser338Cys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β338	S338N	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:3963 / thyroid carcinoma	Ser338Asn	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β339	D339A	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Recessive lethal, with E343A, TUB2p	Asp339Ala	Reijo et al. 1994. Mol Biol Cell 5:29-43	https://pubmed.ncbi.nlm.nih.gov/8186463/	Saccharomyces cerevisiae, budding yeast, fungus
		β339	S339G	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	TUBB SNP, DOID:9256 / colorectal cancer	Ser339Gly	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P07437	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β340	S340S	Q9N2N6	https://www.uniprot.org/uniprotkb/Q9N2N6/entry	E. focardii	Cold stable adaptation (correlation, EFBT3)	Ser340Ser	Chiappori et al. 2012. Proteins 80:1154-60	https://pubmed.ncbi.nlm.nih.gov/22275059/	Euplotes focardii, extremophile, Antarctic ciliate
		β340	Y340C	P99024	https://www.uniprot.org/uniprotkb/P99024/entry	M. musculus	Tubb5, viable heterozygote	Tyr340Cys	Mutagenetix	https://mutagenetix.utsouthwestern.edu/incidental/incidental_rec.cfm?mid=213001	Mus musculus, mouse, tubulin beta-5	Wang et al. 2015. PNAS 112:E440-449 (PMID 25605905)
		β340	Y340C	P99024	https://www.uniprot.org/uniprotkb/P99024/entry	M. musculus	Tubb5, viable heterozygote	Tyr340Cys	Mutagenetix	https://mutagenetix.utsouthwestern.edu/incidental/incidental_rec.cfm?mid=213190	Mus musculus, mouse, tubulin beta-5	Wang et al. 2015. PNAS 112:E440-449 (PMID 25605905)
		β340	Y340C	Q922F4	https://www.uniprot.org/uniprotkb/Q922F4/entry	M. musculus	Tubb6, viable heterozygote	Tyr340Cys	Mutagenetix	https://mutagenetix.utsouthwestern.edu/incidental/incidental_rec.cfm?mid=270316	Mus musculus, mouse, tubulin beta-6	Wang et al. 2015. PNAS 112:E440-449 (PMID 25605905)
		β340	Y340N	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:1324 / lung cancer	Tyr340Asn	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β341	V349I	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Female infertility, tubulin beta-8	Val349Ile	Yang et al. 2021. Clin Genet 99:208-214	https://pubmed.ncbi.nlm.nih.gov/33009822/	Homo sapiens, human, clinical
		β342	A342T	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:363 / uterine cancer	Ala342Thr	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β342	V342L	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:3571 / liver cancer	Val342Leu	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β343	D343N	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:363 / uterine cancer	Asp343Asn	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β343	E343A	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Recessive lethal, with D339A, TUB2p	Glu343Ala	Reijo et al. 1994. Mol Biol Cell 5:29-43	https://pubmed.ncbi.nlm.nih.gov/8186463/	Saccharomyces cerevisiae, budding yeast, fungus
		β343	E343D	Q13885	https://www.uniprot.org/uniprotkb/Q13885/entry	H. sapiens	TBB2A SNP, DOID:184 / bone cancer	Glu343Asp	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13885	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β343	Q343K	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with Q292K, Q220K, Q337K, tubulin beta-4A	Gln343Lys	ClinVar 267780	https://www.ncbi.nlm.nih.gov/clinvar/variation/267780	Homo sapiens, human, clinical
		β344	M344L	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Uncertain significance, with M299L, M350L, M227L, tubulin beta-4A	Met344Leu	ClinVar 429972	https://www.ncbi.nlm.nih.gov/clinvar/variation/429972	Homo sapiens, human, clinical
		β344	W344R	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Uncertain significance, with W395R, W389R, W272R, tubulin beta-4A	Trp344Arg	ClinVar 522029	https://www.ncbi.nlm.nih.gov/clinvar/variation/522029	Homo sapiens, human, clinical
		β344	W344X	Q18817	https://www.uniprot.org/uniprotkb/Q18817/entry	C. elegans	Albendazole resistance, ben-1	Trp344X	Pallotto et al. 2022. Genetics 221:iyac093	https://pubmed.ncbi.nlm.nih.gov/35731216/	Caenorhabditis elegans, nematode, roundworm
		β344	W344X	P12456	https://www.uniprot.org/uniprotkb/P12456/entry	C. elegans	Mechanosensitive, mild semi-dominant, mec-7	Trp344X	Savage et al. 1994. J Cell Sci 107:2165-75	https://pubmed.ncbi.nlm.nih.gov/7983175/	Caenorhabditis elegans, nematode, roundworm
		β345	D345H	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Fibrosis of extraocular muscles, with D417H, tubulin beta-3	Asp345His	ClinVar 6965	https://www.ncbi.nlm.nih.gov/clinvar/variation/6965	Homo sapiens, human, clinical
		β345	D345N	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Fibrosis of extraocular muscles, with D417N, tubulin beta-3	Asp345Asn	ClinVar 6966	https://www.ncbi.nlm.nih.gov/clinvar/variation/6966	Homo sapiens, human, clinical
		β345	I345F	Q13885	https://www.uniprot.org/uniprotkb/Q13885/entry	H. sapiens	Cortical dysplasia, brain malformations, with I260F, tubulin beta-2A	Ile345Phe	ClinVar 212495	https://www.ncbi.nlm.nih.gov/clinvar/variation/212495	Homo sapiens, human, clinical
		β345	I345V	Q9BUF5	https://www.uniprot.org/uniprotkb/Q9BUF5/entry	H. sapiens	TBB6 SNP, DOID:1909 / melanoma	Ile345Val	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BUF5	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β345	L345F	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:1324 / lung cancer	Leu345Phe	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β345	M345I	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with M351I, M300I, M228I, tubulin beta-4A	Met345Ile	ClinVar 267782	https://www.ncbi.nlm.nih.gov/clinvar/variation/267782	Homo sapiens, human, clinical
		β346	P346L	P68371	https://www.uniprot.org/uniprotkb/P68371/entry	H. sapiens	TBB4B SNP, DOID:0070003 / blastoma	Pro346Leu	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P68371	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β346	P346L	P68371	https://www.uniprot.org/uniprotkb/P68371/entry	H. sapiens	TBB4B SNP, DOID:1793 / pancreatic cancer	Pro346Leu	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P68371	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β346	P346L	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:11054 / urinary bladder cancer	Pro346Leu	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β346	P346R	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:2994 / germ cell cancer	Pro346Arg	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β346	P346R	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:2394 / ovarian cancer	Pro346Arg	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β346	P346S	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:1909 / melanoma	Pro346Ser	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β346	P346T	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:1324 / lung cancer	Pro346Thr	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β347	N347K	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Female infertility, tubulin beta-8	Asn347Lys	Jia et al. 2020. J Assist Reprod Genet 37:2713-2722	https://pubmed.ncbi.nlm.nih.gov/32949002/	Homo sapiens, human, clinical
		β347	N347S	A2AQ07	https://www.uniprot.org/uniprotkb/A2AQ07/entry	M. musculus	Tubb1, viable heterozygote	Asn347Ser	Mutagenetix	https://mutagenetix.utsouthwestern.edu/incidental/incidental_rec.cfm?mid=297473	Mus musculus, mouse, tubulin beta-1	Wang et al. 2015. PNAS 112:E440-449 (PMID 25605905)
		β348	ΔE27-A33	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Defects in oocyte meiosis, tubulin beta-8	ΔGlu27-Ala33	Feng et al. 2016. J Med Genet 53:662-71	https://pubmed.ncbi.nlm.nih.gov/27273344/	Homo sapiens, human, clinical
		β348	N348K	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:3963 / thyroid carcinoma	Asn348Lys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β348	N348S	P69893	https://www.uniprot.org/uniprotkb/P69893/entry	C. griseus	Paclitaxel resistant, tubulin beta-5	Asn348Ser	Yin et al. 2012. Pharm Res 29:2994-3006	https://pubmed.ncbi.nlm.nih.gov/22669706/	Cricetulus griseus, chinese hamster, rodent
		β348	N348S	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Defects in oocyte meiosis, tubulin beta-8	Asn348Ser	Feng et al. 2016. J Med Genet 53:662-71	https://pubmed.ncbi.nlm.nih.gov/27273344/	Homo sapiens, human, clinical
		β348	T143X	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Defects in oocyte meiosis, tubulin beta-8, frameshift with stop after 154 aa	Thr143X	Feng et al. 2016. J Med Genet 53:662-71	https://pubmed.ncbi.nlm.nih.gov/27273344/	Homo sapiens, human, clinical
		β349	V349D	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	TUBB SNP, DOID:363 / uterine cancer	Val349Asp	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P07437	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β349	V349I	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:363 / uterine cancer	Val349Ile	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β349	V349M	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:10283 / prostate cancer	Val349Met	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β349	V349M	P68371	https://www.uniprot.org/uniprotkb/P68371/entry	H. sapiens	TBB4B SNP, DOID:5041 / esophageal cancer	Val349Met	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P68371	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β350	K350E	P04690	https://www.uniprot.org/uniprotkb/P04690/entry	C. reinhardtii	Resistant to microtubule disrupting drugs, Tub2	Lys350Glu	Lee et al. 1990. Plant Cell 2:1051-7	https://pubmed.ncbi.nlm.nih.gov/2152107/	Chlamydomonas reinhardtii, green alga	also see Schibler & Huang. 1991. J Cell Biol 113:605-14 (PMID 1673126)
		β350	K350E	P04690	https://www.uniprot.org/uniprotkb/P04690/entry	C. reinhardtii	Propyzamide resistant, tub2	Lys350Glu	Kato-Minoura et al. 2020. PLoS One 15(11):e0242694	https://pubmed.ncbi.nlm.nih.gov/33227038/	Chlamydomonas reinhardtii, green alga
		β350	K350M	P41352	https://www.uniprot.org/uniprotkb/P41352/entry	T. thermophila	Paclitaxel hypersensitive, btu1-1	Lys350Met	Smith et al. 2004. Eukaryot Cell 3:1217-26	https://pubmed.ncbi.nlm.nih.gov/15470250/	Tetrahymena thermophila, ciliate, protozoan
		β350	K350M	P04690	https://www.uniprot.org/uniprotkb/P04690/entry	C. reinhardtii	Resistant to microtubule disrupting drugs, Tub2	Lys350Met	Lee et al. 1990. Plant Cell 2:1051-7	https://pubmed.ncbi.nlm.nih.gov/2152107/	Chlamydomonas reinhardtii, green alga	also see Schibler & Huang. 1991. J Cell Biol 113:605-14 (PMID 1673126)
		β350	K350N	Q9CWF2	https://www.uniprot.org/uniprotkb/Q9CWF2/entry	M. musculus	Tubb2b, viable heterozygote	Lys350Asn	Mutagenetix	https://mutagenetix.utsouthwestern.edu/incidental/incidental_rec.cfm?mid=724171	Mus musculus, mouse, tubulin beta-2B	Wang et al. 2015. PNAS 112:E440-449 (PMID 25605905)
		β350	K350N	Q9CWF2	https://www.uniprot.org/uniprotkb/Q9CWF2/entry	M. musculus	Tubb2b, viable heterozygote	Lys350Asn	Mutagenetix	https://mutagenetix.utsouthwestern.edu/incidental/incidental_rec.cfm?mid=724239	Mus musculus, mouse, tubulin beta-2B	Wang et al. 2015. PNAS 112:E440-449 (PMID 25605905)
		β350	K350N	P07437	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	Indanocine resistant, 2-Methoxyestradiol resistant, tubulin beta	Lys350Asn	Hua et al. 2001. Cancer Res 61:7248-54	https://pubmed.ncbi.nlm.nih.gov/11585762/	Homo sapiens, human, clinical
		β350	K350N	P69893	https://www.uniprot.org/uniprotkb/P69893/entry	C. griseus	Colcimid & vinblastine resistant, CHO cell line, tubulin beta-5	Lys350Asn	Hari et al. 2003. Mol Cancer Therap 2:597-605	https://pubmed.ncbi.nlm.nih.gov/12883031/	Cricetulus griseus, chinese hamster, rodent
		β350	K350N	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	Indanocine & 2-Methoxyestradiol resistant, MDA-MB-435 line, tubulin beta	Lys350Asn	Gökmen-Polar et al. 2005. Cancer Res 65:9406-14	https://pubmed.ncbi.nlm.nih.gov/16230404/	Homo sapiens, human, clinical
		β350	K350N	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	2-methoxyestradiol resistant, tubulin beta	Lys350Asn	Liaw et al. 2008. Mol Cancer Ther 7:3150-9	https://pubmed.ncbi.nlm.nih.gov/18852118/	Homo sapiens, human, clinical
		β350	K350T	P68371	https://www.uniprot.org/uniprotkb/P68371/entry	H. sapiens	Resistance to TK216, A673 EWS cells, tubulin beta-4B	Lys350Thr	Povedano et al. 2022. Cell Chem Biol 29: 1325–1332	https://pubmed.ncbi.nlm.nih.gov/35803262/	Homo sapiens, human, clinical	Microtubule destabilizing drug
		β350	K350T	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Uncertain significance, with K278T, K395T, K401T, tubulin beta-4A	Lys350Thr	ClinVar 871906	https://www.ncbi.nlm.nih.gov/clinvar/variation/871906	Homo sapiens, human, clinical
		β350	M350L	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Uncertain significance, with M299L, M227L, M344L, tubulin beta-4A	M350Leu	ClinVar 429972	https://www.ncbi.nlm.nih.gov/clinvar/variation/429972	Homo sapiens, human, clinical
		β351	M351I	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with M300I, M345I, M228I, tubulin beta-4A	Met351Ile	ClinVar 267782	https://www.ncbi.nlm.nih.gov/clinvar/variation/267782	Homo sapiens, human, clinical
		β351	S351F	P24636	https://www.uniprot.org/uniprotkb/P24636/entry	A. thaliana	Twisting, TUB4	Ser351Phe	Ishida et al. 2007. PNAS 104:8544-9	https://pubmed.ncbi.nlm.nih.gov/17488810/	Arabidopsis thaliana, plant
		β351	T351A	P69893	https://www.uniprot.org/uniprotkb/P69893/entry	C. griseus	Paclitaxel resistant, tubulin beta-5	Thr351Ala	Yin et al. 2012. Pharm Res 29:2994-3006	https://pubmed.ncbi.nlm.nih.gov/22669706/	Cricetulus griseus, chinese hamster, rodent
		β351	T351I	P53373	https://www.uniprot.org/uniprotkb/P53373/entry	B. cinerea	Resistant to procymidone & zoxamide, with E198K, correlation, beta-tubulin	Thr351Ile	Adnan et al. 2019. Phytopathol Res 1:17	https://phytopatholres.biomedcentral.com/articles/10.1186/s42483-019-0024-8	Botrytis cinerea, fungus, plant pathogen
		β351	T351I	P53373	https://www.uniprot.org/uniprotkb/P53373/entry	B. cinerera	Zoxamide resistant, only with E198K, correlation, beta-tubulin	Thr351Ile	Adnan et al. 2018. Plant Disease 102:1299-1306	https://pubmed.ncbi.nlm.nih.gov/30673571/	Botrytis cinerea, fungus, plant pathogen
		β351	T351M	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:9256 / colorectal cancer	Thr351Met	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β351	T351S	P68371	https://www.uniprot.org/uniprotkb/P68371/entry	H. sapiens	TBB4B SNP, DOID:2994 / germ cell cancer	Thr351Ser	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P68371	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β351	T351S	Q9D6F9	https://www.uniprot.org/uniprotkb/Q9D6F9/entry	M. musculus	Tubb4a, viable heterozygote	Thr351Ser	Mutagenetix	https://mutagenetix.utsouthwestern.edu/incidental/incidental_rec.cfm?mid=254129	Mus musculus, mouse, tubulin beta-4A	Wang et al. 2015. PNAS 112:E440-449 (PMID 25605905)
		β351	T351V	P68371	https://www.uniprot.org/uniprotkb/P68371/entry	H. sapiens	Invasive ductal, high grade; doxorubicin treatment, also contains V333I, N332A, N335S, A365S	Thr351Val	Wang et al. 2017. Protoplasma 254:1163-1173	https://pubmed.ncbi.nlm.nih.gov/27943021/	Homo sapiens, human, clinical	Tubulin beta-4B chain
		β351	T351V	P68371	https://www.uniprot.org/uniprotkb/P68371/entry	H. sapiens	Invasive ductal, high grade; no treatment, also contains L44P, S275A, Q292R, A315T, V333I, N332A, N335S, A365S	Thr351Val	Wang et al. 2017. Protoplasma 254:1163-1173	https://pubmed.ncbi.nlm.nih.gov/27943021/	Homo sapiens, human, clinical	Tubulin beta-4B chain
		β351	T351V	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	Invasive ductal, low grade; no treatment, also contains L112P, A364S, V365S	Thr351Val	Wang et al. 2017. Protoplasma 254:1163-1173	https://pubmed.ncbi.nlm.nih.gov/27943021/	Homo sapiens, human, clinical	Tubulin beta-1 chain
		β351	V351L	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:11934 / head and neck cancer	Val351Leu	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β351	V351T	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Invasive ductal, high grade; doxorubicin treatment, also contains V180A, T315A, A332N, I333V, S335N, S365A, I374T	Val351Thr	Wang et al. 2017. Protoplasma 254:1163-1173	https://pubmed.ncbi.nlm.nih.gov/27943021/	Homo sapiens, human, clinical	Tubulin beta-3 chain
		β351	V351T	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Invasive mucinous, low grade; no treatment, also contains D249E, M293V, T315A, A332N, I333V, S335N, A352V, S364A, S365V	Val351Thr	Wang et al. 2017. Protoplasma 254:1163-1173	https://pubmed.ncbi.nlm.nih.gov/27943021/	Homo sapiens, human, clinical	Tubulin beta-3 chain
		β351	V351T	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Invasive ductal, low grade; taxane treatment, also contains T166A, I189V, S239C, T315A, A332N, I333V, S335N	Val351Thr	Wang et al. 2017. Protoplasma 254:1163-1173	https://pubmed.ncbi.nlm.nih.gov/27943021/	Homo sapiens, human, clinical	Tubulin beta-3 chain
		β352	A352S	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:1115 / sarcoma	Ala352Ser	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β352	A352S	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with A397S, A280S, A403S, tubulin beta-4A	Ala352Ser	ClinVar 807519	https://www.ncbi.nlm.nih.gov/clinvar/variation/807519	Homo sapiens, human, clinical
		β352	A352T	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:10534 / stomach cancer	Ala352Thr	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β352	A352T	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:1909 / melanoma	Ala352Thr	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β352	A352T	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Hypomyelination, abasal ganglia & cerebellum atrophy, tubulin beta-4A, 2 patients	Ala352Thr	Hamilton et al. 2014. Brain 137:1921-30	https://pubmed.ncbi.nlm.nih.gov/24785942/	Homo sapiens, human, clinical
		β352	A352T	P12456	https://www.uniprot.org/uniprotkb/P12456/entry	C. elegans	Antimorph, short TRN neurites, mec-7	Ala352Thr	Zheng et al. 2017 Mol Biol Cell 28: 2786-2801	https://pubmed.ncbi.nlm.nih.gov/28835377/	Caenorhabditis elegans, nematode, roundworm	also see Lee et al. 2021. Mol Biol Cell. 15:331-347 (PMID 33378215)
		β352	A352T	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with A403T, A280T, A397T, tubulin beta-4A	Ala352Thr	ClinVar 267785	https://www.ncbi.nlm.nih.gov/clinvar/variation/267785	Homo sapiens, human, clinical
		β352	A352V	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:1909 / melanoma	Ala352Val	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β352	A352V	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:363 / uterine cancer	Ala352Val	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β352	A352V	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:10534 / stomach cancer	Ala352Val	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β352	A352V	Q9BUF5	https://www.uniprot.org/uniprotkb/Q9BUF5/entry	H. sapiens	TBB6 SNP, DOID:4362 / cervical cancer	Ala352Val	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BUF5	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β352	A352V	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:363 / uterine cancer	Ala352Val	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β352	A352V	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Invasive mucinous, low grade; no treatment, also contains D249E, M293V, T315A, A332N, I333V, S335N, V351T, S364A, S365V	Ala352Val	Wang et al. 2017. Protoplasma 254:1163-1173	https://pubmed.ncbi.nlm.nih.gov/27943021/	Homo sapiens, human, clinical	Tubulin beta-3 chain
		β353	V353A	Q9D6F9	https://www.uniprot.org/uniprotkb/Q9D6F9/entry	M. musculus	Tubb4a, viable heterozygote	Val353Ala	Mutagenetix	https://mutagenetix.utsouthwestern.edu/incidental/incidental_rec.cfm?mid=308346	Mus musculus, mouse, tubulin beta-4A	Wang et al. 2015. PNAS 112:E440-449 (PMID 25605905)
		β353	V353I	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	Microcephaly, tubulin beta	Val353Ile	Breuss et al. 2012. Cell Rep 2:1554-62	https://pubmed.ncbi.nlm.nih.gov/23246003/	Homo sapiens, human, clinical
		β353	V353I	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Infertility due to arrest in oocyte maturation, tubulin beta-8	Val353Ile	Chen et al. 2017. Hum Reprod 32:457-464.	https://pubmed.ncbi.nlm.nih.gov/27989988/	Homo sapiens, human, clinical
		β353	V353I	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Female infertility, tubulin beta-8	Val353Ile	Chen et al. 2019. Eur J Hum Genet 27:300-307	https://pubmed.ncbi.nlm.nih.gov/30297906/	Homo sapiens, human, clinical
		β353	V353I	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	Cortical dysplasia, brain malformations, with V281I, V309I, V151I, V373I, tubulin beta	Val353Ile	ClinVar 127190	https://www.ncbi.nlm.nih.gov/clinvar/variation/127190	Homo sapiens, human, clinical
		β353	V353M	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:363 / uterine cancer	Val353Met	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β353	V353M	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:1909 / melanoma	Val353Met	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β353	V353M	Q13885	https://www.uniprot.org/uniprotkb/Q13885/entry	H. sapiens	TBB2A SNP, DOID:11054 / urinary bladder cancer	Val353Met	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13885	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β353	V353M	Q9BVA1	https://www.uniprot.org/uniprotkb/Q9BVA1/entry	H. sapiens	TBB2B SNP, DOID:11054 / urinary bladder cancer	Val353Met	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BVA1	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β353	V353M	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Uncertain significance, with V281M, tubulin beta-3	Val353Met	ClinVar 808167	https://www.ncbi.nlm.nih.gov/clinvar/variation/808167	Homo sapiens, human, clinical
		β354	C354A	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Benomyl resistant, decreased growth, cold stable, TUB2p	Cys354Ala	Gupta et al. 2001. Cell Motil Cytoskeleton 49:67-77	https://pubmed.ncbi.nlm.nih.gov/11443737/	Saccharomyces cerevisiae, budding yeast, fungus
		β354	C354R	Q9BVA1	https://www.uniprot.org/uniprotkb/Q9BVA1/entry	H. sapiens	Cerebellar dysplasia, tubulin beta-2B	Cys354Arg	Romaniello et al. 2017. Eur Radiol 27:5080-5092	https://pubmed.ncbi.nlm.nih.gov/28677066/	Homo sapiens, human, clinical
		β354	C354S	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Benomyl resistant, decreased growth, cold stable, TUB2p	Cys354Ser	Gupta et al. 2001. Cell Motil Cytoskeleton 49:67-77	https://pubmed.ncbi.nlm.nih.gov/11443737/	Saccharomyces cerevisiae, budding yeast, fungus
		β354	C354W	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with C405W, C399W, C282W, tubulin beta-4A	Cys354Trp	ClinVar 453295	https://www.ncbi.nlm.nih.gov/clinvar/variation/453295	Homo sapiens, human, clinical
		β354	C354Y	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Hypomyelination, basal ganglia & cerebellum atrophy, tubulin beta-4A	Cys354Tyr	Hamilton et al. 2014. Brain 137:1921-30	https://pubmed.ncbi.nlm.nih.gov/24785942/	Homo sapiens, human, clinical
		β354	C354Y	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Female infertility, tubulin beta-8	Cys354Tyr	Chen et al. 2019. Eur J Hum Genet 27:300-307	https://pubmed.ncbi.nlm.nih.gov/30297906/	Homo sapiens, human, clinical
		β354	C354Y	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with C405Y, C399Y, C282Y, tubulin beta-4A	Cys354Tyr	ClinVar 267786	https://www.ncbi.nlm.nih.gov/clinvar/variation/267786	Homo sapiens, human, clinical
		β355	D355A	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:363 / uterine cancer	Asp355Ala	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β355	D355D	Q9N2N6	https://www.uniprot.org/uniprotkb/Q9N2N6/entry	E. focardii	Cold stable adaptation (correlation, EFBT4)	Asn355Asn	Chiappori et al. 2012. Proteins 80:1154-60	https://pubmed.ncbi.nlm.nih.gov/22275059/	Euplotes focardii, extremophile, Antarctic ciliate
		β355	D355E	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with D283E, D400E, D406E, tubulin beta-4A	Asp355Glu	ClinVar 807518	https://www.ncbi.nlm.nih.gov/clinvar/variation/807518	Homo sapiens, human, clinical
		β355	D355N	Q9BUF5	https://www.uniprot.org/uniprotkb/Q9BUF5/entry	H. sapiens	TBB6 SNP, DOID:10534 / stomach cancer	Asp355Asn	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BUF5	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β355	D355V	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:363 / uterine cancer	Asp355Val	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β355	D355V	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Early-onset progressive spastic paraplegia, TUBB4A	Asp355Val	Sagnelli et al. J Neurol 263:591-3	https://pubmed.ncbi.nlm.nih.gov/26810722/	Homo sapiens, human, clinical
		β355	D355Y	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:3571 / liver cancer	Asp355Tyr	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β355	G356G	Q7XYS0	https://www.uniprot.org/uniprotkb/Q7XYS0/entry	C. caldarium	Heat stable adaptation (correlation)	Gly356Gly	Arnold MS thesis (VPI)	https://vtechworks.lib.vt.edu/h&le/10919/9745?show=full	Cyanidium caldarium, extremophile, algae
		β355	G356G	A0A125YTB7	https://www.uniprot.org/uniprotkb/A0A125YTB7/entry	C. merolae	Heat stable adaptation (correlation)	Gly356Gly	Arnold MS thesis (VPI)	https://vtechworks.lib.vt.edu/h&le/10919/9745?show=full	Cyanidioschyzon merolae, extremophile, algae
		β355	V355V	Q9N2N6	https://www.uniprot.org/uniprotkb/Q9N2N6/entry	E. focardii	Cold stable adaptation (correlation, EFBT3)	Val355Val	Chiappori et al. 2012. Proteins 80:1154-60	https://pubmed.ncbi.nlm.nih.gov/22275059/	Euplotes focardii, extremophile, Antarctic ciliate
		β357	E357K	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	Cortical dysplasia, brain malformations, with E401K, E329K, E421K, E199K, tubulin beta	Glu357Lys	ClinVar 127191	https://www.ncbi.nlm.nih.gov/clinvar/variation/127191	Homo sapiens, human, clinical
		β357	F357S	Q9BUF5	https://www.uniprot.org/uniprotkb/Q9BUF5/entry	H. sapiens	Facial palsy, ptosis, velopharyngeal dysfunction, with F394S, F322S, F248S, F329S, tubulin beta-6	Phe357Ser	ClinVar 444894	https://www.ncbi.nlm.nih.gov/clinvar/variation/444894	Homo sapiens, human, clinical
		β357	P357L	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:2394 / ovarian cancer	Pro357Leu	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β357	P357L	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:363 / uterine cancer	Pro357Leu	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β357	P357L	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Cerebellar dysplasia, tubulin beta-3, 2 patients	Pro357Leu	Oegema et al. 2015. Hum Mol Genet 24:5213-25	https://pubmed.ncbi.nlm.nih.gov/26130693/	Homo sapiens, human, clinical
		β357	P357L	P12456	https://www.uniprot.org/uniprotkb/P12456/entry	C. elegans	Antimorph, short TRN neurites, mec-7	Pro357Leu	Zheng et al. 2017 Mol Biol Cell 28: 2786-2801	https://pubmed.ncbi.nlm.nih.gov/28835377/	Caenorhabditis elegans, nematode, roundworm	also see Lee et al. 2021. Mol Biol Cell. 15:331-347 (PMID 33378215)
		β357	P357L	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Cerebellar dysplasia, tubulin beta-3	Pro357Leu	Cabet 2021. Ultrasound Obstet Gynecol 57: 493 – 497	https://pubmed.ncbi.nlm.nih.gov/32149430/	Homo sapiens, human, clinical
		β357	P357L	Q13885	https://www.uniprot.org/uniprotkb/Q13885/entry	H. sapiens	Tubulinopathy, brain malformations, 2 patients, tubulin beta-2A	Pro357Leu	Brock et al. 2021. J Med Genet 58:33-40	https://pubmed.ncbi.nlm.nih.gov/32571897/	Homo sapiens, human, clinical	3 unrelated patients
		β357	P357L	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	Computational prediction, nsSNP causes protein destablization	Pro357Leu	Hussain et al. 2022. J Biomol Struct Dyn 11:1-11.	https://pubmed.ncbi.nlm.nih.gov/36218086/	Computational modeling, clinical
		β357	P357S	P12456	https://www.uniprot.org/uniprotkb/P12456/entry	C. elegans	Loss-of-function, shortened PLM-PN, with Q424L, mec-7	Pro357Ser	Lee et al. 2021. Mol Biol Cell. 15:331-347	https://pubmed.ncbi.nlm.nih.gov/33378215/	Caenorhabditis elegans, nematode, roundworm
		β358	A358P	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Malignant tumor of prostate, with A430P, tubulin beta-3, tubulin beta-3	Ala358Pro	ClinVar 219299	https://www.ncbi.nlm.nih.gov/clinvar/variation/219299	Homo sapiens, human, clinical
		β358	P358A	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Female infertility, tubulin beta-8	Pro358Ala	Chen et al. 2019. Eur J Hum Genet 27:300-307	https://pubmed.ncbi.nlm.nih.gov/30297906/	Homo sapiens, human, clinical
		β358	P358L	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:2531 / hematologic cancer	Pro358Leu	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β358	P358L	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:0070003 / blastoma	Pro358Leu	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β358	P358L	P12456	https://www.uniprot.org/uniprotkb/P12456/entry	C. elegans	Antimorph, short TRN neurites, mec-7	Pro358Leu	Zheng et al. 2017 Mol Biol Cell 28: 2786-2801	https://pubmed.ncbi.nlm.nih.gov/28835377/	Caenorhabditis elegans, nematode, roundworm	also see Lee et al. 2021. Mol Biol Cell. 15:331-347 (PMID 33378215)
		β358	P358L	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Female infertility, tubulin beta-8	Pro358Leu	Chen et al. 2019. Eur J Hum Genet 27:300-307	https://pubmed.ncbi.nlm.nih.gov/30297906/	Homo sapiens, human, clinical
		β358	P358L	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Female infertility, tubulin beta-8	Pro358Leu	Yang et al. 2021. Clin Genet 99:208-214	https://pubmed.ncbi.nlm.nih.gov/33009822/	Homo sapiens, human, clinical
		β358	P358L	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Infertility, oocyte maturation arrest, tubulin beta-8	Pro358Leu	Yao et al. 2022. J Ovar Research 15:38	https://pubmed.ncbi.nlm.nih.gov/35354490/	Homo sapiens, human, clinical
		β358	P358R	P10878	https://www.uniprot.org/uniprotkb/P10878/entry	T. gondii	Suppressor of G142S α1-tubulin defects, β1-tubulin	Pro358Arg	Ma et al. 2008. Genetics 180:845-56	https://pubmed.ncbi.nlm.nih.gov/18780736/	Toxoplasma gondii, parasite, protozoan
		β358	P358S	P12456	https://www.uniprot.org/uniprotkb/P12456/entry	C. elegans	Antimorph, shortened TRN neurites, mec-7	Pro358Ser	Lee et al. 2021. Mol Biol Cell. 15:331-347	https://pubmed.ncbi.nlm.nih.gov/33378215/	Caenorhabditis elegans, nematode, roundworm
		β358	P358T	Q13885	https://www.uniprot.org/uniprotkb/Q13885/entry	H. sapiens	Global cerebral loss, tubulin beta-2A	Pro358Thr	Brar et al. 2022. Prenatal Diagnosis 42:1686–1693	https://pubmed.ncbi.nlm.nih.gov/36403095/	Homo sapiens, human, clinical	1072C>A
		β358	Q358Q	Q9N2N6	https://www.uniprot.org/uniprotkb/Q9N2N6/entry	E. focardii	Cold stable adaptation (correlation, EFBT3)	Gln358Gln	Chiappori et al. 2012. Proteins 80:1154-60	https://pubmed.ncbi.nlm.nih.gov/22275059/	Euplotes focardii, extremophile, Antarctic ciliate
		β359	A359V	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Conflicting interpretations of pathogenicity, with A365V, A314V, A242V, tubulin beta-4A	Ala359Val	ClinVar 267783	https://www.ncbi.nlm.nih.gov/clinvar/variation/267783	Homo sapiens, human, clinical
		β359	R359C	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	TUBB SNP, DOID:11054 / urinary bladder cancer	Arg359Cys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P07437	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β359	R359H	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:363 / uterine cancer	Arg359His	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β359	R359H	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:1909 / melanoma	Arg359His	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β359	R359H	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:9256 / colorectal cancer	Arg359His	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β359	R359H	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:3070 / malignant glioma	Arg359His	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β359	R359P	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	TUBB SNP, DOID:1324 / lung cancer	Arg359Pro	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P07437	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β359	R359Q	P68371	https://www.uniprot.org/uniprotkb/P68371/entry	H. sapiens	TBB4B SNP, DOID:11054 / urinary bladder cancer	Arg359Gln	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P68371	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β359	R359Q	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:363 / uterine cancer	Arg359Gln	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β359	R359S	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:1909 / melanoma	Arg359Ser	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β359	R359S	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:9256 / colorectal cancer	Arg359Ser	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β359	R359W	P68371	https://www.uniprot.org/uniprotkb/P68371/entry	H. sapiens	TBB4B SNP, DOID:1324 / lung cancer	Arg359Trp	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P68371	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β359	R359W	P68371	https://www.uniprot.org/uniprotkb/P68371/entry	H. sapiens	TBB4B SNP, DOID:4362 / cervical cancer	Arg359Trp	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P68371	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β359	R359W	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:3571 / liver cancer	Arg359Trp	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β360	G360E	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:1115 / sarcoma	Gly360Glu	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β360	G360R	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:1324 / lung cancer	Gly360Arg	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β360	G360S	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:10283 / prostate cancer	Gly360Ser	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β360	G360S	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:363 / uterine cancer	Gly360Ser	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β360	G360S	Q9BUF5	https://www.uniprot.org/uniprotkb/Q9BUF5/entry	H. sapiens	TBB6 SNP, DOID:1909 / melanoma	Gly360Ser	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BUF5	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β360	G360S	Q9BUF5	https://www.uniprot.org/uniprotkb/Q9BUF5/entry	H. sapiens	TBB6 SNP, DOID:11054 / urinary bladder cancer	Gly360Ser	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BUF5	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β360	R360R	Q9N2N6	https://www.uniprot.org/uniprotkb/Q9N2N6/entry	E. focardii	Cold stable adaptation (correlation, EFBT3)	Arg360Arg	Chiappori et al. 2012. Proteins 80:1154-60	https://pubmed.ncbi.nlm.nih.gov/22275059/	Euplotes focardii, extremophile, Antarctic ciliate
		β361	L361H	Q9BVA1	https://www.uniprot.org/uniprotkb/Q9BVA1/entry	H. sapiens	Cerebellar dysplasia, with K362L, 363Q insertion, tubulin beta-2B	Leu361His	Romaniello et al. 2017. Eur Radiol 27:5080-5092	https://pubmed.ncbi.nlm.nih.gov/28677066/	Homo sapiens, human, clinical
		β361	L361I	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Likely pathogenic, with L289I, tubulin beta-3	Leu361Ile	ClinVar 421147	https://www.ncbi.nlm.nih.gov/clinvar/variation/421147	Homo sapiens, human, clinical
		β362	D363D	Q7XYS0	https://www.uniprot.org/uniprotkb/Q7XYS0/entry	C. caldarium	Heat stable adaptation (correlation)	Asp363Asp	Arnold MS thesis (VPI)	https://vtechworks.lib.vt.edu/h&le/10919/9745?show=full	Cyanidium caldarium, extremophile, algae
		β362	D363D	A0A125YTB7	https://www.uniprot.org/uniprotkb/A0A125YTB7/entry	C. merolae	Heat stable adaptation (correlation)	Asp363Asp	Arnold MS thesis (VPI)	https://vtechworks.lib.vt.edu/h&le/10919/9745?show=full	Cyanidioschyzon merolae, extremophile, algae
		β362	K362L	Q9BVA1	https://www.uniprot.org/uniprotkb/Q9BVA1/entry	H. sapiens	Cerebellar dysplasia, with L361H, 363Q insertion, tubulin beta-2B	Lys362Leu	Romaniello et al. 2017. Eur Radiol 27:5080-5092	https://pubmed.ncbi.nlm.nih.gov/28677066/	Homo sapiens, human, clinical
		β362	K362N	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:1324 / lung cancer	Lys362Asn	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β362	K362N	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	TUBB SNP, DOID:3963 / thyroid carcinoma	Lys362Asn	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P07437	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β362	K362Q	Q9CWF2	https://www.uniprot.org/uniprotkb/Q9CWF2/entry	M. musculus	Tubb2b, viable heterozygote	Lys362Gln	Mutagenetix	https://mutagenetix.utsouthwestern.edu/incidental/incidental_rec.cfm?mid=226617	Mus musculus, mouse, tubulin beta-2B	Wang et al. 2015. PNAS 112:E440-449 (PMID 25605905)
		β362	N362D	A2AQ07	https://www.uniprot.org/uniprotkb/A2AQ07/entry	M. musculus	Tubb1, viable heterozygote	Asn362Asp	Mutagenetix	https://mutagenetix.utsouthwestern.edu/incidental/incidental_rec.cfm?mid=717349	Mus musculus, mouse, tubulin beta-1	Wang et al. 2015. PNAS 112:E440-449 (PMID 25605905)
		β363	M363I	Q9BUF5	https://www.uniprot.org/uniprotkb/Q9BUF5/entry	H. sapiens	TBB6 SNP, DOID:10534 / stomach cancer	Met363Ile	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BUF5	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β363	M363T	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Defects in oocyte meiosis, tubulin beta-8	Met300Thr	Feng et al. 2016. N Engl J Med 374:223-32	https://pubmed.ncbi.nlm.nih.gov/26789871/	Homo sapiens, human, clinical
		β363	M363T	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Oocyte maturation defect, tubulin beta-8	Met363Thr	ClinVar 221268	https://www.ncbi.nlm.nih.gov/clinvar/variation/223145	Homo sapiens, human, clinical
		β363	M363V	P10878	https://www.uniprot.org/uniprotkb/P10878/entry	T. gondii	Suppressor of G142S α1-tubulin defects, β1-tubulin	Met363Val	Ma et al. 2008. Genetics 180:845-56	https://pubmed.ncbi.nlm.nih.gov/18780736/	Toxoplasma gondii, parasite, protozoan
		β363	363Qins	Q9BVA1	https://www.uniprot.org/uniprotkb/Q9BVA1/entry	H. sapiens	Cerebellar dysplasia, with L361H, K362L, tubulin beta-2B	363Gln ins	Romaniello et al. 2017. Eur Radiol 27:5080-5092	https://pubmed.ncbi.nlm.nih.gov/28677066/	Homo sapiens, human, clinical
		β364	A364D	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:1324 / lung cancer	Ala364Asp	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β364	A364D	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with A415D, A292D, A409D, tubulin beta-4A	Ala364Asp	ClinVar 267787	https://www.ncbi.nlm.nih.gov/clinvar/variation/267787	Homo sapiens, human, clinical
		β364	A364S	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	Invasive ductal, low grade; no treatment, also contains L112P, T351V, V365S	Ala364Ser	Wang et al. 2017. Protoplasma 254:1163-1173	https://pubmed.ncbi.nlm.nih.gov/27943021/	Homo sapiens, human, clinical	Tubulin beta-1 chain
		β364	A364T	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:1793 / pancreatic cancer	Ala364Thr	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β364	A364T	P69893	https://www.uniprot.org/uniprotkb/P69893/entry	C. griseus	Paclitaxel resistant, tubulin beta-5	Ala364Thr	Yin et al. 2012. Pharm Res 29:2994-3006	https://pubmed.ncbi.nlm.nih.gov/22669706/	Cricetulus griseus, chinese hamster, rodent
		β364	A364T	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	Paclitaxel resistant, human ovarian cancer cell line, tubulin beta	Ala364Thr	Giannakakou et al. 1997. J Biol Chem 272:17118-25	https://pubmed.ncbi.nlm.nih.gov/9202030/	Homo sapiens, human, clinical
		β364	A364V	Q9BUF5	https://www.uniprot.org/uniprotkb/Q9BUF5/entry	H. sapiens	TBB6 SNP, DOID:363 / uterine cancer	Ala364Val	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BUF5	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β364	M364T	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Uncertain significance, with M436T, tubulin beta-3	Met364Thr	ClinVar 546220	https://www.ncbi.nlm.nih.gov/clinvar/variation/546220	Homo sapiens, human, clinical
		β364	S364A	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Invasive ductal, high grade; taxane treatment, also contains I189V, A218T, A275S, Q291R, K297R, R320P, T386S	Ser364Ala	Wang et al. 2017. Protoplasma 254:1163-1173	https://pubmed.ncbi.nlm.nih.gov/27943021/	Homo sapiens, human, clinical	Tubulin beta-3 chain
		β364	S364A	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Invasive mucinous, low grade; no treatment, also contains D249E, M293V, T315A, A332N, I333V, S335N, V351T, A352V, S365V	Ser364Ala	Wang et al. 2017. Protoplasma 254:1163-1173	https://pubmed.ncbi.nlm.nih.gov/27943021/	Homo sapiens, human, clinical	Tubulin beta-3 chain
		β365	A365S	P68371	https://www.uniprot.org/uniprotkb/P68371/entry	H. sapiens	Invasive ductal, high grade; doxorubicin treatment, also contains V333I, N332A, N335S, T351V	Ala365Ser	Wang et al. 2017. Protoplasma 254:1163-1173	https://pubmed.ncbi.nlm.nih.gov/27943021/	Homo sapiens, human, clinical	Tubulin beta-4B chain
		β365	A365S	P68371	https://www.uniprot.org/uniprotkb/P68371/entry	H. sapiens	Invasive ductal, high grade; no treatment, also contains L44P, S275A, Q292R, A315T, V333I, N332A, N335S, T351V	Ala365Ser	Wang et al. 2017. Protoplasma 254:1163-1173	https://pubmed.ncbi.nlm.nih.gov/27943021/	Homo sapiens, human, clinical	Tubulin beta-4B chain
		β365	A365T	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:1793 / pancreatic cancer	Ala365Thr	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β365	A365T	P68371	https://www.uniprot.org/uniprotkb/P68371/entry	H. sapiens	TBB4B SNP, DOID:11934 / head and neck cancer	Ala365Thr	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P68371	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β365	A365T	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:10534 / stomach cancer	Ala365Thr	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β365	A365V	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:2531 / hematologic cancer	Ala365Val	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β365	A365V	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:363 / uterine cancer	Ala365Val	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β365	A365V	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:10534 / stomach cancer	Ala365Val	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β365	A365V	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Conflicting interpretations of pathogenicity, with A314V, A359V, A242V, tubulin beta-4A	Ala365Val	ClinVar 267783	https://www.ncbi.nlm.nih.gov/clinvar/variation/267783	Homo sapiens, human, clinical
		β365	C366C	Q7XYS0	https://www.uniprot.org/uniprotkb/Q7XYS0/entry	C. caldarium	Heat stable adaptation (correlation)	Cys366Cys	Arnold MS thesis (VPI)	https://vtechworks.lib.vt.edu/h&le/10919/9745?show=full	Cyanidium caldarium, extremophile, algae
		β365	C366C	A0A125YTB7	https://www.uniprot.org/uniprotkb/A0A125YTB7/entry	C. merolae	Heat stable adaptation (correlation)	Cys366Cys	Arnold MS thesis (VPI)	https://vtechworks.lib.vt.edu/h&le/10919/9745?show=full	Cyanidioschyzon merolae, extremophile, algae
		β365	G365S	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	Likely benign, with G437S, G457S, G235S, G393S, tubulin beta	Gly365Ser	ClinVar 382889	https://www.ncbi.nlm.nih.gov/clinvar/variation/382889	Homo sapiens, human, clinical
		β365	S365A	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Invasive ductal, high grade; doxorubicin treatment, also contains V180A, T315A, A332N, I333V, S335N, V351T, I374T	Ser365Ala	Wang et al. 2017. Protoplasma 254:1163-1173	https://pubmed.ncbi.nlm.nih.gov/27943021/	Homo sapiens, human, clinical	Tubulin beta-3 chain
		β365	S365V	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Invasive mucinous, low grade; no treatment, also contains D249E, M293V, T315A, A332N, I333V, S335N, V351T, A352V, S364A	Ser365Val	Wang et al. 2017. Protoplasma 254:1163-1173	https://pubmed.ncbi.nlm.nih.gov/27943021/	Homo sapiens, human, clinical	Tubulin beta-3 chain
		β365	V365D	P69893	https://www.uniprot.org/uniprotkb/P69893/entry	C. griseus	Paclitaxel resistant, expressed in human KB3 cell line, tubulin beta-5	Val365Asp	Yin et al. 2012. Pharm Res 29:2994-3006	https://pubmed.ncbi.nlm.nih.gov/22669706/	Cricetulus griseus, chinese hamster, rodent
		β365	V365S	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	Invasive ductal, low grade; no treatment, also contains L112P, T351V, A364S	Val365Ser	Wang et al. 2017. Protoplasma 254:1163-1173	https://pubmed.ncbi.nlm.nih.gov/27943021/	Homo sapiens, human, clinical	Tubulin beta-1 chain
		β366	E366D	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	Likely pathogenic, with E410D, E338D, E430D, E208D, tubulin beta	Glu366Asp	ClinVar 426178	https://www.ncbi.nlm.nih.gov/clinvar/variation/426178	Homo sapiens, human, clinical
		β366	E366Q	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Uncertain significance, with E438Q, tubulin beta-3	Glu366Gln	ClinVar 644964	https://www.ncbi.nlm.nih.gov/clinvar/variation/644964	Homo sapiens, human, clinical
		β366	T366N	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:1612 / breast cancer	Thr366Asn	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β367	A367E	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with A439E, A490E, A484E, tubulin beta-4A	Ala367Glu	ClinVar 537238	https://www.ncbi.nlm.nih.gov/clinvar/variation/537238	Homo sapiens, human, clinical
		β367	A367V	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with A439V, A484V, A490V, tubulin beta-4A	Ala367Val	ClinVar 656505	https://www.ncbi.nlm.nih.gov/clinvar/variation/656505	Homo sapiens, human, clinical
		β367	F367I	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Hypomyelination, basal ganglia & cerebellum atrophy, tubulin beta-4A	Phe367Ile	Hamilton et al. 2014. Brain 137:1921-30	https://pubmed.ncbi.nlm.nih.gov/24785942/	Homo sapiens, human, clinical
		β367	F367I	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with F418I, F295I, F412I, tubulin beta-4A	Phe367Ile	ClinVar 267788	https://www.ncbi.nlm.nih.gov/clinvar/variation/267788	Homo sapiens, human, clinical
		β367	F367L	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:1793 / pancreatic cancer	Phe367Leu	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β367	F367L	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:10283 / prostate cancer	Phe367Leu	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β367	F367L	P69893	https://www.uniprot.org/uniprotkb/P69893/entry	C. griseus	Paclitaxel resistant, tubulin beta-5	Phe367Leu	Yin et al. 2012. Pharm Res 29:2994-3006	https://pubmed.ncbi.nlm.nih.gov/22669706/	Cricetulus griseus, chinese hamster, rodent
		β367	F367L	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Hypomyelination, basal ganglia & cerebellum atrophy, tubulin beta-4A	Phe367Leu	Hamilton et al. 2014. Brain 137:1921-30	https://pubmed.ncbi.nlm.nih.gov/24785942/	Homo sapiens, human, clinical
		β367	F367L	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Female infertility, tubulin beta-8	Phe367Leu	Chen et al. 2019. Eur J Hum Genet 27:300-307	https://pubmed.ncbi.nlm.nih.gov/30297906/	Homo sapiens, human, clinical
		β367	F367L	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with F418L, F295L, F412L, tubulin beta-4A	Phe367Leu	ClinVar 267789	https://www.ncbi.nlm.nih.gov/clinvar/variation/267789	Homo sapiens, human, clinical
		β367	F367L	Q13885	https://www.uniprot.org/uniprotkb/Q13885/entry	H. sapiens	Cortical dysplasia, other brain malformations, with F282L, tubulin beta-2A	Phe367Leu	ClinVar 813942	https://www.ncbi.nlm.nih.gov/clinvar/variation/813942	Homo sapiens, human, clinical
		β368	I368F	P04690	https://www.uniprot.org/uniprotkb/P04690/entry	C. reinhardtii	Propyzamide resistant, tub2	Ile368Phe	Kato-Minoura et al. 2020. PLoS One 15(11):e0242694	https://pubmed.ncbi.nlm.nih.gov/33227038/	Chlamydomonas reinhardtii, green alga
		β368	I368T	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:5041 / esophageal cancer	Ile368Thr	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β368	I368T	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Female infertility, 2 patients, tubulin beta-8	Ile368Thr	Zhao et al. 2020. J Assist Reprod Genet 37:1837-47.	https://pubmed.ncbi.nlm.nih.gov/32524331/	Homo sapiens, human, clinical
		β368	I368V	Q25024	https://www.uniprot.org/uniprotkb/Q25024/entry	H. contortus	Benzimidazole resistant (association), isotype not specified	Ile368Val	Kwa et al. 1994. Mol Biochem Parasitol 63:299-303	https://pubmed.ncbi.nlm.nih.gov/7911975/	Haemonchus contortus (Barber pole worm), parasite
		β368	M368R	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with M374R, M323R, M251R, tubulin beta-4A	M368Arg	ClinVar 267784	https://www.ncbi.nlm.nih.gov/clinvar/variation/267784	Homo sapiens, human, clinical
		β369	G369D	Q9BUF5	https://www.uniprot.org/uniprotkb/Q9BUF5/entry	H. sapiens	TBB6 SNP, DOID:1793 / pancreatic cancer	Gly369Asp	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BUF5	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β369	G369E	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:1909 / melanoma	Gly369Glu	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β369	G369E	P12456	https://www.uniprot.org/uniprotkb/P12456/entry	C. elegans	Loss-of-function, short PLM-PN, mec-7	Gly369Glu	Zheng et al. 2017 Mol Biol Cell 28: 2786-2801	https://pubmed.ncbi.nlm.nih.gov/28835377/	Caenorhabditis elegans, nematode, roundworm	also see Lee et al. 2021. Mol Biol Cell. 15:331-347 (PMID 33378215)
		β369	G369E	P12456	https://www.uniprot.org/uniprotkb/P12456/entry	C. elegans	Mechanosensitive, severe recessive, mec-7	Gly369Glu	Savage et al. 1994. J Cell Sci 107:2165-75	https://pubmed.ncbi.nlm.nih.gov/7983175/	Caenorhabditis elegans, nematode, roundworm
		β369	G369R	P12456	https://www.uniprot.org/uniprotkb/P12456/entry	C. elegans	Mechanosensitive, severe semidominant, mec-7	Gly369Arg	Savage et al. 1994. J Cell Sci 107:2165-75	https://pubmed.ncbi.nlm.nih.gov/7983175/	Caenorhabditis elegans, nematode, roundworm
		β371	N371K	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:2531 / hematologic cancer	Asn371Lys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β371	S371N	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:363 / uterine cancer	Ser371Asn	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β372	S372L	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Likely benign, with S444L, tubulin beta-3	Ser372Leu	ClinVar 160189	https://www.ncbi.nlm.nih.gov/clinvar/variation/160189	Homo sapiens, human, clinical
		β372	T372A	P69893	https://www.uniprot.org/uniprotkb/P69893/entry	C. griseus	Paclitaxel resistant, with Y281H, CHO cell line, tubulin beta-5	Thr372Ala	Yin et al. 2012. Pharm Res 29:2994-3006	https://pubmed.ncbi.nlm.nih.gov/22669706/	Cricetulus griseus, chinese hamster, rodent
		β372	T372A	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	Diaphragmatic paralysis and circumferential skin creases Kunze type, tubulin beta	Thr372Ala	Fang et al. 2022. Mol Genet Genomic Med 10:e2003	https://pubmed.ncbi.nlm.nih.gov/35747986/	Homo sapiens, human, clinical
		β372	T372M	P68371	https://www.uniprot.org/uniprotkb/P68371/entry	H. sapiens	TBB4B SNP, DOID:10534 / stomach cancer	Thr372Met	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P68371	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β372	T372M	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:363 / uterine cancer	Thr372Met	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β372	T372M	Q9BUF5	https://www.uniprot.org/uniprotkb/Q9BUF5/entry	H. sapiens	TBB6 SNP, DOID:363 / uterine cancer	Thr372Met	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BUF5	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β372	T372P	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Cold sensitive microtubules, with I374V, Q375R, TUB2p	Thr372Pro	Huffaker et al. 1988. J Cell Biol 106:1997-2010	https://pubmed.ncbi.nlm.nih.gov/3290223/	Saccharomyces cerevisiae, budding yeast, fungus
		β373	A373T	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:3963 / thyroid carcinoma	Ala373Thr	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β373	A373V	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:9256 / colorectal cancer	Ala373Val	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β373	A373V	Q9ERD7	https://www.uniprot.org/uniprotkb/Q9ERD7/entry	M. musculus	Tubb3, viable heterozygote	Ala373Val	Mutagenetix	https://mutagenetix.utsouthwestern.edu/incidental/incidental_rec.cfm?mid=100834	Mus musculus, mouse, tubulin beta-3	Wang et al. 2015. PNAS 112:E440-449 (PMID 25605905)
		β373	V373I	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	Cortical dysplasia, brain malformations, with V353I, V281I, V309I, V151I, tubulin beta	Val373Ile	ClinVar 127190	https://www.ncbi.nlm.nih.gov/clinvar/variation/127190	Homo sapiens, human, clinical
		β374	A374T	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Likely benign, with A446T, tubulin beta-3	Ala374Thr	ClinVar 728804	https://www.ncbi.nlm.nih.gov/clinvar/variation/728804	Homo sapiens, human, clinical
		β374	I374N	Q9D6F9	https://www.uniprot.org/uniprotkb/Q9D6F9/entry	M. musculus	Tubb4a, viable heterozygote	Ile374Asn	Mutagenetix	https://mutagenetix.utsouthwestern.edu/incidental/incidental_rec.cfm?mid=537699	Mus musculus, mouse, tubulin beta-4A	Wang et al. 2015. PNAS 112:E440-449 (PMID 25605905)
		β374	I374T	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Invasive ductal, high grade; doxorubicin treatment, also contains V180A, T315A, A332N, I333V, S335N, V351T, S365A	Ile374Thr	Wang et al. 2017. Protoplasma 254:1163-1173	https://pubmed.ncbi.nlm.nih.gov/27943021/	Homo sapiens, human, clinical	Tubulin beta-3 chain
		β374	I374V	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Cold sensitive microtubules, with T372P, Q375R, TUB2p	Ile374Val	Huffaker et al. 1988. J Cell Biol 106:1997-2010	https://pubmed.ncbi.nlm.nih.gov/3290223/	Saccharomyces cerevisiae, budding yeast, fungus
		β374	M374R	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with M323R, M251R, M368R, tubulin beta-4A	M374Arg	ClinVar 267784	https://www.ncbi.nlm.nih.gov/clinvar/variation/267784	Homo sapiens, human, clinical
		β375	Q375K	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:1324 / lung cancer	Gln375Lys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β375	Q375R	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Cold sensitive microtubules, with T372P, I374V, TUB2p	Gln375Arg	Huffaker et al. 1988. J Cell Biol 106:1997-2010	https://pubmed.ncbi.nlm.nih.gov/3290223/	Saccharomyces cerevisiae, budding yeast, fungus
		β375	Q375X	Q18817	https://www.uniprot.org/uniprotkb/Q18817/entry	C. elegans	Albendazole resistance, ben-1	Gln375X	Pallotto et al. 2022. Genetics 221:iyac093	https://pubmed.ncbi.nlm.nih.gov/35731216/	Caenorhabditis elegans, nematode, roundworm
		β376	E376A	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Wild-type, with K379A, TUB2p	Glu376Ala	Reijo et al. 1994. Mol Biol Cell 5:29-43	https://pubmed.ncbi.nlm.nih.gov/8186463/	Saccharomyces cerevisiae, budding yeast, fungus
		β376	E376D	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:363 / uterine cancer	Glu376Asp	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β376	E376G	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:1324 / lung cancer	Glu376Gly	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β376	E376G	P69893	https://www.uniprot.org/uniprotkb/P69893/entry	C. griseus	Paclitaxel resistant, with V60A, CHO cell line, tubulin beta-5	Glu376Gly	Yin et al. 2012. Pharm Res 29:2994-3006	https://pubmed.ncbi.nlm.nih.gov/22669706/	Cricetulus griseus, chinese hamster, rodent
		β376	E376K	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:1909 / melanoma	Glu376Lys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β377	L377F	P12456	https://www.uniprot.org/uniprotkb/P12456/entry	C. elegans	Neomorph, ectopic ALM-PN, mec-7	Leu377Phe	Zheng et al. 2017 Mol Biol Cell 28: 2786-2801	https://pubmed.ncbi.nlm.nih.gov/28835377/	Caenorhabditis elegans, nematode, roundworm	also see Lee et al. 2021. Mol Biol Cell. 15:331-347 (PMID 33378215)
		β377	L377M	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:1115 / sarcoma	Leu377Met	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β377	L377P	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Female infertility, tubulin beta-8	Leu377Pro	Zhao et al. 2020. J Assist Reprod Genet 37:1837-47.	https://pubmed.ncbi.nlm.nih.gov/32524331/	Homo sapiens, human, clinical
		β377	L377P	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Female infertility, tubulin beta-8	Leu377Pro	Yang et al. 2021. Clin Genet 99:208-214	https://pubmed.ncbi.nlm.nih.gov/33009822/	Homo sapiens, human, clinical
		β378	F378L	P68371	https://www.uniprot.org/uniprotkb/P68371/entry	H. sapiens	TBB4B SNP, DOID:11054 / urinary bladder cancer	Phe378Leu	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P68371	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β378	F378L	P68371	https://www.uniprot.org/uniprotkb/P68371/entry	H. sapiens	TBB4B SNP, DOID:10534 / stomach cancer	Phe378Leu	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P68371	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β378	F378L	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:2994 / germ cell cancer	Phe378Leu	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β378	F378L	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:2394 / ovarian cancer	Phe378Leu	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β379	I379I	Q9N2N6	https://www.uniprot.org/uniprotkb/Q9N2N6/entry	E. focardii	Cold stable adaptation (correlation, EFBT4)	Ile379Ile	Chiappori et al. 2012. Proteins 80:1154-60	https://pubmed.ncbi.nlm.nih.gov/22275059/	Euplotes focardii, extremophile, Antarctic ciliate
		β379	K379A	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Wild-type, with E376A, TUB2p	Lys379Ala	Reijo et al. 1994. Mol Biol Cell 5:29-43	https://pubmed.ncbi.nlm.nih.gov/8186463/	Saccharomyces cerevisiae, budding yeast, fungus
		β379	K379N	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:1324 / lung cancer	Lys379Asn	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β379	R379R	Q9N2N6	https://www.uniprot.org/uniprotkb/Q9N2N6/entry	E. focardii	Cold stable adaptation (correlation, EFBT3)	Arg379Arg	Chiappori et al. 2012. Proteins 80:1154-60	https://pubmed.ncbi.nlm.nih.gov/22275059/	Euplotes focardii, extremophile, Antarctic ciliate
		β380	R380A	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Wild-type, with D383A, TUB2p	Arg380Ala	Reijo et al. 1994. Mol Biol Cell 5:29-43	https://pubmed.ncbi.nlm.nih.gov/8186463/	Saccharomyces cerevisiae, budding yeast, fungus
		β380	R380C	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:363 / uterine cancer	Arg380Cys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β380	R380C	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:363 / uterine cancer	Arg380Cys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β380	R380C	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Extraocular congenital fibrosis syndrome, tubulin beta-3	Arg380Cys	Tischfield et al. 2010. Cell 140:74-87	https://pubmed.ncbi.nlm.nih.gov/20074521/	Homo sapiens, human, clinical
		β380	R380C	Q9BVA1	https://www.uniprot.org/uniprotkb/Q9BVA1/entry	H. sapiens	Cortical malformations, tubulin beta-2B	Arg380Cys	Cushion et al. 2013. Brain 136:536-48	https://pubmed.ncbi.nlm.nih.gov/23361065/	Homo sapiens, human, clinical
		β380	R380C	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Inhibited axonal transport of vesicles and mitochondria, tubulin beta-3	Arg380Cys	Niwa et al. 2013. EMBO J 32:1352-64	https://pubmed.ncbi.nlm.nih.gov/23503589/	Homo sapiens, human, clinical	Model for CFEOM3
		β380	R380C	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Cerebellar dysplasia, tubulin beta-3	Arg380Cys	Romaniello et al. 2017. Eur Radiol 27:5080-5092	https://pubmed.ncbi.nlm.nih.gov/28677066/	Homo sapiens, human, clinical
		β380	R380C	Q9BVA1	https://www.uniprot.org/uniprotkb/Q9BVA1/entry	H. sapiens	Cerebellar dysplasia, tubulin beta-2B	Arg380Cys	Romaniello et al. 2017. Eur Radiol 27:5080-5092	https://pubmed.ncbi.nlm.nih.gov/28677066/	Homo sapiens, human, clinical
		β380	R380C	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Human oocyte maturation defects and female infertility, TUBB8	Arg380Cys	Lin et al. 2023. Reprod Biomed Online 46(2):244-254	https://pubmed.ncbi.nlm.nih.gov/36463079/	Homo sapiens, human, clinical	2 patients
		β380	R380C	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Congenital fibrosis of the extraocular muscles, with R308C, tubulin beta-3	Arg380Cys	ClinVar 219257	https://www.ncbi.nlm.nih.gov/clinvar/variation/219257	Homo sapiens, human, clinical
		β380	R380H	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:2394 / ovarian cancer	Arg380His	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β380	R380H	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:363 / uterine cancer	Arg380His	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β380	R380H	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:10534 / stomach cancer	Arg380His	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β380	R380H	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:263 / kidney cancer	Arg380His	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β380	R380H	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:1793 / pancreatic cancer	Arg380His	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β380	R380H	P68371	https://www.uniprot.org/uniprotkb/P68371/entry	H. sapiens	TBB4B SNP, DOID:1909 / melanoma	Arg380His	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P68371	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β380	R380H	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:1909 / melanoma	Arg380His	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β380	R380H	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:9256 / colorectal cancer	Arg380His	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β380	R380H	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:1793 / pancreatic cancer	Arg380His	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β380	R380H	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:363 / uterine cancer	Arg380His	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β380	R380H	Q9BUF5	https://www.uniprot.org/uniprotkb/Q9BUF5/entry	H. sapiens	TBB6 SNP, DOID:3070 / malignant glioma	Arg380His	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BUF5	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β380	R380H	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Female infertility, 4 patients, tubulin beta-8	Arg380His	Zhao et al. 2020. J Assist Reprod Genet 37:1837-47.	https://pubmed.ncbi.nlm.nih.gov/32524331/	Homo sapiens, human, clinical
		β380	R380H	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Female infertility, tubulin beta-8	Arg380His	Yang et al. 2021. Clin Genet 99:208-214	https://pubmed.ncbi.nlm.nih.gov/33009822/	Homo sapiens, human, clinical
		β380	R380H	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Human oocyte maturation defects and female infertility, TUBB8	Arg380His	Lin et al. 2023. Reprod Biomed Online 46(2):244-254	https://pubmed.ncbi.nlm.nih.gov/36463079/	Homo sapiens, human, clinical
		β380	R380H	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Uncertain significance, with R308H, tubulin beta-3	Arg380His	ClinVar 429413	https://www.ncbi.nlm.nih.gov/clinvar/variation/429413	Homo sapiens, human, clinical
		β380	R380L	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:3963 / thyroid carcinoma	Arg380Leu	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β380	R380L	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:3571 / liver cancer	Arg380Leu	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β380	R380S	Q9BVA1	https://www.uniprot.org/uniprotkb/Q9BVA1/entry	H. sapiens	Cortical malformations, tubulin beta-2B	Arg380Ser	Cushion et al. 2013. Brain 136:536-48	https://pubmed.ncbi.nlm.nih.gov/23361065/	Homo sapiens, human, clinical
		β380	R380S	P12456	https://www.uniprot.org/uniprotkb/P12456/entry	C. elegans	Neomorph, ectopic ALM-PN, mec-7	Arg380Ser	Zheng et al. 2017 Mol Biol Cell 28: 2786-2801	https://pubmed.ncbi.nlm.nih.gov/28835377/	Caenorhabditis elegans, nematode, roundworm	also see Lee et al. 2021. Mol Biol Cell. 15:331-347 (PMID 33378215)
		β381	V381D	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:1612 / breast cancer	Val381Asp	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β382	S382C	P68371	https://www.uniprot.org/uniprotkb/P68371/entry	H. sapiens	TBB4B SNP, DOID:3963 / thyroid carcinoma	Ser382Cys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P68371	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β383	D383A	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Wild-type, with R380A, TUB2p	Asp383Ala	Reijo et al. 1994. Mol Biol Cell 5:29-43	https://pubmed.ncbi.nlm.nih.gov/8186463/	Saccharomyces cerevisiae, budding yeast, fungus
		β383	E383D	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:363 / uterine cancer	Glu383Asp	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β383	E383D	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:2394 / ovarian cancer	Glu383Asp	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β383	E383D	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:2994 / germ cell cancer	Glu383Asp	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β383	E383K	A2AQ07	https://www.uniprot.org/uniprotkb/A2AQ07/entry	M. musculus	Tubb1, viable heterozygote	Glu383Lys	Mutagenetix	https://mutagenetix.utsouthwestern.edu/incidental/incidental_rec.cfm?mid=326783	Mus musculus, mouse, tubulin beta-1	Wang et al. 2015. PNAS 112:E440-449 (PMID 25605905)
		β386	T386M	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:1909 / melanoma	Thr386Met	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β386	T386M	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:169 / neuroendocrine tumor	Thr386Met	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β386	T386S	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Invasive ductal, high grade; taxane treatment, also contains I189V, A218T, A275S, Q291R, K297R, R320P, S364A	Thr386Ser	Wang et al. 2017. Protoplasma 254:1163-1173	https://pubmed.ncbi.nlm.nih.gov/27943021/	Homo sapiens, human, clinical	Tubulin beta-3 chain
		β386	T386S	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Uncertain significance, with T314S, tubulin beta-3	Thr386Ser	ClinVar 872056	https://www.ncbi.nlm.nih.gov/clinvar/variation/872056	Homo sapiens, human, clinical
		β387	A387D	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:1324 / lung cancer	Ala387Asp	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β388	M388I	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:363 / uterine cancer	Met388Ile	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β388	M388I	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Hypomyelination, basal ganglia & cerebellum atrophy, tubulin beta-4A	Met388Ile	Hamilton et al. 2014. Brain 137:1921-30	https://pubmed.ncbi.nlm.nih.gov/24785942/	Homo sapiens, human, clinical
		β388	M388I	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with M439I, M316I, M433I, tubulin beta-4A	Met388Ile	ClinVar 209201	https://www.ncbi.nlm.nih.gov/clinvar/variation/209201	Homo sapiens, human, clinical
		β388	M388I	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Microcephaly, cerebellar hypoplasia, hypomyelination, with M439I, M316I, M433I, tubulin beta-4A	Met388Ile	ClinVar 267792	https://www.ncbi.nlm.nih.gov/clinvar/variation/267792	Homo sapiens, human, clinical
		β388	M388T	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Hypomyelination, basal ganglia & cerebellum atrophy, tubulin beta-4A	Met388Thr	Hamilton et al. 2014. Brain 137:1921-30	https://pubmed.ncbi.nlm.nih.gov/24785942/	Homo sapiens, human, clinical
		β388	M388T	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Hypomyelinating leukodystrophy, TUBB4A	Met388Thr	Tonduti et al. 2016. Eur J Paediatr Neurol 20:323-30	https://pubmed.ncbi.nlm.nih.gov/26643067/	Homo sapiens, human, clinical
		β388	M388T	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Lissencephaly, tubulin beta-3	Met388Thr	Di Donato et al. 2018. Genet Med 20:1354-1364	https://pubmed.ncbi.nlm.nih.gov/29671837/	Homo sapiens, human, clinical
		β388	M388T	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Female infertility, tubulin beta-8	Met388Thr	Yang et al. 2021. Clin Genet 99:208-214	https://pubmed.ncbi.nlm.nih.gov/33009822/	Homo sapiens, human, clinical
		β388	M388T	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with M439T, M316T, M433T, tubulin beta-4A	Met388Thr	ClinVar 267791	https://www.ncbi.nlm.nih.gov/clinvar/variation/267791	Homo sapiens, human, clinical
		β388	M388T	Q13885	https://www.uniprot.org/uniprotkb/Q13885/entry	H. sapiens	Uncertain significance, with M303T, tubulin beta-2A	Met388Thr	ClinVar 437124	https://www.ncbi.nlm.nih.gov/clinvar/variation/437124	Homo sapiens, human, clinical
		β388	M388V	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Malformation of cortical development, tubulin beta-3	Met388Val	Poirier et al. 2010. Hum Mol Genet 19:4462-73	https://pubmed.ncbi.nlm.nih.gov/20829227/	Homo sapiens, human, clinical
		β388	M388V	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Inhibited axonal transport of vesicles and mitochondria, tubulin beta-3	Met388Val	Niwa et al. 2013. EMBO J 32:1352-64	https://pubmed.ncbi.nlm.nih.gov/23503589/	Homo sapiens, human, clinical	Model for MCD
		β388	M388V	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Hypomyelination, basal ganglia & cerebellum atrophy, tubulin beta-4A	Met388Val	Hamilton et al. 2014. Brain 137:1921-30	https://pubmed.ncbi.nlm.nih.gov/24785942/	Homo sapiens, human, clinical
		β388	M388V	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Hypomyelination, basal ganglia & cerebellum atrophy, tubulin beta-4A	Met388Val	Miyatake et al. 2014. Neurology 82:2230-7	https://pubmed.ncbi.nlm.nih.gov/24850488/	Homo sapiens, human, clinical
		β388	M388V	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Malformation of cortical development, fetal sample, tubulin beta-3	Met388Val	Fallet-Bianco et al. 2014. Acta Neuropathol Commun 2:69	https://pubmed.ncbi.nlm.nih.gov/25059107/	Homo sapiens, human, clinical
		β388	M388V	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Cortical dysplasia, brain malformations, with M316V, tubulin beta-3	Met388Val	ClinVar 236243	https://www.ncbi.nlm.nih.gov/clinvar/variation/236243	Homo sapiens, human, clinical
		β388	M388V	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with M439V, M433V, M316V, tubulin beta-4A	Met388Val	ClinVar 267790	https://www.ncbi.nlm.nih.gov/clinvar/variation/267790	Homo sapiens, human, clinical
		β389	F389V	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Uncertain significance, with F317V, tubulin beta-3	Phe389Val	ClinVar 430430	https://www.ncbi.nlm.nih.gov/clinvar/variation/430430	Homo sapiens, human, clinical
		β389	W389R	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Uncertain significance, with W344R, W395R, W272R, tubulin beta-4A	W389Arg	ClinVar 522029	https://www.ncbi.nlm.nih.gov/clinvar/variation/522029	Homo sapiens, human, clinical
		β390	K390A	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Cold sensitive, benomyl supersensitive, with K392A, TUB2p	Lys390Ala	Reijo et al. 1994. Mol Biol Cell 5:29-43	https://pubmed.ncbi.nlm.nih.gov/8186463/	Saccharomyces cerevisiae, budding yeast, fungus
		β390	R390L	Q9BVA1	https://www.uniprot.org/uniprotkb/Q9BVA1/entry	H. sapiens	Bilateral ventriculomegaly, tubulin beta-2B	Arg390Leu	Brar et al. 2022. Prenatal Diagnosis 42:1686–1693	https://pubmed.ncbi.nlm.nih.gov/36403095/	Homo sapiens, human, clinical	1172G>T
		β390	R390P	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Uncertain significance, with R318P, tubulin beta-3	Arg390Pro	ClinVar 282046	https://www.ncbi.nlm.nih.gov/clinvar/variation/282046	Homo sapiens, human, clinical
		β390	R390Q	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:9256 / colorectal cancer	Arg390Gln	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β390	R390Q	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:10534 / stomach cancer	Arg390Gln	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β390	R390Q	Q9BVA1	https://www.uniprot.org/uniprotkb/Q9BVA1/entry	H. sapiens	Uner Tan syndrome (mental retardation), tubulin beta-2B	Arg390Gln	Breuss et al. 2017. Hum Mol Genet 26:258-269	https://pubmed.ncbi.nlm.nih.gov/28013290/	Homo sapiens, human, clinical
		β390	R390Q	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Hypersensitive to depolymerizing drugs, TUB2p	Arg390Gln	Breuss et al. 2017. Hum Mol Genet 26:258-269	https://pubmed.ncbi.nlm.nih.gov/28013290/	Saccharomyces cerevisiae, budding yeast, fungus
		β390	R390W	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:1793 / pancreatic cancer	Arg390Trp	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β391	R391C	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:1793 / pancreatic cancer	Arg391Cys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β391	R391C	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:2394 / ovarian cancer	Arg391Cys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β391	R391C	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:2994 / germ cell cancer	Arg391Cys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β391	R391C	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:0070003 / blastoma	Arg391Cys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β391	R391C	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:3571 / liver cancer	Arg391Cys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β391	R391C	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:363 / uterine cancer	Arg391Cys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β391	R391C	Q9BUF5	https://www.uniprot.org/uniprotkb/Q9BUF5/entry	H. sapiens	TBB6 SNP, DOID:10283 / prostate cancer	Arg391Cys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BUF5	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β391	R391C	P68371	https://www.uniprot.org/uniprotkb/P68371/entry	H. sapiens	Leber congenital amaurosis, tubulin beta-4B	Arg391Cys	Luscan et al. 2017. Am J Hum Genet 101:1006-12	https://pubmed.ncbi.nlm.nih.gov/29198720/	Homo sapiens, human, clinical
		β391	R391C	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Female infertility, tubulin beta-8	Arg391Cys	Chen et al. 2019. Eur J Hum Genet 27:300-307	https://pubmed.ncbi.nlm.nih.gov/30297906/	Homo sapiens, human, clinical
		β391	R391C	P68371	https://www.uniprot.org/uniprotkb/P68371/entry	H. sapiens	Ophthalmologic and hearing impairments, TUBB4B	Arg391Cys	Maasz et al. 2022. Eur J Med Gen 65: 104471	https://pubmed.ncbi.nlm.nih.gov/35240325/	Homo sapiens, human, clinical	Mother, 2 children
		β391	R391C	P68371	https://www.uniprot.org/uniprotkb/P68371/entry	H. sapiens	Leber congenital amaurosis with early-onset deafness, tubulin beta-4B	Arg391Cys	ClinVar 492939	https://www.ncbi.nlm.nih.gov/clinvar/variation/492939	Homo sapiens, human, clinical
		β391	R391C	Q13885	https://www.uniprot.org/uniprotkb/Q13885/entry	H. sapiens	Cortical dysplasia, other brain malformations, with R306C, tubulin beta-2A	Arg391Cys	ClinVar 521900	https://www.ncbi.nlm.nih.gov/clinvar/variation/521900	Homo sapiens, human, clinical
		β391	R391H	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:363 / uterine cancer	Arg391His	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β391	R391H	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:1793 / pancreatic cancer	Arg391His	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β391	R391H	P68371	https://www.uniprot.org/uniprotkb/P68371/entry	H. sapiens	TBB4B SNP, DOID:363 / uterine cancer	Arg391His	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P68371	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β391	R391H	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:363 / uterine cancer	Arg391His	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β391	R391H	Q9BUF5	https://www.uniprot.org/uniprotkb/Q9BUF5/entry	H. sapiens	TBB6 SNP, DOID:1612 / breast cancer	Arg391His	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BUF5	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β391	R391H	Q9BVA1	https://www.uniprot.org/uniprotkb/Q9BVA1/entry	H. sapiens	TBB2B SNP, DOID:10534 / stomach cancer	Arg391His	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BVA1	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β391	R391H	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Hypomyelination without basal ganglia abnormalities, TUBB4A	Arg391His	Pizzino et al. 2014. Neurology 83:898-902	https://pubmed.ncbi.nlm.nih.gov/25085639/	Homo sapiens, human, clinical
		β391	R391H	P68371	https://www.uniprot.org/uniprotkb/P68371/entry	H. sapiens	Leber congenital amaurosis, tubulin beta-4B	Arg391His	Luscan et al. 2017. Am J Hum Genet 101:1006-12	https://pubmed.ncbi.nlm.nih.gov/29198720/	Homo sapiens, human, clinical
		β391	R391H	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Female infertility, 2 patients, tubulin beta-8	Arg391His	Zhao et al. 2020. J Assist Reprod Genet 37:1837-47.	https://pubmed.ncbi.nlm.nih.gov/32524331/	Homo sapiens, human, clinical
		β391	R391H	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Female infertility, tubulin beta-8	Arg391His	Yang et al. 2021. Clin Genet 99:208-214	https://pubmed.ncbi.nlm.nih.gov/33009822/	Homo sapiens, human, clinical
		β391	R391H	P12456	https://www.uniprot.org/uniprotkb/P12456/entry	C. elegans	Antimorph, shortened TRN neurites, mec-7	Arg391His	Lee et al. 2021. Mol Biol Cell. 15:331-347	https://pubmed.ncbi.nlm.nih.gov/33378215/	Caenorhabditis elegans, nematode, roundworm
		β391	R391H	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Human oocyte maturation defects and female infertility, TUBB8	Arg391His	Lin et al. 2023. Reprod Biomed Online 46(2):244-254	https://pubmed.ncbi.nlm.nih.gov/36463079/	Homo sapiens, human, clinical
		β391	R391H	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with R442H, R436H, R319H, tubulin beta-4A	Arg391His	ClinVar 267793	https://www.ncbi.nlm.nih.gov/clinvar/variation/267793	Homo sapiens, human, clinical
		β391	R391H	Q13885	https://www.uniprot.org/uniprotkb/Q13885/entry	H. sapiens	Likely pathogenic, with R306H, tubulin beta-2A	Arg391His	ClinVar 382096	https://www.ncbi.nlm.nih.gov/clinvar/variation/382096	Homo sapiens, human, clinical
		β391	R391H	P68371	https://www.uniprot.org/uniprotkb/P68371/entry	H. sapiens	Leber congenital amaurosis with early-onset deafness, tubulin beta-4B	Arg391His	ClinVar 492938	https://www.ncbi.nlm.nih.gov/clinvar/variation/492938	Homo sapiens, human, clinical
		β391	R391L	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Human oocyte maturation arrest and female infertility, TUBB8	Arg391Leu	Li et al. 2022. Eur J Obstet Gynecol Reprod Biol 279:132-139	https://pubmed.ncbi.nlm.nih.gov/36335766/	Homo sapiens, human, clinical
		β391	R391L	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Pathogenic, with R319L, tubulin beta-3	Arg391Leu	ClinVar 265354	https://www.ncbi.nlm.nih.gov/clinvar/variation/265354	Homo sapiens, human, clinical
		β391	R391L	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with R442L, R436L, R319L, tubulin beta-4A	Arg391Leu	ClinVar 419697	https://www.ncbi.nlm.nih.gov/clinvar/variation/419697	Homo sapiens, human, clinical
		β391	R391M	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:9256 / colorectal cancer	Arg391Met	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β391	R391M	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:363 / uterine cancer	Arg391Met	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β391	R391T	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Cold sensitive microtubules, TUB2p	Arg391Thr	Huffaker et al. 1988. J Cell Biol 106:1997-2010	https://pubmed.ncbi.nlm.nih.gov/3290223/	Saccharomyces cerevisiae, budding yeast, fungus
		β391	R391W	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	TUBB SNP, DOID:3963 / thyroid carcinoma	Arg391Trp	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P07437	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β392	K392A	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Cold sensitive, benomyl supersensitive, with K390A, TUB2p	Lys392Ala	Reijo et al. 1994. Mol Biol Cell 5:29-43	https://pubmed.ncbi.nlm.nih.gov/8186463/	Saccharomyces cerevisiae, budding yeast, fungus
		β393	A393D	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Female infertility, tubulin beta-8	Ala393Asp	Yang et al. 2021. Clin Genet 99:208-214	https://pubmed.ncbi.nlm.nih.gov/33009822/	Homo sapiens, human, clinical
		β393	A393T	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:1909 / melanoma	Ala393Thr	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β393	A393T	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:9256 / colorectal cancer	Ala393Thr	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β393	A394T	P12411	https://www.uniprot.org/uniprotkb/P12411/entry	A. thaliana	Twisting, TUB1	Ala394Thr	Ishida et al. 2007. PNAS 104:8544-9	https://pubmed.ncbi.nlm.nih.gov/17488810/	Arabidopsis thaliana, plant
		β393	A393T	P12456	https://www.uniprot.org/uniprotkb/P12456/entry	C. elegans	Antimorph, short TRN neurites, mec-7	Ala393Thr	Zheng et al. 2017 Mol Biol Cell 28: 2786-2801	https://pubmed.ncbi.nlm.nih.gov/28835377/	Caenorhabditis elegans, nematode, roundworm	also see Lee et al. 2021. Mol Biol Cell. 15:331-347 (PMID 33378215)
		β393	A393T	P12456	https://www.uniprot.org/uniprotkb/P12456/entry	C. elegans	Mechanosensitive, dominant, mec-7	Ala393Thr	Savage et al. 1994. J Cell Sci 107:2165-75	https://pubmed.ncbi.nlm.nih.gov/7983175/	Caenorhabditis elegans, nematode, roundworm
		β393	A393V	P10878	https://www.uniprot.org/uniprotkb/P10878/entry	T. gondii	Suppressor of G142S α1-tubulin defects, β1-tubulin	Ala393Val	Ma et al. 2008. Genetics 180:845-56	https://pubmed.ncbi.nlm.nih.gov/18780736/	Toxoplasma gondii, parasite, protozoan
		β393	A393V	P12456	https://www.uniprot.org/uniprotkb/P12456/entry	C. elegans	Antimorph, short TRN neurites, mec-7	Ala393Val	Zheng et al. 2017 Mol Biol Cell 28: 2786-2801	https://pubmed.ncbi.nlm.nih.gov/28835377/	Caenorhabditis elegans, nematode, roundworm	also see Lee et al. 2021. Mol Biol Cell. 15:331-347 (PMID 33378215)
		β393	A393V	Q13885	https://www.uniprot.org/uniprotkb/Q13885/entry	H. sapiens	Cortical dysplasia, other brain malformations, with A308V, tubulin beta-2A	Ala393Val	ClinVar 800924	https://www.ncbi.nlm.nih.gov/clinvar/variation/800924	Homo sapiens, human, clinical
		β393	G393S	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	Likely benign, with G437S, G365S, G457S, G235S, tubulin beta	Gly393Ser	ClinVar 382889	https://www.ncbi.nlm.nih.gov/clinvar/variation/382889	Homo sapiens, human, clinical
		β394	F394A	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Blocked polymerization, with W397E, TUB2p	Phe394Ala	Johnson et al. 2011. Biochemistry:8636-44	https://pubmed.ncbi.nlm.nih.gov/21888381/	Saccharomyces cerevisiae, budding yeast, fungus
		β394	F394C	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with F445C, F439C, F322C, tubulin beta-4A	Phe394Cys	ClinVar 267794	https://www.ncbi.nlm.nih.gov/clinvar/variation/267794	Homo sapiens, human, clinical
		β394	F394L	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:1612 / breast cancer	Phe394Leu	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β394	F394S	Q9BUF5	https://www.uniprot.org/uniprotkb/Q9BUF5/entry	H. sapiens	Facial palsy, bilateral ptosis, tubulin beta-6	Phe394Ser	Fazeli et al. 2017. Human Mol Gen 26: 4055–66	https://pubmed.ncbi.nlm.nih.gov/29016863/	Homo sapiens, human, clinical
		β394	F394S	Q9BUF5	https://www.uniprot.org/uniprotkb/Q9BUF5/entry	H. sapiens	Facial palsy, ptosis, velopharyngeal dysfunction, with F322S, F248S, F329S, F357S, tubulin beta-6	Phe394Ser	ClinVar 444894	https://www.ncbi.nlm.nih.gov/clinvar/variation/444894	Homo sapiens, human, clinical
		β394	F394S	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Torsion dystonia, with F445S, F322S, F439S, tubulin beta-4A	Phe394Ser	ClinVar 689794	https://www.ncbi.nlm.nih.gov/clinvar/variation/689794	Homo sapiens, human, clinical
		β395	K395T	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Uncertain significance, with K278T, K350T, K401T, tubulin beta-4A	Lys395Thr	ClinVar 871906	https://www.ncbi.nlm.nih.gov/clinvar/variation/871906	Homo sapiens, human, clinical
		β395	L395D	P69893	https://www.uniprot.org/uniprotkb/P69893/entry	C. griseus	Paclitaxel resistant, with S275C, CHO cell line, tubulin beta-5	Leu395Asp	Yin et al. 2012. Pharm Res 29:2994-3006	https://pubmed.ncbi.nlm.nih.gov/22669706/	Cricetulus griseus, chinese hamster, rodent
		β395	W395R	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Uncertain significance, with W344R, W389R, W272R, tubulin beta-4A	Trp395Arg	ClinVar 522029	https://www.ncbi.nlm.nih.gov/clinvar/variation/522029	Homo sapiens, human, clinical
		β396	H396Q	P10878	https://www.uniprot.org/uniprotkb/P10878/entry	T. gondii	Suppressor of F52Y α1-tubulin defects, β1-tubulin	His396Gln	Ma et al. 2008. Genetics 180:845-56	https://pubmed.ncbi.nlm.nih.gov/18780736/	Toxoplasma gondii, parasite, protozoan
		β396	H396Y	Q13885	https://www.uniprot.org/uniprotkb/Q13885/entry	H. sapiens	TBB2A SNP, DOID:363 / uterine cancer	His396Tyr	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13885	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β396	H396Y	Q13885	https://www.uniprot.org/uniprotkb/Q13885/entry	H. sapiens	Tubulinopathy, brain malformations, tubulin beta-2A	His396Tyr	Brock et al. 2021. J Med Genet 58:33-40	https://pubmed.ncbi.nlm.nih.gov/32571897/	Homo sapiens, human, clinical
		β397	A397S	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with A280S, A352S, A403S, tubulin beta-4A	Ala397Ser	ClinVar 807519	https://www.ncbi.nlm.nih.gov/clinvar/variation/807519	Homo sapiens, human, clinical
		β397	A397T	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with A403T, A352T, A280T, tubulin beta-4A	Ala397Thr	ClinVar 267785	https://www.ncbi.nlm.nih.gov/clinvar/variation/267785	Homo sapiens, human, clinical
		β397	W397E	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Blocked polymerization, with F394A, TUB2p	Trp397Glu	Johnson et al. 2011. Biochemistry:8636-44	https://pubmed.ncbi.nlm.nih.gov/21888381/	Saccharomyces cerevisiae, budding yeast, fungus
		β397	W397G	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Female infertility, tubulin beta-8	Trp397Gly	Yang et al. 2021. Clin Genet 99:208-214	https://pubmed.ncbi.nlm.nih.gov/33009822/	Homo sapiens, human, clinical
		β398	F398L	Q9BUF5	https://www.uniprot.org/uniprotkb/Q9BUF5/entry	H. sapiens	TBB6 SNP, DOID:9256 / colorectal cancer	Phe398Leu	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BUF5	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β398	Y398C	P69893	https://www.uniprot.org/uniprotkb/P69893/entry	C. griseus	Revertant of D45Y, CHO cell line, tubulin beta-5	Tyr398Cys	Wang et al. 2006. J Biol Chem 281:13628-35	https://pubmed.ncbi.nlm.nih.gov/16554299/	Cricetulus griseus, chinese hamster, rodent
		β398	Y398H	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	TUBB SNP, DOID:2531 / hematologic cancer	Tyr398His	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P07437	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β398	Y398H	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:363 / uterine cancer	Tyr398His	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β398	Y398H	Q9D6F9	https://www.uniprot.org/uniprotkb/Q9D6F9/entry	M. musculus	Tubb4a, viable heterozygote	Tyr398His	Mutagenetix	https://mutagenetix.utsouthwestern.edu/incidental/incidental_rec.cfm?mid=508137	Mus musculus, mouse, tubulin beta-4A	Wang et al. 2015. PNAS 112:E440-449 (PMID 25605905)
		β399	C399W	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with C354W, C405W, C282W, tubulin beta-4A	Cys399Trp	ClinVar 453295	https://www.ncbi.nlm.nih.gov/clinvar/variation/453295	Homo sapiens, human, clinical
		β399	C399Y	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with C405Y, C354Y, C282Y, tubulin beta-4A	Cys399Tyr	ClinVar 267786	https://www.ncbi.nlm.nih.gov/clinvar/variation/267786	Homo sapiens, human, clinical
		β399	T399M	P68371	https://www.uniprot.org/uniprotkb/P68371/entry	H. sapiens	TBB4B SNP, DOID:363 / uterine cancer	Thr399Met	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P68371	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β399	T399M	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:3070 / malignant glioma	Thr399Met	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β399	T399S	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Likely benign, with T327S, tubulin beta-3	Thr399Ser	ClinVar 437133	https://www.ncbi.nlm.nih.gov/clinvar/variation/437133	Homo sapiens, human, clinical
		β400	D400E	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with D283E, D355E, D406E, tubulin beta-4A	Asp400Glu	ClinVar 807518	https://www.ncbi.nlm.nih.gov/clinvar/variation/807518	Homo sapiens, human, clinical
		β400	S400R	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:1324 / lung cancer	Ser400Arg	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β401	E401A	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Cold sensitive, with D404A, TUB2p	Glu401Ala	Reijo et al. 1994. Mol Biol Cell 5:29-43	https://pubmed.ncbi.nlm.nih.gov/8186463/	Saccharomyces cerevisiae, budding yeast, fungus
		β401	E401A	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	dominant lethal with D404A, E407A, TUB2p	Asp404Ala	Reijo et al. 1994. Mol Biol Cell 5:29-43	https://pubmed.ncbi.nlm.nih.gov/8186463/	Saccharomyces cerevisiae, budding yeast, fungus
		β401	E401G	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	Computational prediction, nsSNP causes protein destablization	Glu401Gly	Hussain et al. 2022. J Biomol Struct Dyn 11:1-11.	https://pubmed.ncbi.nlm.nih.gov/36218086/	Computational modeling, clinical
		β401	E401K	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:0070003 / blastoma	Glu401Lys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β401	E401K	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:3571 / liver cancer	Glu401Lys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β401	E401K	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:363 / uterine cancer	Glu401Lys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β401	E401K	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	Microcephaly, tubulin beta	Glu401Lys	Breuss et al. 2012. Cell Rep 2:1554-62	https://pubmed.ncbi.nlm.nih.gov/23246003/	Homo sapiens, human, clinical
		β401	E401K	P99024	https://www.uniprot.org/uniprotkb/P99024/entry	M. musculus	Reduction in brain size and in body weight, motor coordination defects,	Glu401Lys	Breuss et al. 2017. Behav Brain Res 323:47-55	https://pubmed.ncbi.nlm.nih.gov/28130172/	Mus musculus, mouse
		β401	E401K	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	Microcephaly phenotypes, tubulin beta	Glu401Lys	Madrigal et al. 2019. Gene 695:12-17	https://pubmed.ncbi.nlm.nih.gov/30738969/	Homo sapiens, human, clinical
		β401	E401K	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	Cortical dysplasia, brain malformations, with E357K, E329K, E421K, E199K, tubulin beta	Glu401Lys	ClinVar 127191	https://www.ncbi.nlm.nih.gov/clinvar/variation/127191	Homo sapiens, human, clinical
		β401	E401Q	P68371	https://www.uniprot.org/uniprotkb/P68371/entry	H. sapiens	TBB4B SNP, DOID:1324 / lung cancer	Glu401Gln	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P68371	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β401	E401V	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	Computational prediction, nsSNP causes protein destablization	Glu401Val	Hussain et al. 2022. J Biomol Struct Dyn 11:1-11.	https://pubmed.ncbi.nlm.nih.gov/36218086/	Computational modeling, clinical
		β401	K401T	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Uncertain significance, with K278T, K395T, K350T, tubulin beta-4A	Lys401Thr	ClinVar 871906	https://www.ncbi.nlm.nih.gov/clinvar/variation/871906	Homo sapiens, human, clinical
		β402	G402A	Q9ERD7	https://www.uniprot.org/uniprotkb/Q9ERD7/entry	M. musculus	Tubb3, viable heterozygote	Gly402Ala	Mutagenetix	https://mutagenetix.utsouthwestern.edu/incidental/incidental_rec.cfm?mid=459085	Mus musculus, mouse, tubulin beta-3	Wang et al. 2015. PNAS 112:E440-449 (PMID 25605905)
		β402	G402D	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:363 / uterine cancer	Gly402Asp	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β402	G402E	P61857	https://www.uniprot.org/uniprotkb/P61857/entry	D. melanogaster	B2t mutation, testes specific tubulin	Gly402Glu	Fackenthal et al. 1995. Genetics 139:267-86	https://pubmed.ncbi.nlm.nih.gov/7705629/	Drosophila, fruitfly
		β402	G402R	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:1909 / melanoma	Gly402Arg	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β402	G402R	P12456	https://www.uniprot.org/uniprotkb/P12456/entry	C. elegans	Loss-of-function, shortened PLM-PN, mec-7	Gly402Arg	Lee et al. 2021. Mol Biol Cell. 15:331-347	https://pubmed.ncbi.nlm.nih.gov/33378215/	Caenorhabditis elegans, nematode, roundworm
		β402	G402R	P12456	https://www.uniprot.org/uniprotkb/P12456/entry	C. elegans	Mechanosensitive, mild recessive, mec-7	Gly402Arg	Savage et al. 1994. J Cell Sci 107:2165-75	https://pubmed.ncbi.nlm.nih.gov/7983175/	Caenorhabditis elegans, nematode, roundworm
		β402	G402W	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:3963 / thyroid carcinoma	Gly402Trp	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β402	G402X	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Female infertility, tubulin beta-8	Gly402X	Yang et al. 2021. Clin Genet 99:208-214	https://pubmed.ncbi.nlm.nih.gov/33009822/	Homo sapiens, human, clinical
		β403	A403S	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with A397S, A280S, A352S, tubulin beta-4A	Ala403Ser	ClinVar 807519	https://www.ncbi.nlm.nih.gov/clinvar/variation/807519	Homo sapiens, human, clinical
		β403	A403T	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with A352T, A280T, A397T, tubulin beta-4A	Ala403Thr	ClinVar 267785	https://www.ncbi.nlm.nih.gov/clinvar/variation/267785	Homo sapiens, human, clinical
		β403	M403I	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Likely pathogenic, with M331I, tubulin beta-3	Met403Ile	ClinVar 429849	https://www.ncbi.nlm.nih.gov/clinvar/variation/429849	Homo sapiens, human, clinical
		β403	M403T	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:1909 / melanoma	Met403Thr	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β403	M403V	P68371	https://www.uniprot.org/uniprotkb/P68371/entry	H. sapiens	TBB4B SNP, DOID:10283 / prostate cancer	Met403Val	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P68371	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β403	M403X	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Female infertility, tubulin beta-8	Met403X	Chen et al. 2019. Eur J Hum Genet 27:300-307	https://pubmed.ncbi.nlm.nih.gov/30297906/	Homo sapiens, human, clinical
		β404	D404A	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Cold sensitive, with E401A, TUB2p	Asp404Ala	Reijo et al. 1994. Mol Biol Cell 5:29-43	https://pubmed.ncbi.nlm.nih.gov/8186463/	Saccharomyces cerevisiae, budding yeast, fungus
		β404	D404A	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	dominant lethal with E401A, E407A, TUB2p	Asp404Ala	Reijo et al. 1994. Mol Biol Cell 5:29-43	https://pubmed.ncbi.nlm.nih.gov/8186463/	Saccharomyces cerevisiae, budding yeast, fungus
		β404	D404N	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:4362 / cervical cancer	Asp404Asn	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β404	D404N	Q18817	https://www.uniprot.org/uniprotkb/Q18817/entry	C. elegans	Benzimidazole resistant, no correlation (ben-1, tbb-5)	Asp404Asn	Hahnel et al. 2018. PLoS Pathog 14:e1007226	https://pubmed.ncbi.nlm.nih.gov/30372484/	Caenorhabditis elegans, nematode, roundworm
		β405	C405W	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with C354W, C399W, C282W, tubulin beta-4A	Cys405Trp	ClinVar 453295	https://www.ncbi.nlm.nih.gov/clinvar/variation/453295	Homo sapiens, human, clinical
		β405	C405Y	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with C354Y, C399Y, C282Y, tubulin beta-4A	Cys405Tyr	ClinVar 267786	https://www.ncbi.nlm.nih.gov/clinvar/variation/267786	Homo sapiens, human, clinical
		β405	E405A	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Recessive lethal, with E407A, TUB2p	Glu405Ala	Reijo et al. 1994. Mol Biol Cell 5:29-43	https://pubmed.ncbi.nlm.nih.gov/8186463/	Saccharomyces cerevisiae, budding yeast, fungus
		β405	E405K	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:2394 / ovarian cancer	Glu405Lys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β405	E405K	Q9BUF5	https://www.uniprot.org/uniprotkb/Q9BUF5/entry	H. sapiens	TBB6 SNP, DOID:8618 / oral cavity cancer	Glu405Lys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BUF5	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β405	I405L	A2AQ07	https://www.uniprot.org/uniprotkb/A2AQ07/entry	M. musculus	Tubb1, viable heterozygote	Ile405Leu	Mutagenetix	https://mutagenetix.utsouthwestern.edu/incidental/incidental_rec.cfm?mid=100566	Mus musculus, mouse, tubulin beta-1	Wang et al. 2015. PNAS 112:E440-449 (PMID 25605905)
		β406	D406E	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with D283E, D355E, D400E, tubulin beta-4A	Asp406Glu	ClinVar 807518	https://www.ncbi.nlm.nih.gov/clinvar/variation/807518	Homo sapiens, human, clinical
		β406	M406I	P68371	https://www.uniprot.org/uniprotkb/P68371/entry	H. sapiens	TBB4B SNP, DOID:1909 / melanoma	Met406Ile	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P68371	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β406	M406I	P68371	https://www.uniprot.org/uniprotkb/P68371/entry	H. sapiens	TBB4B SNP, DOID:9256 / colorectal cancer	Met406Ile	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P68371	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β407	E407A	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Recessive lethal, with E405A, TUB2p	Glu405Ala	Reijo et al. 1994. Mol Biol Cell 5:29-43	https://pubmed.ncbi.nlm.nih.gov/8186463/	Saccharomyces cerevisiae, budding yeast, fungus
		β407	E407A	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	dominant lethal with E401A, D404A, TUB2p	Asp404Ala	Reijo et al. 1994. Mol Biol Cell 5:29-43	https://pubmed.ncbi.nlm.nih.gov/8186463/	Saccharomyces cerevisiae, budding yeast, fungus
		β407	E407K	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	TUBB SNP, DOID:11054 / urinary bladder cancer	Glu407Lys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P07437	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β407	E407K	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:9256 / colorectal cancer	Glu407Lys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β407	E407K	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:9256 / colorectal cancer	Glu407Lys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β407	E407K	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:1909 / melanoma	Glu407Lys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β407	E407K	P12456	https://www.uniprot.org/uniprotkb/P12456/entry	C. elegans	Mechanosensitive, mild recessive, mec-7	Glu407Lys	Savage et al. 1994. J Cell Sci 107:2165-75	https://pubmed.ncbi.nlm.nih.gov/7983175/	Caenorhabditis elegans, nematode, roundworm
		β407	E407L	P12456	https://www.uniprot.org/uniprotkb/P12456/entry	C. elegans	Neomorph, ectopic ALM-PN, mec-7	Glu407Leu	Zheng et al. 2017 Mol Biol Cell 28: 2786-2801	https://pubmed.ncbi.nlm.nih.gov/28835377/	Caenorhabditis elegans, nematode, roundworm	also see Lee et al. 2021. Mol Biol Cell. 15:331-347 (PMID 33378215)
		β408	F408I	P68371	https://www.uniprot.org/uniprotkb/P68371/entry	H. sapiens	TBB4B SNP, DOID:2994 / germ cell cancer	Phe408Ile	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P68371	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β408	F408I	P68371	https://www.uniprot.org/uniprotkb/P68371/entry	H. sapiens	TBB4B SNP, DOID:2394 / ovarian cancer	Phe408Ile	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P68371	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β408	Q408Q	Q9N2N6	https://www.uniprot.org/uniprotkb/Q9N2N6/entry	E. focardii	Cold stable adaptation (correlation, EFBT4)	Gln408Gln	Chiappori et al. 2012. Proteins 80:1154-60	https://pubmed.ncbi.nlm.nih.gov/22275059/	Euplotes focardii, extremophile, Antarctic ciliate
		β409	A409D	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with A415D, A364D, A292D, tubulin beta-4A	Ala409Asp	ClinVar 267787	https://www.ncbi.nlm.nih.gov/clinvar/variation/267787	Homo sapiens, human, clinical
		B409	I409I	Q9N2N6	https://www.uniprot.org/uniprotkb/Q9N2N6/entry	E. focardii	Cold stable adaptation (correlation, EFBT4)	Ile409Ile	Chiappori et al. 2012. Proteins 80:1154-60	https://pubmed.ncbi.nlm.nih.gov/22275059/	Euplotes focardii, extremophile, Antarctic ciliate
		β410	E410A	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:363 / uterine cancer	Glu410Ala	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β410	E410A	Q9BUF5	https://www.uniprot.org/uniprotkb/Q9BUF5/entry	H. sapiens	TBB6 SNP, DOID:1324 / lung cancer	Glu410Ala	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BUF5	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β410	E410A	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Reduced affinity for kinesin binding, TUB2p	Glu410Ala	Uchimura et al. 2006. EMBO J 25:5932-41	https://pubmed.ncbi.nlm.nih.gov/17124495/	Saccharomyces cerevisiae, budding yeast, fungus
		β410	E410A	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Recessive lethal, with E412A, TUB2p	Glu410Ala	Reijo et al. 1994. Mol Biol Cell 5:29-43	https://pubmed.ncbi.nlm.nih.gov/8186463/	Saccharomyces cerevisiae, budding yeast, fungus
		β410	E410D	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	Likely pathogenic, with E338D, E430D, E366D, E208D, tubulin beta	Glu410Asp	ClinVar 426178	https://www.ncbi.nlm.nih.gov/clinvar/variation/426178	Homo sapiens, human, clinical
		β410	E410G	Q9D6F9	https://www.uniprot.org/uniprotkb/Q9D6F9/entry	M. musculus	Tubb4a, viable heterozygote	Glu410Gly	Mutagenetix	https://mutagenetix.utsouthwestern.edu/incidental/incidental_rec.cfm?mid=531206	Mus musculus, mouse, tubulin beta-4A	Wang et al. 2015. PNAS 112:E440-449 (PMID 25605905)
		β410	E410G	A2AQ07	https://www.uniprot.org/uniprotkb/A2AQ07/entry	M. musculus	Tubb1, viable heterozygote	Glu410Gly	Mutagenetix	https://mutagenetix.utsouthwestern.edu/incidental/incidental_rec.cfm?mid=62007	Mus musculus, mouse, tubulin beta-1	Wang et al. 2015. PNAS 112:E440-449 (PMID 25605905)
		β410	E410K	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:11054 / urinary bladder cancer	Glu410Lys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β410	E410K	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:10534 / stomach cancer	Glu410Lys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β410	E410K	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:1612 / breast cancer	Glu410Lys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β410	E410K	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Extraocular congenital fibrosis syndrome, tubulin beta-3, 6 patients	Glu410Lys	Tischfield et al. 2010. Cell 140:74-87	https://pubmed.ncbi.nlm.nih.gov/20074521/	Homo sapiens, human, clinical
		β410	E410K	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Inhibited axonal transport of vesicles and mitochondria, tubulin beta-3	Glu410Lys	Niwa et al. 2013. EMBO J 32:1352-64	https://pubmed.ncbi.nlm.nih.gov/23503589/	Homo sapiens, human, clinical	Model for CFEOM3
		β410	E410K	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Extraocular congenital fibrosis syndrome, tubulin beta-3, 2 patients	Glu410Lys	MacKinnon et al. 2014. Ophthalmology 121:1461-8	https://pubmed.ncbi.nlm.nih.gov/24612975/	Homo sapiens, human, clinical	Previously reported
		β410	E410K	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Hypomyelinating leukoencephalopathy, tubulin beta-4A, 2 patients	Glu410Lys	Miyatake et al. 2014. Neurology 82:2230-7	https://pubmed.ncbi.nlm.nih.gov/24850488/	Homo sapiens, human, clinical
		β410	E410K	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Cerebellar dysplasia, tubulin beta-3	Glu410Lys	Romaniello et al. 2017. Eur Radiol 27:5080-5092	https://pubmed.ncbi.nlm.nih.gov/28677066/	Homo sapiens, human, clinical
		β410	E410K	P12456	https://www.uniprot.org/uniprotkb/P12456/entry	C. elegans	Antimorph, short TRN neurites, mec-7	Glu410K	Zheng et al. 2017 Mol Biol Cell 28: 2786-2801	https://pubmed.ncbi.nlm.nih.gov/28835377/	Caenorhabditis elegans, nematode, roundworm	also see Lee et al. 2021. Mol Biol Cell. 15:331-347 (PMID 33378215)
		β410	E410K	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Atypical Moebius syndrome, tubulin beta-3	Glu410Lys	Nakamura et al. 2018. Brain Dev 40:233-237	https://pubmed.ncbi.nlm.nih.gov/29289389/	Homo sapiens, human, clinical
		β410	E410K	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Female infertility, tubulin beta-8	Glu410Lys	Chen et al. 2019. Eur J Hum Genet 27:300-307	https://pubmed.ncbi.nlm.nih.gov/30297906/	Homo sapiens, human, clinical
		β410	E410K	Q13885	https://www.uniprot.org/uniprotkb/Q13885/entry	H. sapiens	Tubulinopathy, brain malformations, tubulin beta-2A	Glu410Lys	Brock et al. 2021. J Med Genet 58:33-40	https://pubmed.ncbi.nlm.nih.gov/32571897/	Homo sapiens, human, clinical
		β410	E410K	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Congenital fibrosis of the extraocular muscles, tubulin beta-3	Glu410Lys	Dentici et al. 2020. Am J Med Genet A 182:1977-1984	https://pubmed.ncbi.nlm.nih.gov/32573066/	Homo sapiens, human, clinical
		β410	E410K	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Atypical Möbius syndrome, nonalcoholic fatty liver disease, TUBB3	Glu410Lys	Mori et al. 2022. J Clin Endocry & Metab 107: e38–e43	https://pubmed.ncbi.nlm.nih.gov/34435630/	Homo sapiens, human, clinical
		β410	E410K	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Isolated hypomyelination, increased microtubule stability, tubulin beta-4A	Glu410Lys	Xiao et al. 2022. Mol Neurobiol 59:5056-69	https://pubmed.ncbi.nlm.nih.gov/35668344/	Homo sapiens, human, clinical
		β410	E410K	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Isolated hypomyelination, tubulin beta-4A	Glu410Lys	Xiao et al. 2022. Mol Neurobiol 59:5056-69.	https://pubmed.ncbi.nlm.nih.gov/35668344/	Homo sapiens, human, clinical
		β410	E410K	Q9BVA1	https://www.uniprot.org/uniprotkb/Q9BVA1/entry	H. sapiens	Cerebellar hypoplasia, tubulin beta-2B	Glu410Lys	Brar et al. 2022. Prenatal Diagnosis 42:1686–1693	https://pubmed.ncbi.nlm.nih.gov/36403095/	Homo sapiens, human, clinical	1228G>C
		β410	E410K	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with E461K, E338K, E455K, tubulin beta-4A	Glu410Lys	ClinVar 135658	https://www.ncbi.nlm.nih.gov/clinvar/variation/135658	Homo sapiens, human, clinical
		β410	E410K	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Cortical dysplasia, other brain malformations, with E338K, tubulin beta-3	Glu410Lys	ClinVar 6967	https://www.ncbi.nlm.nih.gov/clinvar/variation/6967	Homo sapiens, human, clinical
		β410	E410K	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Cerebellar atrophy, TUBB4A	Glu410Lys	Blumkin et al. 2014. Neurogenetics 15:107-13	https://pubmed.ncbi.nlm.nih.gov/24526230/	Homo sapiens, human, clinical
		β410	E410V	Q9BVA1	https://www.uniprot.org/uniprotkb/Q9BVA1/entry	H. sapiens	TBB2B SNP, DOID:0070003 / blastoma	Glu410Val	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BVA1	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β410	E410V	Q9BVA1	https://www.uniprot.org/uniprotkb/Q9BVA1/entry	H. sapiens	TBB2B SNP, DOID:3571 / liver cancer	Glu410Val	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BVA1	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β410	E410V	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Extraocular congenital fibrosis syndrome, tubulin beta-3	Glu410Val	MacKinnon et al. 2014. Ophthalmology 121:1461-8	https://pubmed.ncbi.nlm.nih.gov/24612975/	Homo sapiens, human, clinical
		β410	E410X	P12456	https://www.uniprot.org/uniprotkb/P12456/entry	C. elegans	Mechanosensitive, severe recessive, mec-7	Glu410X	Savage et al. 1994. J Cell Sci 107:2165-75	https://pubmed.ncbi.nlm.nih.gov/7983175/	Caenorhabditis elegans, nematode, roundworm
		β411	A411D	A0A8E5HT31	https://www.uniprot.org/uniprotkb/A0A8E5HT31/entry	U. virens	Carbendazin resistance, Uvβ1Tub	Ala411Asp	Song et al. 2022. J Fungi 8:1311	https://pubmed.ncbi.nlm.nih.gov/36547644/	Ustilaginoidea, fungus, rice false smut
		β411	A411T	Q9CWF2	https://www.uniprot.org/uniprotkb/Q9CWF2/entry	M. musculus	Tubb2b, viable heterozygote	Ala411Thr	Mutagenetix	https://mutagenetix.utsouthwestern.edu/incidental/incidental_rec.cfm?mid=518719	Mus musculus, mouse, tubulin beta-2B	Wang et al. 2015. PNAS 112:E440-449 (PMID 25605905)
		β411	A411V	Q9BUF5	https://www.uniprot.org/uniprotkb/Q9BUF5/entry	H. sapiens	TBB6 SNP, DOID:2531 / hematologic cancer	Ala411Val	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BUF5	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β412	E412A	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Kinesin binding unaffected, TUB1p	Glu412Ala	Uchimura et al. 2006. EMBO J 25:5932-41	https://pubmed.ncbi.nlm.nih.gov/17124495/	Saccharomyces cerevisiae, budding yeast, fungus
		β412	E412A	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Recessive lethal, with E410A, TUB2p	Glu412Ala	Reijo et al. 1994. Mol Biol Cell 5:29-43	https://pubmed.ncbi.nlm.nih.gov/8186463/	Saccharomyces cerevisiae, budding yeast, fungus
		β412	E412D	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	TUBB SNP, DOID:263 / kidney cancer	Glu412Asp	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P07437	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β412	E412D	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	TUBB SNP, DOID:3571 / liver cancer	Glu412Asp	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P07437	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β412	E412G	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:10534 / stomach cancer	Glu412Gly	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β412	E412K	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	TUBB SNP, DOID:11054 / urinary bladder cancer	Glu412Lys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P07437	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β412	E412K	P68371	https://www.uniprot.org/uniprotkb/P68371/entry	H. sapiens	TBB4B SNP, DOID:4362 / cervical cancer	Glu412Lys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P68371	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β412	E412K	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:2394 / ovarian cancer	Glu412Lys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β412	E412K	Q9BVA1	https://www.uniprot.org/uniprotkb/Q9BVA1/entry	H. sapiens	TBB2B SNP, DOID:1324 / lung cancer	Glu412Lys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BVA1	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β412	E412Q	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	TUBB SNP, DOID:1612 / breast cancer	Glu412Gln	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P07437	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β412	F412I	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with F418I, F367I, F295I, tubulin beta-4A	Phe412Ile	ClinVar 267788	https://www.ncbi.nlm.nih.gov/clinvar/variation/267788	Homo sapiens, human, clinical
		β412	F412L	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with F418L, F367L, F295L, tubulin beta-4A	Phe412Leu	ClinVar 267789	https://www.ncbi.nlm.nih.gov/clinvar/variation/267789	Homo sapiens, human, clinical
		β414	N414H	Q13885	https://www.uniprot.org/uniprotkb/Q13885/entry	H. sapiens	Likely pathogenic, with N329H, tubulin beta-2A	Asn414His	ClinVar 372880	https://www.ncbi.nlm.nih.gov/clinvar/variation/372880	Homo sapiens, human, clinical
		β414	N414K	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Encephalopathy, epilepsy, slowed microtubule growth, tubulin beta-4A	Asn414Lys	Curiel et al. 2017. Hum Mol Genet 26:4506-4518	https://pubmed.ncbi.nlm.nih.gov/28973395/	Homo sapiens, human, clinical
		β414	N414K	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Female infertility, tubulin beta-8	Asn414Lys	Yang et al. 2021. Clin Genet 99:208-214	https://pubmed.ncbi.nlm.nih.gov/33009822/	Homo sapiens, human, clinical
		β414	N414K	Q9D6F9	https://www.uniprot.org/uniprotkb/Q9D6F9/entry	M. musculus	Tremulous phenotype, mutant mouse Jittering (Jit), Tubb4a	Asn414Lys	Fertuzinhos et al. Sci. Adv. 8, eabf7262	https://pubmed.ncbi.nlm.nih.gov/35171680/	Mus musculus, mouse	Mouse model of tubulinopathy
		β414	N414S	Q922F4	https://www.uniprot.org/uniprotkb/Q922F4/entry	M. musculus	Tubb6, viable heterozygote	Asn414Ser	Mutagenetix	https://mutagenetix.utsouthwestern.edu/incidental/incidental_rec.cfm?mid=154595	Mus musculus, mouse, tubulin beta-6	Wang et al. 2015. PNAS 112:E440-449 (PMID 25605905)
		β415	A415D	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with A364D, A292D, A409D, tubulin beta-4A	Ala415Asp	ClinVar 267787	https://www.ncbi.nlm.nih.gov/clinvar/variation/267787	Homo sapiens, human, clinical
		β415	I415V	A2AQ07	https://www.uniprot.org/uniprotkb/A2AQ07/entry	M. musculus	Tubb1, viable heterozygote	Ile415Val	Mutagenetix	https://mutagenetix.utsouthwestern.edu/incidental/incidental_rec.cfm?mid=452704	Mus musculus, mouse, tubulin beta-1	Wang et al. 2015. PNAS 112:E440-449 (PMID 25605905)
		β415	M415I	P68371	https://www.uniprot.org/uniprotkb/P68371/entry	H. sapiens	TBB4B SNP, DOID:1612 / breast cancer	Met415Ile	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P68371	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β415	M415I	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Infertility due to arrest in oocyte maturation, with E194K, tubulin beta-8	Met415Ile	Chen et al. 2017. Hum Reprod 32:457-464.	https://pubmed.ncbi.nlm.nih.gov/27989988/	Homo sapiens, human, clinical
		β415	M415L	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:1324 / lung cancer	Met415Leu	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β415	M415V	P69893	https://www.uniprot.org/uniprotkb/P69893/entry	C. griseus	Paclitaxel resistant, tubulin beta-5	Met415Val	Yin et al. 2012. Pharm Res 29:2994-3006	https://pubmed.ncbi.nlm.nih.gov/22669706/	Cricetulus griseus, chinese hamster, rodent
		β416	H416Q	A2AQ07	https://www.uniprot.org/uniprotkb/A2AQ07/entry	M. musculus	Tubb1, viable heterozygote	His416Gln	Mutagenetix	https://mutagenetix.utsouthwestern.edu/incidental/incidental_rec.cfm?mid=479579	Mus musculus, mouse, tubulin beta-1	Wang et al. 2015. PNAS 112:E440-449 (PMID 25605905)
		β416	N416A	P69893	https://www.uniprot.org/uniprotkb/P69893/entry	C. griseus	Paclitaxel resistant, with T178A, CHO cell line, tubulin beta-5	Asn416Ala	Yin et al. 2012. Pharm Res 29:2994-3006	https://pubmed.ncbi.nlm.nih.gov/22669706/	Cricetulus griseus, chinese hamster, rodent
		β416	N416I	Q9D6F9	https://www.uniprot.org/uniprotkb/Q9D6F9/entry	M. musculus	Tubb4a, viable heterozygote	Asn416leI	Mutagenetix	https://mutagenetix.utsouthwestern.edu/incidental/incidental_rec.cfm?mid=701573	Mus musculus, mouse, tubulin beta-4A	Wang et al. 2015. PNAS 112:E440-449 (PMID 25605905)
		β416	N416S	Q9BUF5	https://www.uniprot.org/uniprotkb/Q9BUF5/entry	H. sapiens	TBB6 SNP, DOID:2531 / hematologic cancer	Asn416Ser	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BUF5	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β416	N416S	P99024	https://www.uniprot.org/uniprotkb/P99024/entry	M. musculus	Tubb5, viable heterozygote	Asn416Ser	Mutagenetix	https://mutagenetix.utsouthwestern.edu/incidental/incidental_rec.cfm?mid=431048	Mus musculus, mouse, tubulin beta-5	Wang et al. 2015. PNAS 112:E440-449 (PMID 25605905)
		β416	N416S	Q13885	https://www.uniprot.org/uniprotkb/Q13885/entry	H. sapiens	Likely pathogenic, with N331S, tubulin beta-2A	Asn416Ser	ClinVar 624121	https://www.ncbi.nlm.nih.gov/clinvar/variation/624121	Homo sapiens, human, clinical
		β417	D417A	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Recessive lethal, with E421A	Asp417Ala	Uchimura et al. 2006. EMBO J 25:5932-41	https://pubmed.ncbi.nlm.nih.gov/17124495/	Saccharomyces cerevisiae, budding yeast, fungus
		β417	D417H	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Extraocular congenital fibrosis syndrome, tubulin beta-3	Asp417His	Tischfield et al. 2010. Cell 140:74-87	https://pubmed.ncbi.nlm.nih.gov/20074521/	Homo sapiens, human, clinical
		β417	D417H	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Inhibited axonal transport of vesicles and mitochondria, tubulin beta-3	Asp417His	Niwa et al. 2013. EMBO J 32:1352-64	https://pubmed.ncbi.nlm.nih.gov/23503589/	Homo sapiens, human, clinical	Model for CFEOM3
		β417	D417H	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Reduces the affinity of tubulin for TOG domains & colchicine, tubulin beta-3	Asp417His	Ti et al. 2016. Dev Cell 37:72-84	https://pubmed.ncbi.nlm.nih.gov/27046833/	Homo sapiens, human, clinical
		β417	D417H	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Disruption of netrin-1 mediated axonal repulsion, tubulin beta-3, HeLa cells	Asp417His	Shao et al. 2019. PLoS One 14:e0218811	https://pubmed.ncbi.nlm.nih.gov/31226147/	Homo sapiens, human, clinical
		β417	D417H	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Fibrosis of extraocular muscles, with D345H, tubulin beta-3	Asp417His	ClinVar 6965	https://www.ncbi.nlm.nih.gov/clinvar/variation/6965	Homo sapiens, human, clinical
		β417	D417N	Q13885	https://www.uniprot.org/uniprotkb/Q13885/entry	H. sapiens	TBB2A SNP, DOID:9256 / colorectal cancer	Asp417Gln	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13885	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β417	D417N	Q9BUF5	https://www.uniprot.org/uniprotkb/Q9BUF5/entry	H. sapiens	TBB6 SNP, DOID:363 / uterine cancer	Asp417Asn	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BUF5	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β417	D417N	Q9BUF5	https://www.uniprot.org/uniprotkb/Q9BUF5/entry	H. sapiens	TBB6 SNP, DOID:11054 / urinary bladder cancer	Asp417Asn	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BUF5	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β417	D417N	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Extraocular congenital fibrosis syndrome, tubulin beta-3, 4 patients	Asp417Asn	Tischfield et al. 2010. Cell 140:74-87	https://pubmed.ncbi.nlm.nih.gov/20074521/	Homo sapiens, human, clinical
		β417	D417N	Q9BVA1	https://www.uniprot.org/uniprotkb/Q9BVA1/entry	H. sapiens	Symmetric polymicrogyria & pachygyria, tubulin beta-2B	Asp417Asn	Guerrini et al. 2012. Eur J Hum Genet 20:995-8	https://pubmed.ncbi.nlm.nih.gov/22333901/	Homo sapiens, human, clinical
		β417	D417N	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Defects in oocyte meiosis, tubulin beta-8	Asp417Asn	Feng et al. 2016. N Engl J Med 374:223-32	https://pubmed.ncbi.nlm.nih.gov/26789871/	Homo sapiens, human, clinical
		β417	D417N	Q13885	https://www.uniprot.org/uniprotkb/Q13885/entry	H. sapiens	Progressive spastic ataxia, impaired kinesin binding, tubulin beta-2A	Asp417Asn	Sferra et al. 2018. Hum Mol Genet 27:1892-1904	https://pubmed.ncbi.nlm.nih.gov/29547997/	Homo sapiens, human, clinical
		β417	D417N	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Oocyte maturation defect, tubulin beta-8	Asp417Asn	ClinVar 221268	https://www.ncbi.nlm.nih.gov/clinvar/variation/221269	Homo sapiens, human, clinical
		β417	D417N	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Fibrosis of extraocular muscles, with D345N, tubulin beta-3	Asp417Asn	ClinVar 6966	https://www.ncbi.nlm.nih.gov/clinvar/variation/6966	Homo sapiens, human, clinical
		β417	D417Y	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Female infertility, tubulin beta-8	Asp417Tyr	Chen et al. 2019. Eur J Hum Genet 27:300-307	https://pubmed.ncbi.nlm.nih.gov/30297906/	Homo sapiens, human, clinical
		β417	E417A	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Recessive lethal, with E421A, TUB2p	Glu421Ala	Reijo et al. 1994. Mol Biol Cell 5:29-43	https://pubmed.ncbi.nlm.nih.gov/8186463/	Saccharomyces cerevisiae, budding yeast, fungus
		β418	F418I	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with F367I, F295I, F412I, tubulin beta-4A	Phe418Ile	ClinVar 267788	https://www.ncbi.nlm.nih.gov/clinvar/variation/267788	Homo sapiens, human, clinical
		β418	F418L	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with F367L, F295L, F412L, tubulin beta-4A	Phe418Leu	ClinVar 267789	https://www.ncbi.nlm.nih.gov/clinvar/variation/267789	Homo sapiens, human, clinical
		β418	L418M	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:363 / uterine cancer	Leu418Met	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β419	V419E	Q9D6F9	https://www.uniprot.org/uniprotkb/Q9D6F9/entry	M. musculus	Tubb4a, viable heterozygote	Val419Glu	Mutagenetix	https://mutagenetix.utsouthwestern.edu/incidental/incidental_rec.cfm?mid=699163	Mus musculus, mouse, tubulin beta-4A	Wang et al. 2015. PNAS 112:E440-449 (PMID 25605905)
		β419	V419I	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	TUBB SNP, DOID:363 / uterine cancer	Val419Ile	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P07437	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β419	V419M	Q9D6F9	https://www.uniprot.org/uniprotkb/Q9D6F9/entry	M. musculus	Tubb4a, viable heterozygote	Val419Met	Mutagenetix	https://mutagenetix.utsouthwestern.edu/incidental/incidental_rec.cfm?mid=36031	Mus musculus, mouse, tubulin beta-4A	Wang et al. 2015. PNAS 112:E440-449 (PMID 25605905)
		β420	S420C	Q13885	https://www.uniprot.org/uniprotkb/Q13885/entry	H. sapiens	TBB2A SNP, DOID:0070003 / blastoma	Ser420Cys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13885	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β420	S420C	Q13885	https://www.uniprot.org/uniprotkb/Q13885/entry	H. sapiens	TBB2A SNP, DOID:3571 / liver cancer	Ser420Cys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13885	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β420	S420F	Q9BVA1	https://www.uniprot.org/uniprotkb/Q9BVA1/entry	H. sapiens	TBB2B SNP, DOID:3953 / adrenal gland cancer	Ser420Phe	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BVA1	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β420	S420P	A2AQ07	https://www.uniprot.org/uniprotkb/A2AQ07/entry	M. musculus	Tubb1, viable heterozygote	Ser420Pro	Mutagenetix	https://mutagenetix.utsouthwestern.edu/incidental/incidental_rec.cfm?mid=20863	Mus musculus, mouse, tubulin beta-1	Wang et al. 2015. PNAS 112:E440-449 (PMID 25605905)
		β421	E421A	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Reduced affinity for kinesin binding, TUB2p	Glu421Ala	Uchimura et al. 2006. EMBO J 25:5932-41	https://pubmed.ncbi.nlm.nih.gov/17124495/	Saccharomyces cerevisiae, budding yeast, fungus
		β421	E421A	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Recessive lethal, with D417A, TUB2p	Glu421Ala	Reijo et al. 1994. Mol Biol Cell 5:29-43	https://pubmed.ncbi.nlm.nih.gov/8186463/	Saccharomyces cerevisiae, budding yeast, fungus
		β421	E421D	P68371	https://www.uniprot.org/uniprotkb/P68371/entry	H. sapiens	TBB4B SNP, DOID:3571 / liver cancer	Glu421Asp	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P68371	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β421	E421D	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Monocular elevation deficiency, tubulin beta-3	Glu421Asp	Thomas et al. 2020. Br J Ophthalmol 104:547-550	https://pubmed.ncbi.nlm.nih.gov/31302631/	Homo sapiens, human, clinical
		β421	E421K	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:11054 / urinary bladder cancer	Glu421Lys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β421	E421K	Q9BVA1	https://www.uniprot.org/uniprotkb/Q9BVA1/entry	H. sapiens	Polymicrogyria, tubulin beta-2B	Glu421Lys	Cederquist et al. 2012. Hum Mol Genet 21:5484-99	https://pubmed.ncbi.nlm.nih.gov/23001566/	Homo sapiens, human, clinical
		β421	E421K	Q9BVA1	https://www.uniprot.org/uniprotkb/Q9BVA1/entry	H. sapiens	Cerebellar dysplasia, tubulin beta-2B	Glu421Lys	Romaniello et al. 2017. Eur Radiol 27:5080-5092	https://pubmed.ncbi.nlm.nih.gov/28677066/	Homo sapiens, human, clinical
		β421	E421K	Q9BVA1	https://www.uniprot.org/uniprotkb/Q9BVA1/entry	H. sapiens	Lissencephaly, tubulin beta-2B	Glu421Lys	Di Donato et al. 2018. Genet Med 20:1354-1364	https://pubmed.ncbi.nlm.nih.gov/29671837/	Homo sapiens, human, clinical
		β421	E421K	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	Cortical dysplasia, brain malformations, with E401K, E357K, E329K, E199K, tubulin beta	Glu421Lys	ClinVar 127191	https://www.ncbi.nlm.nih.gov/clinvar/variation/127191	Homo sapiens, human, clinical
		β421	Δ421-424	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Cold sensitive microtubules, TUB2p	Δ421-424	Huffaker et al. 1988. J Cell Biol 106:1997-2010	https://pubmed.ncbi.nlm.nih.gov/3290223/	Saccharomyces cerevisiae, budding yeast, fungus
		β422	Y422C	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	Taxol and epothilone resistant HeLa cell line, tubulin beta	Tyr422Cys	He et al. 2001. Mol Cancer Ther 1:3-10	https://pubmed.ncbi.nlm.nih.gov/12467233/	Homo sapiens, human, clinical
		β422	Y422H	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:3963 / thyroid carcinoma	Tyr422His	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β422	Y422H	Q922F4	https://www.uniprot.org/uniprotkb/Q922F4/entry	M. musculus	Tubb6, viable heterozygote	Tyr422His	Mutagenetix	https://mutagenetix.utsouthwestern.edu/incidental/incidental_rec.cfm?mid=301427	Mus musculus, mouse, tubulin beta-6	Wang et al. 2015. PNAS 112:E440-449 (PMID 25605905)
		β422	Y422H	Q9CWF2	https://www.uniprot.org/uniprotkb/Q9CWF2/entry	M. musculus	Tubb2b, viable heterozygote	Tyr422His	Mutagenetix	https://mutagenetix.utsouthwestern.edu/incidental/incidental_rec.cfm?mid=512462	Mus musculus, mouse, tubulin beta-2B	Wang et al. 2015. PNAS 112:E440-449 (PMID 25605905)
		β422	Q423R	Q9BUF5	https://www.uniprot.org/uniprotkb/Q9BUF5/entry	H. sapiens	TBB6 SNP, DOID:2531 / hematologic cancer	Gln423Arg	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BUF5	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β422	Y422S	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	Computational prediction, nsSNP causes protein destablization	Tyr422Ser	Hussain et al. 2022. J Biomol Struct Dyn 11:1-11.	https://pubmed.ncbi.nlm.nih.gov/36218086/	Computational modeling, clinical
		β423	Q423R	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:9256 / colorectal cancer	Gln423Arg	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β424	C424C	Q9N2N6	https://www.uniprot.org/uniprotkb/Q9N2N6/entry	E. focardii	Cold stable adaptation (correlation, EFBT4)	Cys424Cys	Chiappori et al. 2012. Proteins 80:1154-60	https://pubmed.ncbi.nlm.nih.gov/22275059/	Euplotes focardii, extremophile, Antarctic ciliate
		β424	G71E	P12456	https://www.uniprot.org/uniprotkb/P12456/entry	C. elegans	Loss-of-function, shortened PLM-PN, mec-7	Gly71Glu	Lee et al. 2021. Mol Biol Cell. 15:331-347	https://pubmed.ncbi.nlm.nih.gov/33378215/	Caenorhabditis elegans, nematode, roundworm
		β424	Q424X	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Female infertility, tubulin beta-8	Gln424X	Chen et al. 2019. Eur J Hum Genet 27:300-307	https://pubmed.ncbi.nlm.nih.gov/30297906/	Homo sapiens, human, clinical
		β424	Q424H	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Laryngeal and cervical dystonia, TUBB4A	Gln424His	Bally et al. 2021. Neurology 96: e1887-97	https://pubmed.ncbi.nlm.nih.gov/32943487/	Homo sapiens, human, clinical
		β424	Q424H	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Increased microtubule polymerization, tubulin beta-4A	Gln424His	Krajka et al. 2022. Sci. Adv. 8:eabj9229.	https://pubmed.ncbi.nlm.nih.gov/35275727/	Homo sapiens, human, clinical
		β424	Q424L	P12456	https://www.uniprot.org/uniprotkb/P12456/entry	C. elegans	Loss-of-function, shortened PLM-PN, with P357S, mec-7	Gln424Leu	Lee et al. 2021. Mol Biol Cell. 15:331-347	https://pubmed.ncbi.nlm.nih.gov/33378215/	Caenorhabditis elegans, nematode, roundworm
		β424	Q424R	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Female infertility, tubulin beta-8	Gln424Arg	Yang et al. 2021. Clin Genet 99:208-214	https://pubmed.ncbi.nlm.nih.gov/33009822/	Homo sapiens, human, clinical
		β425	C425C	Q9N2N6	https://www.uniprot.org/uniprotkb/Q9N2N6/entry	E. focardii	Cold stable adaptation (correlation, EFBT3)	Cys425Cys	Chiappori et al. 2012. Proteins 80:1154-60	https://pubmed.ncbi.nlm.nih.gov/22275059/	Euplotes focardii, extremophile, Antarctic ciliate
		β425	F425V	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:9256 / colorectal cancer	Phe425Val	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β425	Y425C	Q9CWF2	https://www.uniprot.org/uniprotkb/Q9CWF2/entry	M. musculus	Tubb2b, viable heterozygote	Tyr425Cys	Mutagenetix	https://mutagenetix.utsouthwestern.edu/incidental/incidental_rec.cfm?mid=544067	Mus musculus, mouse, tubulin beta-2B	Wang et al. 2015. PNAS 112:E440-449 (PMID 25605905)
		β426	Q426E	P68371	https://www.uniprot.org/uniprotkb/P68371/entry	H. sapiens	TBB4B SNP, DOID:1324 / lung cancer	Gln426Glu	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P68371	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β426	Q426R	Q9BUF5	https://www.uniprot.org/uniprotkb/Q9BUF5/entry	H. sapiens	TBB6 SNP, DOID:3963 / thyroid carcinoma	Gln426Arg	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BUF5	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β426	Q426R	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:363 / uterine cancer	Gln426Arg	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β427	D427N	P68371	https://www.uniprot.org/uniprotkb/P68371/entry	H. sapiens	TBB4B SNP, DOID:10534 / stomach cancer	Asp427Asn	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P68371	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β427	D427N	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:1324 / lung cancer	Asp427Asn	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β428	A428T	P68371	https://www.uniprot.org/uniprotkb/P68371/entry	H. sapiens	TBB4B SNP, DOID:1612 / breast cancer	Ala428Thr	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P68371	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β428	A428T	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:1909 / melanoma	Ala428Thr	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β428	A428T	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:9256 / colorectal cancer	Ala428Thr	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β428	A428T	Q13885	https://www.uniprot.org/uniprotkb/Q13885/entry	H. sapiens	TBB2A SNP, DOID:9256 / colorectal cancer	Ala428Thr	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13885	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β428	A428V	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:1324 / lung cancer	Ala428Val	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β428	A428V	P68371	https://www.uniprot.org/uniprotkb/P68371/entry	H. sapiens	TBB4B SNP, DOID:10283 / prostate cancer	Ala428Val	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P68371	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β428	A428V	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:363 / uterine cancer	Ala428Val	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β429	T429M	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:3070 / malignant glioma	Thr429Met	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β429	T429M	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:9256 / colorectal cancer	Thr429Met	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β429	T429M	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Female infertility, tubulin beta-8	Thr429Met	Chen et al. 2019. Eur J Hum Genet 27:300-307	https://pubmed.ncbi.nlm.nih.gov/30297906/	Homo sapiens, human, clinical
		β429	T429M	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Infertility, early embryonic developmental arrest, tubulin beta-8	Thr429Met	Zhang et al. 2023. J Assist Reprod Genet 40:753-763.	https://pubmed.ncbi.nlm.nih.gov/36735156/	Homo sapiens, human, clinical
		β430	A430P	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:10283 / prostate cancer	Ala430Pro	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β430	A430P	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:1793 / pancreatic cancer	Ala430Pro	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β430	A430P	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Malignant tumor of prostate, with A358P, tubulin beta-3, tubulin beta-3	Ala430Pro	ClinVar 219299	https://www.ncbi.nlm.nih.gov/clinvar/variation/219299	Homo sapiens, human, clinical
		β430	A430S	P68371	https://www.uniprot.org/uniprotkb/P68371/entry	H. sapiens	TBB4B SNP, DOID:3571 / liver cancer	Ala430Ser	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P68371	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β430	A430T	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	TUBB SNP, DOID:9256 / colorectal cancer	Ala430Thr	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P07437	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β430	A430T	Q9BUF5	https://www.uniprot.org/uniprotkb/Q9BUF5/entry	H. sapiens	TBB6 SNP, DOID:1324 / lung cancer	Ala430Thr	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BUF5	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β430	E430D	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	Likely pathogenic, with E410D, E338D, E366D, E208D, tubulin beta	Glu430Asp	ClinVar 426178	https://www.ncbi.nlm.nih.gov/clinvar/variation/426178	Homo sapiens, human, clinical
		β431	D431N	Q9BVA1	https://www.uniprot.org/uniprotkb/Q9BVA1/entry	H. sapiens	TBB2B SNP, DOID:3571 / liver cancer	Asp431Asn	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BVA1	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β431	D431N	Q9BVA1	https://www.uniprot.org/uniprotkb/Q9BVA1/entry	H. sapiens	TBB2B SNP, DOID:0070003 / blastoma	Asp431Asn	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BVA1	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β431	E431A	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Dominant lethal, with D432A, TUB2p	Glu431Ala	Reijo et al. 1994. Mol Biol Cell 5:29-43	https://pubmed.ncbi.nlm.nih.gov/8186463/	Saccharomyces cerevisiae, budding yeast, fungus
		β431	E431D	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:9256 / colorectal cancer	Glu431Asp	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β431	E431D	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:1909 / melanoma	Glu431Asp	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β431	E431X	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Benomyl supersensitive, TUB2p	Glu431X	Aiken et al. 2014. Curr Biol. 24:1295-1303	https://pubmed.ncbi.nlm.nih.gov/24835459/	Saccharomyces cerevisiae, budding yeast, fungus
		β432	D432A	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Dominant lethal, with E431A, TUB2p	Asp432Ala	Reijo et al. 1994. Mol Biol Cell 5:29-43	https://pubmed.ncbi.nlm.nih.gov/8186463/	Saccharomyces cerevisiae, budding yeast, fungus
		β432	E432G	Q13885	https://www.uniprot.org/uniprotkb/Q13885/entry	H. sapiens	TBB2A SNP, DOID:1909 / melanoma	Glu432Gly	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13885	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β432	E432G	Q13885	https://www.uniprot.org/uniprotkb/Q13885/entry	H. sapiens	TBB2A SNP, DOID:9256 / colorectal cancer	Glu432Gly	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13885	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β432	E432K	Q13885	https://www.uniprot.org/uniprotkb/Q13885/entry	H. sapiens	TBB2A SNP, DOID:363 / uterine cancer	Glu432Lys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13885	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β432	E432K	Q13885	https://www.uniprot.org/uniprotkb/Q13885/entry	H. sapiens	TBB2A SNP, DOID:1612 / breast cancer	Glu432Lys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13885	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β433	D433A	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Benomyl supersensitive, with E434A, E435A, TUB2p	Asp433Ala	Reijo et al. 1994. Mol Biol Cell 5:29-43	https://pubmed.ncbi.nlm.nih.gov/8186463/	Saccharomyces cerevisiae, budding yeast, fungus
		β433	D433E	P61857	https://www.uniprot.org/uniprotkb/P61857/entry	D. melanogaster	Inability to make central pair (axoneme) microtubules, with A434G (betaTub85D)	Asp433Glu	Nielsen et al. 2001. Curr Biol 11:529-33	https://pubmed.ncbi.nlm.nih.gov/11413005/	Drosophila, fruitfly
		β433	M433I	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with M388I, M439I, M316I, tubulin beta-4A	Met433Ile	ClinVar 209201	https://www.ncbi.nlm.nih.gov/clinvar/variation/209201	Homo sapiens, human, clinical
		β433	M433I	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Microcephaly, cerebellar hypoplasia, hypomyelination, with M439I, M388I, M316I, tubulin beta-4A	Met433Ile	ClinVar 267792	https://www.ncbi.nlm.nih.gov/clinvar/variation/267792	Homo sapiens, human, clinical
		β433	M433T	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with M439T, M388T, M316T, tubulin beta-4A	Met433Thr	ClinVar 267791	https://www.ncbi.nlm.nih.gov/clinvar/variation/267791	Homo sapiens, human, clinical
		β433	M433V	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with M439V, M388V, M316V, tubulin beta-4A	Met433Val	ClinVar 267790	https://www.ncbi.nlm.nih.gov/clinvar/variation/267790	Homo sapiens, human, clinical
		β434	A434G	P61857	https://www.uniprot.org/uniprotkb/P61857/entry	D. melanogaster	Inability to make central pair (axoneme) microtubules, with D433E (betaTub85D)	Ala434Gly	Nielsen et al. 2001. Curr Biol 11:529-33	https://pubmed.ncbi.nlm.nih.gov/11413005/	Drosophila, fruitfly
		β434	E434A	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Benomyl supersensitive, with D433A, E435A, TUB2p	Glu434Ala	Reijo et al. 1994. Mol Biol Cell 5:29-43	https://pubmed.ncbi.nlm.nih.gov/8186463/	Saccharomyces cerevisiae, budding yeast, fungus
		β434	E434E	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	Oocyte maturation arrest, tubulin beta-8	Glu434dup	Zhu et al. 2022. Front. Endocrinol. 13:1016563.	https://pubmed.ncbi.nlm.nih.gov/36440233/	Homo sapiens, human, clinical
		β434	G434E	Q13885	https://www.uniprot.org/uniprotkb/Q13885/entry	H. sapiens	TBB2A SNP, DOID:9256 / colorectal cancer	Gly434Glu	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13885	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β434	G434E	Q13885	https://www.uniprot.org/uniprotkb/Q13885/entry	H. sapiens	TBB2A SNP, DOID:1909 / melanoma	Gly434Glu	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13885	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β434	G434R	Q13885	https://www.uniprot.org/uniprotkb/Q13885/entry	H. sapiens	TBB2A SNP, DOID:1909 / melanoma	Gly434Arg	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13885	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β435	E435A	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Benomyl supersensitive, with D433A, E434A, TUB2p	Glu435Ala	Reijo et al. 1994. Mol Biol Cell 5:29-43	https://pubmed.ncbi.nlm.nih.gov/8186463/	Saccharomyces cerevisiae, budding yeast, fungus
		β435	E435D	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:3571 / liver cancer	Glu435Asp	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β435	E435G	Q9BVA1	https://www.uniprot.org/uniprotkb/Q9BVA1/entry	H. sapiens	TBB2B SNP, DOID:363 / uterine cancer	Glu435Gly	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BVA1	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β435	E435K	P68371	https://www.uniprot.org/uniprotkb/P68371/entry	H. sapiens	TBB4B SNP, DOID:11934 / head and neck cancer	Glu435Lys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P68371	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β436	E436Q	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:4362 / cervical cancer	Glu436Gln	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β436	M436T	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Uncertain significance, with M364T, tubulin beta-3	Met436Thr	ClinVar 546220	https://www.ncbi.nlm.nih.gov/clinvar/variation/546220	Homo sapiens, human, clinical
		β436	R436H	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with R442H, R391H, R319H, tubulin beta-4A	Arg436His	ClinVar 267793	https://www.ncbi.nlm.nih.gov/clinvar/variation/267793	Homo sapiens, human, clinical
		β436	R436L	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with R391L, R442L, R319L, tubulin beta-4A	Arg436Leu	ClinVar 419697	https://www.ncbi.nlm.nih.gov/clinvar/variation/419697	Homo sapiens, human, clinical
		β437	D437A	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Wild-type, with E438A, TUB2p	Asp437Ala	Reijo et al. 1994. Mol Biol Cell 5:29-43	https://pubmed.ncbi.nlm.nih.gov/8186463/	Saccharomyces cerevisiae, budding yeast, fungus
		β437	E437D	Q13885	https://www.uniprot.org/uniprotkb/Q13885/entry	H. sapiens	TBB2A SNP, DOID:9256 / colorectal cancer	Glu437Asp	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13885	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β437	E437D	P41352	https://www.uniprot.org/uniprotkb/P41352/entry	T. thermophila	With E438D & E439D, lethal cytokinesis defect	Glu437Asp	Thazhath et al. 2002. Nat Cell Biol 4:256-9	https://pubmed.ncbi.nlm.nih.gov/11862218/	Tetrahymena thermophila, ciliate, protozoan
		β437	E437Q	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:1909 / melanoma	Glu437Gln	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β437	V180I	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	Paclitaxel resistant non-small cell lung cancer, tubulin-beta	Val180Ile	de Castro et al. 2003. Lung Cancer 41:41-8	https://pubmed.ncbi.nlm.nih.gov/12826311/	Homo sapiens, human, clinical
		β437	P182S	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	Paclitaxel resistant non-small cell lung cancer, tubulin-beta	Pro182Ser	de Castro et al. 2003. Lung Cancer 41:41-8	https://pubmed.ncbi.nlm.nih.gov/12826311/	Homo sapiens, human, clinical
		β437	G437S	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	Likely benign, with G365S, G457S, G235S, G393S, tubulin beta	Gly437Ser	ClinVar 382889	https://www.ncbi.nlm.nih.gov/clinvar/variation/382889	Homo sapiens, human, clinical
		β438	E438A	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Wild-type, with D437A, TUB2p	Glu438Ala	Reijo et al. 1994. Mol Biol Cell 5:29-43	https://pubmed.ncbi.nlm.nih.gov/8186463/	Saccharomyces cerevisiae, budding yeast, fungus
		β438	E438D	P41352	https://www.uniprot.org/uniprotkb/P41352/entry	T. thermophila	With E437D & E439D, lethal cytokinesis defect	Glu438Asp	Thazhath et al. 2002. Nat Cell Biol 4:256-9	https://pubmed.ncbi.nlm.nih.gov/11862218/	Tetrahymena thermophila, ciliate, protozoan
		β438	E438G	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:363 / uterine cancer	Glu438Gly	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β438	E438K	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:9256 / colorectal cancer	Glu438Lys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β438	E438Q	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Uncertain significance, with E366Q, tubulin beta-3	Glu438Gln	ClinVar 644964	https://www.ncbi.nlm.nih.gov/clinvar/variation/644964	Homo sapiens, human, clinical
		β439	A439E	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with A490E, A367E, A484E, tubulin beta-4A	Ala439Glu	ClinVar 537238	https://www.ncbi.nlm.nih.gov/clinvar/variation/537238	Homo sapiens, human, clinical
		β439	A439S	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:1324 / lung cancer	Ala439Ser	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β439	A439V	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:363 / uterine cancer	Ala439Val	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β439	A439V	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:9256 / colorectal cancer	Ala439Val	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β439	A439V	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with A367V, A484V, A490V, tubulin beta-4A	Ala439Val	ClinVar 656505	https://www.ncbi.nlm.nih.gov/clinvar/variation/656505	Homo sapiens, human, clinical
		β439	E439D	P41352	https://www.uniprot.org/uniprotkb/P41352/entry	T. thermophila	With E437D & E438D, lethal cytokinesis defect	Glu439Asp	Thazhath et al. 2002. Nat Cell Biol 4:256-9	https://pubmed.ncbi.nlm.nih.gov/11862218/	Tetrahymena thermophila, ciliate, protozoan
		β439	E439G	P68371	https://www.uniprot.org/uniprotkb/P68371/entry	H. sapiens	TBB4B SNP, DOID:1612 / breast cancer	Glu439Gly	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P68371	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β439	F439C	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with F445C, F394C, F322C, tubulin beta-4A	Phe439Cys	ClinVar 267794	https://www.ncbi.nlm.nih.gov/clinvar/variation/267794	Homo sapiens, human, clinical
		β439	F439S	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Torsion dystonia, with F445S, F322S, F394S, tubulin beta-4A	Phe439Ser	ClinVar 689794	https://www.ncbi.nlm.nih.gov/clinvar/variation/689794	Homo sapiens, human, clinical
		β439	M439I	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with M388I, M316I, M433I, tubulin beta-4A	Met439Ile	ClinVar 209201	https://www.ncbi.nlm.nih.gov/clinvar/variation/209201	Homo sapiens, human, clinical
		β439	M439I	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Microcephaly, cerebellar hypoplasia, hypomyelination, with M388I, M316I, M433I, tubulin beta-4A	Met439Ile	ClinVar 267792	https://www.ncbi.nlm.nih.gov/clinvar/variation/267792	Homo sapiens, human, clinical
		β439	M439T	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with M388T, M316T, M433T, tubulin beta-4A	Met439Thr	ClinVar 267791	https://www.ncbi.nlm.nih.gov/clinvar/variation/267791	Homo sapiens, human, clinical
		β439	M439V	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with M388V, M433V, M316V, tubulin beta-4A	Met439Val	ClinVar 267790	https://www.ncbi.nlm.nih.gov/clinvar/variation/267790	Homo sapiens, human, clinical
		β439	N439X	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Benomyl supersensitive, TUB2p	Asn439X	Aiken et al. 2014. Curr Biol. 24:1295-1303	https://pubmed.ncbi.nlm.nih.gov/24835459/	Saccharomyces cerevisiae, budding yeast, fungus
		β439	T439M	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:10534 / stomach cancer	Thr439Met	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β440	E440D	Q13885	https://www.uniprot.org/uniprotkb/Q13885/entry	H. sapiens	TBB2A SNP, DOID:1324 / lung cancer	Glu440Asp	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13885	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β440	E440G	Q13885	https://www.uniprot.org/uniprotkb/Q13885/entry	H. sapiens	TBB2A SNP, DOID:1324 / lung cancer	Glu440Gly	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13885	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β440	E440K	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:1909 / melanoma	Glu440Lys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β440	E440K	Q3ZCM7	https://www.uniprot.org/uniprotkb/Q3ZCM7/entry	H. sapiens	TBB8 SNP, DOID:9256 / colorectal cancer	Glu440Lys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3ZCM7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β440	E440K	Q9BVA1	https://www.uniprot.org/uniprotkb/Q9BVA1/entry	H. sapiens	TBB2B SNP, DOID:1324 / lung cancer	Glu440Lys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BVA1	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β440	E440K	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:363 / uterine cancer	Glu440Lys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		β440	E440Q	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:3571 / liver cancer	Glu440Gln	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		NA	D441A	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Wild-type, TUB2p	Asp441Ala	Reijo et al. 1994. Mol Biol Cell 5:29-43	https://pubmed.ncbi.nlm.nih.gov/8186463/	Saccharomyces cerevisiae, budding yeast, fungus
		NA	D441E	Q9ERD7	https://www.uniprot.org/uniprotkb/Q9ERD7/entry	M. musculus	Tubb3, viable heterozygote	Asp441Glu	Mutagenetix	https://mutagenetix.utsouthwestern.edu/incidental/incidental_rec.cfm?mid=399663	Mus musculus, mouse, tubulin beta-3	Wang et al. 2015. PNAS 112:E440-449 (PMID 25605905)
		NA	E441D	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:1612 / breast cancer	Glu441Asp	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		NA	E441K	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:1324 / lung cancer	Glu441Lys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		NA	E442D	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:363 / uterine cancer	Glu442Asp	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		NA	E442G	P68371	https://www.uniprot.org/uniprotkb/P68371/entry	H. sapiens	TBB4B SNP, DOID:363 / uterine cancer	Glu442Gly	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P68371	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		NA	E442K	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:363 / uterine cancer	Glu442Lys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		NA	E442K	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:1324 / lung cancer	Glu442Lys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		NA	E442K	Q9BVA1	https://www.uniprot.org/uniprotkb/Q9BVA1/entry	H. sapiens	TBB2B SNP, DOID:1324 / lung cancer	Glu442Lys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BVA1	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		NA	E442K	Q9BVA1	https://www.uniprot.org/uniprotkb/Q9BVA1/entry	H. sapiens	TBB2B SNP, DOID:5041 / esophageal cancer	Glu442Lys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BVA1	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		NA	E442Q	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	TUBB SNP, DOID:11054 / urinary bladder cancer	Glu442Gln	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P07437	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		NA	E442Q	Q9BUF5	https://www.uniprot.org/uniprotkb/Q9BUF5/entry	H. sapiens	TBB6 SNP, DOID:1612 / breast cancer	Glu442Gln	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BUF5	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		NA	E442V	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	TBB4A SNP, DOID:10534 / stomach cancer	Glu442Val	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04350	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		NA	R442H	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with R391H, R436H, R319H, tubulin beta-4A	Arg442His	ClinVar 267793	https://www.ncbi.nlm.nih.gov/clinvar/variation/267793	Homo sapiens, human, clinical
		NA	R442L	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with R391L, R436L, R319L, tubulin beta-4A	Arg442Leu	ClinVar 419697	https://www.ncbi.nlm.nih.gov/clinvar/variation/419697	Homo sapiens, human, clinical
		NA	D443G	Q13885	https://www.uniprot.org/uniprotkb/Q13885/entry	H. sapiens	TBB2A SNP, DOID:363 / uterine cancer	Asp443Gly	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13885	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		NA	D443H	Q13885	https://www.uniprot.org/uniprotkb/Q13885/entry	H. sapiens	TBB2A SNP, DOID:4362 / cervical cancer	Asp443His	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13885	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		NA	D443V	Q9BVA1	https://www.uniprot.org/uniprotkb/Q9BVA1/entry	H. sapiens	TBB2B SNP, DOID:9256 / colorectal cancer	Asp443V	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BVA1	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		NA	E443G	Q9ERD7	https://www.uniprot.org/uniprotkb/Q9ERD7/entry	M. musculus	Tubb3, viable heterozygote	Glu443Gly	Mutagenetix	https://mutagenetix.utsouthwestern.edu/incidental/incidental_rec.cfm?mid=556854	Mus musculus, mouse, tubulin beta-3	Wang et al. 2015. PNAS 112:E440-449 (PMID 25605905)
		NA	E443K	Q9BUF5	https://www.uniprot.org/uniprotkb/Q9BUF5/entry	H. sapiens	TBB6 SNP, DOID:363 / uterine cancer	Glu443Lys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BUF5	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		NA	E443Q	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	TUBB SNP, DOID:1612 / breast cancer	Glu443Gln	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/P07437	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		NA	V443M	Q9D6F9	https://www.uniprot.org/uniprotkb/Q9D6F9/entry	M. musculus	Tubb4a, viable heterozygote	Val443Met	Mutagenetix	https://mutagenetix.utsouthwestern.edu/incidental/incidental_rec.cfm?mid=572766	Mus musculus, mouse, tubulin beta-4A	Wang et al. 2015. PNAS 112:E440-449 (PMID 25605905)
		NA	E444D	Q13885	https://www.uniprot.org/uniprotkb/Q13885/entry	H. sapiens	TBB2A SNP, DOID:1612 / breast cancer	Glu444Asp	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13885	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		NA	E444K	Q13885	https://www.uniprot.org/uniprotkb/Q13885/entry	H. sapiens	TBB2A SNP, DOID:263 / kidney cancer	Glu444Lys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13885	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		NA	E444K	Q13885	https://www.uniprot.org/uniprotkb/Q13885/entry	H. sapiens	TBB2A SNP, DOID:11054 / urinary bladder cancer	Glu444Lys	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13885	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		NA	S444L	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:1909 / melanoma	Ser444Leu	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		NA	S444L	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:9256 / colorectal cancer	Ser444Leu	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		NA	S444L	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Likely benign, with S372L, tubulin beta-3	Ser444Leu	ClinVar 160189	https://www.ncbi.nlm.nih.gov/clinvar/variation/160189	Homo sapiens, human, clinical
		NA	E445D	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:3571 / liver cancer	Glu445Asp	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		NA	F445C	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with F394C, F439C, F322C, tubulin beta-4A	Phe445Cys	ClinVar 267794	https://www.ncbi.nlm.nih.gov/clinvar/variation/267794	Homo sapiens, human, clinical
		NA	F445S	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Torsion dystonia, with F322S, F439S, F394S, tubulin beta-4A	Phe445Ser	ClinVar 689794	https://www.ncbi.nlm.nih.gov/clinvar/variation/689794	Homo sapiens, human, clinical
		NA	A446T	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	Likely benign, with A374T, tubulin beta-3	Ala446Thr	ClinVar 728804	https://www.ncbi.nlm.nih.gov/clinvar/variation/728804	Homo sapiens, human, clinical
		NA	Q446X	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Benomyl supersensitive, TUB2p	Gln446X	Aiken et al. 2014. Curr Biol. 24:1295-1303	https://pubmed.ncbi.nlm.nih.gov/24835459/	Saccharomyces cerevisiae, budding yeast, fungus
		NA	G448S	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:0070003 / blastoma	Gly448Ser	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		NA	G448S	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:3571 / liver cancer	Gly448Ser	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		NA	D449A	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Benomyl supersensitive, with E450A, TUB2p	Asp449Ala	Reijo et al. 1994. Mol Biol Cell 5:29-43	https://pubmed.ncbi.nlm.nih.gov/8186463/	Saccharomyces cerevisiae, budding yeast, fungus
		NA	P449L	Q13509	https://www.uniprot.org/uniprotkb/Q13509/entry	H. sapiens	TBB3 SNP, DOID:363 / uterine cancer	Pro449Leu	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q13509	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		NA	E450A	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Benomyl supersensitive, with D449A, TUB2p	Glu450Ala	Reijo et al. 1994. Mol Biol Cell 5:29-43	https://pubmed.ncbi.nlm.nih.gov/8186463/	Saccharomyces cerevisiae, budding yeast, fungus
		NA	G450E	Q9H4B7	https://www.uniprot.org/uniprotkb/Q9H4B7/entry	H. sapiens	TBB1 SNP, DOID:5041 / esophageal cancer	Gly450Glu	BioMuta	https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9H4B7	Homo sapiens, human, cancer SNP	See Dingerdissen et al. 2018. Nucleic Acids Res PMID 30053270
		NA	K450R	Q9ERD7	https://www.uniprot.org/uniprotkb/Q9ERD7/entry	M. musculus	Tubb3, viable heterozygote	Lys450Arg	Mutagenetix	https://mutagenetix.utsouthwestern.edu/incidental/incidental_rec.cfm?mid=323562	Mus musculus, mouse, tubulin beta-3	Wang et al. 2015. PNAS 112:E440-449 (PMID 25605905)
		NA	E454A	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Benomyl supersensitive, with E457A, TUB2p	Glu454Ala	Reijo et al. 1994. Mol Biol Cell 5:29-43	https://pubmed.ncbi.nlm.nih.gov/8186463/	Saccharomyces cerevisiae, budding yeast, fungus
		NA	E455K	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with E410K, E461K, E338K, tubulin beta-4A	Glu455Lys	ClinVar 135658	https://www.ncbi.nlm.nih.gov/clinvar/variation/135658	Homo sapiens, human, clinical
		NA	E457A	P02557	https://www.uniprot.org/uniprotkb/P02557/entry	S. cerevisiae	Benomyl supersensitive, with E454A, TUB2p	Glu457Ala	Reijo et al. 1994. Mol Biol Cell 5:29-43	https://pubmed.ncbi.nlm.nih.gov/8186463/	Saccharomyces cerevisiae, budding yeast, fungus
		NA	G457S	P07437	https://www.uniprot.org/uniprotkb/P07437/entry	H. sapiens	Likely benign, with G437S, G365S, G235S, G393S, tubulin beta	Gly457Ser	ClinVar 382889	https://www.ncbi.nlm.nih.gov/clinvar/variation/382889	Homo sapiens, human, clinical
		NA	E461K	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with E410K, E338K, E455K, tubulin beta-4A	Glu461Lys	ClinVar 135658	https://www.ncbi.nlm.nih.gov/clinvar/variation/135658	Homo sapiens, human, clinical
		NA	A484E	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with A439E, A490E, A367E, tubulin beta-4A	Ala484Glu	ClinVar 537238	https://www.ncbi.nlm.nih.gov/clinvar/variation/537238	Homo sapiens, human, clinical
		NA	A484V	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with A367V, A439V, A490V, tubulin beta-4A	Ala484Val	ClinVar 656505	https://www.ncbi.nlm.nih.gov/clinvar/variation/656505	Homo sapiens, human, clinical
		NA	A490E	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with A439E, A367E, A484E, tubulin beta-4A	Ala490Glu	ClinVar 537238	https://www.ncbi.nlm.nih.gov/clinvar/variation/537238	Homo sapiens, human, clinical
		NA	A490V	P04350	https://www.uniprot.org/uniprotkb/P04350/entry	H. sapiens	Leukodystrophy, hypomyelinating, with A367V, A439V, A484V, tubulin beta-4A	Ala490Val	ClinVar 656505	https://www.ncbi.nlm.nih.gov/clinvar/variation/656505	Homo sapiens, human, clinical